RU94046294A - Стероидные гликозиды для лечения гиперхолестеринэмии - Google Patents

Стероидные гликозиды для лечения гиперхолестеринэмии

Info

Publication number
RU94046294A
RU94046294A RU94046294/04A RU94046294A RU94046294A RU 94046294 A RU94046294 A RU 94046294A RU 94046294/04 A RU94046294/04 A RU 94046294/04A RU 94046294 A RU94046294 A RU 94046294A RU 94046294 A RU94046294 A RU 94046294A
Authority
RU
Russia
Prior art keywords
steroid glycosides
hypercholesterolemia treatment
hypercholesterolemia
treatment
agents
Prior art date
Application number
RU94046294/04A
Other languages
English (en)
Inventor
Поль Денинно Майкл
Us]
Эндрю Маккарти Питер
Original Assignee
Пфайзер Инк. (US)
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. (US), Пфайзер Инк. filed Critical Пфайзер Инк. (US)
Publication of RU94046294A publication Critical patent/RU94046294A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Некоторые стероидные гликозиды, пригодные для использования в качестве гипохолестеринэмических агентов и в качестве антиатеросклеротических агентов.

Claims (1)

  1. Некоторые стероидные гликозиды, пригодные для использования в качестве гипохолестеринэмических агентов и в качестве антиатеросклеротических агентов.
RU94046294/04A 1992-06-26 1993-05-06 Стероидные гликозиды для лечения гиперхолестеринэмии RU94046294A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90491492A 1992-06-26 1992-06-26
US07/904,914 1992-06-26

Publications (1)

Publication Number Publication Date
RU94046294A true RU94046294A (ru) 1996-10-10

Family

ID=25419965

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046294/04A RU94046294A (ru) 1992-06-26 1993-05-06 Стероидные гликозиды для лечения гиперхолестеринэмии

Country Status (19)

Country Link
US (2) US5629295A (ru)
EP (4) EP0796863A2 (ru)
JP (2) JPH07504921A (ru)
KR (1) KR950702203A (ru)
CN (1) CN1085561A (ru)
AP (1) AP489A (ru)
AU (1) AU4226593A (ru)
BG (1) BG99261A (ru)
BR (1) BR9306619A (ru)
CA (1) CA2139104A1 (ru)
CZ (1) CZ331094A3 (ru)
HR (1) HRP930994A2 (ru)
IL (1) IL106055A0 (ru)
MX (1) MX9303826A (ru)
OA (1) OA10121A (ru)
RU (1) RU94046294A (ru)
SK (1) SK158394A3 (ru)
WO (1) WO1994000480A1 (ru)
YU (1) YU44793A (ru)

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ES2074006B1 (es) * 1993-07-05 1996-03-16 Pfizer Glicosidos esteroidales para tratar hipercolesterolemia.
FI96243C (fi) * 1993-10-26 1996-05-27 Ilmari Paakkinen Menetelmä ja laite rakeisten maamassojen ominaisuuksien mittaamiseksi
US5698526A (en) * 1993-12-28 1997-12-16 Pfizer Inc. Steroidal glycosides
CA2180148A1 (en) * 1993-12-28 1995-07-06 Michael Paul Deninno Hypocholesterolemic agents
FR2722690B1 (fr) * 1994-07-21 1996-10-25 Univ Montpellier Ii Compositions de saponines et/ou de leurs formes aglycones et leurs applications comme medicaments
SI9520092A (en) * 1994-08-30 1997-12-31 Pfizer Spirostanyl glycosidal crystals
WO1996009827A2 (en) * 1994-09-20 1996-04-04 Pfizer Inc. Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
WO1996038466A1 (en) * 1995-05-29 1996-12-05 Pfizer Inc. Steroidal glycosides
US5698527A (en) * 1995-08-08 1997-12-16 Merck & Co., Inc. Steroidal glycosides as antihyperlipidemic agents
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
CN1198622C (zh) * 1998-03-26 2005-04-27 植物药物公共有限公司 用于治疗阿尔茨海默病的甾类皂苷及其衍生物
JP3370610B2 (ja) * 1998-08-21 2003-01-27 武田薬品工業株式会社 害虫防除剤
US20030060425A1 (en) * 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
US6343258B1 (en) 1999-08-13 2002-01-29 ALEXIS Brian Method for testing for readiness for harvesting of tribulus terrestris l. having high steroidal saponin content
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
CA2389670A1 (en) * 1999-11-01 2001-05-10 Forbes Medi-Tech Inc. Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
US6207638B1 (en) 2000-02-23 2001-03-27 Pacifichealth Laboratories, Inc. Nutritional intervention composition for enhancing and extending satiety
AU2002232575A1 (en) 2000-12-15 2002-06-24 Pacifichealth Laboratories, Inc. Nutritional composition for improving the efficacy of a lipase inhibitor
US6429190B1 (en) 2000-12-15 2002-08-06 Pacifichealth Laboratories, Inc. Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK)
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US6703530B2 (en) * 2002-02-28 2004-03-09 General Electric Company Chemical reactor system and process
KR101130212B1 (ko) * 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
US7718792B2 (en) * 2002-10-28 2010-05-18 Phytopharm Plc Stereospecific reduction of sapogen-3-ones
ATE439347T1 (de) 2004-11-23 2009-08-15 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
CN102066397B (zh) * 2008-04-18 2013-09-11 里亚塔医药公司 包含抗炎症药效团的化合物以及使用方法
AU2009274037B2 (en) * 2008-07-22 2015-07-09 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
WO2011145022A1 (en) 2010-05-21 2011-11-24 Pfizer Inc. 2-phenyl benzoylamides
EP2680874A2 (en) 2011-03-04 2014-01-08 Pfizer Inc Edn3-like peptides and uses thereof
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
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CN113574055A (zh) 2019-01-18 2021-10-29 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

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US3178418A (en) 1963-02-26 1965-04-13 Glaxo Lab Ltd Monobromination at the 11-position of hecogenin and 3-lower alkanoyl esters thereof
DE2926463A1 (de) * 1978-07-05 1980-01-24 Roecar Holdings Nv Spiroketaline und ihre verwendung
US4260603A (en) * 1979-01-02 1981-04-07 Pegel Karl H Sterol glycoside with activity as prostaglandin synthetase inhibitor
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US4602003A (en) 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
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US5017562A (en) * 1987-02-11 1991-05-21 Regents Of The University Of Minnesota Crystalline saponin-containing complex
FR2621316B1 (fr) * 1987-10-02 1991-06-21 Nativelle Sa Ets Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant
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JPH06511250A (ja) * 1991-10-04 1994-12-15 ザ、プロクター、エンド、ギャンブル、カンパニー コレステロール低下化合物及びそれらの製造方法
WO1993011150A1 (en) * 1991-11-25 1993-06-10 Pfizer Inc. Method for making steroidal peracyl glycosides
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Also Published As

Publication number Publication date
BG99261A (en) 1995-06-30
WO1994000480A1 (en) 1994-01-06
YU44793A (sh) 1996-10-09
AP489A (en) 1996-05-02
JPH09309897A (ja) 1997-12-02
MX9303826A (es) 1994-02-28
US5629295A (en) 1997-05-13
EP0796864A2 (en) 1997-09-24
KR950702203A (ko) 1995-06-19
SK158394A3 (en) 1995-05-10
EP0796862A2 (en) 1997-09-24
HRP930994A2 (en) 1996-08-31
CZ331094A3 (en) 1995-09-13
JPH07504921A (ja) 1995-06-01
BR9306619A (pt) 1998-12-08
US5703052A (en) 1997-12-30
IL106055A0 (en) 1993-10-20
EP0647234A1 (en) 1995-04-12
CA2139104A1 (en) 1994-01-06
CN1085561A (zh) 1994-04-20
EP0796863A2 (en) 1997-09-24
OA10121A (en) 1996-12-18
AU4226593A (en) 1994-01-24
AP9300539A0 (en) 1993-07-31

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