PE27799A1 - Formulaciones y formas polimorficas de desferrioxamina y su preparacion - Google Patents
Formulaciones y formas polimorficas de desferrioxamina y su preparacionInfo
- Publication number
- PE27799A1 PE27799A1 PE1997001097A PE00109797A PE27799A1 PE 27799 A1 PE27799 A1 PE 27799A1 PE 1997001097 A PE1997001097 A PE 1997001097A PE 00109797 A PE00109797 A PE 00109797A PE 27799 A1 PE27799 A1 PE 27799A1
- Authority
- PE
- Peru
- Prior art keywords
- despherrioxamine
- refers
- salt
- acid
- crystal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA FORMULACION PARENTERAL DE LIBERACION SOSTENIDA, QUE COMPRENDE: PARTICULAS DE 5� A 10� DE UNA SAL DE DESFERRIOXAMINA-B DE UN ACIDO SULFONICO ALIFATICO DE AL MENOS 8 CARBONOS, SUSPENDIDA EN ACEITE. TAMBIEN SE REFIERE A UNA FORMA CRISTALINA DE 1-DECANSULFONATO DE DESFERRIOXAMINA DE FORMULA (I), CARACTERIZADO POR UN PUNTO DE FUSION DE 154�C A 158�C, Y POR UN PATRON DE DIFRACCION DE RAYOS X EN 2U�: 3,1 4,2 7,3 8,4 9,4 10,5 13,7 16,8 17,4 18,0 18,4 19,6 20,1 20,9 22,3 23,7 25,1 25,6. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE DICHO CRISTAL, QUE COMPRENDE: CALENTAR UNA SOLUCION DE METANOSULFONATO DE DESFERRIOXAMINA; AGREGAR UNA CANTIDAD EQUIMOLAR DE UNA SAL DE ACIDO 1-DECANSULFONICO; INDUCIR LA CRISTALIZACION CON UN CRISTAL DE SIEMBRA Y CONTINUAR AGREGANDO EL RESTO DE LA CANTIDAD EQUIMOLAR DE LA SAL DE ACIDO 1-DECANSULFONICO, OBTENIENDOSE UNA SOLUCION SATURADA EN CALIENTE DE 1-DECANSULFONATO DE DESFERRIOXAMINA EN UN SOLVENTE POLAR, A UNA TEMPERATURA ELEVADA; LA CRISTALIZACION OCURRE A UNA VELOCIDAD DE ENFRIAMIENTO DE 1�C/MINUTO. ESTE CRISTAL MAS ESTABLE, NO MOSTRARA UNA TRANSFORMACION DE ESTADO SOLIDO, INDEPENDIENTE DE LA FASE DE DISPERSION, EN LA PRODUCCION, ALMACENAMIENTO Y USO PARA EL TRATAMIENTO UNA ENFERMEDAD DE SOBRECARGA DE Fe o Al, MALARIA, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH302496 | 1996-12-10 | ||
| GBGB9625878.5A GB9625878D0 (en) | 1996-12-12 | 1996-12-12 | Compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE27799A1 true PE27799A1 (es) | 1999-03-18 |
Family
ID=25691970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997001097A PE27799A1 (es) | 1996-12-10 | 1997-12-05 | Formulaciones y formas polimorficas de desferrioxamina y su preparacion |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0944586A2 (es) |
| KR (1) | KR20000069376A (es) |
| CN (1) | CN1239946A (es) |
| AR (1) | AR009655A1 (es) |
| AU (1) | AU5983998A (es) |
| BR (1) | BR9713570A (es) |
| CA (1) | CA2274761A1 (es) |
| CO (1) | CO4910160A1 (es) |
| CZ (1) | CZ204499A3 (es) |
| ID (1) | ID22388A (es) |
| IL (1) | IL130203A0 (es) |
| PE (1) | PE27799A1 (es) |
| PL (1) | PL334316A1 (es) |
| TR (1) | TR199901260T2 (es) |
| WO (1) | WO1998025887A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090016517A (ko) * | 1999-12-23 | 2009-02-13 | 벨루스 헬스 (인터내셔널) 리미티드 | 대뇌 아밀로이드 혈관병증을 조절하는 화합물 및 방법 |
| GB0117645D0 (en) | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
| DE10223913A1 (de) * | 2002-05-29 | 2003-12-11 | Bayer Cropscience Ag | Verfahren zur Herstellung spezifischer Kristallmodifikationen polymorpher Substanzen |
| WO2017068090A1 (en) | 2015-10-23 | 2017-04-27 | Vifor (International) Ag | Novel ferroportin inhibitors |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛（國際）股份有限公司 | 新穎的鐵螯合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH438351A (de) * | 1959-09-25 | 1967-06-30 | Ciba Geigy | Verfahren zur Herstellung neuer Wuchsstoffe |
| FR1898M (fr) * | 1961-04-07 | 1963-07-08 | Ciba Geigy | Nouvelle substance utilisable en thérapeutique. |
| GB9211779D0 (en) * | 1992-06-03 | 1992-07-15 | Ciba Geigy Ag | Amine salts |
-
1997
- 1997-12-05 PE PE1997001097A patent/PE27799A1/es not_active Application Discontinuation
- 1997-12-05 AR ARP970105722A patent/AR009655A1/es unknown
- 1997-12-08 CA CA002274761A patent/CA2274761A1/en not_active Abandoned
- 1997-12-08 EP EP97954727A patent/EP0944586A2/en not_active Withdrawn
- 1997-12-08 KR KR1019997005104A patent/KR20000069376A/ko not_active Application Discontinuation
- 1997-12-08 ID IDW990473A patent/ID22388A/id unknown
- 1997-12-08 BR BR9713570-4A patent/BR9713570A/pt not_active Application Discontinuation
- 1997-12-08 IL IL13020397A patent/IL130203A0/xx unknown
- 1997-12-08 CZ CZ992044A patent/CZ204499A3/cs unknown
- 1997-12-08 CN CN97180523A patent/CN1239946A/zh active Pending
- 1997-12-08 AU AU59839/98A patent/AU5983998A/en not_active Abandoned
- 1997-12-08 TR TR1999/01260T patent/TR199901260T2/xx unknown
- 1997-12-08 WO PCT/EP1997/006849 patent/WO1998025887A2/en not_active Application Discontinuation
- 1997-12-08 PL PL97334316A patent/PL334316A1/xx unknown
- 1997-12-10 CO CO97072069A patent/CO4910160A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2274761A1 (en) | 1998-06-18 |
| AU5983998A (en) | 1998-07-03 |
| BR9713570A (pt) | 2000-03-14 |
| CZ204499A3 (cs) | 1999-09-15 |
| WO1998025887A2 (en) | 1998-06-18 |
| AR009655A1 (es) | 2000-04-26 |
| CO4910160A1 (es) | 2000-04-24 |
| PL334316A1 (en) | 2000-02-14 |
| ID22388A (id) | 1999-10-07 |
| IL130203A0 (en) | 2000-06-01 |
| EP0944586A2 (en) | 1999-09-29 |
| TR199901260T2 (xx) | 1999-10-21 |
| KR20000069376A (ko) | 2000-11-25 |
| WO1998025887A3 (en) | 1998-08-13 |
| CN1239946A (zh) | 1999-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |