CN109790161B - 具有glp-1受体激动剂作用的吡唑并吡啶衍生物 - Google Patents
具有glp-1受体激动剂作用的吡唑并吡啶衍生物 Download PDFInfo
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- CN109790161B CN109790161B CN201780059135.7A CN201780059135A CN109790161B CN 109790161 B CN109790161 B CN 109790161B CN 201780059135 A CN201780059135 A CN 201780059135A CN 109790161 B CN109790161 B CN 109790161B
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016-187605 | 2016-09-26 | ||
| JP2016187605 | 2016-09-26 | ||
| PCT/JP2017/034620 WO2018056453A1 (ja) | 2016-09-26 | 2017-09-26 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109790161A CN109790161A (zh) | 2019-05-21 |
| CN109790161B true CN109790161B (zh) | 2022-03-11 |
Family
ID=61689595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780059135.7A Active CN109790161B (zh) | 2016-09-26 | 2017-09-26 | 具有glp-1受体激动剂作用的吡唑并吡啶衍生物 |
Country Status (38)
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| JP2021501768A (ja) * | 2017-11-02 | 2021-01-21 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Ｂ型肝炎ウイルス（ｈｂｖ）に対し活性を有する新規の高活性なピラゾロ−ピペリジン置換インドール−２−カルボキサミド |
| JP7461104B2 (ja) * | 2017-11-29 | 2024-04-03 | 中外製薬株式会社 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体を含有する医薬組成物 |
| US10934279B2 (en) | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| CA3140972C (en) * | 2019-05-20 | 2024-06-18 | Pfizer Inc. | Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases |
| JP7360301B2 (ja) | 2019-11-08 | 2023-10-12 | Ｋｙｂ株式会社 | 作動流体供給システム |
| FI4097099T3 (fi) | 2020-02-07 | 2024-07-30 | Gasherbrum Bio Inc | Heterosyklisiä glp-1-agonisteja |
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| WO2021249492A1 (zh) * | 2020-06-10 | 2021-12-16 | 南京明德新药研发有限公司 | 甲基取代的苯并二噁唑类化合物及其应用 |
| IL299704A (en) * | 2020-07-20 | 2023-03-01 | Eccogene Shanghai Co Ltd | Tetrahydropyrazolo-pyrazinyl-dihydroimidazolone or tetrahydropyrazolo-pyridinyl-dihydroimidazolone compounds and methods of using them |
| CR20230066A (es) * | 2020-08-06 | 2023-05-29 | Gasherbrum Bio Inc | Agonistas del glp-1 heterocíclicos |
| JP2023538949A (ja) | 2020-08-28 | 2023-09-12 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| JP2023539584A (ja) | 2020-09-01 | 2023-09-15 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
| EP4211133A4 (en) * | 2020-09-07 | 2024-11-27 | Gasherbrum Bio, Inc. | HETEROCYCLIC GLP-1 AGONISTS |
| JP2023540609A (ja) * | 2020-09-10 | 2023-09-25 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| US12454511B2 (en) * | 2020-10-08 | 2025-10-28 | Eli Lilly And Company | 6-methoxy-3,4-dihydro-1H-isoquinolin compounds |
| WO2022078152A1 (zh) | 2020-10-12 | 2022-04-21 | 杭州中美华东制药有限公司 | 苯并咪唑酮类glp-1受体激动剂及其用途 |
| US20240246959A1 (en) | 2020-11-27 | 2024-07-25 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | Benzimidazole derivative and preparation method therefor and medical use thereof |
| US20240208952A1 (en) | 2021-03-22 | 2024-06-27 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | Thiophene glp-1 receptor agonist and use thereof |
| WO2022202864A1 (ja) | 2021-03-24 | 2022-09-29 | 塩野義製薬株式会社 | 縮合環を有するｇｌｐ－１受容体作動薬を含有する医薬組成物 |
| CN117098758A (zh) | 2021-06-24 | 2023-11-21 | 杭州中美华东制药有限公司 | Glp-1受体激动剂及其组合物和用途 |
| WO2023016546A1 (en) * | 2021-08-12 | 2023-02-16 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| WO2023025201A1 (zh) * | 2021-08-24 | 2023-03-02 | 南京明德新药研发有限公司 | 咪唑并环类化合物及其应用 |
| CN118948849A (zh) | 2021-09-08 | 2024-11-15 | 盐野义制药株式会社 | 用于预防和治疗与抗肥胖作用有关的疾病的药物 |
| HRP20251161T1 (hr) | 2021-09-27 | 2025-11-21 | Terns Pharmaceuticals, Inc. | Benzimidazol karboksilne kisele kao agonisti glp-1r |
| TW202334129A (zh) | 2021-10-25 | 2023-09-01 | 美商拓臻製藥公司 | 作為ｇｌｐ—１ｒ促效劑的化合物 |
| CN119343339A (zh) * | 2022-01-24 | 2025-01-21 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| JP2025506473A (ja) * | 2022-02-09 | 2025-03-11 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| WO2023164050A1 (en) | 2022-02-23 | 2023-08-31 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| IL316629A (en) * | 2022-05-11 | 2024-12-01 | Lilly Co Eli | GLP1 drug compounds |
| WO2023220112A1 (en) | 2022-05-11 | 2023-11-16 | Eli Lilly And Company | Glp1 tablet compositions |
| JPWO2024063143A1 (enExample) | 2022-09-22 | 2024-03-28 | ||
| CN118791482B (zh) * | 2022-11-20 | 2025-09-09 | 药康众拓(北京)医药科技有限公司 | 一种氘代吲唑类化合物、药物组合物及其应用 |
| AU2023404652A1 (en) * | 2022-11-28 | 2025-05-01 | The University Of Melbourne | Pharmaceutical combinations and uses thereof |
| WO2024129676A1 (en) * | 2022-12-13 | 2024-06-20 | Eli Lilly And Company | Dosage regime of orforglipron for treating a subject with type 2 diabetes (t2d), obesity, or overweight with at least one weight related comorbidity |
| KR20250121439A (ko) | 2022-12-19 | 2025-08-12 | 일라이 릴리 앤드 캄파니 | Glp1 ra 및 그의 중간체의 제조 방법 |
| EP4652167A1 (en) * | 2023-01-17 | 2025-11-26 | Fochon Biosciences, Ltd. | Glp-1r agonists and uses thereof |
| IL322686A (en) | 2023-02-16 | 2025-10-01 | Gasherbrum Bio Inc | Heterocyclic glp-1 agonists |
| TW202506131A (zh) | 2023-04-07 | 2025-02-16 | 美商拓臻製藥公司 | ＧＬＰ－１Ｒ及ＴＨＲβ激動劑之組合以及其使用方法 |
| TW202502322A (zh) * | 2023-06-29 | 2025-01-16 | 大陸商韋恩生物科技有限公司 | 一種glp-1受體激動劑及其製備方法和用途 |
| CN120574223B (zh) * | 2023-06-30 | 2025-11-18 | 正大天晴药业集团股份有限公司 | 含多稠环结构的化合物 |
| WO2025011664A1 (zh) * | 2023-07-12 | 2025-01-16 | 歌礼制药(中国)有限公司 | Glp-1r激动剂的制剂及其制备方法 |
| AR133241A1 (es) | 2023-07-13 | 2025-09-10 | Aconcagua Bio Inc | Compuestos, composiciones y métodos |
| TW202521528A (zh) | 2023-07-13 | 2025-06-01 | 美商雅空嘉閣生物公司 | 化合物、組合物及方法 |
| WO2025026270A1 (zh) * | 2023-07-28 | 2025-02-06 | 上海翰森生物医药科技有限公司 | 一种苯并含氮杂环类衍生物调节剂、其制备方法和应用 |
| WO2025026436A1 (zh) * | 2023-08-02 | 2025-02-06 | 韦恩生物科技有限公司 | 一种含氮并环化合物及其制备方法和用途 |
| WO2025057134A2 (en) * | 2023-09-14 | 2025-03-20 | Ascletis Pharma (China) Co., Limited | Glp-1r agonist and therapeutic method thereof |
| WO2025069009A1 (en) | 2023-09-29 | 2025-04-03 | Graviton Bioscience Bv | Rock2 inhibitors in the treatment of obesity |
| WO2025097835A1 (zh) | 2023-11-10 | 2025-05-15 | 重庆医药工业研究院有限责任公司 | 一种glp-1r激动剂化合物及其应用 |
| WO2025103443A1 (zh) * | 2023-11-16 | 2025-05-22 | 海思科医药集团股份有限公司 | 一种咪唑-2-酮衍生物及其在医药上的应用 |
| WO2025108361A1 (zh) * | 2023-11-21 | 2025-05-30 | 江苏恒瑞医药股份有限公司 | 杂环类化合物、其制备方法及其在医药上的应用 |
| US12291530B1 (en) | 2023-11-24 | 2025-05-06 | Ascletis Pharma (China) Co., Limited | GLP-1R agonist and therapeutic method thereof |
| WO2025119206A1 (en) * | 2023-12-05 | 2025-06-12 | Fortvita Biologics Inc. | Glp-1 receptor targeting compounds and uses thereof |
| WO2025124357A1 (zh) * | 2023-12-14 | 2025-06-19 | 广东众生睿创生物科技有限公司 | 一种杂环glp-1受体激动剂及其应用 |
| WO2025131043A1 (zh) * | 2023-12-22 | 2025-06-26 | 石药集团百克(山东)生物制药股份有限公司 | 一类多环化合物及其用途 |
| CN117447493A (zh) * | 2023-12-25 | 2024-01-26 | 药康众拓(北京)医药科技有限公司 | 氘代吲哚嗪类化合物、药物组合物及其应用 |
| KR20250102249A (ko) | 2023-12-27 | 2025-07-07 | 주식회사 종근당 | Glp-1 수용체 작용제 및 이의 용도 |
| WO2025148997A1 (zh) * | 2024-01-10 | 2025-07-17 | 海思科医药集团股份有限公司 | 一种四氢吡啶并吡唑衍生物及其在医药上的应用 |
| WO2025158275A1 (en) | 2024-01-24 | 2025-07-31 | Pfizer Inc. | Combination therapy using glucose-dependent insulinotropic polypeptide receptor antagonist compounds and glp-1 receptor agonist compounds |
| WO2025162065A1 (zh) * | 2024-01-30 | 2025-08-07 | 海创药业股份有限公司 | 一种具有glp-1受体激动剂作用的小分子化合物及其用途 |
| WO2025171340A1 (en) | 2024-02-08 | 2025-08-14 | Aconcagua Bio, Inc. | The treatment of calcitonin- and/or amylin-receptor associated conditions |
| WO2025171341A2 (en) | 2024-02-08 | 2025-08-14 | Aconcagua Bio, Inc. | Compounds and compositions for treating conditions associated with calcitonin receptor and/or amylin receptor activity |
| WO2025176130A1 (zh) * | 2024-02-19 | 2025-08-28 | 上海壹迪生物技术有限公司 | 一种含吡唑并环类化合物、其药物组合物及其用途 |
| WO2025189141A1 (en) | 2024-03-08 | 2025-09-12 | Annapurna Bio, Inc. | Methods for treating obesity and increasing weight loss |
| WO2025209515A1 (zh) * | 2024-04-03 | 2025-10-09 | 广州市联瑞制药有限公司 | 一种glp-1受体激动剂及其制备方法和应用 |
| WO2025237355A1 (zh) * | 2024-05-17 | 2025-11-20 | 成都地奥九泓制药厂 | 一种glp-1受体激动剂化合物、其制备方法及其应用 |
| CN119101040B (zh) * | 2024-11-08 | 2025-03-21 | 杭州澳赛诺医药技术有限公司 | 一种通过去对称化合成芳基取代的手性四氢吡喃环的方法 |
| CN120309500B (zh) * | 2025-06-19 | 2025-08-15 | 南昌大学 | 奥格列龙原料中间体及合成方法与奥格列龙原料合成方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1771231A (zh) * | 2002-08-26 | 2006-05-10 | 武田药品工业株式会社 | 钙受体调节性化合物及其用途 |
| CN101621931A (zh) * | 2006-11-27 | 2010-01-06 | H.隆德贝克有限公司 | 杂芳基酰胺衍生物 |
| CN101959405A (zh) * | 2008-03-07 | 2011-01-26 | 转化技术制药公司 | 治疗糖尿病的氧杂二氮杂蒽化合物 |
| CN102378574A (zh) * | 2009-03-30 | 2012-03-14 | 转化技术制药公司 | 取代的偶氮蒽衍生物、药物组合物及其使用方法 |
| WO2014122067A1 (en) * | 2013-02-06 | 2014-08-14 | Boehringer Ingelheim International Gmbh | New indanyloxydihydrobenzofuranylacetic acids |
| WO2016038045A1 (en) * | 2014-09-08 | 2016-03-17 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Pyrazolopyridine derivatives and their use in therapy |
| CN105919998A (zh) * | 2009-07-09 | 2016-09-07 | 拉夸里亚创药株式会社 | 用于治疗与异常肠胃运动有关的疾病的酸泵拮抗剂 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998438A (en) | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
| WO1999050262A1 (en) | 1998-04-01 | 1999-10-07 | Janssen Pharmaceutica N.V. | Pde iv inhibiting pyridine derivatives |
| CA2494700C (en) * | 2002-08-26 | 2011-06-28 | Takeda Pharmaceutical Company Limited | Calcium receptor modulating compound and use thereof |
| DE10360774A1 (de) * | 2003-12-23 | 2005-07-28 | Robert Bosch Gmbh | Verfahren zur Herstellung eines Brennstoffeinspritzventils und Brennstoffeinspritzventil |
| WO2006048727A1 (en) | 2004-11-02 | 2006-05-11 | Pfizer Products Inc. | Piperazinylphenalkyl lactam/amine ligands for the 5ht1b receptor |
| HUE028347T2 (en) | 2008-06-10 | 2016-12-28 | Abbvie Inc | Tricyclic compounds |
| RU2600440C3 (ru) | 2010-12-16 | 2021-12-10 | Ново Нордиск А/С | Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты |
| WO2013010904A1 (en) | 2011-07-15 | 2013-01-24 | Janssen Pharmaceuticals, Inc. | Novel substituted indole derivatives as gamma secretase modulators |
| JP6381445B2 (ja) * | 2011-12-08 | 2018-08-29 | リサーチ トライアングル インスティテュート | ニューロペプチドｓレセプター（ｎｐｓｒ）アンタゴニストの組成物および方法 |
| CN103086955B (zh) | 2013-02-19 | 2014-10-15 | 中国医学科学院医药生物技术研究所 | 3-氨基-4-烷氧亚胺基哌啶的制备方法 |
| US9776995B2 (en) | 2013-06-12 | 2017-10-03 | Amgen Inc. | Bicyclic sulfonamide compounds as sodium channel inhibitors |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| FI4097099T3 (fi) | 2020-02-07 | 2024-07-30 | Gasherbrum Bio Inc | Heterosyklisiä glp-1-agonisteja |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| CN117645601A (zh) | 2020-06-10 | 2024-03-05 | 重庆康丁医药技术有限公司 | 一种具有心血管益处的glp-1小分子 |
| IL299704A (en) | 2020-07-20 | 2023-03-01 | Eccogene Shanghai Co Ltd | Tetrahydropyrazolo-pyrazinyl-dihydroimidazolone or tetrahydropyrazolo-pyridinyl-dihydroimidazolone compounds and methods of using them |
| EP4210680A1 (en) | 2020-09-07 | 2023-07-19 | Cyprumed GmbH | Improved pharmaceutical formulations of glp-1 receptor agonists |
| CN118987224A (zh) | 2020-12-16 | 2024-11-22 | 香港中文大学 | 一种治疗受试者的衰老相关脑功能障碍的组合物及其应用 |
| CN113480534B (zh) | 2021-07-23 | 2022-05-13 | 广州必贝特医药股份有限公司 | 苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物及其应用 |
| CN114716423A (zh) | 2022-05-20 | 2022-07-08 | 中国科学院上海药物研究所 | 5,6-二氢-1,2,4-三嗪类化合物及其作为glp-1受体激动剂的药学用途 |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1771231A (zh) * | 2002-08-26 | 2006-05-10 | 武田药品工业株式会社 | 钙受体调节性化合物及其用途 |
| CN101621931A (zh) * | 2006-11-27 | 2010-01-06 | H.隆德贝克有限公司 | 杂芳基酰胺衍生物 |
| CN101959405A (zh) * | 2008-03-07 | 2011-01-26 | 转化技术制药公司 | 治疗糖尿病的氧杂二氮杂蒽化合物 |
| CN102378574A (zh) * | 2009-03-30 | 2012-03-14 | 转化技术制药公司 | 取代的偶氮蒽衍生物、药物组合物及其使用方法 |
| CN105919998A (zh) * | 2009-07-09 | 2016-09-07 | 拉夸里亚创药株式会社 | 用于治疗与异常肠胃运动有关的疾病的酸泵拮抗剂 |
| WO2014122067A1 (en) * | 2013-02-06 | 2014-08-14 | Boehringer Ingelheim International Gmbh | New indanyloxydihydrobenzofuranylacetic acids |
| WO2016038045A1 (en) * | 2014-09-08 | 2016-03-17 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Pyrazolopyridine derivatives and their use in therapy |
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