JP2019508433A5 - - Google Patents

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Publication number
JP2019508433A5
JP2019508433A5 JP2018546036A JP2018546036A JP2019508433A5 JP 2019508433 A5 JP2019508433 A5 JP 2019508433A5 JP 2018546036 A JP2018546036 A JP 2018546036A JP 2018546036 A JP2018546036 A JP 2018546036A JP 2019508433 A5 JP2019508433 A5 JP 2019508433A5
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JP
Japan
Prior art keywords
liv
adc
subject
pharmaceutical composition
drug conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018546036A
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English (en)
Japanese (ja)
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JP2019508433A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/022541 external-priority patent/WO2017161007A1/en
Publication of JP2019508433A publication Critical patent/JP2019508433A/ja
Publication of JP2019508433A5 publication Critical patent/JP2019508433A5/ja
Priority to JP2022006944A priority Critical patent/JP2022058676A/ja
Priority to JP2024039750A priority patent/JP2024075639A/ja
Pending legal-status Critical Current

Links

JP2018546036A 2016-03-15 2017-03-15 Liv1−adc及び化学療法剤を用いた併用療法 Pending JP2019508433A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022006944A JP2022058676A (ja) 2016-03-15 2022-01-20 Liv1-adc及び化学療法剤を用いた併用療法
JP2024039750A JP2024075639A (ja) 2016-03-15 2024-03-14 Liv1-adc及び化学療法剤を用いた併用療法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662308639P 2016-03-15 2016-03-15
US62/308,639 2016-03-15
US201662317792P 2016-04-04 2016-04-04
US62/317,792 2016-04-04
US201662367510P 2016-07-27 2016-07-27
US62/367,510 2016-07-27
PCT/US2017/022541 WO2017161007A1 (en) 2016-03-15 2017-03-15 Combination therapy using a liv1-adc and a chemotherapeutic

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022006944A Division JP2022058676A (ja) 2016-03-15 2022-01-20 Liv1-adc及び化学療法剤を用いた併用療法

Publications (2)

Publication Number Publication Date
JP2019508433A JP2019508433A (ja) 2019-03-28
JP2019508433A5 true JP2019508433A5 (enExample) 2020-04-23

Family

ID=59852409

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018546036A Pending JP2019508433A (ja) 2016-03-15 2017-03-15 Liv1−adc及び化学療法剤を用いた併用療法
JP2022006944A Pending JP2022058676A (ja) 2016-03-15 2022-01-20 Liv1-adc及び化学療法剤を用いた併用療法
JP2024039750A Pending JP2024075639A (ja) 2016-03-15 2024-03-14 Liv1-adc及び化学療法剤を用いた併用療法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022006944A Pending JP2022058676A (ja) 2016-03-15 2022-01-20 Liv1-adc及び化学療法剤を用いた併用療法
JP2024039750A Pending JP2024075639A (ja) 2016-03-15 2024-03-14 Liv1-adc及び化学療法剤を用いた併用療法

Country Status (14)

Country Link
US (2) US11325980B2 (enExample)
EP (1) EP3429626A4 (enExample)
JP (3) JP2019508433A (enExample)
KR (3) KR20220157515A (enExample)
CN (1) CN108697801A (enExample)
AU (2) AU2017235545A1 (enExample)
BR (1) BR112018068129A2 (enExample)
CA (1) CA3016485A1 (enExample)
EA (1) EA201891968A1 (enExample)
IL (1) IL261505A (enExample)
MA (1) MA45324A (enExample)
MX (2) MX2018010847A (enExample)
SG (2) SG10201912908QA (enExample)
WO (1) WO2017161007A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3211246A1 (en) 2010-12-06 2012-06-14 Seagen Inc. Humanized antibodies to liv-1 and use of same to treat cancer
EA202091360A1 (ru) * 2017-12-01 2020-08-24 Сиэтл Дженетикс, Инк. Гуманизированные анти-liv1 антитела для лечения рака молочной железы
US12304968B2 (en) * 2018-11-07 2025-05-20 Crispr Therapeutics Ag T-cells expressing anti-LIV1 chimeric antigen receptor
US20210228676A1 (en) * 2019-12-09 2021-07-29 Seagen Inc. Combination Therapy With LIV1-ADC and PD-1 Antagonist
JP2023543026A (ja) * 2020-09-28 2023-10-12 シージェン インコーポレイテッド がんの処置のためのヒト化抗liv1抗体
WO2022198231A1 (en) 2021-03-18 2022-09-22 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
AU2024235054A1 (en) * 2023-03-15 2025-10-02 BioRay Pharmaceutical Co., Ltd. Anti-liv-1 antibody and anti-liv-1 antibody-drug conjugate, and pharmaceutical use thereof
WO2025162207A1 (zh) * 2024-01-31 2025-08-07 上海复宏汉霖生物技术股份有限公司 抗liv1抗体及使用方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880935A (en) 1986-07-11 1989-11-14 Icrf (Patents) Limited Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
FI102355B1 (fi) 1988-02-11 1998-11-30 Bristol Myers Squibb Co Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
AU663727B2 (en) 1991-08-22 1995-10-19 Becton Dickinson & Company Methods and compositions for cancer therapy and for prognosticating responses to cancer therapy
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
CA2132500A1 (en) 1994-09-20 1996-03-21 David Lockwood Manning Methods for predicting the behaviour of breast tumours
DE69626849T2 (de) 1995-12-22 2003-12-24 Bristol-Myers Squibb Co., Princeton Verzweigte hydrazongruppen enthaltende kuppler
US6130237A (en) 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
EP0939824B1 (en) 1996-10-31 2007-06-06 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
US6066778A (en) 1996-11-06 2000-05-23 The Regents Of The University Of Michigan Transgenic mice expressing APC resistant factor V
WO1998034118A1 (en) 1997-01-30 1998-08-06 Yale University Diagnostic methods and compositions based on the distribution of rad51
CA2308029A1 (en) 1997-10-31 1999-05-14 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
WO1999025877A1 (en) 1997-11-18 1999-05-27 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
JP2002507387A (ja) 1997-12-24 2002-03-12 コリクサ コーポレイション 乳癌の免疫療法および診断のための化合物ならびにそれらの使用のための方法
CA2347906A1 (en) 1998-08-04 2000-02-17 Diadexus, Inc. A novel method of diagnosing, monitoring, staging, imaging and treating breast cancer
EP1953229A3 (en) 1998-10-15 2008-12-24 Novartis Vaccines and Diagnostics, Inc. Metastatic breast and colon cancer regulated genes
AU3395900A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
US6762020B1 (en) 1999-03-15 2004-07-13 Protein Design Labs, Inc. Methods of diagnosing breast cancer
US20040141983A1 (en) 1999-03-15 2004-07-22 Protein Design Labs, Inc. Compositions against cancer antigen LIV-1 and uses thereof
EP1263780A2 (en) 2000-01-25 2002-12-11 Genentech, Inc. Liv-1 related protein, polynulceotides encoding the same and use thereof for treatment of cancer
AU2001264099A1 (en) 2000-06-13 2001-12-24 University College Cardiff Consultants Ltd. Zinc transporters
US6964849B2 (en) 2001-01-11 2005-11-15 Curagen Corporation Proteins and nucleic acids encoding same
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
WO2003000012A2 (en) 2001-06-21 2003-01-03 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer
AU2002322280A1 (en) 2001-06-21 2003-01-21 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
US7091186B2 (en) 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
WO2003075855A2 (en) 2002-03-08 2003-09-18 Protein Design Labs, Inc. Antibodies against cancer antigen tmeff2 and uses thereof
JP4741838B2 (ja) 2002-07-31 2011-08-10 シアトル ジェネティクス,インコーポレーテッド 癌、自己免疫疾患または感染症を治療するための薬物結合体およびその使用
MXPA05007940A (es) 2003-01-27 2007-06-14 Biogen Idec Inc Composiciones y metodos para el tratamiento del cancer usando igsf9 y liv-1.
WO2004067564A2 (en) 2003-01-29 2004-08-12 Protein Design Labs, Inc. Compositions against cancer antigen liv-1 and uses thereof
CN104998273A (zh) 2003-11-06 2015-10-28 西雅图基因公司 能够与配体偶联的单甲基缬氨酸化合物
WO2005058961A2 (en) 2003-12-12 2005-06-30 Amgen Inc. Antibodies specific for human galanin, and uses thereof
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
US20060222653A1 (en) 2004-11-12 2006-10-05 Xencor, Inc. Antibodies operably linked to selected chemoattractants
WO2006124269A2 (en) 2005-05-16 2006-11-23 Amgen Fremont Inc. Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
KR20080080482A (ko) * 2005-09-07 2008-09-04 메디뮨 엘엘씨 독소가 컨쥬게이트된 eph 수용체 항체
CN101309933A (zh) * 2005-09-07 2008-11-19 米迪缪尼有限公司 毒素偶联的Eph受体抗体
CN101622273A (zh) 2006-04-13 2010-01-06 诺瓦提斯疫苗和诊断公司 治疗、诊断或检测与liv-1过量表达相关的癌症的方法
PT2099823E (pt) 2006-12-01 2014-12-22 Seattle Genetics Inc Agentes de ligação ao alvo variantes e suas utilizações
RU2009140134A (ru) 2007-04-23 2011-05-27 Вайет (Us) Способы и композиции для лечения и мониторинга лечения связанных с ил-13 нарушений
EP2615115A3 (en) 2007-11-30 2014-01-08 Glaxo Group Limited Antigen-binding constructs
EP2304631A1 (en) 2008-06-16 2011-04-06 Sividon Diagnostics GmbH Algorithms for outcome prediction in patients with node-positive chemotherapy-treated breast cancer
US20110195995A1 (en) 2008-10-14 2011-08-11 Wittliff James L Methods of Optimizing Treatment of Estrogen-Receptor Positive Breast Cancers
WO2010069858A1 (en) 2008-12-19 2010-06-24 F. Hoffmann-La Roche Ag Pharmaceutical composition
US8642270B2 (en) 2009-02-09 2014-02-04 Vm Institute Of Research Prognostic biomarkers to predict overall survival and metastatic disease in patients with triple negative breast cancer
US20110165566A1 (en) 2009-07-09 2011-07-07 Wittliff James L Methods of optimizing treatment of breast cancer
MX2012002766A (es) 2009-09-03 2012-04-02 Genentech Inc Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide.
CA3211246A1 (en) 2010-12-06 2012-06-14 Seagen Inc. Humanized antibodies to liv-1 and use of same to treat cancer
WO2012125712A2 (en) 2011-03-14 2012-09-20 Respira Health, Llc Lung tumor classifier for current and former smokers
WO2013055874A2 (en) 2011-10-14 2013-04-18 Genentech, Inc. Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab
WO2013170263A2 (en) 2012-05-11 2013-11-14 Merrimack Pharmaceuticals, Inc. Dosage and administration of bispecific scfv conjugates in combination with anti-cancer therapeutics
DE202012006349U1 (de) 2012-07-03 2013-07-05 Schuster Engineering Gmbh Schiffsladeanordnung
DK2839860T3 (da) * 2012-10-12 2019-06-17 Medimmune Ltd Pyrrolobenzodiazepiner og konjugater deraf
US10898555B2 (en) 2013-07-02 2021-01-26 Japanese Foundation For Cancer Research Cellular immunity inducing vaccine
EP3130608B1 (en) 2014-04-10 2019-09-04 Daiichi Sankyo Co., Ltd. (anti-her2 antibody)-drug conjugate
EA202091360A1 (ru) * 2017-12-01 2020-08-24 Сиэтл Дженетикс, Инк. Гуманизированные анти-liv1 антитела для лечения рака молочной железы
US12304968B2 (en) 2018-11-07 2025-05-20 Crispr Therapeutics Ag T-cells expressing anti-LIV1 chimeric antigen receptor
GB201908208D0 (en) 2019-06-10 2019-07-24 Univ College Cardiff Consultants Ltd An anti-mitotic agent
US20210228676A1 (en) 2019-12-09 2021-07-29 Seagen Inc. Combination Therapy With LIV1-ADC and PD-1 Antagonist

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