JP2011519868A5

JP2011519868A5 -

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Publication number: JP2011519868A5
Authority: JP; Japan
Prior art keywords: antibody; cancer; inhibitor; drug; ser
Prior art date: 2009-05-04
Legal status : Withdrawn

Application number

JP2011507707A

Other languages

English (en)

Japanese (ja)

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JP2011519868A (ja

Filing date

2009-05-04

Publication date

2012-06-07

2009-05-04 Application filed filed Critical

2009-05-04 Priority claimed from PCT/US2009/042657 external-priority patent/WO2009137378A2/en

2011-07-14 Publication of JP2011519868A publication Critical patent/JP2011519868A/ja

2012-06-07 Publication of JP2011519868A5 publication Critical patent/JP2011519868A5/ja

Status Withdrawn legal-status Critical Current

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-1 AV-299 Chemical compound 0.000 claims description 70
239000003112 inhibitor Substances 0.000 claims description 30
102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 18
239000012634 fragment Substances 0.000 claims description 18
239000002246 antineoplastic agent Substances 0.000 claims description 17
150000001413 amino acids Chemical group 0.000 claims description 16
101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims description 14
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims description 12
229940127089 cytotoxic agent Drugs 0.000 claims description 10
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 10
HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims description 8
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RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 claims description 7
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JP2011507707A 2008-05-05 2009-05-04 癌を処置するための化学療法剤の連続投与 Withdrawn JP2011519868A (ja)