JP2018535203A5 - - Google Patents
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- JP2018535203A5 JP2018535203A5 JP2018520089A JP2018520089A JP2018535203A5 JP 2018535203 A5 JP2018535203 A5 JP 2018535203A5 JP 2018520089 A JP2018520089 A JP 2018520089A JP 2018520089 A JP2018520089 A JP 2018520089A JP 2018535203 A5 JP2018535203 A5 JP 2018535203A5
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- Japan
- Prior art keywords
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- iron
- compound
- Prior art date
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- 0 CC(C)(*C(C)(*)N(*)C(C1*=*(*N(*)*c2nc(C=CC(C)(*)C=C3)c3[n]2)*=*1)=O)C1=NC=CC(C)(*)C=C1 Chemical compound CC(C)(*C(C)(*)N(*)C(C1*=*(*N(*)*c2nc(C=CC(C)(*)C=C3)c3[n]2)*=*1)=O)C1=NC=CC(C)(*)C=C1 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020091830A JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15191176.5 | 2015-10-23 | ||
| EP15191179 | 2015-10-23 | ||
| EP15191176 | 2015-10-23 | ||
| EP15191179.9 | 2015-10-23 | ||
| PCT/EP2016/075306 WO2017068090A1 (en) | 2015-10-23 | 2016-10-21 | Novel ferroportin inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020091830A Division JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535203A JP2018535203A (ja) | 2018-11-29 |
| JP2018535203A5 true JP2018535203A5 (enExample) | 2019-03-14 |
| JP6710754B2 JP6710754B2 (ja) | 2020-06-17 |
Family
ID=57178421
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520089A Active JP6710754B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
| JP2018520090A Active JP6810988B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
| JP2020091830A Active JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520090A Active JP6810988B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
| JP2020091830A Active JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Country Status (32)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102236829B1 (ko) | 2013-03-15 | 2021-04-07 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | 헵시딘 유사체 및 이의 용도 |
| SG10202005377VA (en) * | 2015-10-23 | 2020-07-29 | Vifor Int Ag | Novel ferroportin inhibitors |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| CN108314687A (zh) * | 2017-12-27 | 2018-07-24 | 重庆文理学院 | 1,2-二氢苯并[4,5]咪唑并[1,2-a]吡嗪-3（4H）-酮衍生物的合成 |
| EP3749345A4 (en) | 2018-02-08 | 2022-04-06 | Protagonist Therapeutics, Inc. | CONJUGATED HEPCIDIN MIMETICS |
| US12263205B2 (en) | 2018-04-30 | 2025-04-01 | The Children's Hospital Of Philadelphia | Methods of improving anemias by combining agents |
| US11286243B2 (en) | 2018-12-13 | 2022-03-29 | Global Blood Therapeutics, Inc. | Ferroportin inhibitors and methods of use |
| TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛（國際）股份有限公司 | 新穎的鐵螯合物 |
| AU2020316632B2 (en) * | 2019-07-19 | 2025-09-18 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of transfusion-dependent beta-thalassemia (TDT) |
| US20220323416A1 (en) * | 2019-07-19 | 2022-10-13 | Vifor (International) Ag | Ferroportin-Inhibitors For The Use In The Prevention And Treatment Of Kidney Injuries |
| EP3782702A1 (en) * | 2019-08-21 | 2021-02-24 | AC BioScience SA | Compounds and use thereof for the treatment of infectious diseases and cancer |
| EP4025592B1 (en) | 2019-09-03 | 2025-10-29 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics for use in treating of polycythemia vera |
| KR20220086563A (ko) | 2019-10-22 | 2022-06-23 | 비포르 (인터내셔날) 아게 | 페로포틴 억제제(vit-2763)를 사용한 겸상적혈구병을 치료하기 위한 방법 및 조성물 |
| IL296653A (en) * | 2020-03-24 | 2022-11-01 | Vifor Int Ag | A process for producing profortin inhibitors |
| PE20230845A1 (es) * | 2020-04-28 | 2023-05-23 | Global Blood Therapeutics Inc | Pirimidinas cicloalquiladas como inhibidores de la ferroportina |
| GB202012969D0 (en) * | 2020-08-19 | 2020-09-30 | Univ Of Oxford | Inhibitor compounds |
| JP2024504349A (ja) * | 2021-01-20 | 2024-01-31 | ビフォー （インターナショナル） エージー | 骨髄異形成症候群（ｍｄｓ）の処置において使用するためのフェロポーチン阻害剤 |
| WO2022173818A1 (en) * | 2021-02-09 | 2022-08-18 | University Of Virginia Patent Foundation | Use of biliverdin reductase b inhibitors to allow malaria eradication in patients with g6pd deficiency |
| SMT202500288T1 (it) * | 2021-03-26 | 2025-09-12 | Chiesi Farm Spa | Derivati di tetraidrotieno piridina come inibitori delle ddrs |
| TW202304896A (zh) * | 2021-04-22 | 2023-02-01 | 瑞士商威佛（國際）股份有限公司 | 經修飾的膜鐵運輸蛋白(ferroportin)抑制劑 |
| WO2022266060A1 (en) | 2021-06-14 | 2022-12-22 | Protagonist Therapeutics, Inc. | Hepcidin mimetics for treatment of hereditary hemochromatosis |
| US20240343722A1 (en) | 2021-09-21 | 2024-10-17 | Vifor (International) Ag | N-substituted ferroportin inhibitors |
| JP2025535398A (ja) | 2022-10-21 | 2025-10-24 | ビフォー （インターナショナル） エージー | 二環式フェロポーチン阻害剤 |
| CN115974864B (zh) * | 2022-12-29 | 2025-09-16 | 苏州汉德创宏生化科技有限公司 | 一种2-(3-氮杂环丁基)噻唑盐的合成方法 |
| WO2024200512A1 (en) | 2023-03-27 | 2024-10-03 | Silence Therapeutics Gmbh | Compounds and compositions for use in stem cell transplantation |
| EP4731218A1 (en) | 2023-06-26 | 2026-04-29 | Vifor (International) AG | Ferroportin-inhibitors for the use in the treatment of hereditary haemochromatosis (hh) |
| WO2026041650A1 (en) | 2024-08-20 | 2026-02-26 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of lupus nephritis |
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| CH479616A (de) * | 1959-12-24 | 1969-10-15 | Ciba Geigy | Verfahren zur Herstellung neuer Methylidenverbindungen |
| GB937878A (en) | 1959-12-24 | 1963-09-25 | Ciba Ltd | N-[5-nitro-(2)-furfurylidene]-pyrazole-carboxylic acid hydrazides and process for their manufacture |
| TW533205B (en) | 1996-06-25 | 2003-05-21 | Novartis Ag | Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition |
| US5922761A (en) | 1996-09-06 | 1999-07-13 | Medinox, Inc. | Methods for in vivo reduction of iron levels and compositions useful therefor |
| PE27799A1 (es) | 1996-12-10 | 1999-03-18 | Novartis Ag | Formulaciones y formas polimorficas de desferrioxamina y su preparacion |
| WO1998027108A2 (en) * | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
| JP2002540106A (ja) | 1999-03-22 | 2002-11-26 | ザ・ボード・オブ・ガバナーズ・フォー・ハイヤー・エデュケイション、ステイト・オブ・ロード・アイランド・アンド・プロビデンス・プランテーションズ | オキサゾールおよびチアゾールコンビナトリアル・ライブラリー |
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| EP1074254A3 (en) | 1999-07-20 | 2002-09-11 | MEDIS S.r.l. Medical Infusion Systems | Use of plant polyphenols with vitamines for treating iron overload |
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| DE10063173A1 (de) * | 2000-12-18 | 2002-06-20 | Merck Patent Gmbh | Harnstoff- und Urethanderivate |
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| US6933308B2 (en) | 2002-12-20 | 2005-08-23 | Bristol-Myers Squibb Company | Aminoalkyl thiazole derivatives as KCNQ modulators |
| ATE526964T1 (de) | 2003-07-21 | 2011-10-15 | Merck Serono Sa | Aryl-dicarbonsäurediamide |
| WO2005014576A1 (ja) | 2003-08-12 | 2005-02-17 | Takeda Pharmaceutical Company Limited | イソキノリノン誘導体、その製造法および用途 |
| DE10356409B4 (de) | 2003-11-28 | 2006-12-28 | Biofrontera Discovery Gmbh | Neues Arzneimittel Oxachelin und Derivate |
| FR2870271B1 (fr) | 2004-05-11 | 2008-03-14 | Bruno Merand | Procede de construction d'une maison en bois et moyens pour la mise en oeuvre du procede. |
| WO2006004841A2 (en) * | 2004-06-29 | 2006-01-12 | The Scripps Research Institute | Galanin agonists |
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| EP1889842A4 (en) | 2005-06-08 | 2009-07-29 | Japan Tobacco Inc | HETEROCYCLIC CONNECTION |
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| JP5702293B2 (ja) * | 2008-11-10 | 2015-04-15 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な化合物 |
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| WO2015051362A1 (en) * | 2013-10-04 | 2015-04-09 | Illinois Institute Of Technology | Multifunctional chelators, complexes, and compositions thereof, and methods of using same |
| US20160243201A1 (en) | 2013-11-05 | 2016-08-25 | New York Blood Center, Inc. | Methods and compositions for increasing hepcidin expession using modified iron binding/releasing transferrin |
| US10010535B2 (en) | 2013-11-22 | 2018-07-03 | University Of Florida Research Foundation, Incorporated | Desferrithiocin analogs and uses thereof |
| WO2016090371A2 (en) * | 2014-12-05 | 2016-06-09 | An2H Discovery Limited | Parkin ligase activation methods and compositions |
| SG10202005377VA (en) * | 2015-10-23 | 2020-07-29 | Vifor Int Ag | Novel ferroportin inhibitors |
-
2016
- 2016-10-21 SG SG10202005377VA patent/SG10202005377VA/en unknown
- 2016-10-21 CA CA3002418A patent/CA3002418C/en active Active
- 2016-10-21 JP JP2018520089A patent/JP6710754B2/ja active Active
- 2016-10-21 WO PCT/EP2016/075305 patent/WO2017068089A2/en not_active Ceased
- 2016-10-21 AU AU2016342309A patent/AU2016342309B2/en active Active
- 2016-10-21 US US15/768,025 patent/US10738041B2/en active Active
- 2016-10-21 CN CN202210353448.6A patent/CN114668761B/zh active Active
- 2016-10-21 HR HRP20251038TT patent/HRP20251038T1/hr unknown
- 2016-10-21 US US15/769,148 patent/US10364239B2/en active Active
- 2016-10-21 KR KR1020187011524A patent/KR102352829B1/ko active Active
- 2016-10-21 SI SI201631922T patent/SI3365339T1/sl unknown
- 2016-10-21 LT LTEPPCT/EP2016/075306T patent/LT3365339T/lt unknown
- 2016-10-21 WO PCT/EP2016/075306 patent/WO2017068090A1/en not_active Ceased
- 2016-10-21 RS RS20251013A patent/RS67304B1/sr unknown
- 2016-10-21 HU HUE16797462A patent/HUE073266T2/hu unknown
- 2016-10-21 UA UAA201805740A patent/UA123219C2/uk unknown
- 2016-10-21 PE PE2018000572A patent/PE20181496A1/es unknown
- 2016-10-21 CA CA3002416A patent/CA3002416C/en active Active
- 2016-10-21 TW TW105134089A patent/TWI722031B/zh active
- 2016-10-21 AU AU2016342310A patent/AU2016342310B2/en active Active
- 2016-10-21 MY MYPI2018000549A patent/MY198246A/en unknown
- 2016-10-21 JP JP2018520090A patent/JP6810988B2/ja active Active
- 2016-10-21 PT PT167974625T patent/PT3365339T/pt unknown
- 2016-10-21 CO CONC2018/0004165A patent/CO2018004165A2/es unknown
- 2016-10-21 SM SM20250391T patent/SMT202500391T1/it unknown
- 2016-10-21 SG SG11201802480YA patent/SG11201802480YA/en unknown
- 2016-10-21 MX MX2018004882A patent/MX390514B/es unknown
- 2016-10-21 PL PL16797462.5T patent/PL3365339T3/pl unknown
- 2016-10-21 EP EP16797462.5A patent/EP3365339B1/en active Active
- 2016-10-21 DK DK16797462.5T patent/DK3365339T3/da active
- 2016-10-21 SG SG11201802665VA patent/SG11201802665VA/en unknown
- 2016-10-21 FI FIEP16797462.5T patent/FI3365339T3/fi active
- 2016-10-21 BR BR112018007977-4A patent/BR112018007977B1/pt active IP Right Grant
- 2016-10-21 EP EP16784510.6A patent/EP3364967B1/en active Active
- 2016-10-21 MA MA44474A patent/MA44474B1/fr unknown
- 2016-10-21 CN CN201680061941.3A patent/CN108290878B/zh active Active
- 2016-10-21 ES ES16797462T patent/ES3039644T3/es active Active
- 2016-10-23 JO JOP/2016/0229A patent/JO3780B1/ar active
-
2018
- 2018-03-15 IL IL258159A patent/IL258159B/en unknown
- 2018-03-15 IL IL258158A patent/IL258158B2/en unknown
- 2018-04-06 PH PH12018500769A patent/PH12018500769A1/en unknown
- 2018-04-20 CL CL2018001031A patent/CL2018001031A1/es unknown
- 2018-04-20 MX MX2021015106A patent/MX2021015106A/es unknown
-
2019
- 2019-06-12 US US16/438,596 patent/US11001579B2/en active Active
-
2020
- 2020-05-27 JP JP2020091830A patent/JP6967112B2/ja active Active
- 2020-11-24 AU AU2020277121A patent/AU2020277121C1/en active Active
- 2020-12-03 US US17/110,465 patent/US11066399B2/en active Active
-
2021
- 2021-06-07 US US17/340,692 patent/US20220363675A1/en not_active Abandoned
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