JP2024071370A5 - - Google Patents
Info
- Publication number
- JP2024071370A5 JP2024071370A5 JP2023193597A JP2023193597A JP2024071370A5 JP 2024071370 A5 JP2024071370 A5 JP 2024071370A5 JP 2023193597 A JP2023193597 A JP 2023193597A JP 2023193597 A JP2023193597 A JP 2023193597A JP 2024071370 A5 JP2024071370 A5 JP 2024071370A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- represented
- formula
- following structure
- pharma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025149982A JP2025179208A (ja) | 2022-11-14 | 2025-09-10 | 大環状ｋｒａｓ阻害剤及び使用方法 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263383674P | 2022-11-14 | 2022-11-14 | |
| US63/383,674 | 2022-11-14 | ||
| US202363497978P | 2023-04-24 | 2023-04-24 | |
| US63/497,978 | 2023-04-24 | ||
| US202363582751P | 2023-09-14 | 2023-09-14 | |
| US63/582,751 | 2023-09-14 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025149982A Division JP2025179208A (ja) | 2022-11-14 | 2025-09-10 | 大環状ｋｒａｓ阻害剤及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024071370A JP2024071370A (ja) | 2024-05-24 |
| JP2024071370A5 true JP2024071370A5 (enExample) | 2025-07-22 |
| JP7743484B2 JP7743484B2 (ja) | 2025-09-24 |
Family
ID=91085388
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023193597A Active JP7743484B2 (ja) | 2022-11-14 | 2023-11-14 | 大環状ｋｒａｓ阻害剤及び使用方法 |
| JP2025527103A Pending JP2025539080A (ja) | 2022-11-14 | 2023-11-14 | 大環状ｋｒａｓ阻害剤及び使用方法 |
| JP2025149982A Pending JP2025179208A (ja) | 2022-11-14 | 2025-09-10 | 大環状ｋｒａｓ阻害剤及び使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025527103A Pending JP2025539080A (ja) | 2022-11-14 | 2023-11-14 | 大環状ｋｒａｓ阻害剤及び使用方法 |
| JP2025149982A Pending JP2025179208A (ja) | 2022-11-14 | 2025-09-10 | 大環状ｋｒａｓ阻害剤及び使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20240294551A1 (enExample) |
| EP (1) | EP4598921A1 (enExample) |
| JP (3) | JP7743484B2 (enExample) |
| KR (1) | KR20250095749A (enExample) |
| CN (1) | CN120500482A (enExample) |
| AU (1) | AU2023382606A1 (enExample) |
| CL (1) | CL2025001425A1 (enExample) |
| CO (1) | CO2025006813A2 (enExample) |
| IL (1) | IL320388A (enExample) |
| MX (1) | MX2025005539A (enExample) |
| PE (1) | PE20252237A1 (enExample) |
| TW (1) | TW202430532A (enExample) |
| WO (1) | WO2024107686A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120813588A (zh) | 2023-02-14 | 2025-10-17 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的三环化合物 |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025123007A1 (en) * | 2023-12-08 | 2025-06-12 | Kestrel Therapeutics Inc. | Ras inhibitors and methods of use thereof |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025194057A1 (en) * | 2024-03-14 | 2025-09-18 | Amgen Inc. | Macrocyclic compounds as modulators of kras and uses thereof |
| WO2025194054A1 (en) * | 2024-03-14 | 2025-09-18 | Amgen Inc. | Spirocyclic compounds as modulators of kras and uses thereof |
| WO2025230860A1 (en) * | 2024-04-29 | 2025-11-06 | Amgen Inc. | Solid forms of macrocyclic compounds and uses thereof |
| WO2025230878A1 (en) * | 2024-04-29 | 2025-11-06 | Amgen Inc. | Macrocyclic compounds as modulators of kras and uses thereof |
| WO2025230862A1 (en) * | 2024-04-29 | 2025-11-06 | Amgen Inc. | Macrocyclic amino compounds as modulators of kras and uses therof |
| WO2025240582A1 (en) * | 2024-05-14 | 2025-11-20 | Amgen Inc. | Macrocyclic compounds as modulators of kras and uses thereof |
| WO2025240465A1 (en) * | 2024-05-14 | 2025-11-20 | Amgen Inc. | Processes for preparing macrocyclic compounds |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7622043B2 (ja) * | 2019-08-29 | 2025-01-27 | ミラティ セラピューティクス， インコーポレイテッド | Ｋｒａｓ ｇ１２ｄ阻害剤 |
| CN115003668A (zh) * | 2020-01-21 | 2022-09-02 | 南京明德新药研发有限公司 | 作为kras抑制剂的大环类化合物 |
| IL303446A (en) | 2020-12-15 | 2023-08-01 | Mirati Therapeutics Inc | Azaquinazoline compounds as PAN-KRas inhibitors |
| WO2022133038A1 (en) | 2020-12-16 | 2022-06-23 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| IL304986A (en) | 2021-02-16 | 2023-10-01 | Theras Inc | Compositions and methods for inhibition of ras |
| EP4310091A4 (en) | 2021-03-17 | 2025-04-16 | Genfleet Therapeutics (Shanghai) Inc. | Pyrimidine-fused cyclic compound, preparation method therefor and use thereof |
| WO2022214102A1 (zh) | 2021-04-09 | 2022-10-13 | 杭州英创医药科技有限公司 | 作为kras g12d抑制剂的杂环化合物 |
| CN115304623A (zh) | 2021-04-30 | 2022-11-08 | 四川海思科制药有限公司 | 一种嘧啶并环衍生物及其在医药上的应用 |
-
2023
- 2023-11-14 AU AU2023382606A patent/AU2023382606A1/en active Pending
- 2023-11-14 JP JP2023193597A patent/JP7743484B2/ja active Active
- 2023-11-14 TW TW112143850A patent/TW202430532A/zh unknown
- 2023-11-14 PE PE2025001022A patent/PE20252237A1/es unknown
- 2023-11-14 WO PCT/US2023/079582 patent/WO2024107686A1/en not_active Ceased
- 2023-11-14 KR KR1020257019826A patent/KR20250095749A/ko active Pending
- 2023-11-14 JP JP2025527103A patent/JP2025539080A/ja active Pending
- 2023-11-14 CN CN202380088000.9A patent/CN120500482A/zh active Pending
- 2023-11-14 IL IL320388A patent/IL320388A/en unknown
- 2023-11-14 EP EP23892383.3A patent/EP4598921A1/en active Pending
-
2024
- 2024-03-25 US US18/614,911 patent/US20240294551A1/en active Pending
- 2024-10-30 US US18/931,588 patent/US20250304599A1/en active Pending
-
2025
- 2025-04-11 US US19/176,333 patent/US20250236631A1/en active Pending
- 2025-05-12 MX MX2025005539A patent/MX2025005539A/es unknown
- 2025-05-14 CL CL2025001425A patent/CL2025001425A1/es unknown
- 2025-05-23 CO CONC2025/0006813A patent/CO2025006813A2/es unknown
- 2025-09-10 JP JP2025149982A patent/JP2025179208A/ja active Pending