AP489A - Steroidal glycosides for treating hypercholesterolemia. - Google Patents

Steroidal glycosides for treating hypercholesterolemia. Download PDF

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Publication number
AP489A
AP489A APAP/P/1993/000539A AP9300539A AP489A AP 489 A AP489 A AP 489A AP 9300539 A AP9300539 A AP 9300539A AP 489 A AP489 A AP 489A
Authority
AP
ARIPO
Prior art keywords
carbonyl
cellobiosyl
methylene
alpha
compound according
Prior art date
Application number
APAP/P/1993/000539A
Other languages
English (en)
Other versions
AP9300539A0 (en
Inventor
Michael Paul Deninno
Peter Andrew Mccarthy
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP9300539A0 publication Critical patent/AP9300539A0/xx
Application granted granted Critical
Publication of AP489A publication Critical patent/AP489A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
APAP/P/1993/000539A 1992-06-26 1993-06-17 Steroidal glycosides for treating hypercholesterolemia. AP489A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90491492A 1992-06-26 1992-06-26

Publications (2)

Publication Number Publication Date
AP9300539A0 AP9300539A0 (en) 1993-07-31
AP489A true AP489A (en) 1996-05-02

Family

ID=25419965

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1993/000539A AP489A (en) 1992-06-26 1993-06-17 Steroidal glycosides for treating hypercholesterolemia.

Country Status (19)

Country Link
US (2) US5629295A (ru)
EP (4) EP0647234A1 (ru)
JP (2) JPH07504921A (ru)
KR (1) KR950702203A (ru)
CN (1) CN1085561A (ru)
AP (1) AP489A (ru)
AU (1) AU4226593A (ru)
BG (1) BG99261A (ru)
BR (1) BR9306619A (ru)
CA (1) CA2139104A1 (ru)
CZ (1) CZ331094A3 (ru)
HR (1) HRP930994A2 (ru)
IL (1) IL106055A0 (ru)
MX (1) MX9303826A (ru)
OA (1) OA10121A (ru)
RU (1) RU94046294A (ru)
SK (1) SK158394A3 (ru)
WO (1) WO1994000480A1 (ru)
YU (1) YU44793A (ru)

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PL311278A1 (en) * 1993-04-28 1996-02-05 Pfizer Crystalline glycosidal spirostantil monohydrate
US5502038A (en) * 1993-06-21 1996-03-26 Medical Research Foundation Of Oregon Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption
ES2074006B1 (es) * 1993-07-05 1996-03-16 Pfizer Glicosidos esteroidales para tratar hipercolesterolemia.
FI96243C (fi) * 1993-10-26 1996-05-27 Ilmari Paakkinen Menetelmä ja laite rakeisten maamassojen ominaisuuksien mittaamiseksi
AU7948394A (en) * 1993-12-28 1995-07-17 Pfizer Inc. Hypocholesterolemic agents
WO1995018144A1 (en) * 1993-12-28 1995-07-06 Pfizer Inc. Steroidal glycosides
FR2722690B1 (fr) * 1994-07-21 1996-10-25 Univ Montpellier Ii Compositions de saponines et/ou de leurs formes aglycones et leurs applications comme medicaments
MX9701525A (es) * 1994-08-30 1997-05-31 Pfizer Cristales de glicosidos de espiroestanilo.
JPH09511753A (ja) * 1994-09-20 1997-11-25 ファイザー・インコーポレーテッド コレステロール吸収阻害薬とコレステロール合成阻害薬の併用
WO1996038466A1 (en) * 1995-05-29 1996-12-05 Pfizer Inc. Steroidal glycosides
US5698527A (en) * 1995-08-08 1997-12-16 Merck & Co., Inc. Steroidal glycosides as antihyperlipidemic agents
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
JP3768100B2 (ja) * 1998-03-26 2006-04-19 ファイトファーム・ピーエルシー アルツハイマー病を治療するためのステロイドサポゲニンとその誘導体
JP3370610B2 (ja) * 1998-08-21 2003-01-27 武田薬品工業株式会社 害虫防除剤
US20030060425A1 (en) * 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
US6343258B1 (en) 1999-08-13 2002-01-29 ALEXIS Brian Method for testing for readiness for harvesting of tribulus terrestris l. having high steroidal saponin content
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
CA2389670A1 (en) * 1999-11-01 2001-05-10 Forbes Medi-Tech Inc. Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
US6207638B1 (en) 2000-02-23 2001-03-27 Pacifichealth Laboratories, Inc. Nutritional intervention composition for enhancing and extending satiety
US6429190B1 (en) 2000-12-15 2002-08-06 Pacifichealth Laboratories, Inc. Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK)
AU2002232575A1 (en) 2000-12-15 2002-06-24 Pacifichealth Laboratories, Inc. Nutritional composition for improving the efficacy of a lipase inhibitor
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US6703530B2 (en) * 2002-02-28 2004-03-09 General Electric Company Chemical reactor system and process
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
CN102727501A (zh) * 2002-03-27 2012-10-17 菲特法姆股份有限公司 皂角苷配基及其衍生物的用途
PT1558627E (pt) * 2002-10-28 2010-05-06 Phytopharm Plc Reduçao estereoespecífica de sapogen-3-onas
AP2007003979A0 (en) 2004-11-23 2007-06-30 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
JP5564490B2 (ja) * 2008-04-18 2014-07-30 リアタ ファーマシューティカルズ インコーポレイテッド 抗炎症性ファルマコアを含む化合物および使用法
JP5758801B2 (ja) 2008-07-22 2015-08-05 トラスティーズ・オブ・ダートマス・カレッジＴｒｕｓｔｅｅｓ ｏｆ Ｄａｒｔｍｏｕｔｈ Ｃｏｌｌｅｇｅ 単環式シアノエノンおよびその使用方法説明
JP2013528172A (ja) 2010-05-21 2013-07-08 ファイザー・インク ２−フェニルベンゾイルアミド
JP2014513923A (ja) 2011-03-04 2014-06-19 ファイザー・インク Ｅｄｎ３様ペプチドおよびその使用
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
EP2986599A1 (en) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
BR112021013807A2 (pt) 2019-01-18 2021-11-30 Astrazeneca Ab Inibidores de pcsk9 e seus métodos de uso

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159431A2 (en) * 1984-04-20 1985-10-30 Medical Research Foundation Of Oregon Tigogenin-cellobioside and its heptaacetate, methods for their preparation, and pharmaceutical compositions containing tigogenin-cellobioside
EP0403150A2 (en) * 1989-06-13 1990-12-19 Pfizer Inc. Process for the preparation of tigogenin beta-cellobioside

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US3178418A (en) 1963-02-26 1965-04-13 Glaxo Lab Ltd Monobromination at the 11-position of hecogenin and 3-lower alkanoyl esters thereof
DE2926463A1 (de) * 1978-07-05 1980-01-24 Roecar Holdings Nv Spiroketaline und ihre verwendung
US4260603A (en) * 1979-01-02 1981-04-07 Pegel Karl H Sterol glycoside with activity as prostaglandin synthetase inhibitor
NZ193564A (en) * 1979-05-02 1985-01-31 Aruba Pty Ltd Steroid alkaloids from solanum sodomeum and pharmaceutical compositions
US4602003A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
ES8404693A1 (es) * 1982-08-12 1984-05-01 Nativelle Sa Ets Procedimiento de preparacion de nuevos amino-14 esteroides.
ES8404694A1 (es) * 1982-08-20 1984-05-01 Nativelle Sa Ets Procedimiento de preparacion de nuevos derivos de amino-14 esteroides
IT1188184B (it) 1985-08-14 1988-01-07 Texcontor Ets Sali ammonici quaternari di polisaccaridi ad attivita' ipocolesterolemizzante
US5017562A (en) * 1987-02-11 1991-05-21 Regents Of The University Of Minnesota Crystalline saponin-containing complex
FR2621316B1 (fr) * 1987-10-02 1991-06-21 Nativelle Sa Ets Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant
HUT67341A (en) * 1991-07-23 1995-03-28 Schering Corp Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof
WO1993005790A1 (en) * 1991-09-27 1993-04-01 Procter & Gamble Pharmaceuticals, Inc. Use of 14-aminosteroids for the manufacture of a medicament to slow the rate of progression of myocardial structural damages characteristic of congestive heart failure
ES2114948T3 (es) * 1991-10-04 1998-06-16 Procter & Gamble Compuestos disminuidores del colesterol y procedimiento para prepararlos.
AU659506B2 (en) * 1991-11-25 1995-05-18 Pfizer Inc. Method for making steroidal peracyl glycosides
US5530107A (en) * 1992-10-15 1996-06-25 Pfizer Inc. Method for making steroidal peracyl glycosides
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159431A2 (en) * 1984-04-20 1985-10-30 Medical Research Foundation Of Oregon Tigogenin-cellobioside and its heptaacetate, methods for their preparation, and pharmaceutical compositions containing tigogenin-cellobioside
EP0403150A2 (en) * 1989-06-13 1990-12-19 Pfizer Inc. Process for the preparation of tigogenin beta-cellobioside

Also Published As

Publication number Publication date
BG99261A (en) 1995-06-30
CN1085561A (zh) 1994-04-20
EP0796863A2 (en) 1997-09-24
AP9300539A0 (en) 1993-07-31
EP0647234A1 (en) 1995-04-12
EP0796862A2 (en) 1997-09-24
JPH07504921A (ja) 1995-06-01
CZ331094A3 (en) 1995-09-13
HRP930994A2 (en) 1996-08-31
YU44793A (sh) 1996-10-09
SK158394A3 (en) 1995-05-10
EP0796864A2 (en) 1997-09-24
OA10121A (en) 1996-12-18
WO1994000480A1 (en) 1994-01-06
US5629295A (en) 1997-05-13
BR9306619A (pt) 1998-12-08
IL106055A0 (en) 1993-10-20
CA2139104A1 (en) 1994-01-06
AU4226593A (en) 1994-01-24
US5703052A (en) 1997-12-30
RU94046294A (ru) 1996-10-10
JPH09309897A (ja) 1997-12-02
KR950702203A (ko) 1995-06-19
MX9303826A (es) 1994-02-28

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