JP2018522850A5 - - Google Patents
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- JP2018522850A5 JP2018522850A5 JP2017565142A JP2017565142A JP2018522850A5 JP 2018522850 A5 JP2018522850 A5 JP 2018522850A5 JP 2017565142 A JP2017565142 A JP 2017565142A JP 2017565142 A JP2017565142 A JP 2017565142A JP 2018522850 A5 JP2018522850 A5 JP 2018522850A5
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- Prior art keywords
- cancer
- antagonist
- seq
- administered
- chain variable
- Prior art date
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- 238000000034 method Methods 0.000 claims description 92
- 239000003814 drug Substances 0.000 claims description 74
- 229940123751 PD-L1 antagonist Drugs 0.000 claims description 62
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 58
- 206010028980 Neoplasm Diseases 0.000 claims description 41
- 201000011510 cancer Diseases 0.000 claims description 36
- 102000008096 B7-H1 Antigen Human genes 0.000 claims description 27
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 27
- 229940124674 VEGF-R inhibitor Drugs 0.000 claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 17
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 14
- 239000005557 antagonist Substances 0.000 claims description 13
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical group CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims description 12
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 11
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims description 11
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 11
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims description 11
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 9
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 9
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 9
- 238000003364 immunohistochemistry Methods 0.000 claims description 8
- 229960003005 axitinib Drugs 0.000 claims description 7
- 230000003442 weekly effect Effects 0.000 claims description 7
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 6
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 6
- 208000017604 Hodgkin disease Diseases 0.000 claims description 6
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims description 6
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 6
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 6
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 6
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 6
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 6
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 6
- 238000003556 assay Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 238000012360 testing method Methods 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 4
- 201000001441 melanoma Diseases 0.000 claims description 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 3
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 3
- 208000034578 Multiple myelomas Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 206010038389 Renal cancer Diseases 0.000 claims description 3
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims description 3
- 201000003444 follicular lymphoma Diseases 0.000 claims description 3
- 201000010982 kidney cancer Diseases 0.000 claims description 3
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 208000025113 myeloid leukemia Diseases 0.000 claims description 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 3
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims description 2
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims description 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims 2
- 229940121647 egfr inhibitor Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 29
- 238000011127 radiochemotherapy Methods 0.000 description 10
- 229940123494 CD20 antagonist Drugs 0.000 description 9
- 238000002648 combination therapy Methods 0.000 description 9
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 description 6
- 229960002707 bendamustine Drugs 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 description 5
- 229960002756 azacitidine Drugs 0.000 description 5
- 238000002721 intensity-modulated radiation therapy Methods 0.000 description 4
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 3
- 208000020990 adrenal cortex carcinoma Diseases 0.000 description 3
- 208000007128 adrenocortical carcinoma Diseases 0.000 description 3
- 229950002916 avelumab Drugs 0.000 description 3
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 3
- 229960004316 cisplatin Drugs 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 206010044412 transitional cell carcinoma Diseases 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000002055 immunohistochemical effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 208000019465 refractory cytopenia of childhood Diseases 0.000 description 2
- 229960004641 rituximab Drugs 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 208000023747 urothelial carcinoma Diseases 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 description 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021074021A JP2021113220A (ja) | 2015-06-16 | 2021-04-26 | Ｐｄ−ｌ１アンタゴニスト併用療法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562180543P | 2015-06-16 | 2015-06-16 | |
| US62/180,543 | 2015-06-16 | ||
| US201562219995P | 2015-09-17 | 2015-09-17 | |
| US62/219,995 | 2015-09-17 | ||
| US201662286501P | 2016-01-25 | 2016-01-25 | |
| US62/286,501 | 2016-01-25 | ||
| US201662337489P | 2016-05-17 | 2016-05-17 | |
| US62/337,489 | 2016-05-17 | ||
| PCT/US2016/037498 WO2016205277A1 (en) | 2015-06-16 | 2016-06-15 | Pd-l1 antagonist combination treatments |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021074021A Division JP2021113220A (ja) | 2015-06-16 | 2021-04-26 | Ｐｄ−ｌ１アンタゴニスト併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522850A JP2018522850A (ja) | 2018-08-16 |
| JP2018522850A5 true JP2018522850A5 (enExample) | 2019-07-18 |
| JP6876629B2 JP6876629B2 (ja) | 2021-05-26 |
Family
ID=56236125
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565142A Active JP6876629B2 (ja) | 2015-06-16 | 2016-06-15 | Ｐｄ−ｌ１アンタゴニスト併用療法 |
| JP2021074021A Pending JP2021113220A (ja) | 2015-06-16 | 2021-04-26 | Ｐｄ−ｌ１アンタゴニスト併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021074021A Pending JP2021113220A (ja) | 2015-06-16 | 2021-04-26 | Ｐｄ−ｌ１アンタゴニスト併用療法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10869924B2 (enExample) |
| EP (1) | EP3310810A1 (enExample) |
| JP (2) | JP6876629B2 (enExample) |
| KR (1) | KR102712880B1 (enExample) |
| CN (1) | CN107750166B (enExample) |
| AU (1) | AU2016280003B2 (enExample) |
| CA (1) | CA2989586A1 (enExample) |
| IL (1) | IL256245B (enExample) |
| MX (1) | MX390878B (enExample) |
| MY (1) | MY193229A (enExample) |
| PH (1) | PH12017501857B1 (enExample) |
| RU (1) | RU2766890C2 (enExample) |
| TW (1) | TWI772261B (enExample) |
| UA (1) | UA126892C2 (enExample) |
| WO (1) | WO2016205277A1 (enExample) |
Families Citing this family (38)
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| SMT202000561T1 (it) | 2011-11-28 | 2021-01-05 | Merck Patent Gmbh | Anticorpi anti-pd-l1 e usi relativi |
| KR101503341B1 (ko) | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| CN112263677A (zh) | 2015-02-26 | 2021-01-26 | 默克专利股份公司 | 用于治疗癌症的pd-1/pd-l1抑制剂 |
| SG11201707383PA (en) | 2015-03-13 | 2017-10-30 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| MX390878B (es) | 2015-06-16 | 2025-03-21 | Merck Patent Gmbh | Usos medicos de antagonista de ligando 1 de muerte programada (pd-l1). |
| RU2711380C2 (ru) | 2015-07-16 | 2020-01-16 | Байоксэл Терапьютикс, Инк. | Новый подход к лечению рака с применением иммуномодуляции |
| CN108367072B (zh) | 2015-12-07 | 2022-12-27 | 默克专利股份有限公司 | 含抗-pd-l1抗体avelumab的水性药物制剂 |
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| EP3464356A1 (en) * | 2016-05-26 | 2019-04-10 | Merck Patent GmbH | Pd-1 / pd-l1 inhibitors for cancer treatment |
| BR112019006504A2 (pt) | 2016-10-06 | 2019-06-25 | Pfizer Inc. | regime de dosagem de avelumabe para o tratamento de câncer |
| EP4032911A1 (en) | 2017-01-06 | 2022-07-27 | Eutilex Co., Ltd. | Anti-human 4-1bb antibodies and use thereof |
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| EP3372615A1 (en) | 2017-03-06 | 2018-09-12 | Merck Patent GmbH | Composition comprising avelumab |
| WO2018162446A1 (en) | 2017-03-06 | 2018-09-13 | Merck Patent Gmbh | Aqueous anti-pd-l1 antibody formulation |
| EP3600410A1 (en) | 2017-03-30 | 2020-02-05 | Merck Patent GmbH | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
| JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| JP7474193B2 (ja) * | 2017-06-25 | 2024-04-24 | システィミューン， インク． | 多重特異性抗体とその作製及び使用方法 |
| TW201922793A (zh) * | 2017-11-16 | 2019-06-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｐｄ－１抗體和ｖｅｇｆｒ抑制劑聯合治療小細胞肺癌的用途 |
| EA202091751A1 (ru) * | 2018-01-22 | 2020-11-06 | Бристол-Маерс Сквибб Компани | Композиции и способы лечения рака |
| CA3090620A1 (en) * | 2018-03-06 | 2019-09-12 | Institut Curie | Inhibitor of setdb1 histone methyltransferase for use in cancer combination therapy |
| CA3095076A1 (en) * | 2018-03-29 | 2019-10-03 | Adagene Inc. | Anti-pd-l1 antibodies and use thereof |
| MY202157A (en) * | 2018-04-09 | 2024-04-09 | Oricell Therapeutics Co Ltd | Anti-pd-l1 antibody and use thereof |
| MY204232A (en) | 2018-05-10 | 2024-08-16 | Regeneron Pharma | High concentration vegf receptor fusion protein containing formulations |
| US20210147549A1 (en) * | 2018-07-11 | 2021-05-20 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc-ANTIGEN BINDING DOMAIN CONSTRUCTS TARGETED TO PD-L1 |
| WO2020081767A1 (en) | 2018-10-18 | 2020-04-23 | Genentech, Inc. | Diagnostic and therapeutic methods for sarcomatoid kidney cancer |
| JP2022509448A (ja) * | 2018-10-31 | 2022-01-20 | ジェネンテック， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１シグナル伝達阻害剤に不応答性のがんの処置方法および医薬 |
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| CN113164599B (zh) * | 2018-12-24 | 2023-08-01 | 正大天晴药业集团股份有限公司 | 抗pd-l1单克隆抗体治疗癌症的用途 |
| WO2020151759A1 (zh) | 2019-01-25 | 2020-07-30 | 正大天晴药业集团股份有限公司 | 治疗肿瘤的联用药物组合物 |
| EP3955925A4 (en) * | 2019-04-18 | 2023-03-22 | QLSF Biotherapeutics Inc. | HUMANIZED ANTI-PD-L1 ANTIBODIES |
| CN113905761A (zh) * | 2019-06-10 | 2022-01-07 | 正大天晴药业集团南京顺欣制药有限公司 | 治疗驱动基因阳性肺癌的联用药物组合物 |
| CN110746493A (zh) * | 2019-09-06 | 2020-02-04 | 中国药科大学 | 一种pd-l1拮抗剂多肽及其应用 |
| CN110760517B (zh) * | 2019-10-09 | 2022-04-29 | 天津大学 | 拮抗pd-1骆驼抗体类似物ap基因及蛋白和应用 |
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| EP4144371A4 (en) * | 2020-04-30 | 2024-05-22 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | COMBINATION MEDICINAL PRODUCTS FOR THE TREATMENT OF KIDNEY CANCER |
| WO2022068894A1 (zh) * | 2020-09-30 | 2022-04-07 | 上海齐鲁制药研究中心有限公司 | 同时靶向pd-l1和vegf的双功能分子及其医药用途 |
| WO2022111618A1 (zh) * | 2020-11-26 | 2022-06-02 | 正大天晴药业集团股份有限公司 | 用于治疗肺癌的抗PD-L1抗体和c-Met激酶抑制剂的联用药物组合物 |
| EP4583930A1 (en) | 2023-04-11 | 2025-07-16 | Ocular Therapeutix, Inc. | Ocular implant comprising axitinib polymorph iv |
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-
2016
- 2016-06-15 MX MX2017016324A patent/MX390878B/es unknown
- 2016-06-15 US US15/736,615 patent/US10869924B2/en active Active
- 2016-06-15 UA UAA201800418A patent/UA126892C2/uk unknown
- 2016-06-15 PH PH1/2017/501857A patent/PH12017501857B1/en unknown
- 2016-06-15 KR KR1020187001350A patent/KR102712880B1/ko active Active
- 2016-06-15 EP EP16732440.9A patent/EP3310810A1/en active Pending
- 2016-06-15 CA CA2989586A patent/CA2989586A1/en active Pending
- 2016-06-15 IL IL256245A patent/IL256245B/en unknown
- 2016-06-15 AU AU2016280003A patent/AU2016280003B2/en active Active
- 2016-06-15 CN CN201680035168.3A patent/CN107750166B/zh active Active
- 2016-06-15 RU RU2018101314A patent/RU2766890C2/ru active
- 2016-06-15 JP JP2017565142A patent/JP6876629B2/ja active Active
- 2016-06-15 MY MYPI2017704745A patent/MY193229A/en unknown
- 2016-06-15 WO PCT/US2016/037498 patent/WO2016205277A1/en not_active Ceased
- 2016-06-16 TW TW105118967A patent/TWI772261B/zh active
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2020
- 2020-11-19 US US16/952,620 patent/US20210069326A1/en not_active Abandoned
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2021
- 2021-04-26 JP JP2021074021A patent/JP2021113220A/ja active Pending
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