JP2011515478A5

JP2011515478A5 -

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Publication number: JP2011515478A5
Authority: JP; Japan
Prior art keywords: inhibitor; antibody; cdr; ser; composition
Prior art date: 2009-03-23
Legal status : Pending

Application number

JP2011501946A

Other languages

English (en)

Japanese (ja)

Other versions

JP2011515478A (ja

Filing date

2009-03-23

Publication date

2013-03-14

2009-03-23 Application filed filed Critical

2009-03-23 Priority claimed from PCT/US2009/037953 external-priority patent/WO2009142810A2/en

2011-05-19 Publication of JP2011515478A publication Critical patent/JP2011515478A/ja

2013-03-14 Publication of JP2011515478A5 publication Critical patent/JP2011515478A5/ja

Status Pending legal-status Critical Current

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-1 AV-299 Chemical compound 0.000 claims description 112
239000003112 inhibitor Substances 0.000 claims description 32
239000012634 fragment Substances 0.000 claims description 26
238000000034 method Methods 0.000 claims description 23
239000000203 mixture Substances 0.000 claims description 23
150000001413 amino acids Chemical group 0.000 claims description 22
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims description 16
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 16
239000002246 antineoplastic agent Substances 0.000 claims description 13
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 12
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RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 claims description 12
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JP2011501946A 2008-03-25 2009-03-23 結腸直腸がんを処置または予防するための方法 Pending JP2011515478A (ja)