ES8800160A1 - Procedimiento de obtencion de acidos quinolincarboxilicos con propiedades antibacteriales. - Google Patents
Procedimiento de obtencion de acidos quinolincarboxilicos con propiedades antibacteriales.Info
- Publication number
- ES8800160A1 ES8800160A1 ES554142A ES554142A ES8800160A1 ES 8800160 A1 ES8800160 A1 ES 8800160A1 ES 554142 A ES554142 A ES 554142A ES 554142 A ES554142 A ES 554142A ES 8800160 A1 ES8800160 A1 ES 8800160A1
- Authority
- ES
- Spain
- Prior art keywords
- antibacterial agents
- difluoronaphthyridines
- quinolines
- trifluoro
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 3
- KRGPWURZFNACKU-UHFFFAOYSA-N 3,4-difluoro-1,8-naphthyridine Chemical class N1=CC=CC2=C(F)C(F)=CN=C21 KRGPWURZFNACKU-UHFFFAOYSA-N 0.000 title 1
- DFYPWUZXTWLPSC-UHFFFAOYSA-N 5,6,8-trifluoroquinoline Chemical class N1=CC=CC2=C(F)C(F)=CC(F)=C21 DFYPWUZXTWLPSC-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- IAKJHUOGESWCIE-UHFFFAOYSA-N 2,3-difluoro-1,8-naphthyridine;3,4,5-trifluoroquinoline-2-carboxylic acid Chemical class C1=CN=C2N=C(F)C(F)=CC2=C1.C1=CC(F)=C2C(F)=C(F)C(C(=O)O)=NC2=C1 IAKJHUOGESWCIE-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE ACIDOS QUINOLINCARBOXILICOS CON PROPIEDADES ANTIBACTERIALES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), CON AMINA DE FORMULA (III), EN UN DISOLVENTE NO REACTIVO COMO ETANOL, ENTRE 20 Y 150GC, EN PRESENCIA DE UN ACEPTOR DE ACIDO, COMO PIRIDINA, PARA OBTENER UN COMPUESTO DE FORMULA (I); SIENDO: Z, (III); X, CF O N; N Y N'', INDEPENDIENTEMENTE, 1, 2, 3 O 4, SIEMPRE QUE N+N''=5; N'''', 0, 1 O 2; R1, H, ALQUILO DE C 1 A 6 O UN CATION; R2, ALQUILO DE C 1 A 4, VINILO Y OTROS; R3, H, ALQUILO DE C 1 A 4 Y OTROS; R4, H, HIDROXIALQUILO DE C 2 A 4 Y OTROS; R5 Y R6, H O ALQUILO DE C 1 A 3, Y L, GRUPO SALIENTE, F O CL. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/724,442 US4657913A (en) | 1985-04-18 | 1985-04-18 | Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8800160A1 true ES8800160A1 (es) | 1987-10-16 |
ES554142A0 ES554142A0 (es) | 1987-10-16 |
Family
ID=24910460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES554142A Expired ES8800160A1 (es) | 1985-04-18 | 1986-04-18 | Procedimiento de obtencion de acidos quinolincarboxilicos con propiedades antibacteriales. |
Country Status (22)
Country | Link |
---|---|
US (1) | US4657913A (es) |
EP (1) | EP0202763B1 (es) |
JP (1) | JPS61243077A (es) |
KR (1) | KR890005199B1 (es) |
CN (1) | CN1012064B (es) |
AR (1) | AR240458A1 (es) |
AT (1) | ATE47853T1 (es) |
AU (1) | AU587811B2 (es) |
DD (1) | DD244553A5 (es) |
DE (1) | DE3666820D1 (es) |
DK (1) | DK172786A (es) |
ES (1) | ES8800160A1 (es) |
FI (1) | FI861574A (es) |
GR (1) | GR860998B (es) |
HU (1) | HU195498B (es) |
IL (1) | IL78528A (es) |
NO (1) | NO166080C (es) |
NZ (1) | NZ215868A (es) |
OA (1) | OA08236A (es) |
PH (1) | PH23770A (es) |
PT (1) | PT82414B (es) |
ZA (1) | ZA862388B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE58742B1 (en) * | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
DE3685157D1 (de) * | 1985-06-26 | 1992-06-11 | Daiichi Seiyaku Co | Pyridoncarbonsaeurederivate. |
AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
GB8612137D0 (en) * | 1986-05-19 | 1986-06-25 | Fujisawa Pharmaceutical Co | Quinolone compounds |
FR2607506B1 (fr) * | 1986-12-02 | 1989-01-06 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2607504B1 (fr) * | 1986-12-02 | 1989-01-27 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2607503B1 (fr) * | 1986-12-02 | 1989-02-24 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
DE3711193A1 (de) * | 1987-04-02 | 1988-10-13 | Bayer Ag | 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate |
US5290934A (en) * | 1987-04-16 | 1994-03-01 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
US5563138A (en) * | 1987-04-16 | 1996-10-08 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
US4851418A (en) * | 1987-08-21 | 1989-07-25 | Warner-Lambert Company | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
JPH0794452B2 (ja) * | 1987-10-16 | 1995-10-11 | 大日本製薬株式会社 | 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
WO1989005643A1 (en) * | 1987-12-18 | 1989-06-29 | Pfizer Inc. | Heterocyclic-substituted quinoline-carboxylic acids |
DE3814517A1 (de) * | 1988-02-05 | 1989-08-17 | Bayer Ag | Chinolon- und naphthyridoncarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
MY105136A (en) | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
US4992449A (en) * | 1990-02-01 | 1991-02-12 | American Cyanamid Company | 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
FR2692577B1 (fr) * | 1992-05-26 | 1996-02-02 | Bouchara Sa | Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant. |
TW425394B (en) * | 1996-04-24 | 2001-03-11 | Daiichi Seiyaku Co | Antimicrobial quinolone derivatives having 3-(N-cycloalkyl) aminomethylpyrrolidine group |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3963736A (en) * | 1970-01-28 | 1976-06-15 | Sumitomo Chemical Company, Limited | Preparation of 1-(lower alkyl)-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acids |
US3907808A (en) * | 1971-05-17 | 1975-09-23 | Sterling Drug Inc | 1,4-Dihydro-4-oxo-7-pyridyl-3-quinolinecarboxylic acid derivatives |
US4292317A (en) * | 1977-09-20 | 1981-09-29 | Laboratorie Roger Bellon | 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them |
JPS5845426B2 (ja) * | 1978-09-29 | 1983-10-08 | 杏林製薬株式会社 | 置換キノリンカルボン酸誘導体 |
SE440354B (sv) * | 1981-02-19 | 1985-07-29 | Kyorin Seiyaku Kk | Kinolinkarboxylsyraderivat |
ES8304117A1 (es) * | 1981-06-11 | 1983-02-16 | Warner Lambert Co | "un procedimiento para preparar sales de compuestos de naftiridina y quinoleina". |
US4477449A (en) * | 1982-04-19 | 1984-10-16 | Warner-Lambert Company | Certain 1,8-naphthyridine compounds useful as antibacterial agents |
IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
IE58742B1 (en) * | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
AU4042085A (en) * | 1985-03-27 | 1986-10-02 | Brugnoli, Angelo | Energy system using hydrostatic pressure air compressor |
-
1985
- 1985-04-18 US US06/724,442 patent/US4657913A/en not_active Expired - Fee Related
-
1986
- 1986-04-01 ZA ZA862388A patent/ZA862388B/xx unknown
- 1986-04-03 AU AU55615/86A patent/AU587811B2/en not_active Ceased
- 1986-04-14 FI FI861574A patent/FI861574A/fi not_active Application Discontinuation
- 1986-04-15 GR GR860998A patent/GR860998B/el unknown
- 1986-04-15 DD DD86289148A patent/DD244553A5/de not_active IP Right Cessation
- 1986-04-15 DE DE8686302812T patent/DE3666820D1/de not_active Expired
- 1986-04-15 EP EP86302812A patent/EP0202763B1/en not_active Expired
- 1986-04-15 AT AT86302812T patent/ATE47853T1/de not_active IP Right Cessation
- 1986-04-16 DK DK172786A patent/DK172786A/da active IP Right Grant
- 1986-04-16 IL IL78528A patent/IL78528A/xx unknown
- 1986-04-17 AR AR303682A patent/AR240458A1/es active
- 1986-04-17 NO NO861509A patent/NO166080C/no unknown
- 1986-04-17 NZ NZ215868A patent/NZ215868A/xx unknown
- 1986-04-17 PH PH33665A patent/PH23770A/en unknown
- 1986-04-17 OA OA58838A patent/OA08236A/xx unknown
- 1986-04-17 PT PT82414A patent/PT82414B/pt not_active IP Right Cessation
- 1986-04-17 JP JP61087237A patent/JPS61243077A/ja active Pending
- 1986-04-17 HU HU861617A patent/HU195498B/hu not_active IP Right Cessation
- 1986-04-18 ES ES554142A patent/ES8800160A1/es not_active Expired
- 1986-04-18 CN CN86102683A patent/CN1012064B/zh not_active Expired
- 1986-04-18 KR KR1019860002997A patent/KR890005199B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT82414A (en) | 1986-05-01 |
AU587811B2 (en) | 1989-08-31 |
NO166080C (no) | 1991-05-29 |
KR890005199B1 (ko) | 1989-12-18 |
ATE47853T1 (de) | 1989-11-15 |
IL78528A (en) | 1990-09-17 |
EP0202763A1 (en) | 1986-11-26 |
CN86102683A (zh) | 1986-12-03 |
DK172786D0 (da) | 1986-04-16 |
DK172786A (da) | 1986-10-19 |
ZA862388B (en) | 1987-11-25 |
DD244553A5 (de) | 1987-04-08 |
EP0202763B1 (en) | 1989-11-08 |
NZ215868A (en) | 1988-08-30 |
AU5561586A (en) | 1986-10-23 |
AR240458A1 (es) | 1990-04-30 |
FI861574A (fi) | 1986-10-19 |
NO166080B (no) | 1991-02-18 |
CN1012064B (zh) | 1991-03-20 |
ES554142A0 (es) | 1987-10-16 |
JPS61243077A (ja) | 1986-10-29 |
OA08236A (en) | 1987-10-30 |
PH23770A (en) | 1989-11-03 |
NO861509L (no) | 1986-10-20 |
GR860998B (en) | 1986-08-12 |
HUT41020A (en) | 1987-03-30 |
DE3666820D1 (en) | 1989-12-14 |
US4657913A (en) | 1987-04-14 |
KR860008164A (ko) | 1986-11-12 |
IL78528A0 (en) | 1986-08-31 |
FI861574A0 (fi) | 1986-04-14 |
HU195498B (en) | 1988-05-30 |
PT82414B (pt) | 1988-05-27 |
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