JP2018533909A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018533909A5 JP2018533909A5 JP2018510735A JP2018510735A JP2018533909A5 JP 2018533909 A5 JP2018533909 A5 JP 2018533909A5 JP 2018510735 A JP2018510735 A JP 2018510735A JP 2018510735 A JP2018510735 A JP 2018510735A JP 2018533909 A5 JP2018533909 A5 JP 2018533909A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric polypeptide
- polypeptide assembly
- item
- antigen
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 191
- 229920001184 polypeptide Polymers 0.000 claims description 185
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 185
- 230000027455 binding Effects 0.000 claims description 72
- 210000004027 cell Anatomy 0.000 claims description 64
- 239000000427 antigen Substances 0.000 claims description 57
- 108091007433 antigens Proteins 0.000 claims description 57
- 102000036639 antigens Human genes 0.000 claims description 57
- 206010028980 Neoplasm Diseases 0.000 claims description 47
- 239000012636 effector Substances 0.000 claims description 28
- 150000001413 amino acids Chemical class 0.000 claims description 23
- 210000004881 tumor cell Anatomy 0.000 claims description 22
- 239000003550 marker Substances 0.000 claims description 21
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 20
- 102100023123 Mucin-16 Human genes 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 102000040430 polynucleotide Human genes 0.000 claims description 20
- 108091033319 polynucleotide Proteins 0.000 claims description 20
- 239000002157 polynucleotide Substances 0.000 claims description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 17
- 108091005804 Peptidases Proteins 0.000 claims description 16
- INZOTETZQBPBCE-NYLDSJSYSA-N 3-sialyl lewis Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@H](O)CO)[C@@H]([C@@H](NC(C)=O)C=O)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 INZOTETZQBPBCE-NYLDSJSYSA-N 0.000 claims description 15
- 239000004365 Protease Substances 0.000 claims description 15
- 201000011510 cancer Diseases 0.000 claims description 14
- 102000001301 EGF receptor Human genes 0.000 claims description 12
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 12
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 12
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims description 11
- 241000282414 Homo sapiens Species 0.000 claims description 11
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 11
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims description 10
- 102100038083 Endosialin Human genes 0.000 claims description 10
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 10
- 101710120463 Prostate stem cell antigen Proteins 0.000 claims description 10
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims description 10
- 102100034902 Transmembrane 4 L6 family member 1 Human genes 0.000 claims description 10
- 101710097359 Transmembrane 4 L6 family member 1 Proteins 0.000 claims description 10
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 10
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims description 9
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 9
- 238000000099 in vitro assay Methods 0.000 claims description 9
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims description 8
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 8
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims description 7
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims description 7
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims description 7
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims description 7
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims description 7
- -1 cMET Proteins 0.000 claims description 7
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 7
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 7
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 6
- 102100034608 Angiopoietin-2 Human genes 0.000 claims description 6
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 6
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 6
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 6
- 108010055196 EphA2 Receptor Proteins 0.000 claims description 6
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims description 6
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims description 6
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims description 6
- 102100035139 Folate receptor alpha Human genes 0.000 claims description 6
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 6
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 6
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 claims description 6
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 6
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 6
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 6
- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 claims description 6
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 6
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 6
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 6
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims description 6
- 108010041012 Integrin alpha4 Proteins 0.000 claims description 6
- 102000003735 Mesothelin Human genes 0.000 claims description 6
- 108090000015 Mesothelin Proteins 0.000 claims description 6
- 102100034256 Mucin-1 Human genes 0.000 claims description 6
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 6
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims description 6
- 230000004913 activation Effects 0.000 claims description 6
- 210000002950 fibroblast Anatomy 0.000 claims description 6
- 210000004180 plasmocyte Anatomy 0.000 claims description 6
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 6
- 102000005962 receptors Human genes 0.000 claims description 6
- 108020003175 receptors Proteins 0.000 claims description 6
- 101150047061 tag-72 gene Proteins 0.000 claims description 6
- 101710145634 Antigen 1 Proteins 0.000 claims description 5
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 5
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims description 5
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims description 5
- 102100036305 C-C chemokine receptor type 8 Human genes 0.000 claims description 5
- 108700012439 CA9 Proteins 0.000 claims description 5
- 102100038078 CD276 antigen Human genes 0.000 claims description 5
- 101710185679 CD276 antigen Proteins 0.000 claims description 5
- 108010058905 CD44v6 antigen Proteins 0.000 claims description 5
- 102100025222 CD63 antigen Human genes 0.000 claims description 5
- 102100025221 CD70 antigen Human genes 0.000 claims description 5
- 108010009685 Cholinergic Receptors Proteins 0.000 claims description 5
- 102100035167 Coiled-coil domain-containing protein 54 Human genes 0.000 claims description 5
- 102100034573 Desmoglein-4 Human genes 0.000 claims description 5
- 101710183213 Desmoglein-4 Proteins 0.000 claims description 5
- 108060006698 EGF receptor Proteins 0.000 claims description 5
- 101710144543 Endosialin Proteins 0.000 claims description 5
- 102000003693 Hedgehog Proteins Human genes 0.000 claims description 5
- 108090000031 Hedgehog Proteins Proteins 0.000 claims description 5
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 5
- 101000716063 Homo sapiens C-C chemokine receptor type 8 Proteins 0.000 claims description 5
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims description 5
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims description 5
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 5
- 101000737052 Homo sapiens Coiled-coil domain-containing protein 54 Proteins 0.000 claims description 5
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims description 5
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 5
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 5
- 101000972284 Homo sapiens Mucin-3A Proteins 0.000 claims description 5
- 101000972286 Homo sapiens Mucin-4 Proteins 0.000 claims description 5
- 101000972282 Homo sapiens Mucin-5AC Proteins 0.000 claims description 5
- 101000972276 Homo sapiens Mucin-5B Proteins 0.000 claims description 5
- 101000972273 Homo sapiens Mucin-7 Proteins 0.000 claims description 5
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 5
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 5
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 5
- 101000928535 Homo sapiens Protein delta homolog 1 Proteins 0.000 claims description 5
- 101000824971 Homo sapiens Sperm surface protein Sp17 Proteins 0.000 claims description 5
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 5
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims description 5
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 5
- 108010076557 Matrix Metalloproteinase 14 Proteins 0.000 claims description 5
- 102100034263 Mucin-2 Human genes 0.000 claims description 5
- 108010008705 Mucin-2 Proteins 0.000 claims description 5
- 102100022497 Mucin-3A Human genes 0.000 claims description 5
- 102100022693 Mucin-4 Human genes 0.000 claims description 5
- 102100022496 Mucin-5AC Human genes 0.000 claims description 5
- 102100022494 Mucin-5B Human genes 0.000 claims description 5
- 102100022492 Mucin-7 Human genes 0.000 claims description 5
- 108010063954 Mucins Proteins 0.000 claims description 5
- 102100029527 Natural cytotoxicity triggering receptor 3 ligand 1 Human genes 0.000 claims description 5
- 101710201161 Natural cytotoxicity triggering receptor 3 ligand 1 Proteins 0.000 claims description 5
- 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 claims description 5
- KUIFHYPNNRVEKZ-VIJRYAKMSA-N O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine Chemical compound OC(=O)[C@@H](N)[C@@H](C)O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O KUIFHYPNNRVEKZ-VIJRYAKMSA-N 0.000 claims description 5
- 102000035195 Peptidases Human genes 0.000 claims description 5
- 102100036467 Protein delta homolog 1 Human genes 0.000 claims description 5
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims description 5
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims description 5
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 5
- 102000034337 acetylcholine receptors Human genes 0.000 claims description 5
- SRHNADOZAAWYLV-XLMUYGLTSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](NC(C)=O)[C@H](O)O[C@@H]2CO)O[C@H]2[C@H]([C@H](O)[C@H](O)[C@H](C)O2)O)O[C@H](CO)[C@H](O)[C@@H]1O SRHNADOZAAWYLV-XLMUYGLTSA-N 0.000 claims description 5
- 230000001605 fetal effect Effects 0.000 claims description 5
- 125000002446 fucosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)[C@@H](O1)C)* 0.000 claims description 5
- 150000002270 gangliosides Chemical class 0.000 claims description 5
- 102000039446 nucleic acids Human genes 0.000 claims description 5
- 108020004707 nucleic acids Proteins 0.000 claims description 5
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 210000002307 prostate Anatomy 0.000 claims description 5
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims description 4
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- QCQYVCMYGCHVMR-AAZUGDAUSA-N n-[(2r,3r,4s,5r)-4,5,6-trihydroxy-1-oxo-3-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-yl]acetamide Chemical compound CC(=O)N[C@@H](C=O)[C@H]([C@@H](O)[C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O QCQYVCMYGCHVMR-AAZUGDAUSA-N 0.000 claims description 4
- 108010067787 Proteoglycans Proteins 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 125000001151 peptidyl group Chemical group 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 230000009471 action Effects 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 1
- 101710151806 72 kDa type IV collagenase Proteins 0.000 claims 1
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 108010091175 Matriptase Proteins 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 claims 1
- 102100031358 Urokinase-type plasminogen activator Human genes 0.000 claims 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 32
- 238000003556 assay Methods 0.000 description 16
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 14
- 206010009944 Colon cancer Diseases 0.000 description 10
- 208000005718 Stomach Neoplasms Diseases 0.000 description 9
- 206010017758 gastric cancer Diseases 0.000 description 9
- 201000011549 stomach cancer Diseases 0.000 description 9
- 102100023635 Alpha-fetoprotein Human genes 0.000 description 8
- 206010006187 Breast cancer Diseases 0.000 description 8
- 208000026310 Breast neoplasm Diseases 0.000 description 8
- 201000009030 Carcinoma Diseases 0.000 description 8
- 206010025538 Malignant ascites Diseases 0.000 description 8
- 206010033128 Ovarian cancer Diseases 0.000 description 8
- 206010061535 Ovarian neoplasm Diseases 0.000 description 8
- 239000002771 cell marker Substances 0.000 description 8
- 208000029742 colonic neoplasm Diseases 0.000 description 6
- 201000001441 melanoma Diseases 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000013604 expression vector Substances 0.000 description 5
- 102000037865 fusion proteins Human genes 0.000 description 5
- 108020001507 fusion proteins Proteins 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 4
- 206010004593 Bile duct cancer Diseases 0.000 description 4
- 241000282693 Cercopithecidae Species 0.000 description 4
- 206010008342 Cervix carcinoma Diseases 0.000 description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 206010014733 Endometrial cancer Diseases 0.000 description 4
- 206010014759 Endometrial neoplasm Diseases 0.000 description 4
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 4
- 208000022072 Gallbladder Neoplasms Diseases 0.000 description 4
- 208000017604 Hodgkin disease Diseases 0.000 description 4
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 4
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 4
- 208000008839 Kidney Neoplasms Diseases 0.000 description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 4
- 206010027406 Mesothelioma Diseases 0.000 description 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 4
- 206010060862 Prostate cancer Diseases 0.000 description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 206010038389 Renal cancer Diseases 0.000 description 4
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 description 4
- 206010061934 Salivary gland cancer Diseases 0.000 description 4
- 206010039491 Sarcoma Diseases 0.000 description 4
- 208000000453 Skin Neoplasms Diseases 0.000 description 4
- 206010041067 Small cell lung cancer Diseases 0.000 description 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 4
- 208000002495 Uterine Neoplasms Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 208000009956 adenocarcinoma Diseases 0.000 description 4
- 208000026900 bile duct neoplasm Diseases 0.000 description 4
- 201000000053 blastoma Diseases 0.000 description 4
- 230000006037 cell lysis Effects 0.000 description 4
- 201000010881 cervical cancer Diseases 0.000 description 4
- 208000006990 cholangiocarcinoma Diseases 0.000 description 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 4
- 230000003013 cytotoxicity Effects 0.000 description 4
- 231100000135 cytotoxicity Toxicity 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 201000008184 embryoma Diseases 0.000 description 4
- 201000004101 esophageal cancer Diseases 0.000 description 4
- 201000003444 follicular lymphoma Diseases 0.000 description 4
- 201000010175 gallbladder cancer Diseases 0.000 description 4
- 201000010536 head and neck cancer Diseases 0.000 description 4
- 208000014829 head and neck neoplasm Diseases 0.000 description 4
- 208000006359 hepatoblastoma Diseases 0.000 description 4
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 4
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 201000010982 kidney cancer Diseases 0.000 description 4
- 206010024627 liposarcoma Diseases 0.000 description 4
- 201000007270 liver cancer Diseases 0.000 description 4
- 208000014018 liver neoplasm Diseases 0.000 description 4
- 201000005202 lung cancer Diseases 0.000 description 4
- 208000020816 lung neoplasm Diseases 0.000 description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 4
- 201000002528 pancreatic cancer Diseases 0.000 description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 description 4
- 201000002628 peritoneum cancer Diseases 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 4
- 238000001542 size-exclusion chromatography Methods 0.000 description 4
- 201000000849 skin cancer Diseases 0.000 description 4
- 208000000587 small cell lung carcinoma Diseases 0.000 description 4
- 201000002314 small intestine cancer Diseases 0.000 description 4
- 201000002510 thyroid cancer Diseases 0.000 description 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 4
- 206010046766 uterine cancer Diseases 0.000 description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 3
- 108010074708 B7-H1 Antigen Proteins 0.000 description 3
- 241000689227 Cora <basidiomycete fungus> Species 0.000 description 3
- 102000000588 Interleukin-2 Human genes 0.000 description 3
- 108010002350 Interleukin-2 Proteins 0.000 description 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 3
- 208000024770 Thyroid neoplasm Diseases 0.000 description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 3
- 230000003187 abdominal effect Effects 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000011269 treatment regimen Methods 0.000 description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
- 208000003950 B-cell lymphoma Diseases 0.000 description 2
- 208000023328 Basedow disease Diseases 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 101150029707 ERBB2 gene Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 208000024869 Goodpasture syndrome Diseases 0.000 description 2
- 208000015023 Graves' disease Diseases 0.000 description 2
- 208000030836 Hashimoto thyroiditis Diseases 0.000 description 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 description 2
- 102100037850 Interferon gamma Human genes 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- 102000016611 Proteoglycans Human genes 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 206010042971 T-cell lymphoma Diseases 0.000 description 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 description 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 description 2
- 208000008383 Wilms tumor Diseases 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 210000004405 cytokine-induced killer cell Anatomy 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 208000022669 mucinous neoplasm Diseases 0.000 description 2
- 206010028417 myasthenia gravis Diseases 0.000 description 2
- 208000025113 myeloid leukemia Diseases 0.000 description 2
- 230000002071 myeloproliferative effect Effects 0.000 description 2
- 230000001613 neoplastic effect Effects 0.000 description 2
- 201000008026 nephroblastoma Diseases 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- 208000012639 Balance disease Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 102000011727 Caspases Human genes 0.000 description 1
- 108010076667 Caspases Proteins 0.000 description 1
- 108010059480 Chondroitin Sulfate Proteoglycans Proteins 0.000 description 1
- 102000005598 Chondroitin Sulfate Proteoglycans Human genes 0.000 description 1
- 102100028757 Chondroitin sulfate proteoglycan 4 Human genes 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- 229910052693 Europium Inorganic materials 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 208000002633 Febrile Neutropenia Diseases 0.000 description 1
- BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 102000001398 Granzyme Human genes 0.000 description 1
- 108060005986 Granzyme Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 description 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 231100000002 MTT assay Toxicity 0.000 description 1
- 238000000134 MTT assay Methods 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 102000004503 Perforin Human genes 0.000 description 1
- 108010056995 Perforin Proteins 0.000 description 1
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 238000003349 alamar blue assay Methods 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 238000003782 apoptosis assay Methods 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 210000003443 bladder cell Anatomy 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- BQRGNLJZBFXNCZ-UHFFFAOYSA-N calcein am Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)=C(OC(C)=O)C=C1OC1=C2C=C(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(=O)C)C(OC(C)=O)=C1 BQRGNLJZBFXNCZ-UHFFFAOYSA-N 0.000 description 1
- 238000000423 cell based assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000002782 cell morphology assay Methods 0.000 description 1
- 238000009643 clonogenic assay Methods 0.000 description 1
- 231100000096 clonogenic assay Toxicity 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 206010052015 cytokine release syndrome Diseases 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 230000006624 extrinsic pathway Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 229940050526 hydroxyethylstarch Drugs 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000006623 intrinsic pathway Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 210000005265 lung cell Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 210000000066 myeloid cell Anatomy 0.000 description 1
- 210000000651 myofibroblast Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 208000004235 neutropenia Diseases 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 229930192851 perforin Natural products 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 1
- 210000005267 prostate cell Anatomy 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- TUFFYSFVSYUHPA-UHFFFAOYSA-M rhodamine 123 Chemical compound [Cl-].COC(=O)C1=CC=CC=C1C1=C(C=CC(N)=C2)C2=[O+]C2=C1C=CC(N)=C2 TUFFYSFVSYUHPA-UHFFFAOYSA-M 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- JUJBNYBVVQSIOU-UHFFFAOYSA-M sodium;4-[2-(4-iodophenyl)-3-(4-nitrophenyl)tetrazol-2-ium-5-yl]benzene-1,3-disulfonate Chemical compound [Na+].C1=CC([N+](=O)[O-])=CC=C1N1[N+](C=2C=CC(I)=CC=2)=NC(C=2C(=CC(=CC=2)S([O-])(=O)=O)S([O-])(=O)=O)=N1 JUJBNYBVVQSIOU-UHFFFAOYSA-M 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 208000027765 speech disease Diseases 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 208000013066 thyroid gland cancer Diseases 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021115243A JP2021178831A (ja) | 2015-08-28 | 2021-07-12 | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2024065385A JP2024105275A (ja) | 2015-08-28 | 2024-04-15 | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211532P | 2015-08-28 | 2015-08-28 | |
| US62/211,532 | 2015-08-28 | ||
| US201562263319P | 2015-12-04 | 2015-12-04 | |
| US62/263,319 | 2015-12-04 | ||
| US201662278755P | 2016-01-14 | 2016-01-14 | |
| US62/278,755 | 2016-01-14 | ||
| US201662338285P | 2016-05-18 | 2016-05-18 | |
| US62/338,285 | 2016-05-18 | ||
| US201662363046P | 2016-07-15 | 2016-07-15 | |
| US62/363,046 | 2016-07-15 | ||
| US201662379673P | 2016-08-25 | 2016-08-25 | |
| US62/379,673 | 2016-08-25 | ||
| PCT/US2016/049137 WO2017040344A2 (en) | 2015-08-28 | 2016-08-26 | Chimeric polypeptide assembly and methods of making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021115243A Division JP2021178831A (ja) | 2015-08-28 | 2021-07-12 | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533909A JP2018533909A (ja) | 2018-11-22 |
| JP2018533909A5 true JP2018533909A5 (enExample) | 2019-10-03 |
| JP6913670B2 JP6913670B2 (ja) | 2021-08-04 |
Family
ID=58188147
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510735A Active JP6913670B2 (ja) | 2015-08-28 | 2016-08-26 | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2021115243A Pending JP2021178831A (ja) | 2015-08-28 | 2021-07-12 | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2024065385A Pending JP2024105275A (ja) | 2015-08-28 | 2024-04-15 | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021115243A Pending JP2021178831A (ja) | 2015-08-28 | 2021-07-12 | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2024065385A Pending JP2024105275A (ja) | 2015-08-28 | 2024-04-15 | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US11713358B2 (enExample) |
| EP (2) | EP4129327A1 (enExample) |
| JP (3) | JP6913670B2 (enExample) |
| KR (1) | KR20180038560A (enExample) |
| CN (1) | CN108135968A (enExample) |
| AU (1) | AU2016315656A1 (enExample) |
| CA (1) | CA2992306A1 (enExample) |
| CL (1) | CL2018000543A1 (enExample) |
| EA (1) | EA038329B1 (enExample) |
| HK (1) | HK1257218A1 (enExample) |
| IL (3) | IL319047A (enExample) |
| MX (2) | MX2018002226A (enExample) |
| PE (1) | PE20181275A1 (enExample) |
| TW (3) | TW202436342A (enExample) |
| WO (1) | WO2017040344A2 (enExample) |
| ZA (2) | ZA201800570B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106459990B (zh) | 2014-02-07 | 2021-06-01 | 麦克马斯特大学 | 三功能t细胞抗原偶联物及其制备方法和用途 |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| TW201809013A (zh) * | 2016-06-06 | 2018-03-16 | 艾斯克立必恩股份有限公司 | 用於藥物遞送之抗體融合蛋白 |
| CA3068056A1 (en) * | 2017-06-22 | 2018-12-27 | Development Center For Biotechnology | Asymmetric heterodimeric fc-scfv fusion anti-globo h and anti-cd3 bispecifc antibody and uses thereof in cancer therapy |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| WO2019071358A1 (en) | 2017-10-12 | 2019-04-18 | Mcmaster University | Y182T MUTATION T CELL ANTIGEN COUPLEUR AND METHODS AND USES THEREOF |
| WO2019126576A1 (en) * | 2017-12-21 | 2019-06-27 | Amunix Pharmaceuticals, Inc. | Release segments and binding compositions comprising same |
| AU2019282836B2 (en) * | 2018-06-07 | 2025-09-04 | Cullinan Oncology, Inc. | Multi-specific binding proteins and methods of use thereof |
| US11110123B2 (en) | 2018-07-17 | 2021-09-07 | Triumvira Immunologics Usa, Inc. | T cell-antigen coupler with various construct optimizations |
| US10640562B2 (en) | 2018-07-17 | 2020-05-05 | Mcmaster University | T cell-antigen coupler with various construct optimizations |
| BR112021001616A2 (pt) | 2018-07-31 | 2021-05-04 | Amgen Inc. | formulações farmacêuticas de anticorpos mascarados |
| IL280880B2 (en) | 2018-08-27 | 2025-04-01 | Regeneron Pharma | Using Raman Spectroscopy in Downstream Purification |
| WO2020127618A1 (en) * | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted agonistic cd28 antigen binding molecules |
| KR20210128399A (ko) * | 2019-02-20 | 2021-10-26 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 암-표적화되고, 바이러스-암호화된, 조절 가능한 t 세포 (catvert) 또는 nk 세포 (catvern) 링커 |
| BR112021023048A2 (pt) | 2019-05-21 | 2022-04-19 | Novartis Ag | Moléculas de ligação a cd19 e usos das mesmas |
| WO2020264208A1 (en) * | 2019-06-26 | 2020-12-30 | Amunix Pharmaceuticals, Inc. | Egfr antigen binding fragments and compositions comprising same |
| CN115175933A (zh) * | 2019-06-26 | 2022-10-11 | 阿穆尼克斯制药公司 | Cd3抗原结合片段和包含其的组合物 |
| US20210040174A1 (en) * | 2019-08-08 | 2021-02-11 | Navrogen, Inc. | Composition and Use of Humoral Immune Suppressor Antagonists for the Treatment of Humoral Immune Suppressed Diseases |
| EP3819312A1 (en) * | 2019-11-10 | 2021-05-12 | Amgen, Inc | Dosing regimen for anti-dll3 agents |
| IL293725A (en) | 2019-12-11 | 2022-08-01 | Cullinan Oncology Inc | Anti-cd19 antibodies and multispecific binding proteins |
| CN116925237A (zh) | 2019-12-31 | 2023-10-24 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| WO2021139744A1 (en) | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
| JP2023529557A (ja) * | 2020-05-04 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗ｅｎｐｐ１抗体の阻害 |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| CA3182372A1 (en) | 2020-06-25 | 2021-12-30 | Amunix Pharmaceuticals, Inc. | Her-2 targeted bispecific compositions and methods for making and using the same |
| MX2022016389A (es) * | 2020-06-25 | 2023-04-11 | Amunix Pharmaceuticals Inc | Conjugados de citocina. |
| ES3040950T3 (en) | 2020-08-11 | 2025-11-06 | Janux Therapeutics Inc | Cleavable linker compositions and methods |
| JP2023545684A (ja) | 2020-09-30 | 2023-10-31 | ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド | ポリペプチドコンジュゲートおよび使用の方法 |
| WO2022098797A1 (en) * | 2020-11-04 | 2022-05-12 | Fred Hutchinson Cancer Research Center | Therapeutic targeting of mesothelin in acute myeloid leukemia with chimeric antigen receptor t cell therapy |
| JP2023549537A (ja) * | 2020-11-16 | 2023-11-27 | エイビー セラピューティクス インコーポレイテッド | 多重特異性抗体およびその使用方法 |
| CA3199212A1 (en) * | 2020-11-27 | 2022-06-02 | Junji DONG | Cldn18.2 antibody and use thereof |
| MX2023006817A (es) | 2020-12-09 | 2023-08-14 | Janux Therapeutics Inc | Composiciones y metodos relacionados con anticuerpos activados por tumores dirigidos a psma y antigenos de celulas efectoras. |
| WO2022179562A1 (en) * | 2021-02-24 | 2022-09-01 | Hangzhou Qihan Biotechnology Co., Ltd. | Chimeric antigen receptors in immune cells |
| WO2022178751A1 (en) * | 2021-02-25 | 2022-09-01 | Shanghai Allygen Biologics Co., Ltd. | Targeting conjugates comprising effector molecules and uses thereof |
| KR20240037892A (ko) | 2021-06-01 | 2024-03-22 | 트리움비라 이뮤놀로직스 유에스에이, 인크. | 클라우딘 18.2 t 세포-항원 커플러 및 이의 용도 |
| CR20230581A (es) * | 2021-06-04 | 2024-02-13 | Amgen Inc | Anticuerpos anti-CCR8 y usos de los mismos |
| US11453723B1 (en) | 2021-06-25 | 2022-09-27 | Mcmaster University | BCMA T cell-antigen couplers and uses thereof |
| CN113481169B (zh) * | 2021-08-11 | 2023-06-16 | 南方医科大学南方医院 | 一种细胞激活依赖性分泌系统及应用 |
| CA3244052A1 (en) | 2022-02-23 | 2023-08-31 | Bright Peak Therapeutics Ag | ACTIVABLE IL-18 POLYPEPTIDES |
| CA3252113A1 (en) | 2022-03-30 | 2023-10-05 | Beijing Ql Biopharmaceutical Co Ltd | Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use |
| CN115192730B (zh) * | 2022-07-13 | 2025-08-08 | 郑州大学 | 一种靶向pd-l1的双特异性多肽纳米药物及其制备方法和应用 |
| IL321437A (en) * | 2022-12-14 | 2025-08-01 | Evolveimmune Therapeutics Inc | Bispecific antibody fusion molecules and methods for using them |
| WO2024150175A1 (en) | 2023-01-11 | 2024-07-18 | Bright Peak Therapeutics Ag | Conditionally activated proteins and methods of use |
| WO2024150174A1 (en) | 2023-01-11 | 2024-07-18 | Bright Peak Therapeutics Ag | Conditionally activated immunocytokines and methods of use |
| AU2024258990A1 (en) | 2023-04-17 | 2025-10-23 | Amunix Pharmaceuticals, Inc. | Compositions targeting epidermal growth factor receptor and methods for making and using the same |
| WO2025041101A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Activatable il-18 immunocytokines and uses thereof |
| WO2025113643A1 (en) | 2023-12-01 | 2025-06-05 | Gilead Sciences Inc. | Anti-fap-light fusion protein and use thereof |
| WO2025122957A1 (en) | 2023-12-08 | 2025-06-12 | Amunix Pharmaceuticals, Inc. | Protease activatable cytokines and methods for making and using the same |
| WO2025162453A1 (zh) * | 2024-02-02 | 2025-08-07 | 北京昌平实验室 | 双特异性抗体前药及其应用 |
| GB2641580A (en) * | 2024-06-07 | 2025-12-10 | T Therapeutics Ltd | Tumour-transforming multispecific proteins |
Family Cites Families (154)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| US4398908A (en) | 1980-11-28 | 1983-08-16 | Siposs George G | Insulin delivery system |
| US4435173A (en) | 1982-03-05 | 1984-03-06 | Delta Medical Industries | Variable rate syringe pump for insulin delivery |
| US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| US4933185A (en) | 1986-09-24 | 1990-06-12 | Massachusetts Institute Of Technology | System for controlled release of biologically active compounds |
| US4976696A (en) | 1987-08-10 | 1990-12-11 | Becton, Dickinson And Company | Syringe pump and the like for delivering medication |
| US5270176A (en) | 1987-11-20 | 1993-12-14 | Hoechst Aktiengesellschaft | Method for the selective cleavage of fusion proteins with lysostaphin |
| JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク，インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| JP2717808B2 (ja) | 1988-08-10 | 1998-02-25 | テルモ株式会社 | シリンジポンプ |
| US6225449B1 (en) | 1991-10-04 | 2001-05-01 | Washington University | Hormone analogs with multiple CTP extensions |
| US5017378A (en) | 1989-05-01 | 1991-05-21 | The University Of Virginia Alumni Patents Foundation | Intraorgan injection of biologically active compounds contained in slow-release microcapsules or microspheres |
| US5599907A (en) | 1989-05-10 | 1997-02-04 | Somatogen, Inc. | Production and use of multimeric hemoglobins |
| US5298022A (en) | 1989-05-29 | 1994-03-29 | Amplifon Spa | Wearable artificial pancreas |
| US5492534A (en) | 1990-04-02 | 1996-02-20 | Pharmetrix Corporation | Controlled release portable pump |
| US5318540A (en) | 1990-04-02 | 1994-06-07 | Pharmetrix Corporation | Controlled release infusion device |
| US5176502A (en) | 1990-04-25 | 1993-01-05 | Becton, Dickinson And Company | Syringe pump and the like for delivering medication |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| AU6267896A (en) | 1995-06-07 | 1996-12-30 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth oftumors |
| AU735900B2 (en) | 1996-03-12 | 2001-07-19 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
| US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| DE69738539T2 (de) | 1996-12-03 | 2009-03-26 | Amgen Fremont Inc. | Vollkommen humane Antikörper die EGFR binden |
| AT405516B (de) | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
| US20020173629A1 (en) | 1997-05-05 | 2002-11-21 | Aya Jakobovits | Human monoclonal antibodies to epidermal growth factor receptor |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| DE69838526T2 (de) | 1998-02-05 | 2008-07-03 | Biosense Webster, Inc., Diamond Bar | Gerät zum Freisetzen eines Medikaments im Herzen |
| US6406632B1 (en) | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| KR100508289B1 (ko) | 1998-04-21 | 2005-08-17 | 마이크로메트 에이지 | Ｃｄ１９×ｃｄ３ 특이 폴리펩티드 및 그의 용도 |
| US7090976B2 (en) | 1999-11-10 | 2006-08-15 | Rigel Pharmaceuticals, Inc. | Methods and compositions comprising Renilla GFP |
| US20030190740A1 (en) | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
| US7666400B2 (en) | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| US20030109428A1 (en) | 1999-12-01 | 2003-06-12 | John Bertin | Novel molecules of the card-related protein family and uses thereof |
| US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| US20030228309A1 (en) | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| US20030049689A1 (en) | 2000-12-14 | 2003-03-13 | Cynthia Edwards | Multifunctional polypeptides |
| PE20020908A1 (es) | 2001-03-21 | 2002-10-26 | Cell Therapeutics Inc | Produccion recombinante de polimeros polianionicos y uso de de los mismos |
| CZ200438A3 (cs) | 2001-06-13 | 2004-06-16 | Genmab A/S | Název neuveden |
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| KR100407467B1 (ko) | 2001-07-12 | 2003-11-28 | 최수봉 | 리모컨 방식의 인슐린 자동주사기 |
| US20040259780A1 (en) | 2001-07-30 | 2004-12-23 | Glasebrook Andrew Lawrence | Method for treating diabetes and obesity |
| US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
| US20080167238A1 (en) | 2001-12-21 | 2008-07-10 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| US20030216551A1 (en) | 2002-03-08 | 2003-11-20 | Diabetogen Biosciences Inc. | Fully human anti-CD3 monoclonal antibodies |
| US7294513B2 (en) | 2002-07-24 | 2007-11-13 | Wyatt Technology Corporation | Method and apparatus for characterizing solutions of small particles |
| ES2559763T3 (es) | 2002-09-10 | 2016-02-15 | Affimed Gmbh | Anticuerpo humano específico de CD3 con propiedades inmunosupresoras |
| PT1572744E (pt) | 2002-12-16 | 2010-09-07 | Genentech Inc | Variantes de imunoglobulina e utilizações destas |
| US20040234609A1 (en) | 2003-05-14 | 2004-11-25 | Collier Katherine D. | Repeat sequence protein polymer active agent congjugates, methods and uses |
| US20070161087A1 (en) | 2003-05-29 | 2007-07-12 | Wolfgang Glaesner | Glp-1 fusion proteins |
| KR20060015602A (ko) | 2003-05-31 | 2006-02-17 | 마이크로메트 에이지 | ＥｐＣＡＭ 에 대한 이중 특이성 항체를 포함하는약학조성물 |
| CA2523716C (en) | 2003-05-31 | 2014-11-25 | Micromet Ag | Human anti-human cd3 binding molecules |
| CA2522586C (en) | 2003-05-31 | 2017-02-21 | Micromet Ag | Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders |
| US7709224B2 (en) | 2003-06-03 | 2010-05-04 | Biosante Pharmaceuticals, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| US20050152979A1 (en) | 2003-09-05 | 2005-07-14 | Cell Therapeutics, Inc. | Hydrophobic drug compositions containing reconstitution enhancer |
| TW200526254A (en) | 2003-09-19 | 2005-08-16 | Novo Nordisk As | Novel GLP-1 derivatives |
| KR101229731B1 (ko) | 2003-10-16 | 2013-03-07 | 암젠 리서치 (뮌헨) 게엠베하 | 다중특이적 탈면역화된 ｃｄ3-바인더 |
| US20050123997A1 (en) | 2003-10-30 | 2005-06-09 | Lollar John S. | Modified fVIII having reduced immunogenicity through mutagenesis of A2 and C2 epitopes |
| NZ548513A (en) | 2004-01-14 | 2010-05-28 | Univ Ohio | Methods of producing peptides/proteins in plants and peptides/proteins produced thereby |
| SI1729795T1 (sl) | 2004-02-09 | 2016-04-29 | Human Genome Sciences, Inc. | Albuminski fuzijski proteini |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| ES2526343T3 (es) | 2004-06-03 | 2015-01-09 | Novimmune Sa | Anticuerpos anti-CD3 y métodos de uso de los mismos |
| AU2005287404B2 (en) | 2004-07-22 | 2009-05-07 | Genentech, Inc. | HER2 antibody composition |
| ES2551852T3 (es) | 2004-07-23 | 2015-11-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| WO2006036834A2 (en) | 2004-09-24 | 2006-04-06 | Amgen Inc. | MODIFIED Fc MOLECULES |
| JP5735194B2 (ja) | 2005-01-25 | 2015-06-17 | セル セラピューティクス インコーポレーテッド | 改善された生体内半減期を有する生物学的に活性なタンパク質 |
| KR100727466B1 (ko) | 2005-02-07 | 2007-06-13 | 주식회사 잉크테크 | 유기 은 착체 화합물, 이의 제조방법 및 이를 이용한박막형성방법 |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| US20100209437A1 (en) | 2005-09-12 | 2010-08-19 | Greg Elson | Anti-CD3 Antibody Fromulations |
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| ES2856451T3 (es) * | 2005-10-11 | 2021-09-27 | Amgen Res Munich Gmbh | Composiciones que comprenden anticuerpos específicos para diferentes especies, y usos de las mismas |
| ES2532124T3 (es) | 2005-12-16 | 2015-03-24 | Amgen Research (Munich) Gmbh | Medios y procedimientos para el tratamiento de enfermedades tumorales |
| EP1971355B1 (en) | 2005-12-20 | 2020-03-11 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| EP1996937A4 (en) | 2006-03-06 | 2009-04-08 | Amunix Inc | GENETIC PACKS AND USES THEREOF |
| NZ572050A (en) | 2006-03-31 | 2011-09-30 | Baxter Int | Factor VIII conjugated to polyethylene glycol |
| WO2008049711A1 (en) | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
| EP2084527A4 (en) * | 2006-11-02 | 2011-07-27 | Seattle Genetics Inc | METHOD FOR TREATING NEOPLASIA, AUTOIMMUNE AND INFLAMMATORY DISEASES |
| PT2155783E (pt) | 2007-04-03 | 2013-11-07 | Amgen Res Munich Gmbh | Domínio de ligação específico inter-espécies |
| KR101589759B1 (ko) | 2007-04-03 | 2016-01-29 | 암젠 리서치 (뮌헨) 게엠베하 | 종간 특이적 ｃｄ３―입실론 결합 도메인 |
| AU2008234019B2 (en) | 2007-04-03 | 2014-05-29 | Amgen Research (Munich) Gmbh | Cross-species-specific bispecific binders |
| DE602008005596D1 (de) | 2007-06-21 | 2011-04-28 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
| BRPI0815416A2 (pt) | 2007-08-15 | 2014-10-21 | Amunix Inc | Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos |
| EP3492488A1 (en) | 2007-08-22 | 2019-06-05 | The Regents of The University of California | Activatable binding polypeptides and methods of identification and use thereof |
| JP2011526303A (ja) | 2008-06-27 | 2011-10-06 | デューク ユニバーシティ | エラスチン様ペプチドを含む治療剤 |
| EP2352763B2 (en) | 2008-10-01 | 2022-09-21 | Amgen Research (Munich) GmbH | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
| BRPI0919840B1 (pt) | 2008-10-01 | 2023-02-28 | Amgen Research (Munich) Gmbh | Molécula de anticorpo de cadeia única biespecífica, seu uso, e composição farmacêutica que a compreende |
| BRPI0919841A2 (pt) | 2008-10-01 | 2014-11-18 | Micromet Ag | Anticorpo de cadeia unica biespecifico de psmaxcd3, especifico de especies cruzadas |
| AU2009299794B2 (en) | 2008-10-01 | 2015-08-13 | Amgen Research (Munich) Gmbh | Cross-species-specific single domain bispecific single chain antibody |
| WO2010081173A2 (en) | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| US8680050B2 (en) | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| WO2010091122A1 (en) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
| US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| HRP20230487T1 (hr) | 2009-02-13 | 2023-07-21 | Immunomedics, Inc. | Imunokonjugati s unutarstaničnom vezom koja se može rascijepiti |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| AU2010258892B2 (en) | 2009-06-08 | 2015-08-13 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| AU2010258898B8 (en) | 2009-06-08 | 2015-02-05 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
| BR112012004094A2 (pt) | 2009-08-24 | 2016-03-08 | Amunix Operating Inc | composições de fator vii de coagulação e métodos para fazer e usar as mesmas |
| WO2011028344A2 (en) | 2009-08-25 | 2011-03-10 | Amunix Operating Inc. | Interleukin-1 receptor antagonist compositions and methods of making and using same |
| JP2013505223A (ja) * | 2009-09-18 | 2013-02-14 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハー | ＥｐＣＡＭｘＣＤ３二重特異性抗体を投与するための投与計画 |
| WO2011084808A2 (en) | 2009-12-21 | 2011-07-14 | Amunix Operating Inc. | Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases |
| IL300733B1 (en) | 2010-03-05 | 2025-10-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeted for immune modulation |
| TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究（慕尼黑）有限責任公司 | 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體 |
| WO2011123830A2 (en) | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
| EP4450523A3 (en) | 2010-04-02 | 2025-03-12 | Amunix Pharmaceuticals, Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
| US8828944B2 (en) | 2010-04-22 | 2014-09-09 | Institut Gustave Roussy | Compounds and uses thereof to induce an immunogenic cancer cell death in a subject |
| EP2710042A2 (en) | 2011-05-16 | 2014-03-26 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| DK2717898T3 (en) * | 2011-06-10 | 2019-03-25 | Bioverativ Therapeutics Inc | COAGULATING COMPOUNDS AND PROCEDURES FOR USE THEREOF |
| PT2755675T (pt) | 2011-09-12 | 2018-10-11 | Amunix Operating Inc | Composições de péptido semelhante a glucagão-2 e métodos para produzir e utilizar as mesmas |
| HRP20221531T1 (hr) | 2012-02-15 | 2023-02-17 | Bioverativ Therapeutics Inc. | Pripravci faktora viii i postupci dobivanja i korištenja istih |
| CN107496932A (zh) | 2012-02-27 | 2017-12-22 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| US20150037334A1 (en) * | 2012-03-01 | 2015-02-05 | Amgen Research (Munich) Gmbh | Long life polypeptide binding molecules |
| AU2013251310B2 (en) | 2012-04-27 | 2018-02-15 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| BR112014030404A2 (pt) | 2012-06-05 | 2017-06-27 | Amunix Operating Inc | proteína de fusão hgh-xten e seu uso no tratamento da deficiência de hormônio do crescimento |
| US9856314B2 (en) * | 2012-06-22 | 2018-01-02 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and methods of using the same |
| CN104736174B (zh) | 2012-07-06 | 2019-06-14 | 根马布私人有限公司 | 具有三重突变的二聚体蛋白质 |
| US10138291B2 (en) * | 2012-07-11 | 2018-11-27 | Bioverativ Therapeutics Inc. | Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof |
| WO2014052462A2 (en) | 2012-09-25 | 2014-04-03 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind interleukin-6 receptor and methods of use thereof |
| RU2015117393A (ru) | 2012-10-08 | 2016-12-10 | Роше Гликарт Аг | Лишенные fc антитела, содержащие два Fab-фрагмента, и способы их применения |
| BR112015022257A8 (pt) | 2013-03-11 | 2018-01-23 | Amunix Operating Inc | tratamento de deficiência do hormônio do crescimento pediátrica com análogos de hormônio do crescimento humano |
| EP3003370B1 (en) | 2013-05-28 | 2020-01-22 | Dcb-Usa Llc | Antibody locker for the inactivation of protein drug |
| TW201536811A (zh) | 2013-05-31 | 2015-10-01 | Biogen Idec Inc | 嵌合ｆｖｉｉ－ｘｔｅｎ分子及其用途 |
| CA2918795A1 (en) | 2013-07-25 | 2015-01-29 | Cytomx Therapeutics, Inc. | Multispecific antibodies, multispecific activatable antibodies and methods of using the same |
| EP3033097B1 (en) * | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| EP3733710A1 (en) | 2013-09-25 | 2020-11-04 | Amgen, Inc | Hetrodimeric v-c-fc-v-c antibody |
| US9540440B2 (en) | 2013-10-30 | 2017-01-10 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| BR112016009919A2 (pt) | 2013-11-04 | 2017-12-05 | Glenmark Pharmaceuticals Sa | imunoglobulina hetero-dimérica ou fragmento da mesma e método para produzir in vitro uma imunoglobulina hetero-dimérica ou fragmento da mesma |
| CN106459153B (zh) | 2014-01-31 | 2021-12-21 | 西托姆克斯治疗公司 | 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法 |
| US10184262B2 (en) | 2014-04-22 | 2019-01-22 | Vestas Wind Systems A/S | Alignment tool, system and method for the connection of wind turbine tower segments |
| WO2016014974A2 (en) | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| EP2982693A1 (en) | 2014-08-07 | 2016-02-10 | Affimed Therapeutics AG | CD3 binding domain |
| RS60305B1 (sr) | 2014-09-05 | 2020-07-31 | Janssen Pharmaceutica Nv | Agensi koji vezuju cd123 i njihove upotrebe |
| CA2960128A1 (en) | 2014-09-25 | 2016-03-31 | Amgen Inc | Protease-activatable bispecific proteins |
| EA201790871A1 (ru) | 2014-11-11 | 2017-11-30 | Амуникс Оперэйтинг Инк. | Нацеленные конъюгатные композиции xten и способы их получения |
| JP7075757B2 (ja) | 2014-11-21 | 2022-05-26 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 制御放出および持続的放出のためのｅｌｐ融合タンパク質 |
| WO2016109823A1 (en) | 2015-01-02 | 2016-07-07 | Amunix Operation Inc. | Treatment of pediatric growth hormone deficiency with human growth hormone analogues |
| CN114478792A (zh) | 2015-01-08 | 2022-05-13 | 根马布股份公司 | 针对cd3和cd20的双特异性抗体 |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| HK1250997A1 (zh) | 2015-05-01 | 2019-01-18 | 基因泰克公司 | 掩蔽抗cd3抗体和使用方法 |
| CA2985125A1 (en) | 2015-05-06 | 2016-11-10 | Janssen Biotech, Inc. | Prostate specific membrane antigen (psma) bispecific binding agents and uses thereof |
| JOP20160154B1 (ar) | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| KR20180085800A (ko) | 2015-12-07 | 2018-07-27 | 젠코어 인코포레이티드 | Cd3 및 psma에 결합하는 이종이합체성 항체 |
| PT3411402T (pt) | 2016-02-03 | 2022-02-01 | Amgen Inc | Construtos de anticorpos biespecíficos engajadores de células t contra bcma e cd3 |
| LT3411404T (lt) | 2016-02-03 | 2022-12-27 | Amgen Research (Munich) Gmbh | Psma ir cd3 bispecifiniai, t ląsteles aktyvuojantys antikūno konstruktai |
| TWI781108B (zh) | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途 |
| JP7215997B2 (ja) | 2016-11-23 | 2023-01-31 | ハープーン セラピューティクス，インク． | 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法 |
| CN110177875B (zh) | 2016-11-28 | 2023-11-28 | 中外制药株式会社 | 包含抗原结合结构域和运送部分的多肽 |
| EP3765493A2 (en) | 2018-03-12 | 2021-01-20 | Genmab A/S | Antibodies |
| DK3797121T3 (da) | 2018-05-23 | 2024-07-08 | Pfizer | Antistoffer, der er specifikke for CD3, og anvendelser deraf |
| RS66901B1 (sr) | 2018-05-24 | 2025-07-31 | Janssen Biotech Inc | Anti-cd3 antitela i njihova upotreba |
-
2016
- 2016-08-25 IL IL319047A patent/IL319047A/en unknown
- 2016-08-26 TW TW113105157A patent/TW202436342A/zh unknown
- 2016-08-26 KR KR1020187008477A patent/KR20180038560A/ko not_active Ceased
- 2016-08-26 EP EP22181008.8A patent/EP4129327A1/en active Pending
- 2016-08-26 TW TW105127596A patent/TWI744247B/zh active
- 2016-08-26 WO PCT/US2016/049137 patent/WO2017040344A2/en not_active Ceased
- 2016-08-26 MX MX2018002226A patent/MX2018002226A/es unknown
- 2016-08-26 EP EP16842718.5A patent/EP3341009A4/en not_active Withdrawn
- 2016-08-26 PE PE2018000320A patent/PE20181275A1/es unknown
- 2016-08-26 JP JP2018510735A patent/JP6913670B2/ja active Active
- 2016-08-26 EA EA201890294A patent/EA038329B1/ru unknown
- 2016-08-26 IL IL307276A patent/IL307276B2/en unknown
- 2016-08-26 CA CA2992306A patent/CA2992306A1/en active Pending
- 2016-08-26 HK HK18116221.7A patent/HK1257218A1/zh unknown
- 2016-08-26 TW TW110136771A patent/TWI835006B/zh active
- 2016-08-26 IL IL256785A patent/IL256785B2/en unknown
- 2016-08-26 CN CN201680050442.4A patent/CN108135968A/zh active Pending
- 2016-08-26 AU AU2016315656A patent/AU2016315656A1/en not_active Abandoned
- 2016-08-26 US US15/753,716 patent/US11713358B2/en active Active
-
2018
- 2018-01-26 ZA ZA2018/00570A patent/ZA201800570B/en unknown
- 2018-02-21 MX MX2024011037A patent/MX2024011037A/es unknown
- 2018-02-28 CL CL2018000543A patent/CL2018000543A1/es unknown
-
2021
- 2021-07-12 JP JP2021115243A patent/JP2021178831A/ja active Pending
- 2021-12-14 ZA ZA2021/10393A patent/ZA202110393B/en unknown
-
2022
- 2022-12-19 US US18/067,948 patent/US11981744B2/en active Active
-
2023
- 2023-06-16 US US18/336,486 patent/US20240018260A1/en active Pending
-
2024
- 2024-04-04 US US18/626,607 patent/US20240279354A1/en not_active Abandoned
- 2024-04-15 JP JP2024065385A patent/JP2024105275A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018533909A5 (enExample) | ||
| CN113286879B (zh) | 用于细胞疗法之多样化抗原结合域、新颖平台及其他增强子 | |
| JP2024105275A (ja) | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 | |
| JP7651481B2 (ja) | Ｃｄ３抗原結合断片およびそれを含む組成物 | |
| US10035856B2 (en) | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells | |
| JP6557657B2 (ja) | 分子 | |
| JP2024123120A (ja) | 放出セグメントおよびそれを含む結合組成物 | |
| JP2022538222A (ja) | Ｅｇｆｒ抗原結合断片およびそれを含む組成物 | |
| CN104395344A (zh) | 抗b7-h6抗体、融合蛋白及其使用方法 | |
| JP2009526010A5 (enExample) | ||
| IL301995A (en) | Cells comprising t cell-antigen couplers and uses thereof | |
| JP2022069441A (ja) | アデノシンおよび／またはメチルチオアデノシンの酵素媒介枯渇方法 | |
| EP4023679A1 (en) | Fusion protein targeting pd-l1 and tgf-beta and use thereof | |
| Tang et al. | Bispecific antibodies progression in malignant melanoma | |
| Qi et al. | Conventional and chemically programmed asymmetric bispecific antibodies targeting folate receptor 1 | |
| Wang et al. | IgG-like bispecific antibody CD3× EpCAM generated by split intein against colorectal cancer | |
| KR20210099615A (ko) | 감마 델타 t-세포 집단의 선택적 생체내 확장을 위한 방법 및 이의 조성물 | |
| Lu et al. | Potent antitumor activity of a bispecific T-cell engager antibody targeting the intracellular antigen KRAS G12V | |
| WO2022253248A1 (zh) | 抗cd3抗体变异体、融合蛋白及应用 | |
| CN116249715A (zh) | 抗ctla4单克隆抗体和嵌合抗原受体 | |
| US20250090662A1 (en) | Composition and method of use recombinant fusion protein to generate car-immune cells | |
| TW202304998A (zh) | 使用限制性條件活化之結合蛋白的治療方法 | |
| CN117597145A (zh) | 使用约束性条件激活的结合蛋白的治疗方法 | |
| Verhaar | Targeting MHC-I related proteins for cancer diagnosis and therap | |
| JP2025526383A (ja) | 阻害性キメラ受容体アーキテクチャ |