RU94031102A - Сульфамиды в качестве антагонистов эндотелина и способ лечения соответствующих заболеваний - Google Patents

Сульфамиды в качестве антагонистов эндотелина и способ лечения соответствующих заболеваний

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Publication number
RU94031102A
RU94031102A RU94031102/04A RU94031102A RU94031102A RU 94031102 A RU94031102 A RU 94031102A RU 94031102/04 A RU94031102/04 A RU 94031102/04A RU 94031102 A RU94031102 A RU 94031102A RU 94031102 A RU94031102 A RU 94031102A
Authority
RU
Russia
Prior art keywords
endotheelin
sulfides
antagonists
corresponding diseases
treating corresponding
Prior art date
Application number
RU94031102/04A
Other languages
English (en)
Other versions
RU2141953C1 (ru
Inventor
Т.Хант Джон
Us]
Original Assignee
Бристоль-Мейерз Сквибб Компани (US)
Бристоль-Мейерз Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристоль-Мейерз Сквибб Компани (US), Бристоль-Мейерз Сквибб Компани filed Critical Бристоль-Мейерз Сквибб Компани (US)
Publication of RU94031102A publication Critical patent/RU94031102A/ru
Application granted granted Critical
Publication of RU2141953C1 publication Critical patent/RU2141953C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Соединения формулы, приведенной в описании, в которой R является фенилом, нафтилом или дифенилилом, каждый из которых может быть замещен, ингибируют эндотелин.

Claims (1)

  1. Соединения формулы, приведенной в описании, в которой R является фенилом, нафтилом или дифенилилом, каждый из которых может быть замещен, ингибируют эндотелин.
RU94031102/04A 1993-08-30 1994-08-29 Сульфамидные соединения или их фармацевтически пригодные соли и способ ингибирования рецепторов ета RU2141953C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US114,251 1993-08-30
US08/114,251 US5965732A (en) 1993-08-30 1993-08-30 Sulfonamide endothelin antagonists

Publications (2)

Publication Number Publication Date
RU94031102A true RU94031102A (ru) 1996-07-10
RU2141953C1 RU2141953C1 (ru) 1999-11-27

Family

ID=22354178

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94031102/04A RU2141953C1 (ru) 1993-08-30 1994-08-29 Сульфамидные соединения или их фармацевтически пригодные соли и способ ингибирования рецепторов ета

Country Status (17)

Country Link
US (1) US5965732A (ru)
EP (1) EP0640596A1 (ru)
JP (1) JPH07109263A (ru)
KR (1) KR950005811A (ru)
CN (1) CN1057295C (ru)
AU (1) AU680522B2 (ru)
CA (1) CA2130971A1 (ru)
CZ (1) CZ288478B6 (ru)
FI (1) FI943926A (ru)
HU (1) HUT68421A (ru)
IL (1) IL110743A (ru)
NO (1) NO305317B1 (ru)
NZ (1) NZ264319A (ru)
PL (1) PL175927B1 (ru)
RU (1) RU2141953C1 (ru)
TW (1) TW411334B (ru)
ZA (1) ZA946571B (ru)

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US5958905A (en) 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US5804585A (en) * 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
AU6187898A (en) * 1997-01-30 1998-08-25 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
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Also Published As

Publication number Publication date
HUT68421A (en) 1995-06-28
PL175927B1 (pl) 1999-03-31
HU9402486D0 (en) 1994-10-28
CZ194894A3 (en) 1995-10-18
IL110743A (en) 1998-10-30
FI943926A0 (fi) 1994-08-26
FI943926A (fi) 1995-03-01
AU7147194A (en) 1995-03-09
RU2141953C1 (ru) 1999-11-27
ZA946571B (en) 1995-03-22
KR950005811A (ko) 1995-03-20
TW411334B (en) 2000-11-11
NZ264319A (en) 1996-02-27
US5965732A (en) 1999-10-12
IL110743A0 (en) 1994-11-11
CN1057295C (zh) 2000-10-11
EP0640596A1 (en) 1995-03-01
NO305317B1 (no) 1999-05-10
NO943190L (no) 1995-03-01
AU680522B2 (en) 1997-07-31
PL304822A1 (en) 1995-03-06
CA2130971A1 (en) 1995-03-01
CZ288478B6 (en) 2001-06-13
CN1106805A (zh) 1995-08-16
NO943190D0 (no) 1994-08-29
JPH07109263A (ja) 1995-04-25

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Effective date: 20020830