BR112017011644A2 - métodos e composições de ativação da ligase parkina - Google Patents

métodos e composições de ativação da ligase parkina

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Publication number
BR112017011644A2
BR112017011644A2 BR112017011644A BR112017011644A BR112017011644A2 BR 112017011644 A2 BR112017011644 A2 BR 112017011644A2 BR 112017011644 A BR112017011644 A BR 112017011644A BR 112017011644 A BR112017011644 A BR 112017011644A BR 112017011644 A2 BR112017011644 A2 BR 112017011644A2
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BR
Brazil
Prior art keywords
parkin ligase
compositions
activation methods
methods
ligase activation
Prior art date
Application number
BR112017011644A
Other languages
English (en)
Inventor
Johnston Jennifer
Original Assignee
An2H Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by An2H Discovery Ltd filed Critical An2H Discovery Ltd
Publication of BR112017011644A2 publication Critical patent/BR112017011644A2/pt

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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02019—Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
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  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
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  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)

Abstract

a presente invenção é dirigida aos métodos e composições para ativar uma ligase parkina por administração a um indivíduo que necessita deles de uma quantidade terapeuticamente eficaz de um composto que rompe pelo menos um dedo de zinco da ligase parkina. a presente invenção é também dirigida aos métodos de tratar e/ou reduzir a incidência de doenças ou condições relacionadas à ativação da ligase parkina.
BR112017011644A 2014-12-05 2015-12-07 métodos e composições de ativação da ligase parkina BR112017011644A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462087972P 2014-12-05 2014-12-05
US201562222008P 2015-09-22 2015-09-22
US201562237400P 2015-10-05 2015-10-05
PCT/US2015/064305 WO2016090371A2 (en) 2014-12-05 2015-12-07 Parkin ligase activation methods and compositions

Publications (1)

Publication Number Publication Date
BR112017011644A2 true BR112017011644A2 (pt) 2018-02-14

Family

ID=56092683

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017011644A BR112017011644A2 (pt) 2014-12-05 2015-12-07 métodos e composições de ativação da ligase parkina

Country Status (11)

Country Link
US (2) US10155936B2 (pt)
EP (1) EP3227437A4 (pt)
JP (1) JP2017538699A (pt)
KR (1) KR20170092634A (pt)
CN (1) CN107249580A (pt)
AU (1) AU2015357487A1 (pt)
BR (1) BR112017011644A2 (pt)
CA (1) CA2968094A1 (pt)
IL (1) IL252425A0 (pt)
MX (1) MX2017007095A (pt)
WO (1) WO2016090371A2 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015357487A1 (en) 2014-12-05 2017-06-08 An2H Discovery Limited Parkin ligase activation methods and compositions
WO2016196955A1 (en) * 2015-06-04 2016-12-08 Drexel University Inhibitors of RAD52 Recombination Protein and Methods Using Same
GB201514015D0 (en) * 2015-08-07 2015-09-23 Arnér Elias S J And Dept Of Health And Human Services Novel pyridazinones and their use in the treatment of cancer
EP3463347A4 (en) * 2016-06-03 2019-12-18 An2H Discovery Limited TRIAZOLBENZAMID DERIVATIVES AND COMPOSITIONS AND METHODS FOR TREATMENT RELATED TO THIS
EP3491353A4 (en) 2016-07-28 2020-02-19 Mayo Foundation for Medical Education and Research SMALL MOLECULE ACTIVATORS OF PARKIN ENZYMATIC FUNCTION
WO2018178237A1 (en) * 2017-03-30 2018-10-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of mitochondrial genetic diseases
CN109745324A (zh) * 2017-11-06 2019-05-14 中国科学院上海生命科学研究院 非经典NF-kB通路的小分子抑制剂及其应用
WO2019100106A1 (en) * 2017-11-24 2019-05-31 The University Of Sydney Antibacterial compounds and methods of use thereof
US10889553B2 (en) 2017-12-01 2021-01-12 Nysnobio Ireland Dac Asymmetric triazole benzamide derivatives and the compositions and methods of treatment regarding the same
CN109988157B (zh) * 2018-01-03 2022-12-27 四川大学 新型小分子化合物、制备方法及在制备抗耐药结核分枝杆菌等分枝杆菌药物方面的用途
WO2019169158A1 (en) * 2018-02-28 2019-09-06 Crestone, Inc. Novel antimycobacterial heterocyclic amides
US20210244712A1 (en) * 2018-04-20 2021-08-12 Nysnobio Ireland Dac Methods for treating patients with cancer having defects in cyclin d regulation
PL3810128T3 (pl) * 2018-06-19 2023-01-30 Universidad Pablo De Olavide Kompozycje do leczenia i/lub zapobiegania chorobom związanym z agregacją białek
KR102066842B1 (ko) * 2018-08-09 2020-01-17 대한민국 10-debc 또는 이의 약학적으로 허용가능한 염을 포함하는 결핵의 예방 또는 치료용 약학적 조성물
KR102091336B1 (ko) * 2018-10-30 2020-03-19 건국대학교 산학협력단 펩타이드 디포밀라아제 활성 저해용 화합물 및 이를 포함하는 조성물
IL264854A (en) * 2019-02-14 2020-08-31 Bahat Anat Spt5 inhibitors and methods of use thereof
WO2021067604A1 (en) * 2019-10-01 2021-04-08 Drexel University Quinoline inhibitors of rad52 and methods of use
KR20210054242A (ko) * 2019-11-05 2021-05-13 아주대학교산학협력단 종양 괴사 인자 알파(TNF-α) 소분자 억제제

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9313866D0 (en) * 1993-07-05 1993-08-18 Diomed Dev Ltd Compositions for the treatment of inflammatory proliferative skin disease and their use
WO2006047631A2 (en) 2004-10-25 2006-05-04 University Of Medicine And Dentistry Of New Jersey Anti-mitotic anti-proliferative compounds
WO2008134474A2 (en) 2007-04-27 2008-11-06 The Board Of Trustees Of The University Of Illinois Compositions and methods including cell death inducers and procaspase activation
JP2010527614A (ja) * 2007-05-21 2010-08-19 エラン・フアルマ・インターナシヨナル・リミテツド パーキン基質およびアッセイ
EP2170867A1 (en) 2007-06-15 2010-04-07 Irm Llc Protein kinase inhibitors and methods for using thereof
KR101014351B1 (ko) 2008-08-04 2011-02-15 한국생명공학연구원 세포외 신호조절 키나제의 활성을 저해하는트리아졸릴-벤즈아미드 유도체 또는 이의 약학적으로허용가능한 염을 유효성분으로 함유하는 암 또는 심혈관계질환의 예방 또는 치료용 조성물
CN102438998A (zh) 2009-02-09 2012-05-02 伊利诺伊大学评议会 作为个性化抗癌药的胱天蛋白酶原活化化合物的设计、合成和评价
PE20121511A1 (es) 2010-01-15 2012-12-06 Janssen Pharmaceuticals Inc Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa
EP2621926B1 (en) 2010-09-30 2017-08-30 Merck Sharp & Dohme Corp. Pyrazolopyrimidine pde10 inhibitors
WO2012067970A2 (en) 2010-11-11 2012-05-24 Ted M Dawson Transcriptional repression leading to parkinson's disease
US8916705B2 (en) 2011-10-14 2014-12-23 The Board of Trustees of The University of Illilnois Procaspase-activating compounds and compositions
FR2987537B1 (fr) 2012-02-23 2015-12-25 Cliris Procede et systeme de supervision d'une scene, notamment dans un site de vente
EP2819661B1 (en) 2012-03-02 2016-11-09 The Board of Trustees of the University of Illionis Potent anticancer activity via dual compound activation
KR102074530B1 (ko) 2012-03-06 2020-02-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 조합 요법에 의한 프로카스파제 ３ 활성화
CN104981461B (zh) 2012-08-03 2017-09-29 伊利诺伊大学评议会 激活酶的化合物及组合物
EP2895462A1 (en) 2012-09-13 2015-07-22 Baden-Württemberg Stiftung gGmbH Specific inhibitors of protein p21 as therapeutic agents
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
AU2015357487A1 (en) 2014-12-05 2017-06-08 An2H Discovery Limited Parkin ligase activation methods and compositions

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Publication number Publication date
WO2016090371A3 (en) 2016-07-28
KR20170092634A (ko) 2017-08-11
CN107249580A (zh) 2017-10-13
MX2017007095A (es) 2017-11-17
WO2016090371A2 (en) 2016-06-09
JP2017538699A (ja) 2017-12-28
EP3227437A2 (en) 2017-10-11
IL252425A0 (en) 2017-07-31
US20160160205A1 (en) 2016-06-09
EP3227437A4 (en) 2018-08-22
CA2968094A1 (en) 2016-06-09
AU2015357487A1 (en) 2017-06-08
US10155936B2 (en) 2018-12-18
US20200087648A1 (en) 2020-03-19

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