DOP2019000074A - Derivado de pirazolopiridina que tiene el efecto agonista del receptor de glp-1 - Google Patents
Derivado de pirazolopiridina que tiene el efecto agonista del receptor de glp-1Info
- Publication number
- DOP2019000074A DOP2019000074A DO2019000074A DO2019000074A DOP2019000074A DO P2019000074 A DOP2019000074 A DO P2019000074A DO 2019000074 A DO2019000074 A DO 2019000074A DO 2019000074 A DO2019000074 A DO 2019000074A DO P2019000074 A DOP2019000074 A DO P2019000074A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- pirazolopiridine
- glp
- receptor
- derived
- compound
- Prior art date
Links
- 102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 title 1
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- AMFYRKOUWBAGHV-UHFFFAOYSA-N 1h-pyrazolo[4,3-b]pyridine Chemical group C1=CN=C2C=NNC2=C1 AMFYRKOUWBAGHV-UHFFFAOYSA-N 0.000 abstract 1
- MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical group C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención proporciona un compuesto representado por la Fórmula (I) en donde un anillo de indol o un anillo de pirrolo[2,3-b]piridina y una estructura de pirazolopiridina se fijan mediante un sustituyente, o una sal del compuesto; solvatos de este; y agentes preventivos o terapéuticos contra la diabetes mellitus no insulinodependiente (diabetes tipo 2), la obesidad, y similares en donde dicho compuesto, sal o solvato se usa como un ingrediente activo. (En la fórmula X, Y, Q1, Q2, R1, R2, R3, R4, R5, R6, R7, R8, R9, n1, n2, Z1, y Z2 representan las sustancias indicadas en la memoria
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016187605 | 2016-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2019000074A true DOP2019000074A (es) | 2019-05-31 |
Family
ID=61689595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2019000074A DOP2019000074A (es) | 2016-09-26 | 2019-03-21 | Derivado de pirazolopiridina que tiene el efecto agonista del receptor de glp-1 |
Country Status (35)
Country | Link |
---|---|
US (5) | US10858356B2 (es) |
EP (3) | EP4134367A1 (es) |
JP (4) | JP6567778B2 (es) |
KR (1) | KR102223227B1 (es) |
CN (1) | CN109790161B (es) |
AU (4) | AU2017330733B2 (es) |
BR (1) | BR112019005322A2 (es) |
CA (1) | CA3038479C (es) |
CL (1) | CL2019000663A1 (es) |
CO (1) | CO2019002595A2 (es) |
CR (1) | CR20190149A (es) |
DK (1) | DK3517538T3 (es) |
DO (1) | DOP2019000074A (es) |
EA (2) | EA037989B1 (es) |
EC (1) | ECSP19020228A (es) |
FI (1) | FI3517538T3 (es) |
HR (1) | HRP20240499T1 (es) |
IL (2) | IL264945B (es) |
JO (1) | JOP20190060A1 (es) |
LT (1) | LT3517538T (es) |
MA (1) | MA46286A (es) |
MX (2) | MX2019003488A (es) |
PE (1) | PE20190709A1 (es) |
PH (1) | PH12019500659A1 (es) |
PL (1) | PL3517538T3 (es) |
PT (1) | PT3517538T (es) |
RS (1) | RS65398B1 (es) |
SA (1) | SA519401409B1 (es) |
SG (1) | SG11201901565VA (es) |
SI (1) | SI3517538T1 (es) |
TN (1) | TN2019000054A1 (es) |
TW (1) | TWI753946B (es) |
UA (1) | UA125586C2 (es) |
WO (1) | WO2018056453A1 (es) |
ZA (1) | ZA201901070B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
CN111527087A (zh) * | 2017-11-02 | 2020-08-11 | 艾库里斯有限及两合公司 | 具有抗乙型肝炎病毒(hbv)活性的新的高活性的吡唑并-哌啶取代的吲哚-2-甲酰胺 |
JP7461104B2 (ja) * | 2017-11-29 | 2024-04-03 | 中外製薬株式会社 | Glp-1受容体アゴニスト作用を持つピラゾロピリジン誘導体を含有する医薬組成物 |
US10934279B2 (en) * | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
JP7360301B2 (ja) | 2019-11-08 | 2023-10-12 | Kyb株式会社 | 作動流体供給システム |
WO2021155841A1 (en) | 2020-02-07 | 2021-08-12 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
WO2021249492A1 (zh) * | 2020-06-10 | 2021-12-16 | 南京明德新药研发有限公司 | 甲基取代的苯并二噁唑类化合物及其应用 |
BR112023000932A2 (pt) * | 2020-07-20 | 2023-10-03 | Eccogene Shanghai Co Ltd | Tetra-hidropirazolo-pirazinil-di-hidroimidazolona ou compostos de tetra-hidropirazolo-piridinil-di-hidroimidazolona e métodos de uso dos mesmos |
CA3190163A1 (en) * | 2020-08-06 | 2022-02-10 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
CN116406360A (zh) | 2020-08-28 | 2023-07-07 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
TW202220985A (zh) | 2020-09-01 | 2022-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
CN116615430A (zh) * | 2020-09-07 | 2023-08-18 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
WO2022078152A1 (zh) | 2020-10-12 | 2022-04-21 | 杭州中美华东制药有限公司 | 苯并咪唑酮类glp-1受体激动剂及其用途 |
WO2022111624A1 (zh) | 2020-11-27 | 2022-06-02 | 深圳信立泰药业股份有限公司 | 一种苯并咪唑类衍生物及其制备方法和医药用途 |
US20240208952A1 (en) | 2021-03-22 | 2024-06-27 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | Thiophene glp-1 receptor agonist and use thereof |
JPWO2022202864A1 (es) | 2021-03-24 | 2022-09-29 | ||
CA3219984A1 (en) | 2021-06-24 | 2022-12-29 | Wenqiang ZHAI | Glp-1 receptor agonist and composition and use thereof |
WO2023016546A1 (en) * | 2021-08-12 | 2023-02-16 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
AU2022344074A1 (en) | 2021-09-08 | 2024-02-29 | Shionogi & Co., Ltd. | Medicine for prevention and treatment of diseases linked to anti-obesity activity |
WO2023138684A1 (en) * | 2022-01-24 | 2023-07-27 | Gasherbrum Bio , Inc. | Heterocyclic glp-1 agonists |
WO2023151574A1 (en) * | 2022-02-09 | 2023-08-17 | Gasherbrum Bio Inc. | Heterocyclic glp-1 agonists |
WO2023220109A1 (en) | 2022-05-11 | 2023-11-16 | Eli Lilly And Company | Glp1 pharmaceutical compositions |
WO2023220112A1 (en) | 2022-05-11 | 2023-11-16 | Eli Lilly And Company | Glp1 tablet compositions |
CN116003403B (zh) * | 2022-11-20 | 2024-07-23 | 药康众拓(北京)医药科技有限公司 | 一种氘代吲唑类化合物、药物组合物及其应用 |
WO2024113004A1 (en) * | 2022-11-28 | 2024-06-06 | The University Of Melbourne | Pharmaceutical combinations and uses thereof |
WO2024129676A1 (en) * | 2022-12-13 | 2024-06-20 | Eli Lilly And Company | Dosage regime of orforglipron for treating a subject with type 2 diabetes (t2d), obesity, or overweight with at least one weight related comorbidity |
WO2024137426A1 (en) | 2022-12-19 | 2024-06-27 | Eli Lilly And Company | Process to make glp1 ra and intermediates therefor |
WO2024153070A1 (en) * | 2023-01-17 | 2024-07-25 | Fochon Biosciences, Ltd. | Glp-1r agonists and uses thereof |
WO2024169952A1 (en) * | 2023-02-16 | 2024-08-22 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
CN117447493A (zh) * | 2023-12-25 | 2024-01-26 | 药康众拓(北京)医药科技有限公司 | 氘代吲哚嗪类化合物、药物组合物及其应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5998438A (en) | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
CA2326045C (en) | 1998-04-01 | 2008-12-09 | Janssen Pharmaceutica N.V. | Pde iv inhibiting pyridine derivatives |
ZA200500782B (en) * | 2002-08-26 | 2007-10-31 | Takeda Pharmaceutical | Calcium receptor modulating compound and use thereof |
NZ538223A (en) | 2002-08-26 | 2008-03-28 | Takeda Pharmaceutical | Calcium receptor modulating compound and use thereof |
DE10360774A1 (de) | 2003-12-23 | 2005-07-28 | Robert Bosch Gmbh | Verfahren zur Herstellung eines Brennstoffeinspritzventils und Brennstoffeinspritzventil |
WO2006048727A1 (en) | 2004-11-02 | 2006-05-11 | Pfizer Products Inc. | Piperazinylphenalkyl lactam/amine ligands for the 5ht1b receptor |
CN101621931A (zh) * | 2006-11-27 | 2010-01-06 | H.隆德贝克有限公司 | 杂芳基酰胺衍生物 |
MX2010009752A (es) | 2008-03-07 | 2010-09-30 | Transtech Pharma Inc | Compuestos de oxadiazoantraceno para el tratamiento de diabetes. |
US8962629B2 (en) | 2008-06-10 | 2015-02-24 | Abbvie Inc. | Tricyclic compounds |
AU2010232750B2 (en) * | 2009-03-30 | 2015-10-29 | Vtv Therapeutics Llc | Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof |
CN105919998B (zh) * | 2009-07-09 | 2021-08-24 | 拉夸里亚创药株式会社 | 用于治疗与异常肠胃运动有关的疾病的酸泵拮抗剂 |
PT2651398T (pt) | 2010-12-16 | 2018-03-09 | Novo Nordisk As | Composições sólidas compreendendo um agonista de glp-1 e um sal de ácido n-(8-(2-hidroxibenzoil)amino) caprílico |
TWI567079B (zh) | 2011-07-15 | 2017-01-21 | 健生醫藥公司 | 作為伽瑪分泌酶調節劑之新穎的經取代的吲哚衍生物 |
CA2858571C (en) * | 2011-12-08 | 2021-03-16 | Research Triangle Institute | Composition and method for neuropeptide s receptor (npsr) antagonists |
JP6314335B2 (ja) * | 2013-02-06 | 2018-04-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新しいインダニルオキシジヒドロベンゾフラニル酢酸 |
CN103086955B (zh) | 2013-02-19 | 2014-10-15 | 中国医学科学院医药生物技术研究所 | 3-氨基-4-烷氧亚胺基哌啶的制备方法 |
US9212182B2 (en) | 2013-06-12 | 2015-12-15 | Amgen Inc. | Bicyclic sulfonamide compounds as sodium channel inhibitors |
EP2993174A1 (en) | 2014-09-08 | 2016-03-09 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Pyrazolopyridine derivatives and their use in therapy |
JOP20190060A1 (ar) * | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
-
2017
- 2017-06-16 JO JOP/2019/0060A patent/JOP20190060A1/ar unknown
- 2017-09-26 PL PL17853220.6T patent/PL3517538T3/pl unknown
- 2017-09-26 CR CR20190149A patent/CR20190149A/es unknown
- 2017-09-26 LT LTEPPCT/JP2017/034620T patent/LT3517538T/lt unknown
- 2017-09-26 BR BR112019005322A patent/BR112019005322A2/pt active Search and Examination
- 2017-09-26 SG SG11201901565VA patent/SG11201901565VA/en unknown
- 2017-09-26 CA CA3038479A patent/CA3038479C/en active Active
- 2017-09-26 PE PE2019000705A patent/PE20190709A1/es unknown
- 2017-09-26 EP EP22180270.5A patent/EP4134367A1/en not_active Withdrawn
- 2017-09-26 DK DK17853220.6T patent/DK3517538T3/da active
- 2017-09-26 US US15/759,872 patent/US10858356B2/en active Active
- 2017-09-26 MA MA046286A patent/MA46286A/fr unknown
- 2017-09-26 PT PT178532206T patent/PT3517538T/pt unknown
- 2017-09-26 RS RS20240426A patent/RS65398B1/sr unknown
- 2017-09-26 EA EA201990518A patent/EA037989B1/ru not_active IP Right Cessation
- 2017-09-26 JP JP2018540344A patent/JP6567778B2/ja active Active
- 2017-09-26 UA UAA201902662A patent/UA125586C2/uk unknown
- 2017-09-26 TN TNP/2019/000054A patent/TN2019000054A1/en unknown
- 2017-09-26 FI FIEP17853220.6T patent/FI3517538T3/fi active
- 2017-09-26 WO PCT/JP2017/034620 patent/WO2018056453A1/ja active Application Filing
- 2017-09-26 CN CN201780059135.7A patent/CN109790161B/zh active Active
- 2017-09-26 EA EA202190802A patent/EA202190802A3/ru unknown
- 2017-09-26 TW TW106132936A patent/TWI753946B/zh active
- 2017-09-26 MX MX2019003488A patent/MX2019003488A/es unknown
- 2017-09-26 SI SI201731497T patent/SI3517538T1/sl unknown
- 2017-09-26 EP EP24154118.4A patent/EP4349840A3/en active Pending
- 2017-09-26 EP EP17853220.6A patent/EP3517538B1/en active Active
- 2017-09-26 AU AU2017330733A patent/AU2017330733B2/en active Active
- 2017-09-26 KR KR1020197008190A patent/KR102223227B1/ko active IP Right Grant
- 2017-09-26 HR HRP20240499TT patent/HRP20240499T1/hr unknown
-
2019
- 2019-02-19 ZA ZA2019/01070A patent/ZA201901070B/en unknown
- 2019-02-20 IL IL264945A patent/IL264945B/en unknown
- 2019-03-14 CL CL2019000663A patent/CL2019000663A1/es unknown
- 2019-03-20 CO CONC2019/0002595A patent/CO2019002595A2/es unknown
- 2019-03-21 DO DO2019000074A patent/DOP2019000074A/es unknown
- 2019-03-25 EC ECSENADI201920228A patent/ECSP19020228A/es unknown
- 2019-03-25 SA SA519401409A patent/SA519401409B1/ar unknown
- 2019-03-26 PH PH12019500659A patent/PH12019500659A1/en unknown
- 2019-03-26 MX MX2022004071A patent/MX2022004071A/es unknown
- 2019-07-31 JP JP2019141806A patent/JP6957564B2/ja active Active
-
2020
- 2020-08-26 AU AU2020223687A patent/AU2020223687B2/en active Active
- 2020-10-07 US US17/065,122 patent/US11814381B2/en active Active
-
2021
- 2021-10-06 JP JP2021164974A patent/JP7280929B2/ja active Active
- 2021-10-11 IL IL287166A patent/IL287166A/en unknown
-
2022
- 2022-07-13 AU AU2022205222A patent/AU2022205222B2/en active Active
-
2023
- 2023-05-12 JP JP2023079006A patent/JP2023100963A/ja active Pending
- 2023-08-11 US US18/448,497 patent/US20230382912A1/en active Pending
-
2024
- 2024-02-22 US US18/584,177 patent/US20240262824A1/en active Pending
- 2024-02-22 US US18/584,672 patent/US20240246971A1/en active Pending
- 2024-03-22 AU AU2024201884A patent/AU2024201884A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DOP2019000074A (es) | Derivado de pirazolopiridina que tiene el efecto agonista del receptor de glp-1 | |
PE20210396A1 (es) | Moduladores de la via de estres integrada | |
SV2017005384A (es) | Compuestos aminopirimidinilo | |
EA201791239A8 (ru) | ТЕТРАГИДРОПИРИДО[3,4-b]ИНДОЛОВЫЕ МОДУЛЯТОРЫ ЭСТРОГЕНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ | |
CO2017000222A2 (es) | Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble | |
CO6541645A2 (es) | Compuestos de indol y su uso farmaceutico | |
AR106211A1 (es) | Derivados de pirazol activos como pesticida | |
CR20180495A (es) | Deribados de indol sustituidos como inhibidores de replicación viral del dengue | |
AR106865A1 (es) | Piridinas sustituidas y métodos de uso | |
MY196172A (en) | Tricyclic Spiro Compound | |
AR110753A1 (es) | Inhibidores selectivos de jak1 | |
CL2019001041A1 (es) | Compuestos terapéuticos y métodos para utilizarlos. | |
CY1124251T1 (el) | Παραγωγα καρβοξαμιδιου | |
MX2017013877A (es) | Compuestos de benzimidazolona y benzotiazolona y su uso como moduladores del receptor ampa. | |
MX2017002275A (es) | Derivado de azaindol que tiene actividad activadora de proteina cinasa activada por monofosfato de adenosina (ampk). | |
UY36123A (es) | Derivados de carboxamida | |
CL2017001720A1 (es) | Nuevos derivados de bencimidazol como agentes antihistamínicos. | |
ECSP19084722A (es) | Compuestos bicíclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias | |
ECSP099759A (es) | Compuesto bicíclico y uso farmacéutico del mismo | |
CO2019004143A2 (es) | Compuestos azaheterocíclicos fusionados y su uso como moduladores de los receptores ampa | |
EA202192092A3 (ru) | Тетрагидро-пиридо[3,4-b]индоловые модуляторы эстрогеновых рецепторов и их применение | |
CU20160170A7 (es) | Derivados de carboxamida | |
AR096803A1 (es) | Bencil-1h-pirazolo[3,4-b]piridinas y su uso | |
NI201500016A (es) | HETEROCICLOS DE 5 MIEMBROS QUE CONTIENEN NITRÓGENO SUSTITUIDOS POR CARBOXAMIDA O SULFONAMIDA COMO MODULADORES PARA EL RECEPTOR NUCLEAR HUÉRFANO RORy |