JP2017522043A5 - - Google Patents

Info

Publication number

JP2017522043A5

JP2017522043A5 JP2017510285A JP2017510285A JP2017522043A5 JP 2017522043 A5 JP2017522043 A5 JP 2017522043A5 JP 2017510285 A JP2017510285 A JP 2017510285A JP 2017510285 A JP2017510285 A JP 2017510285A JP 2017522043 A5 JP2017522043 A5 JP 2017522043A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

variable region

chain variable

Prior art date

2015-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 238000000338 in vitro Methods 0.000 claims description 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 51
• 239000012634 fragment Substances 0.000 claims 16
• 239000000427 antigen Substances 0.000 claims 14
• 102000036639 antigens Human genes 0.000 claims 14
• 108091007433 antigens Proteins 0.000 claims 14
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 3
• 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
• 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
• 230000001363 autoimmune Effects 0.000 claims 2
• 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 238000003259 recombinant expression Methods 0.000 claims 2
• 206010056508 Acquired epidermolysis bullosa Diseases 0.000 claims 1
• 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
• 208000030767 Autoimmune encephalitis Diseases 0.000 claims 1
• 208000023328 Basedow disease Diseases 0.000 claims 1
• 206010018372 Glomerulonephritis membranous Diseases 0.000 claims 1
• 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
• 208000015023 Graves' disease Diseases 0.000 claims 1
• 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
• 208000000209 Isaacs syndrome Diseases 0.000 claims 1
• 208000005777 Lupus Nephritis Diseases 0.000 claims 1
• 206010027145 Melanocytic naevus Diseases 0.000 claims 1
• 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
• 208000012192 Mucous membrane pemphigoid Diseases 0.000 claims 1
• 206010072359 Neuromyotonia Diseases 0.000 claims 1
• 208000007256 Nevus Diseases 0.000 claims 1
• 206010034277 Pemphigoid Diseases 0.000 claims 1
• 208000008223 Pemphigoid Gestationis Diseases 0.000 claims 1
• 201000011152 Pemphigus Diseases 0.000 claims 1
• 241000721454 Pemphigus Species 0.000 claims 1
• 208000025747 Rheumatic disease Diseases 0.000 claims 1
• 208000007502 anemia Diseases 0.000 claims 1
• 206010003246 arthritis Diseases 0.000 claims 1
• 208000000594 bullous pemphigoid Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 238000010494 dissociation reaction Methods 0.000 claims 1
• 230000005593 dissociations Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000011114 epidermolysis bullosa acquisita Diseases 0.000 claims 1
• 206010015037 epilepsy Diseases 0.000 claims 1
• 201000004403 episodic ataxia Diseases 0.000 claims 1
• 206010025135 lupus erythematosus Diseases 0.000 claims 1
• 201000008350 membranous glomerulonephritis Diseases 0.000 claims 1
• 231100000855 membranous nephropathy Toxicity 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 206010028417 myasthenia gravis Diseases 0.000 claims 1
• 208000004235 neutropenia Diseases 0.000 claims 1
• 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
• 230000000552 rheumatic effect Effects 0.000 claims 1
• 238000000926 separation method Methods 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 230000015556 catabolic process Effects 0.000 description 4
• 241000699670 Mus sp. Species 0.000 description 2
• 239000008280 blood Substances 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 108010068617 neonatal Fc receptor Proteins 0.000 description 1
• 239000000126 substance Substances 0.000 description 1