JP2018512138A5 - - Google Patents
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- JP2018512138A5 JP2018512138A5 JP2017550931A JP2017550931A JP2018512138A5 JP 2018512138 A5 JP2018512138 A5 JP 2018512138A5 JP 2017550931 A JP2017550931 A JP 2017550931A JP 2017550931 A JP2017550931 A JP 2017550931A JP 2018512138 A5 JP2018512138 A5 JP 2018512138A5
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- 239000011230 binding agent Substances 0.000 claims 32
- 125000003275 alpha amino acid group Chemical group 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 102000004965 antibodies Human genes 0.000 claims 6
- 108090001123 antibodies Proteins 0.000 claims 6
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 4
- 102000018358 Immunoglobulins Human genes 0.000 claims 4
- 108060003951 Immunoglobulins Proteins 0.000 claims 4
- 102000015728 Mucins Human genes 0.000 claims 4
- 108010063954 Mucins Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000038129 antigens Human genes 0.000 claims 3
- 108091007172 antigens Proteins 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- 230000035693 Fab Effects 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 208000001490 Dengue Diseases 0.000 claims 1
- 206010012310 Dengue fever Diseases 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 101710004393 HAVCR2 Proteins 0.000 claims 1
- 102100016384 HAVCR2 Human genes 0.000 claims 1
- 230000036499 Half live Effects 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 102100017213 LAG3 Human genes 0.000 claims 1
- 108060004270 LAG3 Proteins 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 208000002030 Merkel Cell Carcinoma Diseases 0.000 claims 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 1
- 102100019764 PDCD1 Human genes 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000006265 Renal Cell Carcinoma Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 108060007796 SPATA2 Proteins 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 101700008936 Tim8 Proteins 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 201000002949 dengue disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000006704 ulcerative colitis Diseases 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Claims (28)
- 配列番号３２９のアミノ酸配列を含む相補性決定領域１（ＣＤＲ１）、配列番号３３０のアミノ酸配列を含むＣＤＲ２、及び列番号３３１のアミノ酸配列を含むＣＤＲ３を含む免疫グロブリン重鎖可変（ＶＨ）領域；並びに
配列番号３３２のアミノ酸配列を含むＣＤＲ１、配列番号３３３のアミノ酸配列を含むＣＤＲ２、及び列番号３３４のアミノ酸配列を含むＣＤＲ３を含む免疫グロブリン軽鎖可変（ＶＬ）領域
を含む、Ｔ細胞免疫グロブリン及びムチンタンパク質３（ＴＩＭ−３）結合剤。 - 配列番号３３５のアミノ酸配列を含む相補性決定領域１（ＣＤＲ）、配列番号３３６のアミノ酸配列を含むＣＤＲ２、及び列番号３３７のアミノ酸配列を含むＣＤＲ３を含む免疫グロブリン重鎖可変（ＶＨ）領域；並びに
配列番号３３８のアミノ酸配列を含むＣＤＲ１、配列番号３３９のアミノ酸配列を含むＣＤＲ２、及び列番号３４０のアミノ酸配列を含むＣＤＲ３を含む免疫グロブリン軽鎖可変（ＶＬ）領域
を含む、Ｔ細胞免疫グロブリン及びムチンタンパク質３（ＴＩＭ−３）結合剤。 - 配列番号３２９又は３３５のアミノ酸配列を含む相補性決定領域１（ＣＤＲ１）、配列番号３３０又は３３６のアミノ酸配列を含むＣＤＲ２、及び列番号３３１又は３３７のアミノ酸配列を含むＣＤＲ３を含む免疫グロブリン重鎖可変（ＶＨ）領域；並びに
配列番号３３２又は３３８のアミノ酸配列を含むＣＤＲ１、配列番号３３３又は３３９のアミノ酸配列を含むＣＤＲ２、及び列番号３３４又は３４０のアミノ酸配列を含むＣＤＲ３を含む免疫グロブリン軽鎖可変（ＶＬ）領域
を含む、Ｔ細胞免疫グロブリン及びムチンタンパク質３（ＴＩＭ−３）結合剤。 - ＶＨ領域が配列番号３４又は２３８の配列と少なくとも９０％同一のアミノ酸配列を含み、ＶＬ領域が配列番号１１５又は３２７の配列と少なくとも９０％同一のアミノ酸配列を含む、請求項１〜３のいずれか１項に記載のＴＩＭ−３結合剤。
- 配列番号３４又は２３８の配列と少なくとも９０％同一の、免疫グロブリン重鎖可変（ＶＨ）領域のアミノ酸配列、及び配列番号１１５又は３２７の配列と少なくとも９０％同一の、免疫グロブリン軽鎖可変（ＶＬ）領域のアミノ酸配列を含む、Ｔ細胞免疫グロブリン及びムチンタンパク質３（ＴＩＭ−３）結合剤。
- ＶＨ領域が配列番号３４又は２３８の配列と少なくとも９５％同一のアミノ酸配列を含み、ＶＬ領域が配列番号１１５又は３２７の配列と少なくとも９５％同一のアミノ酸配列を含む、請求項１〜５のいずれか１項に記載のＴＩＭ−３結合剤。
- ＶＨ領域が配列番号３４の配列を含み、ＶＬ領域が配列番号１１５の配列を含む、請求項１又は３〜６のいずれか１項に記載のＴＩＭ−３結合剤。
- ＶＨ領域が配列番号２３８の配列を含み、ＶＬ領域が配列番号３２７の配列を含む、請求項２〜６のいずれか１項に記載のＴＩＭ−３結合剤。
- 抗体、抗体複合体又はそれらの抗原結合断片である、請求項１〜８のいずれか１項に記載のＴＩＭ−３結合剤。
- Ｆ（ａｂ’）２断片、Ｆａｂ’断片、Ｆａｂ断片、Ｆｖ断片、ｓｃＦｖ断片、ｄｓＦｖ断片、ｄＡｂ断片又は一本鎖結合ポリペプチドである、請求項９に記載のＴＩＭ−３結合剤。
- ＴＩＭ−３結合剤がＩｇＧ１、ＩｇＧ２若しくはＩｇＧ４の重鎖定常領域（Ｆｃ）を含む、請求項１〜１０のいずれか１項に記載のＴＩＭ−３結合剤。
- ＴＩＭ−３結合剤が最小のエフェクター機能を有するＦｃ領域含む、請求項１〜１１のいずれか１項に記載のＴＩＭ−３結合剤。
- 請求項１〜１２のいずれか１項に記載のＴＩＭ−３結合剤をコードする単離された核酸配列。
- 請求項１３に記載の単離された核酸配列を含むベクター。
- 請求項１４に記載のベクターを含む単離された細胞。
- （ａ）請求項１〜１２のいずれか１項に記載のＴＩＭ−３結合剤又は請求項１４に記載のベクター及び（ｂ）医薬的に許容される担体を含む、医薬組成物。
- 哺乳動物における、ＴＩＭ−３阻害に応答する病気の治療において使用するための、請求項１〜１２のいずれか１項に記載のＴＩＭ−３結合剤又は請求項１６に記載の医薬組成物。
- 前記病気ががんである、請求項１７に記載のＴＩＭ−３結合剤又は医薬組成物。
- 前記がんが、メラノーマ、腎臓細胞がん、肺がん、膀胱がん、乳がん、子宮頸がん、結腸がん、胆嚢がん、喉頭がん、肝臓がん、甲状腺がん、胃がん、唾液腺がん、前立腺がん、膵臓がん又はメルケル細胞がんである、請求項１８に記載のＴＩＭ−３結合剤又は医薬組成物。
- 前記病気が感染症である、請求項１７に記載のＴＩＭ−３結合剤又は医薬組成物。
- 前記感染症が、ウイルス又は細菌によって引き起こされる、請求項２０に記載のＴＩＭ−３結合剤又は医薬組成物。
- 前記ウイルスが、ヒト免疫不全ウイルス（ＨＩＶ）、呼吸器合胞体ウイルス（ＲＳＶ）、インフルエンザウイルス、デング熱ウイルス又はＢ型肝炎ウイルス（ＨＢＶ）である、請求項２１に記載のＴＩＭ−３結合剤又は医薬組成物。
- 前記病気が自己免疫疾患である、請求項１７に記載のＴＩＭ−３結合剤又は医薬組成物。
- 前記自己免疫疾患が、多発性硬化症、１型真性糖尿病、関節リウマチ、強皮症、クローン病、乾癬、全身性エリトマトーデス（ＳＬＥ）又は潰瘍性大腸炎である、請求項２３に記載のＴＩＭ−３結合剤又は医薬組成物。
- 哺乳動物におけるＴＩＭ−３結合剤の半減期が、３０分〜４５日の間である、請求項１７〜２４のいずれか１項に記載のＴＩＭ−３結合剤又は医薬組成物。
- 前記ＴＩＭ−３結合剤が、約１ピコモーラー（ｐＭ）〜約１００マイクロモーラー（μＭ）の間のＫＤでＴＩＭ−３に結合する、請求項１７〜２５のいずれか１項に記載のＴＩＭ−３結合剤又は医薬組成物。
- 必要に応じて抗体、抗体複合体又はそれらの抗原結合断片であるＰＤ−１結合剤と組み合わせた、請求項１７〜２５のいずれか１項に記載のＴＩＭ−３結合剤又は医薬組成物。
- 必要に応じて抗体、抗体複合体又はそれらの抗原結合断片であるＬＡＧ−３結合剤と組み合わせた、請求項１７〜２５のいずれか１項に記載のＴＩＭ−３結合剤又は医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562141353P | 2015-04-01 | 2015-04-01 | |
| US62/141,353 | 2015-04-01 | ||
| PCT/US2016/025532 WO2016161270A1 (en) | 2015-04-01 | 2016-04-01 | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512138A JP2018512138A (ja) | 2018-05-17 |
| JP2018512138A5 true JP2018512138A5 (ja) | 2019-05-16 |
| JP6949717B2 JP6949717B2 (ja) | 2021-10-13 |
Family
ID=57007695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550931A Active JP6949717B2 (ja) | 2015-04-01 | 2016-04-01 | Ｔ細胞免疫グロブリン及びムチンタンパク質３（ｔｉｍ−３）に対する抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10508149B2 (ja) |
| EP (1) | EP3277321A4 (ja) |
| JP (1) | JP6949717B2 (ja) |
| KR (1) | KR20170133458A (ja) |
| CN (2) | CN114539409A (ja) |
| AU (1) | AU2016242964C1 (ja) |
| BR (1) | BR112017021040A2 (ja) |
| CA (1) | CA2981520A1 (ja) |
| EA (1) | EA201792184A1 (ja) |
| HK (1) | HK1251150A1 (ja) |
| IL (2) | IL283006B2 (ja) |
| MA (1) | MA41867A (ja) |
| MX (1) | MX2017012429A (ja) |
| SG (2) | SG10201909173PA (ja) |
| WO (1) | WO2016161270A1 (ja) |
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- 2016-04-01 CA CA2981520A patent/CA2981520A1/en active Pending
- 2016-04-01 EP EP16774301.2A patent/EP3277321A4/en active Pending
- 2016-04-01 JP JP2017550931A patent/JP6949717B2/ja active Active
- 2016-04-01 US US15/563,924 patent/US10508149B2/en active Active
- 2016-04-01 WO PCT/US2016/025532 patent/WO2016161270A1/en active Application Filing
- 2016-04-01 KR KR1020177031599A patent/KR20170133458A/ko not_active Application Discontinuation
- 2016-04-01 BR BR112017021040A patent/BR112017021040A2/pt active Search and Examination
- 2016-04-01 EA EA201792184A patent/EA201792184A1/ru unknown
- 2016-04-01 IL IL283006A patent/IL283006B2/en unknown
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- 2016-04-01 AU AU2016242964A patent/AU2016242964C1/en active Active
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2017
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2018
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2019
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2022
- 2022-05-03 US US17/661,841 patent/US20220363759A1/en active Pending
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