JP2018524577A5 - - Google Patents
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- JP2018524577A5 JP2018524577A5 JP2017565173A JP2017565173A JP2018524577A5 JP 2018524577 A5 JP2018524577 A5 JP 2018524577A5 JP 2017565173 A JP2017565173 A JP 2017565173A JP 2017565173 A JP2017565173 A JP 2017565173A JP 2018524577 A5 JP2018524577 A5 JP 2018524577A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- receptor
- receptors
- complex
- trimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000005962 receptors Human genes 0.000 claims 23
- 108020003175 receptors Proteins 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 18
- 238000000034 method Methods 0.000 claims 11
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 6
- 239000013638 trimer Substances 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 230000019491 signal transduction Effects 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 238000001327 Förster resonance energy transfer Methods 0.000 claims 1
- 101000801228 Homo sapiens Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 229940126214 compound 3 Drugs 0.000 claims 1
- 238000002050 diffraction method Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 230000003040 nociceptive effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 102000003390 tumor necrosis factor Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1510758.4A GB201510758D0 (en) | 2015-06-18 | 2015-06-18 | Novel TNFa structure for use in therapy |
| GB1510758.4 | 2015-06-18 | ||
| PCT/EP2015/074490 WO2016202411A1 (en) | 2015-06-18 | 2015-10-22 | Mechanism of action |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019154528A Division JP6752344B2 (ja) | 2015-06-18 | 2019-08-27 | 作用機構 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524577A JP2018524577A (ja) | 2018-08-30 |
| JP2018524577A5 true JP2018524577A5 (enExample) | 2018-11-22 |
| JP6659030B2 JP6659030B2 (ja) | 2020-03-04 |
Family
ID=53784155
Family Applications (12)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565173A Active JP6659030B2 (ja) | 2015-06-18 | 2015-10-22 | 作用機構 |
| JP2017565174A Active JP6951256B2 (ja) | 2015-06-18 | 2015-10-22 | 抗体 |
| JP2017565114A Active JP7336178B2 (ja) | 2015-06-18 | 2015-10-22 | 治療における使用のための新規のＴＮＦα構造 |
| JP2017565189A Active JP6948954B2 (ja) | 2015-06-18 | 2015-10-22 | 抗体エピトープ |
| JP2017565155A Active JP6781718B2 (ja) | 2015-06-18 | 2015-10-22 | モジュレータアッセイ |
| JP2019154528A Active JP6752344B2 (ja) | 2015-06-18 | 2019-08-27 | 作用機構 |
| JP2020174314A Pending JP2021038222A (ja) | 2015-06-18 | 2020-10-16 | モジュレータアッセイ |
| JP2021020352A Pending JP2021109880A (ja) | 2015-06-18 | 2021-02-12 | 治療における使用のための新規のＴＮＦα構造 |
| JP2021095909A Abandoned JP2021153592A (ja) | 2015-06-18 | 2021-06-08 | 抗体エピトープ |
| JP2021155537A Active JP7159420B2 (ja) | 2015-06-18 | 2021-09-24 | 抗体 |
| JP2023001089A Pending JP2023052250A (ja) | 2015-06-18 | 2023-01-06 | モジュレータアッセイ |
| JP2023046164A Pending JP2023100010A (ja) | 2015-06-18 | 2023-03-23 | 治療における使用のための新規のＴＮＦα構造 |
Family Applications After (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565174A Active JP6951256B2 (ja) | 2015-06-18 | 2015-10-22 | 抗体 |
| JP2017565114A Active JP7336178B2 (ja) | 2015-06-18 | 2015-10-22 | 治療における使用のための新規のＴＮＦα構造 |
| JP2017565189A Active JP6948954B2 (ja) | 2015-06-18 | 2015-10-22 | 抗体エピトープ |
| JP2017565155A Active JP6781718B2 (ja) | 2015-06-18 | 2015-10-22 | モジュレータアッセイ |
| JP2019154528A Active JP6752344B2 (ja) | 2015-06-18 | 2019-08-27 | 作用機構 |
| JP2020174314A Pending JP2021038222A (ja) | 2015-06-18 | 2020-10-16 | モジュレータアッセイ |
| JP2021020352A Pending JP2021109880A (ja) | 2015-06-18 | 2021-02-12 | 治療における使用のための新規のＴＮＦα構造 |
| JP2021095909A Abandoned JP2021153592A (ja) | 2015-06-18 | 2021-06-08 | 抗体エピトープ |
| JP2021155537A Active JP7159420B2 (ja) | 2015-06-18 | 2021-09-24 | 抗体 |
| JP2023001089A Pending JP2023052250A (ja) | 2015-06-18 | 2023-01-06 | モジュレータアッセイ |
| JP2023046164A Pending JP2023100010A (ja) | 2015-06-18 | 2023-03-23 | 治療における使用のための新規のＴＮＦα構造 |
Country Status (16)
| Country | Link |
|---|---|
| US (12) | US10969393B2 (enExample) |
| EP (8) | EP3311169B1 (enExample) |
| JP (12) | JP6659030B2 (enExample) |
| KR (2) | KR102599907B1 (enExample) |
| CN (6) | CN107771286B (enExample) |
| AU (2) | AU2015398984B2 (enExample) |
| CA (5) | CA2988516A1 (enExample) |
| CL (2) | CL2017003189A1 (enExample) |
| EA (4) | EA201890081A1 (enExample) |
| ES (5) | ES2836769T3 (enExample) |
| GB (1) | GB201510758D0 (enExample) |
| IL (2) | IL256099B2 (enExample) |
| MX (2) | MX2017015481A (enExample) |
| PL (4) | PL3311169T3 (enExample) |
| PT (4) | PT3311169T (enExample) |
| WO (5) | WO2016202412A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1250040A1 (zh) | 2015-03-31 | 2018-11-23 | Sorriso Pharmaceuticals, Inc. | 多肽 |
| JP6895421B2 (ja) | 2015-03-31 | 2021-06-30 | ブイエイチスクエアード リミテッド | ポリペプチド |
| CA2981098A1 (en) | 2015-03-31 | 2016-10-06 | Vhsquared Limited | Peptide construct having a protease-cleavable linker |
| TW201706258A (zh) | 2015-04-17 | 2017-02-16 | 艾伯維有限公司 | 作為ｔｎｆ信號傳遞調節劑之吲唑酮 |
| AR104291A1 (es) | 2015-04-17 | 2017-07-12 | Abbvie Inc | Moduladores tricíclicos de la señalización por tnf |
| TW201702247A (zh) | 2015-04-17 | 2017-01-16 | 艾伯維有限公司 | 作為ｔｎｆ信號傳遞調節劑之吲唑酮 |
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| EP3519438A1 (en) | 2016-09-30 | 2019-08-07 | VHsquared Limited | Compositions |
| GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN110494136A (zh) * | 2017-01-10 | 2019-11-22 | 瑞士苏黎世联邦理工学院 | 细胞保护性化合物及其用途 |
| AU2020294980A1 (en) | 2019-06-21 | 2022-02-17 | Sorriso Pharmaceuticals, Inc. | Polypeptides |
| EP3986931A1 (en) | 2019-06-21 | 2022-04-27 | Sorriso Pharmaceuticals, Inc. | Polypeptides |
| JP7561364B2 (ja) * | 2020-04-30 | 2024-10-04 | 国立大学法人東北大学 | 蛍光偏光免疫分析法 |
Family Cites Families (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2647427B2 (ja) | 1987-04-24 | 1997-08-27 | 帝人株式会社 | 被検者の病態の判定のための検出方法、モノクロ−ナル抗体および検出キット |
| EP1997891A1 (en) | 1988-09-02 | 2008-12-03 | Dyax Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US4908372A (en) | 1988-10-13 | 1990-03-13 | Merrell Dow Pharmaceuticals Inc. | Antihistaminic piperidinyl benzimidazoles |
| DE3843534A1 (de) | 1988-12-23 | 1990-07-12 | Basf Ag | Neue tnf-polypeptide |
| US6448380B2 (en) | 1989-08-07 | 2002-09-10 | Peptech Limited | Tumor necrosis factor antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| WO1991010737A1 (en) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| WO1992002551A1 (en) | 1990-08-02 | 1992-02-20 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| GB9028123D0 (en) | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
| DE69233750D1 (de) | 1991-04-10 | 2009-01-02 | Scripps Research Inst | Bibliotheken heterodimerer Rezeptoren mittels Phagemiden |
| GB9113120D0 (en) | 1991-06-18 | 1991-08-07 | Kodak Ltd | Photographic processing apparatus |
| IT1249708B (it) | 1991-09-23 | 1995-03-09 | Tecnogen Scpa | Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva. |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| WO1993014083A1 (en) | 1992-01-09 | 1993-07-22 | Janssen Pharmaceutica N.V. | Pharmaceutically active substituted benzimidazole derivatives |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| CA2155103A1 (en) | 1993-02-03 | 1994-08-18 | Rudolph Lucas | Tnf-alpha muteins and a process for preparing them |
| CA2119089A1 (en) | 1993-03-29 | 1994-09-30 | David Banner | Tumor necrosis factor muteins |
| WO1995015982A2 (en) | 1993-12-08 | 1995-06-15 | Genzyme Corporation | Process for generating specific antibodies |
| DK1231268T3 (da) | 1994-01-31 | 2005-11-21 | Univ Boston | Polyklonale antistofbiblioteker |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| DE4440613C1 (de) | 1994-11-14 | 1996-07-25 | Leica Ag | Vorrichtung und Verfahren zur Detektion und Demodulation eines intensitätsmodulierten Strahlungsfeldes |
| TW453995B (en) | 1995-12-15 | 2001-09-11 | Novartis Ag | Certain alpha-substituted arylsulfonamido acetohydroxamic acids |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| CN1204230A (zh) | 1997-12-08 | 1999-01-06 | 李建安 | 一种手提电话机用防护罩及其制做方法 |
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| GB9828628D0 (en) * | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
| US7101974B2 (en) | 2000-03-02 | 2006-09-05 | Xencor | TNF-αvariants |
| AU2001287041B2 (en) | 2000-09-01 | 2006-06-08 | Biogen Idec Ma Inc. | Pyridine derivatives useful as CD40:CD154 binding interruptor compounds and use thereof to treat immunological complications |
| WO2002098869A2 (en) | 2001-06-05 | 2002-12-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzo-fused cycloalkyl urea compounds |
| US6632810B2 (en) | 2001-06-29 | 2003-10-14 | Kowa Co., Ltd. | Cyclic diamine compound with condensed-ring groups |
| JP2003040888A (ja) | 2001-07-30 | 2003-02-13 | Sankyo Co Ltd | イミダゾール誘導体 |
| BR0313151A (pt) | 2002-08-01 | 2007-07-17 | Wyeth Corp | métodos e reagentes que se relacionam à inflamação e à apoptose |
| EP1570267B1 (en) | 2002-12-03 | 2011-10-12 | UCB Pharma, S.A. | Assay for identifying antibody producing cells |
| NZ543976A (en) | 2003-05-09 | 2008-04-30 | Pharmexa As | Immunogenic human TNF alpha analogues with reduced cytotoxicity and methods of their preparation |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| CA2527020A1 (en) | 2003-07-01 | 2005-01-13 | Celltech R & D Limited | Modified antibody fab fragments |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| EA013614B1 (ru) | 2003-07-15 | 2010-06-30 | Амджен Инк. | Изолированное антитело к фактору роста нервов (ngf) и способы его применения |
| US7268116B2 (en) | 2003-10-02 | 2007-09-11 | Genhunter Corp. | Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins |
| TW200526780A (en) | 2004-01-06 | 2005-08-16 | Hayashibara Biochem Lab | TNF antagonists and TNF inhibitors comprising the same as the active ingredient |
| GB0411186D0 (en) | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
| CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
| DE102005023617A1 (de) | 2005-05-21 | 2006-11-23 | Aspre Ag | Verfahren zum Mischen von Farben in einem Display |
| WO2007060411A1 (en) | 2005-11-24 | 2007-05-31 | Ucb Pharma S.A. | Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r |
| MX343879B (es) * | 2007-05-21 | 2016-11-25 | Alderbio Holdings Llc | Metodo de humanizacion de anticuerpo de conejo novedoso y anticuerpos de conejo humanizados. |
| TW201531484A (zh) | 2007-05-21 | 2015-08-16 | Alder Biopharmaceuticals Inc | 抗ＴＮＦ-α之抗體及其用途 |
| WO2009020848A2 (en) | 2007-08-03 | 2009-02-12 | Alcon Research, Ltd. | RNAI-RELATED INHIBITION OF TNFα SIGNALING PATHWAY FOR TREATMENT OF GLAUCOMA |
| ES2667729T3 (es) | 2007-09-26 | 2018-05-14 | Ucb Biopharma Sprl | Fusiones de anticuerpos con doble especificidad |
| US9365644B2 (en) | 2008-04-23 | 2016-06-14 | Epitomics, Inc. | Anti-TNFα antibody |
| MX345039B (es) | 2008-06-25 | 2017-01-16 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles que inhiben el tnfa. |
| US20120010158A1 (en) | 2008-11-20 | 2012-01-12 | Panacea Biotec Ltd. | Tumor necrosis factor inhibiting peptides and uses thereof |
| JP2010172307A (ja) | 2009-01-30 | 2010-08-12 | Saitama Medical Univ | 関節リウマチに対する可溶性ＴＮＦα／ＬＴαレセプター薬の薬効予測方法、及び薬効予測装置 |
| WO2010118404A2 (en) | 2009-04-09 | 2010-10-14 | California Institute Of Technology | Methods for creating or identifying compounds that bind tumor necrosis factor alpha |
| BRPI1012524A2 (pt) | 2009-04-16 | 2020-09-29 | Abbott Biotherapeutics Corp | anticorpos anti-tnf-alfa e seus usos |
| BR112012025568A2 (pt) | 2010-04-07 | 2017-03-28 | Abbvie Inc | proteínas de ligação ao tnf-<244>. |
| US8377441B2 (en) | 2010-08-03 | 2013-02-19 | National Cheng Kung University | Treating breast cancer with anti-IL-19 antibody |
| ES2829388T3 (es) | 2010-10-30 | 2021-05-31 | Kindex Therapeutics Llc | Derivados de cis 3,4-dihidroxi-2-(3-metilbutanoil)-5-(-3-metilbutil)-4-(4-metilpentanoil)cyclopent-2-en-1-ona, composiciones sustancialmente puras enantioméricamente y métodos |
| AR084210A1 (es) | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| US20140112929A1 (en) | 2011-06-17 | 2014-04-24 | Glaxo Group Limited | Tumour necrosis factor receptor 1 antagonists |
| CN103930126A (zh) | 2011-08-12 | 2014-07-16 | Bsrc亚历山大.弗莱明 | Tnf超家族三聚化的抑制剂 |
| CN104428293B (zh) * | 2012-06-11 | 2018-06-08 | Ucb生物制药私人有限公司 | 调节TNFα的苯并咪唑类 |
| EP2867674B1 (en) * | 2012-06-28 | 2018-10-10 | UCB Biopharma SPRL | A method for identifying compounds of therapeutic interest |
| GB201212513D0 (en) | 2012-07-13 | 2012-08-29 | Ucb Pharma Sa | Therapeutic agents |
| BR112015000675B1 (pt) * | 2012-07-13 | 2022-07-12 | UCB Biopharma SRL | Derivados de imidazopiridina como moduladores da atividade de tnf |
| WO2014040076A1 (en) | 2012-09-10 | 2014-03-13 | Xencor | Methods of treating neurological diseases |
| KR101759687B1 (ko) | 2013-01-25 | 2017-07-19 | 타이몬, 엘엘씨 | 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법 |
| BR112015022409A2 (pt) | 2013-03-12 | 2017-07-18 | Anellotech Inc | regeneração do catalisador de pirólise catalítica rápida |
| CN105612183A (zh) * | 2013-07-15 | 2016-05-25 | 诺和诺德股份有限公司 | 结合尿激酶纤溶酶原激活物的抗体 |
| CN105814022B (zh) | 2013-12-09 | 2018-09-28 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合的二环杂芳族衍生物 |
| GB201321729D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321733D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321743D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321734D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| GB201321739D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321745D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321735D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| GB201321737D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| GB201321742D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321730D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321728D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321740D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321738D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| GB201321732D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| JP6469692B2 (ja) | 2013-12-09 | 2019-02-13 | ユーシービー バイオファルマ エスピーアールエル | Ｔｎｆ活性のモジュレーターとしてのイミダゾピリジン誘導体 |
| GB201321731D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321744D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321748D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321736D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321749D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321741D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321746D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| PE20170693A1 (es) | 2014-10-03 | 2017-06-13 | Ucb Biopharma Sprl | Derivados de imidazol pentaciclicos fusionados |
| KR20170105558A (ko) * | 2015-01-30 | 2017-09-19 | 각코우호우징 사이타마이카다이가쿠 | 항 alk2 항체 |
| ES2803650T3 (es) | 2015-03-18 | 2021-01-28 | Bristol Myers Squibb Co | Compuestos heterocíclicos útiles como inhibidores de TNF |
| SG11201707469WA (en) | 2015-03-18 | 2017-10-30 | Bristol Myers Squibb Co | Substituted tricyclic heterocyclic compounds |
| US10308652B2 (en) | 2015-03-18 | 2019-06-04 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds useful as inhibitors of TNF |
| AR104291A1 (es) | 2015-04-17 | 2017-07-12 | Abbvie Inc | Moduladores tricíclicos de la señalización por tnf |
| TW201702247A (zh) | 2015-04-17 | 2017-01-16 | 艾伯維有限公司 | 作為ｔｎｆ信號傳遞調節劑之吲唑酮 |
| TW201706258A (zh) | 2015-04-17 | 2017-02-16 | 艾伯維有限公司 | 作為ｔｎｆ信號傳遞調節劑之吲唑酮 |
| GB201509885D0 (en) | 2015-06-08 | 2015-07-22 | Ucb Biopharma Sprl | Therapeutic agents |
| GB201509888D0 (en) | 2015-06-08 | 2015-07-22 | Ucb Biopharma Sprl | Therapeutic agents |
| GB201509893D0 (en) | 2015-06-08 | 2015-07-22 | Ucb Biopharma Sprl | Therapeutic agents |
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| AU2016301215A1 (en) | 2015-08-03 | 2018-03-22 | Bristol-Myers Squibb Company | Cyclic compounds useful as modulators of TNF alpha |
| MA43512A (fr) | 2015-08-03 | 2018-11-07 | Bristol Myers Squibb Co | Composés hétérocycliques utiles en tant que modulateurs du tnf alpha |
| EA201892153A1 (ru) | 2016-04-01 | 2019-04-30 | Юсб Байофарма Спрл | Конденсированные пентациклические производные имидазола в качестве модуляторов активности tnf |
| CN109219608B (zh) | 2016-04-01 | 2021-12-21 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合五环咪唑衍生物 |
| CN109195968B (zh) | 2016-04-01 | 2022-02-11 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合五环咪唑衍生物 |
| WO2017167995A1 (en) | 2016-04-01 | 2017-10-05 | Ucb Biopharma Sprl | Fused hexacyclic imidazole derivatives as modulators of tnf activity |
| GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
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