RU95106823A - Сукциноиламиногидроксиэтиламиносульфонамиды, фармацевтическая композиция, способ ингибирования ретровирусной протеазы, способ лечения ретровирусной инфекции способ лечения спида - Google Patents

Сукциноиламиногидроксиэтиламиносульфонамиды, фармацевтическая композиция, способ ингибирования ретровирусной протеазы, способ лечения ретровирусной инфекции способ лечения спида

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Publication number
RU95106823A
RU95106823A RU95106823/04A RU95106823A RU95106823A RU 95106823 A RU95106823 A RU 95106823A RU 95106823/04 A RU95106823/04 A RU 95106823/04A RU 95106823 A RU95106823 A RU 95106823A RU 95106823 A RU95106823 A RU 95106823A
Authority
RU
Russia
Prior art keywords
treatment
retroviral
succinoylaminohydroxyethylaminosulfonamides
inhibition
pharmaceutical composition
Prior art date
Application number
RU95106823/04A
Other languages
English (en)
Other versions
RU2130016C1 (ru
Inventor
Л.Васкуз Майкл
Us]
Мюллер Ричард
Дж.Тэлли Джон
Гетман Даниел
А.Декреченцо Гэри
Н.Фрескос Джон
Original Assignee
Джи Ди Сирл энд Компани (US)
Джи Ди Сирл энд Компани
Монсанто Компани (US)
Монсанто Компани
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Publication date
Application filed by Джи Ди Сирл энд Компани (US), Джи Ди Сирл энд Компани, Монсанто Компани (US), Монсанто Компани filed Critical Джи Ди Сирл энд Компани (US)
Publication of RU95106823A publication Critical patent/RU95106823A/ru
Application granted granted Critical
Publication of RU2130016C1 publication Critical patent/RU2130016C1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Abstract

Сукциноиламиногидроксиэтила миносульфонамидные соединения являются эффективными ингибиторами ретровирусных протеаз, а в частности, ингибиторами ВИЧ-протеазы.

Claims (1)

  1. Сукциноиламиногидроксиэтила миносульфонамидные соединения являются эффективными ингибиторами ретровирусных протеаз, а в частности, ингибиторами ВИЧ-протеазы.
RU95106823A 1992-08-25 1993-08-25 Производные сукциноиламиногидроксиэтиламиносульфонамида, фармацевтическая композиция, способ ингибирования ретровирусной протеазы, способ лечения ретровирусной инфекции, способ лечения вич-инфекции RU2130016C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93549092A 1992-08-25 1992-08-25
US07/935.490 1992-08-25
US07/935490 1992-08-25
PCT/US1993/007815 WO1994004491A1 (en) 1992-08-25 1993-08-24 N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors

Publications (2)

Publication Number Publication Date
RU95106823A true RU95106823A (ru) 1996-11-20
RU2130016C1 RU2130016C1 (ru) 1999-05-10

Family

ID=25467232

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95106823A RU2130016C1 (ru) 1992-08-25 1993-08-25 Производные сукциноиламиногидроксиэтиламиносульфонамида, фармацевтическая композиция, способ ингибирования ретровирусной протеазы, способ лечения ретровирусной инфекции, способ лечения вич-инфекции

Country Status (15)

Country Link
US (2) US5463104A (ru)
EP (1) EP0656886B1 (ru)
JP (1) JP4091653B2 (ru)
KR (1) KR100296461B1 (ru)
AT (1) ATE154800T1 (ru)
AU (1) AU674702B2 (ru)
CA (1) CA2142998C (ru)
DE (1) DE69311810T2 (ru)
DK (1) DK0656886T3 (ru)
ES (1) ES2103488T3 (ru)
FI (1) FI120342B (ru)
GR (1) GR3024181T3 (ru)
NO (1) NO302883B1 (ru)
RU (1) RU2130016C1 (ru)
WO (1) WO1994004491A1 (ru)

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Also Published As

Publication number Publication date
GR3024181T3 (en) 1997-10-31
CA2142998A1 (en) 1994-03-03
NO950670D0 (no) 1995-02-22
US5463104A (en) 1995-10-31
CA2142998C (en) 2008-01-29
AU5081993A (en) 1994-03-15
RU2130016C1 (ru) 1999-05-10
AU674702B2 (en) 1997-01-09
JPH08500824A (ja) 1996-01-30
JP4091653B2 (ja) 2008-05-28
NO302883B1 (no) 1998-05-04
NO950670L (no) 1995-02-22
ATE154800T1 (de) 1997-07-15
ES2103488T3 (es) 1997-09-16
FI950841A (fi) 1995-02-23
FI120342B (fi) 2009-09-30
DE69311810D1 (de) 1997-07-31
KR100296461B1 (ko) 2001-11-14
FI950841A0 (fi) 1995-02-23
EP0656886B1 (en) 1997-06-25
DK0656886T3 (da) 1998-02-02
US5714605A (en) 1998-02-03
KR950702959A (ko) 1995-08-23
WO1994004491A1 (en) 1994-03-03
DE69311810T2 (de) 1997-11-27
EP0656886A1 (en) 1995-06-14

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