BR112019005322A2 - derivado de pirazolopiridina tendo efeito agonista de receptor glp-1 - Google Patents

derivado de pirazolopiridina tendo efeito agonista de receptor glp-1

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Publication number
BR112019005322A2
BR112019005322A2 BR112019005322A BR112019005322A BR112019005322A2 BR 112019005322 A2 BR112019005322 A2 BR 112019005322A2 BR 112019005322 A BR112019005322 A BR 112019005322A BR 112019005322 A BR112019005322 A BR 112019005322A BR 112019005322 A2 BR112019005322 A2 BR 112019005322A2
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BR
Brazil
Prior art keywords
glp
receptor agonist
agonist effect
compound
pyrazolopyridine derivative
Prior art date
Application number
BR112019005322A
Other languages
English (en)
Inventor
Matsuo Atsushi
Ogawa Hiroko
Kashiwagi Hirotaka
Yoshino Hitoshi
Oguri Kyoko
Aoki Masahide
Nishimoto Masahiro
Hori Nobuyuki
Tanida Satoshi
Tsuchiya Satoshi
Yoshida Shoshin
Kawai Takahiro
Kamon Takuma
Shiraishi Takuya
Sato Tsutomu
Nishimura Yoshikazu
furuta Yoshiyuki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BR112019005322A2 publication Critical patent/BR112019005322A2/pt

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a presente invenção refere-se a um composto representado pela fórmula (i) em que um anel indol ou um anel pirrolo[2,3-b]piridina e um esqueleto de pirazolopiridina são ligados usando um substituinte, ou um sal do composto; solvatos do mesmo; e agentes profiláticos ou terapêuticos para diabetes mellitus não dependente de insulina (diabetes melito tipo 2), obesidade, e similares, em que o referido composto, sal ou solvato é usado como um ingrediente ativo. (na fórmula x, y, q1, q2, r1, r2, r3, r4, r5, r6, r7, r8, r9, n1, n2, z1, e z2 representa substâncias indicadas na presente especificação).
BR112019005322A 2016-09-26 2017-09-26 derivado de pirazolopiridina tendo efeito agonista de receptor glp-1 BR112019005322A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016187605 2016-09-26
PCT/JP2017/034620 WO2018056453A1 (ja) 2016-09-26 2017-09-26 Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体

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BR112019005322A2 true BR112019005322A2 (pt) 2019-07-02

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US (5) US10858356B2 (pt)
EP (3) EP4349840A3 (pt)
JP (4) JP6567778B2 (pt)
KR (1) KR102223227B1 (pt)
CN (1) CN109790161B (pt)
AU (4) AU2017330733B2 (pt)
BR (1) BR112019005322A2 (pt)
CA (1) CA3038479C (pt)
CL (1) CL2019000663A1 (pt)
CO (1) CO2019002595A2 (pt)
CR (1) CR20190149A (pt)
DK (1) DK3517538T3 (pt)
DO (1) DOP2019000074A (pt)
EA (2) EA037989B1 (pt)
EC (1) ECSP19020228A (pt)
FI (1) FI3517538T3 (pt)
HR (1) HRP20240499T1 (pt)
HU (1) HUE066583T2 (pt)
IL (2) IL264945B (pt)
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LT (1) LT3517538T (pt)
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PE (1) PE20190709A1 (pt)
PH (1) PH12019500659A1 (pt)
PL (1) PL3517538T3 (pt)
PT (1) PT3517538T (pt)
RS (1) RS65398B1 (pt)
SA (1) SA519401409B1 (pt)
SG (1) SG11201901565VA (pt)
SI (1) SI3517538T1 (pt)
TN (1) TN2019000054A1 (pt)
TW (1) TWI753946B (pt)
UA (1) UA125586C2 (pt)
WO (1) WO2018056453A1 (pt)
ZA (1) ZA201901070B (pt)

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