JP2019203015A5 - - Google Patents
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- JP2019203015A5 JP2019203015A5 JP2019141806A JP2019141806A JP2019203015A5 JP 2019203015 A5 JP2019203015 A5 JP 2019203015A5 JP 2019141806 A JP2019141806 A JP 2019141806A JP 2019141806 A JP2019141806 A JP 2019141806A JP 2019203015 A5 JP2019203015 A5 JP 2019203015A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- compound according
- solvate
- diabetes
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000001421 hyperglycemia Diseases 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 206010012655 Diabetic complications Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- ZQNPDAVSHFGLIQ-UHFFFAOYSA-N calcium;hydrate Chemical compound O.[Ca] ZQNPDAVSHFGLIQ-UHFFFAOYSA-N 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 239000011877 solvent mixture Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021164974A JP7280929B2 (ja) | 2016-09-26 | 2021-10-06 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016187605 | 2016-09-26 | ||
| JP2016187605 | 2016-09-26 | ||
| JP2018540344A JP6567778B2 (ja) | 2016-09-26 | 2017-09-26 | Ｇｌｐ−１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540344A Division JP6567778B2 (ja) | 2016-09-26 | 2017-09-26 | Ｇｌｐ−１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021164974A Division JP7280929B2 (ja) | 2016-09-26 | 2021-10-06 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019203015A JP2019203015A (ja) | 2019-11-28 |
| JP2019203015A5 true JP2019203015A5 (enExample) | 2020-11-05 |
| JP6957564B2 JP6957564B2 (ja) | 2021-11-02 |
Family
ID=61689595
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540344A Active JP6567778B2 (ja) | 2016-09-26 | 2017-09-26 | Ｇｌｐ−１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
| JP2019141806A Active JP6957564B2 (ja) | 2016-09-26 | 2019-07-31 | Ｇｌｐ−１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
| JP2021164974A Active JP7280929B2 (ja) | 2016-09-26 | 2021-10-06 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
| JP2023079006A Active JP7602573B2 (ja) | 2016-09-26 | 2023-05-12 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540344A Active JP6567778B2 (ja) | 2016-09-26 | 2017-09-26 | Ｇｌｐ−１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021164974A Active JP7280929B2 (ja) | 2016-09-26 | 2021-10-06 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
| JP2023079006A Active JP7602573B2 (ja) | 2016-09-26 | 2023-05-12 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
Country Status (38)
Families Citing this family (68)
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