JP2018535203A5 - - Google Patents
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- JP2018535203A5 JP2018535203A5 JP2018520089A JP2018520089A JP2018535203A5 JP 2018535203 A5 JP2018535203 A5 JP 2018535203A5 JP 2018520089 A JP2018520089 A JP 2018520089A JP 2018520089 A JP2018520089 A JP 2018520089A JP 2018535203 A5 JP2018535203 A5 JP 2018535203A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- compound according
- iron
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(*C(C)(*)N(*)C(C1*=*(*N(*)*c2nc(C=CC(C)(*)C=C3)c3[n]2)*=*1)=O)C1=NC=CC(C)(*)C=C1 Chemical compound CC(C)(*C(C)(*)N(*)C(C1*=*(*N(*)*c2nc(C=CC(C)(*)C=C3)c3[n]2)*=*1)=O)C1=NC=CC(C)(*)C=C1 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020091830A JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15191179 | 2015-10-23 | ||
| EP15191176.5 | 2015-10-23 | ||
| EP15191179.9 | 2015-10-23 | ||
| EP15191176 | 2015-10-23 | ||
| PCT/EP2016/075306 WO2017068090A1 (en) | 2015-10-23 | 2016-10-21 | Novel ferroportin inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020091830A Division JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535203A JP2018535203A (ja) | 2018-11-29 |
| JP2018535203A5 true JP2018535203A5 (enExample) | 2019-03-14 |
| JP6710754B2 JP6710754B2 (ja) | 2020-06-17 |
Family
ID=57178421
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520089A Active JP6710754B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
| JP2018520090A Active JP6810988B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
| JP2020091830A Active JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520090A Active JP6810988B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
| JP2020091830A Active JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US10364239B2 (enExample) |
| EP (2) | EP3365339B1 (enExample) |
| JP (3) | JP6710754B2 (enExample) |
| KR (1) | KR102352829B1 (enExample) |
| CN (2) | CN114668761B (enExample) |
| AU (3) | AU2016342310B2 (enExample) |
| BR (1) | BR112018007977B1 (enExample) |
| CA (2) | CA3002416C (enExample) |
| CL (1) | CL2018001031A1 (enExample) |
| CO (1) | CO2018004165A2 (enExample) |
| DK (1) | DK3365339T3 (enExample) |
| ES (1) | ES3039644T3 (enExample) |
| FI (1) | FI3365339T3 (enExample) |
| HR (1) | HRP20251038T1 (enExample) |
| IL (2) | IL258158B2 (enExample) |
| JO (1) | JO3780B1 (enExample) |
| LT (1) | LT3365339T (enExample) |
| MA (1) | MA44474B1 (enExample) |
| MX (2) | MX390514B (enExample) |
| MY (1) | MY198246A (enExample) |
| PE (1) | PE20181496A1 (enExample) |
| PH (1) | PH12018500769A1 (enExample) |
| PL (1) | PL3365339T3 (enExample) |
| PT (1) | PT3365339T (enExample) |
| RS (1) | RS67304B1 (enExample) |
| SG (3) | SG11201802665VA (enExample) |
| SM (1) | SMT202500391T1 (enExample) |
| TW (1) | TWI722031B (enExample) |
| UA (1) | UA123219C2 (enExample) |
| WO (2) | WO2017068090A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2968443B1 (en) | 2013-03-15 | 2021-09-29 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses thereof |
| CO2018004165A2 (es) * | 2015-10-23 | 2018-09-20 | Vifor Int Ag | Inhibidores de ferroportina |
| JOP20180036A1 (ar) * | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| CN108314687A (zh) * | 2017-12-27 | 2018-07-24 | 重庆文理学院 | 1,2-二氢苯并[4,5]咪唑并[1,2-a]吡嗪-3（4H）-酮衍生物的合成 |
| EP4501952A3 (en) | 2018-02-08 | 2025-04-16 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| WO2019213016A1 (en) | 2018-04-30 | 2019-11-07 | The Children's Hospital Of Philadelphia | Methods of improving anemias by combining agents |
| ES2934492T3 (es) | 2018-12-13 | 2023-02-22 | Global Blood Therapeutics Inc | Inhibidores de ferroportina y métodos de uso |
| TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛（國際）股份有限公司 | 新穎的鐵螯合物 |
| KR20220042150A (ko) * | 2019-07-19 | 2022-04-04 | 비포르 (인터내셔날) 아게 | 신장 손상의 예방 및 치료에의 용도를 위한 페로포틴 억제제 |
| EP3999059A1 (en) * | 2019-07-19 | 2022-05-25 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of transfusion-dependent beta-thalassemia (tdt) |
| EP3782702A1 (en) * | 2019-08-21 | 2021-02-24 | AC BioScience SA | Compounds and use thereof for the treatment of infectious diseases and cancer |
| US20210061872A1 (en) | 2019-09-03 | 2021-03-04 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| EP4048262A1 (en) | 2019-10-22 | 2022-08-31 | Vifor (International) Ag | Methods and compositions for treating sickle cell disease with a ferroportin inhibitor (vit-2763) |
| KR20220157395A (ko) * | 2020-03-24 | 2022-11-29 | 비포르 (인터내셔날) 아게 | 페로포르틴 억제제의 생산 방법 |
| GB202012969D0 (en) * | 2020-08-19 | 2020-09-30 | Univ Of Oxford | Inhibitor compounds |
| US20250268878A1 (en) * | 2021-01-20 | 2025-08-28 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of myelodysplastic syndromes (mds) |
| WO2022173818A1 (en) * | 2021-02-09 | 2022-08-18 | University Of Virginia Patent Foundation | Use of biliverdin reductase b inhibitors to allow malaria eradication in patients with g6pd deficiency |
| MD4313293T2 (ro) * | 2021-03-26 | 2025-08-31 | Chiesi Farm Spa | Derivati de tetrahidrotienopiridine ca inhibitori DDR |
| TW202304896A (zh) * | 2021-04-22 | 2023-02-01 | 瑞士商威佛（國際）股份有限公司 | 經修飾的膜鐵運輸蛋白(ferroportin)抑制劑 |
| WO2023046664A1 (en) | 2021-09-21 | 2023-03-30 | Vifor (International) Ag | N-substituted ferroportin inhibitors |
| EP4605398A1 (en) | 2022-10-21 | 2025-08-27 | Vifor (International) AG | Bicyclic ferroportin inhibitors |
| CN115974864B (zh) * | 2022-12-29 | 2025-09-16 | 苏州汉德创宏生化科技有限公司 | 一种2-(3-氮杂环丁基)噻唑盐的合成方法 |
| WO2024200512A1 (en) | 2023-03-27 | 2024-10-03 | Silence Therapeutics Gmbh | Compounds and compositions for use in stem cell transplantation |
| AU2024310149A1 (en) | 2023-06-26 | 2025-11-20 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of hereditary haemochromatosis (hh) |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB937878A (en) | 1959-12-24 | 1963-09-25 | Ciba Ltd | N-[5-nitro-(2)-furfurylidene]-pyrazole-carboxylic acid hydrazides and process for their manufacture |
| CH479616A (de) * | 1959-12-24 | 1969-10-15 | Ciba Geigy | Verfahren zur Herstellung neuer Methylidenverbindungen |
| TW533205B (en) | 1996-06-25 | 2003-05-21 | Novartis Ag | Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition |
| US5922761A (en) | 1996-09-06 | 1999-07-13 | Medinox, Inc. | Methods for in vivo reduction of iron levels and compositions useful therefor |
| AR009655A1 (es) | 1996-12-10 | 2000-04-26 | Novartis Ag | Una composicion parenteralmente inyectable, un metodo para su preparacion, metodos para el tratamiento de enfermedades, una modificacion decristal de 1-decansulfonato de desferrioxamina, su uso, un proceso para la produccion de dicha modificacion de cristal y una preparacion farmaceutica que |
| WO1998027108A2 (en) | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
| EP1169311A4 (en) | 1999-03-22 | 2004-09-15 | Rhode Island Education | COMBINATORIAL OXAZOLE AND THIAZOLE BANKS |
| EP1074254A3 (en) | 1999-07-20 | 2002-09-11 | MEDIS S.r.l. Medical Infusion Systems | Use of plant polyphenols with vitamines for treating iron overload |
| EP1072265A1 (en) | 1999-07-20 | 2001-01-31 | MEDIS S.r.l. Medical Infusion Systems | Use of plant polyphenols for treating iron overload |
| CN1237061C (zh) * | 2000-09-15 | 2006-01-18 | 阿诺麦德股份有限公司 | 结合趋化因子受体的杂环化合物 |
| DE10063173A1 (de) * | 2000-12-18 | 2002-06-20 | Merck Patent Gmbh | Harnstoff- und Urethanderivate |
| BR0212787A (pt) * | 2001-09-24 | 2005-01-25 | Elan Pharm Inc | Composto ou sal farmaceuticamente aceitável do mesmo, métodos de tratamento ou prevenção de doenças e de preparação de um composto, uso de um composto ou sal, e, composição farmacêutica |
| US20030109548A1 (en) | 2001-11-09 | 2003-06-12 | Royt Paulette W. | Compositions and methods of treating iron excess |
| US6933308B2 (en) | 2002-12-20 | 2005-08-23 | Bristol-Myers Squibb Company | Aminoalkyl thiazole derivatives as KCNQ modulators |
| SI1656139T1 (sl) | 2003-07-21 | 2011-12-30 | Merck Serono Sa | Aril dikarboksamidi |
| WO2005014576A1 (ja) | 2003-08-12 | 2005-02-17 | Takeda Pharmaceutical Company Limited | イソキノリノン誘導体、その製造法および用途 |
| DE10356409B4 (de) | 2003-11-28 | 2006-12-28 | Biofrontera Discovery Gmbh | Neues Arzneimittel Oxachelin und Derivate |
| FR2870271B1 (fr) | 2004-05-11 | 2008-03-14 | Bruno Merand | Procede de construction d'une maison en bois et moyens pour la mise en oeuvre du procede. |
| WO2006004841A2 (en) * | 2004-06-29 | 2006-01-12 | The Scripps Research Institute | Galanin agonists |
| WO2006040646A1 (en) | 2004-10-14 | 2006-04-20 | Pfizer, Inc. | Benzimidazole or indole amides as inhibitors of pin1 |
| JP2008007405A (ja) | 2004-12-07 | 2008-01-17 | Takeda Chem Ind Ltd | カルボキサミド誘導体 |
| CA2597925A1 (en) * | 2005-02-16 | 2006-08-24 | The General Hospital Corporation | Use of a human hemojuvelin product to regulate hepcidin-mediated iron metabolism |
| US20060252807A1 (en) | 2005-04-22 | 2006-11-09 | Kalypsys, Inc. | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders |
| JP2008542276A (ja) * | 2005-05-23 | 2008-11-27 | メルク エンド カムパニー インコーポレーテッド | プロリンビスアミドオレキシン受容体アンタゴニスト |
| EP1889842A4 (en) | 2005-06-08 | 2009-07-29 | Japan Tobacco Inc | HETEROCYCLIC CONNECTION |
| CN101287728A (zh) * | 2005-08-17 | 2008-10-15 | 先灵公司 | 新的高亲和力噻吩基和呋喃基激酶配体 |
| BRPI0618885A8 (pt) | 2005-11-21 | 2018-06-26 | Shionogi & Co | compostos heterocíclicos tendo atividade inibitória de 11beta-hidroxiesteroide deidrogenase tipo i |
| WO2007084390A2 (en) * | 2006-01-13 | 2007-07-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2008082487A2 (en) | 2006-12-20 | 2008-07-10 | Schering Corporation | Novel jnk inhibitors |
| CL2008000666A1 (es) | 2007-03-07 | 2008-06-13 | Xenon Pharmaceuticals Inc | Compuestos derivados de triciclos sustituidos, inhibidores del transportador de metales divalentes-1; y uso para tratar una enfermedad asociada con un trastorno del hierro. |
| AR065785A1 (es) | 2007-03-19 | 2009-07-01 | Xenon Pharmaceuticals Inc | Compuestos biarilo y biheteroarilo de utilidad en el tratamiento de trastornos de hierro |
| CN101646686A (zh) | 2007-03-20 | 2010-02-10 | 明治制果株式会社 | 铁过剩症的预防或治疗剂 |
| CL2008000793A1 (es) | 2007-03-23 | 2008-05-30 | Xenon Pharmaceuticals Inc | Compuestos derivados de dihidroindazol; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno del hierro. |
| EP2133339A4 (en) * | 2007-03-28 | 2010-04-21 | Santen Pharmaceutical Co Ltd | NOVEL (2-AMINOPHENYL) PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE |
| US20100240713A1 (en) | 2007-06-05 | 2010-09-23 | Xenon Pharmaceuticals Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
| WO2009154739A2 (en) | 2008-06-17 | 2009-12-23 | Duke University | Smoothened receptor modulators |
| JP2012500783A (ja) | 2008-08-22 | 2012-01-12 | エヴォテック・アクチエンゲゼルシャフト | 新しいブラジキニンｂ１拮抗薬 |
| JP5507567B2 (ja) | 2008-09-26 | 2014-05-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体拮抗薬としてのアザインダゾール化合物 |
| KR101712576B1 (ko) * | 2008-11-10 | 2017-03-06 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｒ 키나제의 억제제로서 유용한 화합물 |
| CN102282138A (zh) | 2008-11-19 | 2011-12-14 | 先灵公司 | 二酰基甘油酰基转移酶的抑制剂 |
| AU2009334997A1 (en) | 2008-12-30 | 2011-08-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as Raf kinase inhibitors |
| AR077958A1 (es) | 2009-08-27 | 2011-10-05 | Vifor Int Ag | Quinoxalinonas antagonistas de la hepcidina |
| WO2011029832A1 (de) * | 2009-09-09 | 2011-03-17 | Vifor (International) Ag | Neue thiazol- und oxazol-hepcidin-antagonisten |
| BR112012016923A2 (pt) * | 2009-12-22 | 2015-09-01 | Syngenta Participations Ag | Derivados de pirazol |
| AU2012334804B2 (en) | 2011-11-07 | 2016-12-15 | The University Of Queensland | Modulators of C3a receptors |
| CA2855122A1 (en) | 2011-12-09 | 2013-06-13 | The Regents Of The University Of California | Modified mini-hepcidin peptides and methods of using thereof |
| EP2620142A1 (en) * | 2012-01-27 | 2013-07-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Hedgehog signaling pathway involved in energy metabolism |
| KR20140139563A (ko) | 2012-03-22 | 2014-12-05 | 나노테라퓨틱스, 인코포레이티드 | 캡슐화된 디에틸렌트리아민펜타아세테이트 입자들의 경구 전달을 위한 조성물 및 방법 |
| HK1208450A1 (en) * | 2012-05-11 | 2016-03-04 | Abbvie Inc. | Nampt inhibitors |
| CN103508957B (zh) | 2012-06-25 | 2017-02-08 | 中国科学院上海药物研究所 | 羟乙基吡唑类化合物或氨乙基吡唑类化合物及其制备方法和用途 |
| PT2872157T (pt) * | 2012-07-12 | 2020-04-30 | Hangzhou Dac Biotech Co Ltd | Conjugados de moléculas de ligação celular com agentes citotóxicos |
| AR097279A1 (es) * | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| US10441669B2 (en) | 2013-10-04 | 2019-10-15 | Illinois Institute Of Technology | Multifunctional chelators, complexes, and compositions thereof, and methods of using same |
| US20160243201A1 (en) | 2013-11-05 | 2016-08-25 | New York Blood Center, Inc. | Methods and compositions for increasing hepcidin expession using modified iron binding/releasing transferrin |
| US10010535B2 (en) | 2013-11-22 | 2018-07-03 | University Of Florida Research Foundation, Incorporated | Desferrithiocin analogs and uses thereof |
| MX2017007095A (es) * | 2014-12-05 | 2017-11-17 | An2H Discovery Ltd | Metodos y composiciones de activacion de la ligasa parkin. |
| CO2018004165A2 (es) * | 2015-10-23 | 2018-09-20 | Vifor Int Ag | Inhibidores de ferroportina |
-
2016
- 2016-10-21 CO CONC2018/0004165A patent/CO2018004165A2/es unknown
- 2016-10-21 SG SG11201802665VA patent/SG11201802665VA/en unknown
- 2016-10-21 WO PCT/EP2016/075306 patent/WO2017068090A1/en not_active Ceased
- 2016-10-21 US US15/769,148 patent/US10364239B2/en active Active
- 2016-10-21 AU AU2016342310A patent/AU2016342310B2/en active Active
- 2016-10-21 UA UAA201805740A patent/UA123219C2/uk unknown
- 2016-10-21 EP EP16797462.5A patent/EP3365339B1/en active Active
- 2016-10-21 CN CN202210353448.6A patent/CN114668761B/zh active Active
- 2016-10-21 RS RS20251013A patent/RS67304B1/sr unknown
- 2016-10-21 MX MX2018004882A patent/MX390514B/es unknown
- 2016-10-21 SG SG11201802480YA patent/SG11201802480YA/en unknown
- 2016-10-21 LT LTEPPCT/EP2016/075306T patent/LT3365339T/lt unknown
- 2016-10-21 MA MA44474A patent/MA44474B1/fr unknown
- 2016-10-21 TW TW105134089A patent/TWI722031B/zh active
- 2016-10-21 MY MYPI2018000549A patent/MY198246A/en unknown
- 2016-10-21 HR HRP20251038TT patent/HRP20251038T1/hr unknown
- 2016-10-21 CA CA3002416A patent/CA3002416C/en active Active
- 2016-10-21 SM SM20250391T patent/SMT202500391T1/it unknown
- 2016-10-21 ES ES16797462T patent/ES3039644T3/es active Active
- 2016-10-21 KR KR1020187011524A patent/KR102352829B1/ko active Active
- 2016-10-21 WO PCT/EP2016/075305 patent/WO2017068089A2/en not_active Ceased
- 2016-10-21 BR BR112018007977-4A patent/BR112018007977B1/pt active IP Right Grant
- 2016-10-21 CN CN201680061941.3A patent/CN108290878B/zh active Active
- 2016-10-21 SG SG10202005377VA patent/SG10202005377VA/en unknown
- 2016-10-21 EP EP16784510.6A patent/EP3364967A2/en active Pending
- 2016-10-21 PT PT167974625T patent/PT3365339T/pt unknown
- 2016-10-21 DK DK16797462.5T patent/DK3365339T3/da active
- 2016-10-21 JP JP2018520089A patent/JP6710754B2/ja active Active
- 2016-10-21 CA CA3002418A patent/CA3002418C/en active Active
- 2016-10-21 PL PL16797462.5T patent/PL3365339T3/pl unknown
- 2016-10-21 PE PE2018000572A patent/PE20181496A1/es unknown
- 2016-10-21 US US15/768,025 patent/US10738041B2/en active Active
- 2016-10-21 JP JP2018520090A patent/JP6810988B2/ja active Active
- 2016-10-21 AU AU2016342309A patent/AU2016342309B2/en active Active
- 2016-10-21 FI FIEP16797462.5T patent/FI3365339T3/fi active
- 2016-10-23 JO JOP/2016/0229A patent/JO3780B1/ar active
-
2018
- 2018-03-15 IL IL258158A patent/IL258158B2/en unknown
- 2018-03-15 IL IL258159A patent/IL258159B/en unknown
- 2018-04-06 PH PH12018500769A patent/PH12018500769A1/en unknown
- 2018-04-20 CL CL2018001031A patent/CL2018001031A1/es unknown
- 2018-04-20 MX MX2021015106A patent/MX2021015106A/es unknown
-
2019
- 2019-06-12 US US16/438,596 patent/US11001579B2/en active Active
-
2020
- 2020-05-27 JP JP2020091830A patent/JP6967112B2/ja active Active
- 2020-11-24 AU AU2020277121A patent/AU2020277121C1/en active Active
- 2020-12-03 US US17/110,465 patent/US11066399B2/en active Active
-
2021
- 2021-06-07 US US17/340,692 patent/US20220363675A1/en not_active Abandoned
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