MX9303826A - Glicosidos esteroidales como agentes hipocolesterolemicos y agentes antiaterosclerosis. - Google Patents
Glicosidos esteroidales como agentes hipocolesterolemicos y agentes antiaterosclerosis.Info
- Publication number
- MX9303826A MX9303826A MX9303826A MX9303826A MX9303826A MX 9303826 A MX9303826 A MX 9303826A MX 9303826 A MX9303826 A MX 9303826A MX 9303826 A MX9303826 A MX 9303826A MX 9303826 A MX9303826 A MX 9303826A
- Authority
- MX
- Mexico
- Prior art keywords
- agents
- atherosclerosis
- hypocholesterolemic
- steroid glycosides
- glycosides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Ciertos glicósidos esteroidales son útiles como agentes hipocolesterolémicos y agentes antiaterosclerosis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90491492A | 1992-06-26 | 1992-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9303826A true MX9303826A (es) | 1994-02-28 |
Family
ID=25419965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9303826A MX9303826A (es) | 1992-06-26 | 1993-06-25 | Glicosidos esteroidales como agentes hipocolesterolemicos y agentes antiaterosclerosis. |
Country Status (19)
Country | Link |
---|---|
US (2) | US5629295A (es) |
EP (4) | EP0796864A2 (es) |
JP (2) | JPH07504921A (es) |
KR (1) | KR950702203A (es) |
CN (1) | CN1085561A (es) |
AP (1) | AP489A (es) |
AU (1) | AU4226593A (es) |
BG (1) | BG99261A (es) |
BR (1) | BR9306619A (es) |
CA (1) | CA2139104A1 (es) |
CZ (1) | CZ331094A3 (es) |
HR (1) | HRP930994A2 (es) |
IL (1) | IL106055A0 (es) |
MX (1) | MX9303826A (es) |
OA (1) | OA10121A (es) |
RU (1) | RU94046294A (es) |
SK (1) | SK158394A3 (es) |
WO (1) | WO1994000480A1 (es) |
YU (1) | YU44793A (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0647233A1 (en) * | 1992-06-26 | 1995-04-12 | Pfizer Inc. | Steroidal beta-o-cellobioside heptaalkanoate process |
CZ280195A3 (en) * | 1993-04-28 | 1996-02-14 | Pfizer | Crystalline spirostanyl glycoside, monohydrate thereof, pharmaceutical composition based thereon and process for preparing crystalline steroidal glycoside |
US5502038A (en) * | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
ES2074006B1 (es) * | 1993-07-05 | 1996-03-16 | Pfizer | Glicosidos esteroidales para tratar hipercolesterolemia. |
FI96243C (fi) * | 1993-10-26 | 1996-05-27 | Ilmari Paakkinen | Menetelmä ja laite rakeisten maamassojen ominaisuuksien mittaamiseksi |
EP0737202A1 (en) * | 1993-12-28 | 1996-10-16 | Pfizer Inc. | Hypocholesterolemic agents |
AU7948494A (en) * | 1993-12-28 | 1995-07-17 | Pfizer Inc. | Steroidal glycosides |
FR2722690B1 (fr) * | 1994-07-21 | 1996-10-25 | Univ Montpellier Ii | Compositions de saponines et/ou de leurs formes aglycones et leurs applications comme medicaments |
PL318937A1 (en) * | 1994-08-30 | 1997-07-21 | Pfizer | Spirostanyloglycoside crystals |
CA2200436A1 (en) * | 1994-09-20 | 1996-04-04 | Pfizer Inc. | Combination therapy for hypercholesterolemia |
US6150336A (en) * | 1995-05-29 | 2000-11-21 | Pfizer Inc. | Steroidal glycosides |
US5698527A (en) * | 1995-08-08 | 1997-12-16 | Merck & Co., Inc. | Steroidal glycosides as antihyperlipidemic agents |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
DE69929177T2 (de) * | 1998-03-26 | 2006-08-24 | Phytopharm Plc, Godmanchester | Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit |
GB9923076D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
JP3370610B2 (ja) * | 1998-08-21 | 2003-01-27 | 武田薬品工業株式会社 | 害虫防除剤 |
US20030060425A1 (en) * | 1998-11-24 | 2003-03-27 | Ahlem Clarence N. | Immune modulation method using steroid compounds |
GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
US6343258B1 (en) | 1999-08-13 | 2002-01-29 | ALEXIS Brian | Method for testing for readiness for harvesting of tribulus terrestris l. having high steroidal saponin content |
GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
AU1122301A (en) * | 1999-11-01 | 2001-05-14 | Forbes Medi-Tech Inc. | Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols |
GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
US6207638B1 (en) | 2000-02-23 | 2001-03-27 | Pacifichealth Laboratories, Inc. | Nutritional intervention composition for enhancing and extending satiety |
US6429190B1 (en) | 2000-12-15 | 2002-08-06 | Pacifichealth Laboratories, Inc. | Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK) |
WO2002047614A2 (en) | 2000-12-15 | 2002-06-20 | Pacific Health Laboratories, Inc. | Nutritional composition for improving the efficacy of a lipase inhibitor |
GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
US6703530B2 (en) * | 2002-02-28 | 2004-03-09 | General Electric Company | Chemical reactor system and process |
US20050130948A1 (en) * | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
CN102727501A (zh) * | 2002-03-27 | 2012-10-17 | 菲特法姆股份有限公司 | 皂角苷配基及其衍生物的用途 |
KR101092150B1 (ko) * | 2002-10-28 | 2011-12-12 | 파이토팜 피엘씨 | 사포겐-3-온의 입체특이적 환원 |
CA2590533C (en) | 2004-11-23 | 2010-09-07 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
CN102066397B (zh) * | 2008-04-18 | 2013-09-11 | 里亚塔医药公司 | 包含抗炎症药效团的化合物以及使用方法 |
EP2309860B1 (en) * | 2008-07-22 | 2014-01-08 | Trustees of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
EP2571860A1 (en) | 2010-05-21 | 2013-03-27 | Pfizer Inc | 2-phenyl benzoylamides |
EP2680874A2 (en) | 2011-03-04 | 2014-01-08 | Pfizer Inc | Edn3-like peptides and uses thereof |
CU20110244A7 (es) * | 2011-12-27 | 2013-08-29 | Ct De Investigación Y Desarrollo De Medicamentos Cidem | Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios |
BR112015026513A2 (pt) | 2013-04-17 | 2017-07-25 | Pfizer | derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
MX2021008533A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3178418A (en) | 1963-02-26 | 1965-04-13 | Glaxo Lab Ltd | Monobromination at the 11-position of hecogenin and 3-lower alkanoyl esters thereof |
DE2926463A1 (de) * | 1978-07-05 | 1980-01-24 | Roecar Holdings Nv | Spiroketaline und ihre verwendung |
US4260603A (en) * | 1979-01-02 | 1981-04-07 | Pegel Karl H | Sterol glycoside with activity as prostaglandin synthetase inhibitor |
NZ193564A (en) * | 1979-05-02 | 1985-01-31 | Aruba Pty Ltd | Steroid alkaloids from solanum sodomeum and pharmaceutical compositions |
US4602005A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis |
US4602003A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia |
ES524614A0 (es) * | 1982-08-12 | 1984-05-01 | Nativelle Sa Ets | Procedimiento de preparacion de nuevos amino-14 esteroides. |
ES524796A0 (es) * | 1982-08-20 | 1984-05-01 | Nativelle Sa Ets | Procedimiento de preparacion de nuevos derivos de amino-14 esteroides |
IT1188184B (it) | 1985-08-14 | 1988-01-07 | Texcontor Ets | Sali ammonici quaternari di polisaccaridi ad attivita' ipocolesterolemizzante |
US5017562A (en) * | 1987-02-11 | 1991-05-21 | Regents Of The University Of Minnesota | Crystalline saponin-containing complex |
FR2621316B1 (fr) * | 1987-10-02 | 1991-06-21 | Nativelle Sa Ets | Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant |
US5010185A (en) * | 1989-06-13 | 1991-04-23 | Pfizer Inc. | Processes for tigogenin beta-cellobioside |
EP0524595A1 (en) * | 1991-07-23 | 1993-01-27 | Schering Corporation | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
AU2675092A (en) * | 1991-09-27 | 1993-04-27 | Procter & Gamble Pharmaceuticals, Inc. | Use of 14-aminosteroids for the manufacture of a medicament to slow the rate of progression of myocardial structural damages characteristic of congestive heart failure |
DE69225233T2 (de) * | 1991-10-04 | 1998-11-19 | Procter & Gamble | Cholesterinsenkende Verbindungen und Verfahren zu ihrer Herstellung |
JPH0826064B2 (ja) * | 1991-11-25 | 1996-03-13 | ファイザー インク. | ステロイドペルアシルグリコシド類の製法 |
US5530107A (en) * | 1992-10-15 | 1996-06-25 | Pfizer Inc. | Method for making steroidal peracyl glycosides |
LT3595B (en) * | 1993-01-21 | 1995-12-27 | Schering Corp | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
-
1993
- 1993-05-06 WO PCT/US1993/004092 patent/WO1994000480A1/en not_active Application Discontinuation
- 1993-05-06 US US08/351,470 patent/US5629295A/en not_active Expired - Fee Related
- 1993-05-06 CZ CZ943310A patent/CZ331094A3/cs unknown
- 1993-05-06 RU RU94046294/04A patent/RU94046294A/ru unknown
- 1993-05-06 EP EP97200456A patent/EP0796864A2/en not_active Withdrawn
- 1993-05-06 EP EP97200455A patent/EP0796863A2/en not_active Withdrawn
- 1993-05-06 JP JP6502331A patent/JPH07504921A/ja active Pending
- 1993-05-06 AU AU42265/93A patent/AU4226593A/en not_active Abandoned
- 1993-05-06 CA CA002139104A patent/CA2139104A1/en not_active Abandoned
- 1993-05-06 EP EP97200454A patent/EP0796862A2/en not_active Withdrawn
- 1993-05-06 SK SK1583-94A patent/SK158394A3/sk unknown
- 1993-05-06 BR BR9306619A patent/BR9306619A/pt not_active Application Discontinuation
- 1993-05-06 EP EP93910951A patent/EP0647234A1/en not_active Withdrawn
- 1993-06-17 AP APAP/P/1993/000539A patent/AP489A/en active
- 1993-06-17 IL IL106055A patent/IL106055A0/xx unknown
- 1993-06-24 HR HR07/904,914A patent/HRP930994A2/xx not_active Application Discontinuation
- 1993-06-25 YU YU44793A patent/YU44793A/sh unknown
- 1993-06-25 MX MX9303826A patent/MX9303826A/es unknown
- 1993-06-25 CN CN93107620A patent/CN1085561A/zh active Pending
-
1994
- 1994-12-13 BG BG99261A patent/BG99261A/xx unknown
- 1994-12-23 OA OA60598A patent/OA10121A/en unknown
- 1994-12-24 KR KR1019940704728A patent/KR950702203A/ko not_active Application Discontinuation
-
1995
- 1995-06-06 US US08/470,554 patent/US5703052A/en not_active Expired - Fee Related
-
1997
- 1997-02-14 JP JP9030588A patent/JPH09309897A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR950702203A (ko) | 1995-06-19 |
HRP930994A2 (en) | 1996-08-31 |
CN1085561A (zh) | 1994-04-20 |
IL106055A0 (en) | 1993-10-20 |
EP0796863A2 (en) | 1997-09-24 |
CA2139104A1 (en) | 1994-01-06 |
US5629295A (en) | 1997-05-13 |
BR9306619A (pt) | 1998-12-08 |
JPH07504921A (ja) | 1995-06-01 |
US5703052A (en) | 1997-12-30 |
RU94046294A (ru) | 1996-10-10 |
BG99261A (en) | 1995-06-30 |
WO1994000480A1 (en) | 1994-01-06 |
SK158394A3 (en) | 1995-05-10 |
EP0647234A1 (en) | 1995-04-12 |
EP0796862A2 (en) | 1997-09-24 |
CZ331094A3 (en) | 1995-09-13 |
YU44793A (sh) | 1996-10-09 |
AU4226593A (en) | 1994-01-24 |
AP489A (en) | 1996-05-02 |
AP9300539A0 (en) | 1993-07-31 |
OA10121A (en) | 1996-12-18 |
EP0796864A2 (en) | 1997-09-24 |
JPH09309897A (ja) | 1997-12-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9303826A (es) | Glicosidos esteroidales como agentes hipocolesterolemicos y agentes antiaterosclerosis. | |
ES2155874T3 (es) | Composiciones cosmeticas que contienen acido betulinico. | |
ATE133179T1 (de) | Steroid-sulfatase-inhibitoren | |
BR9406667A (pt) | Método e kit de terapia de substituição de hormonio | |
EP1058552A4 (en) | ANTIBIOTIC DERIVATIVES OF STEROIDS | |
GB9616443D0 (en) | Steroidal glycosides as antihyperlipidemic agents | |
DE69607952D1 (de) | Organoboran-polyaminkomplexe und damit hergestellte klebstoffzusammensetzungen | |
ATE229031T1 (de) | 6,7-oxygenierte steroide und deren verwendung | |
DE69014098D1 (de) | Strahlungsaussendende paneele und anzeigeanordnungen. | |
FI946106A (fi) | Steroidaalisia glykosideja | |
ATE215606T1 (de) | Mikrobielle 11alpha-hydroxylierung von steroiden | |
DE69407057D1 (de) | 1,3.5 (10) - estratriene derivate mit oraler wirkung | |
MX9205703A (es) | Compuestos que disminuyen el nivel de colesterol. | |
DE69423053T2 (de) | Relaismatrixendstufe | |
BR9811674A (pt) | Solvatos oxima de eritromicina a | |
DE69531220D1 (de) | Feldemissionselektronenquelle und Bildschirm mit solcher Feldemissionselektronenquelle | |
KR950702118A (ko) | 5-α-환원효소 억제제로서 유용한 17-알킬케톤 스테로이드(17-Alkylketone steroids useful as 5-α-reductase inhibitors) | |
AP9600790A0 (en) | Process for preparation of substituted steroidal dienes and novel intermediates used in said process. | |
AU125438S (en) | A Shirt | |
KR970023114U (ko) | 카울 및 대쉬 패널 구조 | |
KR970037569U (ko) | 카울 및 대쉬 패널 구조 | |
KR970037726U (ko) | 화물 자동차의 프론트 패널의 구조 | |
ECSP961825A (es) | Marcfortinas y parahercuamidas antiparasitarias | |
KR940001537U (ko) | 공기조화기용 판넬 | |
KR940017666U (ko) | 브라운관의 패널 캐리어 |