CO4480032A1 - Cristales de glicosidos de espiroestanilo - Google Patents

Cristales de glicosidos de espiroestanilo

Info

Publication number
CO4480032A1
CO4480032A1 CO95037817A CO95037817A CO4480032A1 CO 4480032 A1 CO4480032 A1 CO 4480032A1 CO 95037817 A CO95037817 A CO 95037817A CO 95037817 A CO95037817 A CO 95037817A CO 4480032 A1 CO4480032 A1 CO 4480032A1
Authority
CO
Colombia
Prior art keywords
3beta
oxi
ona
bis
crystals
Prior art date
Application number
CO95037817A
Other languages
English (en)
Inventor
Douglas J Allen
Richard A Buzon
Harry A Watson Jr
Jonathan B Zung
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO4480032A1 publication Critical patent/CO4480032A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. UN GLICOSIDO DE ESPIROESTANILO CRISTALINO COM- PUESTO POR: (3BETA, 5ALFA 25R)-3-[(BETA-D-4", 6"- BIS-[2-FLUOROFENILCARBAMOIL]CELOBIOSIL)OXI]- ESPI- ROESTAN-12-ONA QUE SON UTILES COMO AGENTES HIPOCO- LESTEROLEMIA O ANTIATEROESCLEROSIS. 8. UN PROCEDIMIENTO PARA PREPARAR UN GLICOSIDO ESTEROIDE CRISTALINO QUE COMPRENDE: LA MEZCLA DE (3BETA, 5ALFA, 25R) -3- [(B-D-4", 6" -BIS[2-FLUOROFENIL-CARBAMOIL]CELOBIOSIL)OXI]-ESPI- ROESTAN-12-ONA EN ACETATO DE ETILO O ACETONITRILO Y DEJAR QUE SE FORME LA (3BETA, 5ALFA, 25R)-3-[(B- D-4", 6"-BIS-[2-FLUOROFENIL-CARBAMOIL]CELOBIOSIL) OXI]-ESPIROESTAN-12-ONA CRISTALINA. 9. EL PROCEDIMIENTO COMO EL REFERIDO EN LA REI- VINDICACION 8, EN EL QUE LA SOLUCION DE ACETATO DE ETILO O ACETONITRILO SE CALIENTA Y DESPUES DE EN- FRIARSE SE FORMAN LOS CRISTALES. FIGURA 1
CO95037817A 1994-08-30 1995-08-23 Cristales de glicosidos de espiroestanilo CO4480032A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29810694A 1994-08-30 1994-08-30

Publications (1)

Publication Number Publication Date
CO4480032A1 true CO4480032A1 (es) 1997-07-09

Family

ID=23149057

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95037817A CO4480032A1 (es) 1994-08-30 1995-08-23 Cristales de glicosidos de espiroestanilo

Country Status (20)

Country Link
US (1) US5804562A (es)
EP (1) EP0778846A1 (es)
JP (1) JPH09510735A (es)
KR (1) KR970705574A (es)
AU (1) AU2265395A (es)
BR (1) BR9503827A (es)
CA (1) CA2198097A1 (es)
CO (1) CO4480032A1 (es)
FI (1) FI970828A (es)
HR (1) HRP950459A2 (es)
IL (1) IL115062A0 (es)
MA (1) MA23651A1 (es)
MX (1) MX9701525A (es)
NO (1) NO970910L (es)
OA (1) OA10402A (es)
PE (1) PE47696A1 (es)
PL (1) PL318937A1 (es)
SI (1) SI9520092A (es)
TR (1) TR199501065A2 (es)
WO (1) WO1996006854A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1198622C (zh) * 1998-03-26 2005-04-27 植物药物公共有限公司 用于治疗阿尔茨海默病的甾类皂苷及其衍生物
GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
KR101130212B1 (ko) * 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU94046294A (ru) * 1992-06-26 1996-10-10 Пфайзер Инк. (US) Стероидные гликозиды для лечения гиперхолестеринэмии
US5698526A (en) * 1993-12-28 1997-12-16 Pfizer Inc. Steroidal glycosides

Also Published As

Publication number Publication date
KR970705574A (ko) 1997-10-09
NO970910D0 (no) 1997-02-27
OA10402A (en) 2001-12-05
AU2265395A (en) 1996-03-22
US5804562A (en) 1998-09-08
CA2198097A1 (en) 1996-03-07
SI9520092A (en) 1997-12-31
WO1996006854A1 (en) 1996-03-07
PL318937A1 (en) 1997-07-21
PE47696A1 (es) 1996-11-12
HRP950459A2 (en) 1997-08-31
FI970828A0 (fi) 1997-02-27
JPH09510735A (ja) 1997-10-28
MA23651A1 (fr) 1996-04-01
BR9503827A (pt) 1996-09-10
FI970828A (fi) 1997-02-27
TR199501065A2 (tr) 1996-06-21
NO970910L (no) 1997-02-27
EP0778846A1 (en) 1997-06-18
IL115062A0 (en) 1995-12-08
MX9701525A (es) 1997-05-31

Similar Documents

Publication Publication Date Title
MX9701292A (es) Compuestos espiro-azabiciclicos utiles en la terapia.
DK272884A (da) 8-chlor-1,5-benzothiazepin-derivater og fremgangsmaade til fremstilling deraf
ES545250A0 (es) Un procedimiento para preparar derivados de 1,8-naftiridina
ES2154398T3 (es) Piridinas 2,3-sustituidas para el tratamiento de la inflamacion.
FI842760A0 (fi) Menetelmä terapeuttisesti aktiivisten imidatsoliumyhdisteiden valmistamiseksi
LV5483A3 (lv) Izohinolinija atvasinajumu iegusanas panemiens
PT67164B (en) Process for the preparation of hydantoin derivatives as therapeutic agents
CO4480032A1 (es) Cristales de glicosidos de espiroestanilo
KR900013950A (ko) (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온 화합물 및 약학적 담체를 함유한 약학적 조성물
DK204686A (da) Quinolylglycinamidderivater og fremgangsmaade til fremstilling deraf
ES2111352T3 (es) Uso de diester fosfato para el tratamiento de enfermedades retinianas.
IT1165252B (it) Procedimento di purificazione dell'acido ursodesossicolico attraverso nuovi derivati
ATE37533T1 (de) Derivate der 4-phenyl-4-oxo-buten-2-saeure, verfahren zu ihrer herstellung, medikamente und mischungen mit diesen derivaten.
ES8102148A1 (es) Metodo de preparar 3-0-(beta-d-glucuronopiranosil)-sojasapo-genol b y similares
BR1101133A (pt) Derivado de sinergistina, (quinuclidinil-3(s) tiometil-5 bem como seus sais farmaceuticamente aceitáveis, processo de preparação do derivado de sinergistina e composição farmacêutica
ES8106516A1 (es) Procedimiento de preparacion de nuevos derivados halovinca- monas y de sus sales de adicion acidas farmaceuticamente aceptables e isomeros opticamente activos de los mismos
ES534859A0 (es) Procedimiento para la obtencion de derivados de 1-(4'-alquilsulfonilfenil)-2-amino-1,3-propandiol n-substituidos
NO167286C (no) Fremgangsmaate for fremstilling av terapeutisk aktive benzotiazepin-derivater.
LU80272A1 (fr) Procede de preparation d'agents therapeutiques antiallergiques
MX9303422A (es) Benzodiazepinas, procedimiento para su preparacion y medicamento que las contiene.
EP0143711A3 (en) Derivatives of n-(methoxyphenacyl)amine, their therapeutical use and process for their preparation
ES534858A0 (es) Procedimiento para la obtencion de derivados de 1-(4'-alquiltiofenil)-2-amino-1,3-propandiol
EP0105458A3 (en) Alpha-aryl-alpha-pyridylalkanoic acid derivatives, process for preparation thereof and pharmaceutical composition comprising the same
ATE27602T1 (de) Tryptaminderivate mit wirkung auf das kardiovaskulaere system und verfahren zu ihrer herstellung.
AR225303A1 (es) Procedimiento para obtener una forma cristalina de n-2-(6-metoxi)-benzotiazolil-n'-fenilurea como anhidrato forma(forma(iv)