|
US778A
(en)
|
|
1838-06-12 |
|
Thomas wright |
|
US4946A
(en)
|
|
1847-01-26 |
|
Improvement in carriage-wheels |
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4740461A
(en)
|
1983-12-27 |
1988-04-26 |
Genetics Institute, Inc. |
Vectors and methods for transformation of eucaryotic cells
|
|
DE3572982D1
(en)
|
1984-03-06 |
1989-10-19 |
Takeda Chemical Industries Ltd |
Chemically modified lymphokine and production thereof
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
DE3668186D1
(de)
|
1985-04-01 |
1990-02-15 |
Celltech Ltd |
Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US4959455A
(en)
|
1986-07-14 |
1990-09-25 |
Genetics Institute, Inc. |
Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
ATE87659T1
(de)
|
1986-09-02 |
1993-04-15 |
Enzon Lab Inc |
Bindungsmolekuele mit einzelpolypeptidkette.
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4912040A
(en)
|
1986-11-14 |
1990-03-27 |
Genetics Institute, Inc. |
Eucaryotic expression system
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
CA2006596C
(en)
|
1988-12-22 |
2000-09-05 |
Rika Ishikawa |
Chemically-modified g-csf
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5976877A
(en)
|
1990-01-08 |
1999-11-02 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses
|
|
FR2656800B1
(fr)
|
1990-01-08 |
1992-05-15 |
Roussy Inst Gustave |
Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
CA2089661C
(en)
|
1990-08-29 |
2007-04-03 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
AU4116793A
(en)
|
1992-04-24 |
1993-11-29 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
|
ATE452975T1
(de)
|
1992-08-21 |
2010-01-15 |
Univ Bruxelles |
Immunoglobuline ohne leichte ketten
|
|
ATE204325T1
(de)
|
1993-04-29 |
2001-09-15 |
Unilever Nv |
Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae
|
|
EP0714409A1
(en)
|
1993-06-16 |
1996-06-05 |
Celltech Therapeutics Limited |
Antibodies
|
|
CN1110557C
(zh)
|
1994-05-06 |
2003-06-04 |
古斯达威罗斯研究所 |
Lag-3蛋白的可溶性多肽组分;生产方法、治疗组合物、抗独特型抗体
|
|
US5532210A
(en)
|
1994-06-08 |
1996-07-02 |
E. I. Du Pont De Nemours And Company |
High temperature superconductor dielectric slow wave structures for accelerators and traveling wave tubes
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
JP2000508226A
(ja)
|
1995-07-21 |
2000-07-04 |
アプライド リサーチ システムズ アース ホールディング エヌ.ヴィ. |
Lag−3タンパク質によるth1リンパ球を検出、同定、単離並びに選択的に標識およびターゲッティングする方法
|
|
JP2000516101A
(ja)
|
1996-11-28 |
2000-12-05 |
アンスティテュ ギュスタブ ルシ |
Lag−3タンパク質の変異体、その発現及び使用
|
|
BR9612821A
(pt)
|
1996-11-29 |
2000-04-11 |
Applied Research Systems |
Métodos para a prevenção de rejeição de enxerto em transplante e para a produção de uma célula de hospedeiro para terapia genética universal
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
EP0900841A1
(en)
|
1997-06-18 |
1999-03-10 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
LAG-3 splice variants
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
JP2002531466A
(ja)
|
1998-12-01 |
2002-09-24 |
プロテイン デザイン ラブス, インコーポレイテッド |
γ−インターフェロンに対するヒト化抗体
|
|
KR101155191B1
(ko)
|
1999-01-15 |
2012-06-13 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
ES2568899T3
(es)
|
1999-04-09 |
2016-05-05 |
Kyowa Hakko Kirin Co., Ltd. |
Procedimiento para controlar la actividad de una molécula inmunofuncional
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
US7795002B2
(en)
|
2000-06-28 |
2010-09-14 |
Glycofi, Inc. |
Production of galactosylated glycoproteins in lower eukaryotes
|
|
DE60114830T2
(de)
|
2000-06-28 |
2006-08-03 |
Glycofi, Inc. |
Verfahren zur herstellung modifizierter glycoproteine
|
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
|
ES2367891T3
(es)
|
2000-09-29 |
2011-11-10 |
Schering Corporation |
Interleucina-10 pegilada.
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
SE0103423D0
(sv)
|
2001-10-12 |
2001-10-12 |
Astrazeneca Ab |
Polymorphism
|
|
AU2003226356A1
(en)
|
2002-04-12 |
2003-10-27 |
Ramot At Tel Aviv University Ltd. |
Prevention of brain inflammation as a result of induced autoimmune response
|
|
ES2439580T5
(en)
|
2003-02-28 |
2025-01-23 |
Univ Johns Hopkins |
T cell regulation
|
|
US7410483B2
(en)
|
2003-05-23 |
2008-08-12 |
Novare Surgical Systems, Inc. |
Hand-actuated device for remote manipulation of a grasping tool
|
|
PE20090047A1
(es)
|
2003-11-10 |
2009-01-26 |
Schering Corp |
Anticuerpo recombinante humanizado anti-interleuquina 10
|
|
DE602005022871D1
(de)
|
2004-06-07 |
2010-09-23 |
Univ Ramot |
Verfahren zur passiven immunisierung gegen eine durch amyloidaggregation gekennzeichnete krankheit oder erkrankung mit vermindertem nervenentzündungsrisiko
|
|
EP1786469A2
(en)
*
|
2004-09-10 |
2007-05-23 |
Wyeth a Corporation of the State of Delaware |
Humanized anti-5t4 antibodies and anti-5t4 antibody / calicheamicin conjugates
|
|
AU2006229549B2
(en)
|
2005-03-31 |
2011-04-07 |
Leiden University Medical Center |
Methods and means for diagnostics, prevention and treatment of Mycobacterium infections and tuberculosis disease
|
|
US9244059B2
(en)
|
2007-04-30 |
2016-01-26 |
Immutep Parc Club Orsay |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
|
NZ587440A
(en)
*
|
2008-02-05 |
2013-01-25 |
Pfizer |
Antibodies specific for human integrin alpha 5 - beta 1 and their uses for treating tumours
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
CN102438652B
(zh)
|
2008-11-12 |
2014-08-13 |
米迪缪尼有限公司 |
抗体制剂
|
|
IL323000A
(en)
|
2010-03-05 |
2025-10-01 |
Univ Johns Hopkins |
Compositions and methods for antibodies and fusion proteins targeted for immune modulation
|
|
CA2840170A1
(en)
|
2011-06-21 |
2012-12-27 |
The Johns Hopkins University |
Focused radiation for augmenting immune-based therapies against neoplasms
|
|
PT2726101T
(pt)
|
2011-06-30 |
2018-11-21 |
Genzyme Corp |
Inibidores da ativação de células t
|
|
EP2773661A4
(en)
|
2011-10-31 |
2015-06-17 |
Merck Sharp & Dohme |
PROCESS FOR PREPARING ANTIBODIES WITH IMPROVED PROPERTIES
|
|
WO2013066765A1
(en)
|
2011-11-01 |
2013-05-10 |
Merck Sharp & Dohme Corp. |
Mutation of tup1 in glycoengineered yeast
|
|
GB201120527D0
(en)
|
2011-11-29 |
2012-01-11 |
Ucl Business Plc |
Method
|
|
JP6441792B2
(ja)
*
|
2012-05-17 |
2018-12-19 |
ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. |
Egfrに結合する抗原結合蛋白質
|
|
US20150132272A1
(en)
|
2012-06-18 |
2015-05-14 |
Yale University |
Compositions and methods for diminishing an immune response
|
|
UY34887A
(es)
*
|
2012-07-02 |
2013-12-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
|
|
AU2013302696B9
(en)
|
2012-08-14 |
2018-08-09 |
Ibc Pharmaceuticals, Inc. |
T-cell redirecting bispecific antibodies for treatment of disease
|
|
CN104884089A
(zh)
|
2012-08-21 |
2015-09-02 |
葛兰素集团有限公司 |
包含单一可变域和甲磺酸卡莫司他(cm)的组合物
|
|
US20150209319A1
(en)
|
2012-08-21 |
2015-07-30 |
Glaxo Group Limited |
Compositions comprising an antibody and camostat mesylate (cm)
|
|
EP3666886A1
(en)
|
2013-03-15 |
2020-06-17 |
Dana-Farber Cancer Institute, Inc. |
Therapeutic peptides
|
|
HUE049957T2
(hu)
|
2013-03-15 |
2020-11-30 |
Glaxosmithkline Ip Dev Ltd |
Lag-3 elleni kötõfehérjék
|
|
CN105073128A
(zh)
|
2013-04-03 |
2015-11-18 |
Ibc药品公司 |
用于诱导对疾病的免疫应答的组合疗法
|
|
HRP20210122T1
(hr)
|
2013-05-02 |
2021-04-16 |
Anaptysbio, Inc. |
Protutijela usmjerena protiv programirane smrti-1 (pd-1)
|
|
WO2014209804A1
(en)
|
2013-06-24 |
2014-12-31 |
Biomed Valley Discoveries, Inc. |
Bispecific antibodies
|
|
AU2014296887A1
(en)
|
2013-08-02 |
2016-01-28 |
Aduro Biotech Holdings, Europe B.V. |
Combining CD27 agonists and immune checkpoint inhibition for immune stimulation
|
|
PL3508502T3
(pl)
|
2013-09-20 |
2023-07-17 |
Bristol-Myers Squibb Company |
Kombinacja przeciwciał anty-lag-3 i przeciwciał anty-pd-1 w leczeniu raka
|
|
US10570204B2
(en)
|
2013-09-26 |
2020-02-25 |
The Medical College Of Wisconsin, Inc. |
Methods for treating hematologic cancers
|
|
JP2016540042A
(ja)
|
2013-11-05 |
2016-12-22 |
コグネート バイオサービシズ, インコーポレイテッド |
がんを処置するためのチェックポイント阻害剤および治療薬の組合せ
|
|
KR20160070095A
(ko)
|
2013-11-05 |
2016-06-17 |
버베리안 노딕 에이/에스 |
종양 항원을 발현하는 폭스바이러스 및 면역 관문 저해제의 길항제 및/또는 효현제를 구비하는 암을 치료하기 위한 복합제 치료제
|
|
CA2932767A1
(en)
|
2013-12-06 |
2015-06-11 |
Dana-Farber Cancer Institute, Inc. |
Therapeutic peptides
|
|
GB201322626D0
(en)
|
2013-12-19 |
2014-02-05 |
Immutep S A |
Combined preparations for the treatment of cancer
|
|
GB201322725D0
(en)
|
2013-12-20 |
2014-02-05 |
Immodulon Therapeutics Ltd |
Cancer therapy
|
|
CA2936244A1
(en)
|
2014-01-21 |
2015-07-30 |
Medimmune, Llc |
Compositions and methods for modulating and redirecting immune responses
|
|
HRP20212033T1
(hr)
|
2014-01-28 |
2022-04-01 |
Bristol-Myers Squibb Company |
Anti-lag-3 antitijela za liječenje hematoloških maligniteta
|
|
LT3116909T
(lt)
*
|
2014-03-14 |
2020-02-10 |
Novartis Ag |
Antikūno molekulės prieš lag-3 ir jų panaudojimas
|
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
|
EP3160497A4
(en)
|
2014-06-27 |
2018-01-17 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Conjugates for immunotherapy
|
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
|
ES2929532T3
(es)
|
2015-01-29 |
2022-11-30 |
Univ Pennsylvania |
Combinaciones de inhibidores de puntos de control y vacunas y su uso en inmunoterapia
|
|
MA41463A
(fr)
|
2015-02-03 |
2017-12-12 |
Anaptysbio Inc |
Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3)
|
|
KR102740444B1
(ko)
|
2015-04-17 |
2024-12-10 |
브리스톨-마이어스 스큅 컴퍼니 |
항-pd-1 항체 및 또 다른 항체의 조합물을 포함하는 조성물
|
|
TWI773646B
(zh)
|
2015-06-08 |
2022-08-11 |
美商宏觀基因股份有限公司 |
結合lag-3的分子和其使用方法
|
|
CA2993177A1
(en)
|
2015-07-22 |
2017-01-26 |
Sorrento Therapeutics, Inc. |
Antibody therapeutics that bind lag3
|
|
EP3317301B1
(en)
|
2015-07-29 |
2021-04-07 |
Novartis AG |
Combination therapies comprising antibody molecules to lag-3
|