JP2019507135A5 - - Google Patents
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- JP2019507135A5 JP2019507135A5 JP2018540141A JP2018540141A JP2019507135A5 JP 2019507135 A5 JP2019507135 A5 JP 2019507135A5 JP 2018540141 A JP2018540141 A JP 2018540141A JP 2018540141 A JP2018540141 A JP 2018540141A JP 2019507135 A5 JP2019507135 A5 JP 2019507135A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 230000027455 binding Effects 0.000 claims 15
- 239000000126 substance Substances 0.000 claims 15
- 102000004965 antibodies Human genes 0.000 claims 6
- 108090001123 antibodies Proteins 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 5
- 230000035693 Fab Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- PQEJXGNZBLONLG-XJDOXCRVSA-N (2R)-2-amino-3-[1-[3-[2-[4-[1,3-bis(2-methoxyethylcarbamoyloxy)propan-2-yloxy]butanoylamino]ethylamino]-3-oxopropyl]-2,5-dioxopyrrolidin-3-yl]sulfanylpropanoic acid Chemical compound COCCNC(=O)OCC(COC(=O)NCCOC)OCCCC(=O)NCCNC(=O)CCN1C(=O)CC(SC[C@H](N)C(O)=O)C1=O PQEJXGNZBLONLG-XJDOXCRVSA-N 0.000 claims 1
- 229920002395 Aptamer Polymers 0.000 claims 1
- 206010003816 Autoimmune disease Diseases 0.000 claims 1
- 241000251730 Chondrichthyes Species 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 206010027665 Immune disorder Diseases 0.000 claims 1
- 206010021425 Immune system disease Diseases 0.000 claims 1
- 229940047124 Interferons Drugs 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 229940047122 Interleukins Drugs 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000000051 modifying Effects 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000002463 transducing Effects 0.000 claims 1
Claims (16)
- ３つの相補性決定領域（ＣＤＲ１、ＣＤＲ２、およびＣＤＲ３）を含む少なくとも１つのターゲティング部分を含むＣＤ８結合物質であって、
（ａ）ＣＤＲ１が、ＧＦＴＦＤＤＹＡＭＳ（配列番号１２）またはＧＦＴＦＤＤＹＡＩＧ（配列番号１３）から選択されるアミノ酸配列を含み、
（ｂ）ＣＤＲ２が、ＴＩＮＷＮＧＧＳＡＥＹＡＥＰＶＫＧ（配列番号１４）またはＣＩＲＶＳＤＧＳＴＹＹＡＤＰＶＫＧ（配列番号１５）から選択されるアミノ酸配列を含み、かつ
（ｃ）ＣＤＲ３が、ＫＤＡＤＬＶＷＹＮＬＳ（配列番号１６）またはＫＤＡＤＬＶＷＹＮＬＲ（配列番号１７）、およびＡＧＳＬＹＴＣＶＱＳＩＶＶＶＰＡＲＰＹＹＤＭＤＹ（配列番号１８）から選択されるアミノ酸配列を含む、
ＣＤ８結合物質。 - 前記ターゲティング部分が、完全長抗体、単一ドメイン抗体、組換え重鎖のみで構成される抗体（ＶＨＨ）、単鎖抗体（ｓｃＦｖ）、サメ重鎖のみで構成される抗体（ＶＮＡＲ）、マイクロタンパク質、ｄａｒｐｉｎ、アンチカリン、アドネクチン、アプタマー、Ｆｖ、Ｆａｂ、Ｆａｂ’、Ｆ（ａｂ’）２、ペプチド模倣分子、受容体に対する天然リガンド、または合成分子である、請求項１に記載のＣＤ８結合物質。
- 前記ターゲティング部分が、単一ドメイン抗体である、請求項１または２に記載のＣＤ８結合物質。
- 前記ターゲティング部分が、ＶＨＨ、ヒト化ＶＨＨ、またはラクダ化ＶＨＨを含む、請求項３に記載のＣＤ８結合物質。
- 前記ターゲティング部分が、ＧＦＴＦＤＤＹＡＭＳ（配列番号１２）のアミノ酸配列を含むＣＤＲ１、ＴＩＮＷＮＧＧＳＡＥＹＡＥＰＶＫＧ（配列番号１４）のアミノ酸配列を含むＣＤＲ２、およびＫＤＡＤＬＶＷＹＮＬＳ（配列番号１６）のアミノ酸配列を含むＣＤＲ３を含む、請求項１〜４のいずれか１項に記載のＣＤ８結合物質。
- 配列番号１９と少なくとも９０％の配列類似性を有するアミノ酸配列を含む、請求項５に記載のＣＤ８結合物質。
- 前記ターゲティング部分が、ＧＦＴＦＤＤＹＡＭＳ（配列番号１２）のアミノ酸配列を含むＣＤＲ１、ＴＩＮＷＮＧＧＳＡＥＹＡＥＰＶＫＧ（配列番号１４）のアミノ酸配列を含むＣＤＲ２、およびＫＤＡＤＬＶＷＹＮＬＲ（配列番号１７）のアミノ酸配列を含むＣＤＲ３を含む、請求項１〜４のいずれか１項に記載のＣＤ８結合物質。
- 配列番号２０と少なくとも９０％の配列類似性を有するアミノ酸配列を含む、請求項７に記載のＣＤ８結合物質。
- 前記ターゲティング部分が、ＧＦＴＦＤＤＹＡＩＧ（配列番号１３）のアミノ酸配列を含むＣＤＲ１、ＣＩＲＶＳＤＧＳＴＹＹＡＤＰＶＫＧ（配列番号１５）のアミノ酸配列を含むＣＤＲ２、およびＡＧＳＬＹＴＣＶＱＳＩＶＶＶＰＡＲＰＹＹＤＭＤＹ（配列番号１８）のアミノ酸配列を含むＣＤＲ３を含む、請求項１〜４のいずれか１項に記載のＣＤ８結合物質。
- 配列番号２１と少なくとも９０％の配列類似性を有するアミノ酸配列を含む、請求項９に記載のＣＤ８結合物質。
- 前記ＣＤ８結合物質が、１種または複数のシグナル伝達物質を含む、請求項１〜１０のいずれか１項に記載のＣＤ８結合物質。
- 前記シグナル伝達物質が、インターフェロン、インターロイキン、腫瘍壊死因子、およびそれらの改変された型の１種または複数から選択される、請求項１１に記載のＣＤ８結合物質。
- 前記ＣＤ８結合物質が、１つまたは複数の追加のターゲティング部分を含む、請求項１〜１２のいずれか１項に記載のＣＤ８結合物質。
- 前記１つまたは複数の追加のターゲティング部分が、腫瘍抗原または免疫細胞上の抗原を認識するまたは機能的に調節する、請求項１３に記載のＣＤ８結合物質。
- 癌、感染症、免疫異常、および／または自己免疫疾患のうちの１種または複数を処置するための薬物の製造のための請求項１〜１４のいずれか１項に記載のＣＤ８結合物質の使用。
- 請求項１〜１５のいずれか１項に記載のＣＤ８結合物質および薬学的に許容可能な賦形剤または担体を含む医薬組成物。
Applications Claiming Priority (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291779P | 2016-02-05 | 2016-02-05 | |
| US201662291772P | 2016-02-05 | 2016-02-05 | |
| US201662291776P | 2016-02-05 | 2016-02-05 | |
| US201662291769P | 2016-02-05 | 2016-02-05 | |
| US201662291774P | 2016-02-05 | 2016-02-05 | |
| US62/291,774 | 2016-02-05 | ||
| US62/291,772 | 2016-02-05 | ||
| US62/291,769 | 2016-02-05 | ||
| US62/291,779 | 2016-02-05 | ||
| US62/291,776 | 2016-02-05 | ||
| US201662335979P | 2016-05-13 | 2016-05-13 | |
| US201662335880P | 2016-05-13 | 2016-05-13 | |
| US201662335965P | 2016-05-13 | 2016-05-13 | |
| US201662336030P | 2016-05-13 | 2016-05-13 | |
| US201662335968P | 2016-05-13 | 2016-05-13 | |
| US62/335,968 | 2016-05-13 | ||
| US62/336,030 | 2016-05-13 | ||
| US62/335,965 | 2016-05-13 | ||
| US62/335,880 | 2016-05-13 | ||
| US62/335,979 | 2016-05-13 | ||
| US201662353607P | 2016-06-23 | 2016-06-23 | |
| US62/353,607 | 2016-06-23 | ||
| US201662411805P | 2016-10-24 | 2016-10-24 | |
| US62/411,805 | 2016-10-24 | ||
| PCT/EP2017/052553 WO2017134306A1 (en) | 2016-02-05 | 2017-02-06 | Cd8 binding agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507135A JP2019507135A (ja) | 2019-03-14 |
| JP2019507135A5 true JP2019507135A5 (ja) | 2020-03-19 |
| JP6991979B2 JP6991979B2 (ja) | 2022-03-04 |
Family
ID=57995193
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541289A Active JP7166923B2 (ja) | 2016-02-05 | 2017-02-06 | 標的療法剤およびその使用 |
| JP2018541357A Active JP7030704B2 (ja) | 2016-02-05 | 2017-02-06 | 二重特異性シグナル伝達物質およびその使用 |
| JP2018540141A Active JP6991979B2 (ja) | 2016-02-05 | 2017-02-06 | Ｃｄ８結合物質 |
| JP2018541133A Active JP7236273B2 (ja) | 2016-02-05 | 2017-02-06 | Ｃｌｅｃ９ａ結合物質 |
| JP2022025686A Active JP7386277B2 (ja) | 2016-02-05 | 2022-02-22 | 二重特異性シグナル伝達物質およびその使用 |
| JP2022110687A Pending JP2022153437A (ja) | 2016-02-05 | 2022-07-08 | 標的療法剤およびその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541289A Active JP7166923B2 (ja) | 2016-02-05 | 2017-02-06 | 標的療法剤およびその使用 |
| JP2018541357A Active JP7030704B2 (ja) | 2016-02-05 | 2017-02-06 | 二重特異性シグナル伝達物質およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541133A Active JP7236273B2 (ja) | 2016-02-05 | 2017-02-06 | Ｃｌｅｃ９ａ結合物質 |
| JP2022025686A Active JP7386277B2 (ja) | 2016-02-05 | 2022-02-22 | 二重特異性シグナル伝達物質およびその使用 |
| JP2022110687A Pending JP2022153437A (ja) | 2016-02-05 | 2022-07-08 | 標的療法剤およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US10988538B2 (ja) |
| EP (7) | EP4059957A1 (ja) |
| JP (6) | JP7166923B2 (ja) |
| CN (9) | CN117024599A (ja) |
| CA (4) | CA3013551A1 (ja) |
| DK (1) | DK3411065T3 (ja) |
| ES (1) | ES2877568T3 (ja) |
| WO (4) | WO2017134306A1 (ja) |
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