JP2019508433A5 - - Google Patents

Download PDF

Info

Publication number
JP2019508433A5
JP2019508433A5 JP2018546036A JP2018546036A JP2019508433A5 JP 2019508433 A5 JP2019508433 A5 JP 2019508433A5 JP 2018546036 A JP2018546036 A JP 2018546036A JP 2018546036 A JP2018546036 A JP 2018546036A JP 2019508433 A5 JP2019508433 A5 JP 2019508433A5
Authority
JP
Japan
Prior art keywords
liv
adc
subject
pharmaceutical composition
drug conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018546036A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019508433A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/022541 external-priority patent/WO2017161007A1/en
Publication of JP2019508433A publication Critical patent/JP2019508433A/ja
Publication of JP2019508433A5 publication Critical patent/JP2019508433A5/ja
Priority to JP2022006944A priority Critical patent/JP2022058676A/ja
Priority to JP2024039750A priority patent/JP2024075639A/ja
Pending legal-status Critical Current

Links

JP2018546036A 2016-03-15 2017-03-15 Liv1−adc及び化学療法剤を用いた併用療法 Pending JP2019508433A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022006944A JP2022058676A (ja) 2016-03-15 2022-01-20 Liv1-adc及び化学療法剤を用いた併用療法
JP2024039750A JP2024075639A (ja) 2016-03-15 2024-03-14 Liv1-adc及び化学療法剤を用いた併用療法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662308639P 2016-03-15 2016-03-15
US62/308,639 2016-03-15
US201662317792P 2016-04-04 2016-04-04
US62/317,792 2016-04-04
US201662367510P 2016-07-27 2016-07-27
US62/367,510 2016-07-27
PCT/US2017/022541 WO2017161007A1 (en) 2016-03-15 2017-03-15 Combination therapy using a liv1-adc and a chemotherapeutic

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022006944A Division JP2022058676A (ja) 2016-03-15 2022-01-20 Liv1-adc及び化学療法剤を用いた併用療法

Publications (2)

Publication Number Publication Date
JP2019508433A JP2019508433A (ja) 2019-03-28
JP2019508433A5 true JP2019508433A5 (enExample) 2020-04-23

Family

ID=59852409

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018546036A Pending JP2019508433A (ja) 2016-03-15 2017-03-15 Liv1−adc及び化学療法剤を用いた併用療法
JP2022006944A Pending JP2022058676A (ja) 2016-03-15 2022-01-20 Liv1-adc及び化学療法剤を用いた併用療法
JP2024039750A Pending JP2024075639A (ja) 2016-03-15 2024-03-14 Liv1-adc及び化学療法剤を用いた併用療法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022006944A Pending JP2022058676A (ja) 2016-03-15 2022-01-20 Liv1-adc及び化学療法剤を用いた併用療法
JP2024039750A Pending JP2024075639A (ja) 2016-03-15 2024-03-14 Liv1-adc及び化学療法剤を用いた併用療法

Country Status (14)

Country Link
US (2) US11325980B2 (enExample)
EP (1) EP3429626A4 (enExample)
JP (3) JP2019508433A (enExample)
KR (3) KR20230169462A (enExample)
CN (1) CN108697801A (enExample)
AU (2) AU2017235545A1 (enExample)
BR (1) BR112018068129A2 (enExample)
CA (1) CA3016485A1 (enExample)
EA (1) EA201891968A1 (enExample)
IL (1) IL261505A (enExample)
MA (1) MA45324A (enExample)
MX (2) MX2018010847A (enExample)
SG (2) SG11201807526SA (enExample)
WO (1) WO2017161007A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3156420T (pt) 2010-12-06 2019-05-27 Seattle Genetics Inc Anticorpos humanizados a liv-1 e seu uso para tratar o cancro
CA3084495A1 (en) * 2017-12-01 2019-06-06 Seattle Genetics, Inc. Humanized anti-liv1 antibodies for the treatment of breast cancer
EA202191257A1 (ru) 2018-11-07 2021-12-06 Криспр Терапьютикс Аг Противораковая терапия на основе иммуноцитов, связывающих liv1
MX2022006891A (es) * 2019-12-09 2022-09-09 Seagen Inc Terapia combinada con liv1-adc y antagonista de pd-1.
TW202229346A (zh) * 2020-09-28 2022-08-01 美商西根公司 用於治療癌症之人化抗liv1抗體
JP2024510435A (ja) 2021-03-18 2024-03-07 シージェン インコーポレイテッド 生体活性化合物の内部移行複合体からの選択的薬物放出
WO2024188339A1 (zh) * 2023-03-15 2024-09-19 浙江博锐生物制药有限公司 抗liv-1抗体和抗liv-1抗体药物偶联物及其药物用途
WO2025162207A1 (zh) * 2024-01-31 2025-08-07 上海复宏汉霖生物技术股份有限公司 抗liv1抗体及使用方法
WO2026057076A1 (zh) * 2024-09-14 2026-03-19 杭州博之锐生物制药有限公司 基于抗liv-1抗体-药物偶联物的耐药癌症的治疗
WO2026057074A1 (zh) * 2024-09-14 2026-03-19 杭州博之锐生物制药有限公司 抗liv-1抗体-药物偶联物的组合疗法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880935A (en) 1986-07-11 1989-11-14 Icrf (Patents) Limited Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
IL89220A (en) 1988-02-11 1994-02-27 Bristol Myers Squibb Co Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1993003741A1 (en) 1991-08-22 1993-03-04 Becton, Dickinson & Company Methods and compositions for cancer therapy and for prognosticating responses to cancer therapy
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
CA2132500A1 (en) 1994-09-20 1996-03-21 David Lockwood Manning Methods for predicting the behaviour of breast tumours
EP0871490B1 (en) 1995-12-22 2003-03-19 Bristol-Myers Squibb Company Branched hydrazone linkers
US6130237A (en) 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
CA2269634C (en) 1996-10-31 2010-08-17 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
US6066778A (en) 1996-11-06 2000-05-23 The Regents Of The University Of Michigan Transgenic mice expressing APC resistant factor V
WO1998034118A1 (en) 1997-01-30 1998-08-06 Yale University Diagnostic methods and compositions based on the distribution of rad51
WO1999023230A1 (en) 1997-10-31 1999-05-14 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
JP2001523472A (ja) 1997-11-18 2001-11-27 アボット・ラボラトリーズ 乳房の疾患の検出に有用な試薬および方法
CA2316397A1 (en) 1997-12-24 1999-07-08 Corixa Corporation Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
WO2000008210A1 (en) 1998-08-04 2000-02-17 Diadexus Llc A novel method of diagnosing, monitoring, staging, imaging and treating breast cancer
EP1121437B1 (en) 1998-10-15 2008-02-20 Novartis Vaccines and Diagnostics, Inc. Metastatic breast and colon cancer regulated genes
AU3395900A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
US6762020B1 (en) 1999-03-15 2004-07-13 Protein Design Labs, Inc. Methods of diagnosing breast cancer
US20040141983A1 (en) 1999-03-15 2004-07-22 Protein Design Labs, Inc. Compositions against cancer antigen LIV-1 and uses thereof
IL150592A0 (en) 2000-01-25 2003-02-12 Genentech Inc Liv-1 related protein, polynucleotides encoding the same and use thereof for treatment of cancer
WO2001096372A2 (en) 2000-06-13 2001-12-20 University College Cardiff Consultants Ltd Zinc transporters proteins and their use in medicinal preparations
US6964849B2 (en) 2001-01-11 2005-11-15 Curagen Corporation Proteins and nucleic acids encoding same
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
AU2002322280A1 (en) 2001-06-21 2003-01-21 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
AU2002324451A1 (en) 2001-06-21 2003-01-08 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer
US7091186B2 (en) 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
WO2003075855A2 (en) 2002-03-08 2003-09-18 Protein Design Labs, Inc. Antibodies against cancer antigen tmeff2 and uses thereof
ES2369542T3 (es) 2002-07-31 2011-12-01 Seattle Genetics, Inc. Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa.
RS20050577A (sr) 2003-01-27 2007-09-21 Biogen Idec Ma Inc., PREPARATI I POSTUPCI ZA TRETIRANjE KANCERA KORIŠĆENjEM IGSF9 I LIV-1
WO2004067564A2 (en) 2003-01-29 2004-08-12 Protein Design Labs, Inc. Compositions against cancer antigen liv-1 and uses thereof
ES2605443T3 (es) 2003-11-06 2017-03-14 Seattle Genetics, Inc. Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
US7371381B2 (en) 2003-12-12 2008-05-13 Amgen Inc. Anti-galanin antibodies and uses thereof
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
US20060222653A1 (en) 2004-11-12 2006-10-05 Xencor, Inc. Antibodies operably linked to selected chemoattractants
WO2006124269A2 (en) 2005-05-16 2006-11-23 Amgen Fremont Inc. Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
CN101309933A (zh) * 2005-09-07 2008-11-19 米迪缪尼有限公司 毒素偶联的Eph受体抗体
KR20080080482A (ko) * 2005-09-07 2008-09-04 메디뮨 엘엘씨 독소가 컨쥬게이트된 eph 수용체 항체
KR20090010194A (ko) 2006-04-13 2009-01-29 노바티스 백신즈 앤드 다이아그노스틱스, 인크. 암의 치료, 진단 또는 검출 방법
PL2099823T5 (pl) 2006-12-01 2023-02-20 Seagen Inc. Wariant środków wiążących cel i jego zastosowania
US20090068195A1 (en) 2007-04-23 2009-03-12 Wyeth Methods and compositions for treating and monitoring treatment of il-13-associated disorders
TW200944231A (en) 2007-11-30 2009-11-01 Glaxo Group Ltd Antigen-binding constructs
WO2010003773A1 (en) 2008-06-16 2010-01-14 Siemens Medical Solutions Diagnostics Gmbh Algorithms for outcome prediction in patients with node-positive chemotherapy-treated breast cancer
WO2010045234A1 (en) 2008-10-14 2010-04-22 University Of Louisville Research Foundation, Inc. Methods of optimizing treatment of estrogen-receptor positive breast cancers
WO2010069858A1 (en) 2008-12-19 2010-06-24 F. Hoffmann-La Roche Ag Pharmaceutical composition
US8642270B2 (en) 2009-02-09 2014-02-04 Vm Institute Of Research Prognostic biomarkers to predict overall survival and metastatic disease in patients with triple negative breast cancer
US20110165566A1 (en) 2009-07-09 2011-07-07 Wittliff James L Methods of optimizing treatment of breast cancer
JP5996429B2 (ja) 2009-09-03 2016-09-21 ジェネンテック, インコーポレイテッド 関節リウマチの治療、診断及びモニターするための方法
PT3156420T (pt) 2010-12-06 2019-05-27 Seattle Genetics Inc Anticorpos humanizados a liv-1 e seu uso para tratar o cancro
WO2012125712A2 (en) 2011-03-14 2012-09-20 Respira Health, Llc Lung tumor classifier for current and former smokers
HUE044352T2 (hu) * 2011-10-14 2019-10-28 Hoffmann La Roche Pertuzumab, Trastuzumab, Docetaxel és Carboplatin korai stádiumú mellrák kezelésére
WO2013170263A2 (en) 2012-05-11 2013-11-14 Merrimack Pharmaceuticals, Inc. Dosage and administration of bispecific scfv conjugates in combination with anti-cancer therapeutics
DE202012006349U1 (de) 2012-07-03 2013-07-05 Schuster Engineering Gmbh Schiffsladeanordnung
DK2839860T3 (da) 2012-10-12 2019-06-17 Medimmune Ltd Pyrrolobenzodiazepiner og konjugater deraf
US10898555B2 (en) 2013-07-02 2021-01-26 Japanese Foundation For Cancer Research Cellular immunity inducing vaccine
US11185594B2 (en) * 2014-04-10 2021-11-30 Daiichi Sankyo Company, Limited (Anti-HER2 antibody)-drug conjugate
CA3084495A1 (en) * 2017-12-01 2019-06-06 Seattle Genetics, Inc. Humanized anti-liv1 antibodies for the treatment of breast cancer
EA202191257A1 (ru) 2018-11-07 2021-12-06 Криспр Терапьютикс Аг Противораковая терапия на основе иммуноцитов, связывающих liv1
GB201908208D0 (en) 2019-06-10 2019-07-24 Univ College Cardiff Consultants Ltd An anti-mitotic agent
MX2022006891A (es) 2019-12-09 2022-09-09 Seagen Inc Terapia combinada con liv1-adc y antagonista de pd-1.

Similar Documents

Publication Publication Date Title
Glassman et al. Mechanistic considerations for the use of monoclonal antibodies for cancer therapy
JP6177133B2 (ja) Cd38を特異的に認識する抗体とボルテゾミブを含有する抗腫瘍性の組合せ
Koga et al. Antitumor effect of antitissue factor antibody‐MMAE conjugate in human pancreatic tumor xenografts
US20230235083A1 (en) Combination therapy using a liv1-adc and a chemotherapeutic
PH12019502484A1 (en) Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof
JP2019503387A5 (enExample)
JP2018522850A5 (enExample)
JP2019516748A5 (enExample)
JP2020508317A5 (enExample)
RU2016148927A (ru) Лечение рака легкого с помощью комбинации антитела против pd-1 и другого противоракового средства
JP2016520082A5 (enExample)
JP2019517505A5 (enExample)
JP2021501776A5 (enExample)
JP2019524713A5 (enExample)
CA3150274A1 (en) Treatment of cancers with antibody drug conjugates (adc) that bind to 191p4d12 proteins
WO2011101328A3 (en) Treatment with a humanized igg class anti egfr antibody and an antibody against insulin like growth factor 1 receptor
JP2022541591A5 (enExample)
KR20210084560A (ko) Pd-1/pd-l1 신호전달 억제제에 반응하지 않는 암을 치료하기 위한 방법 및 약제
Hu et al. Review of dose justifications for antibody-drug conjugate approvals from clinical pharmacology perspective: a focus on exposure-response analyses
Pretelli et al. Antibody-drug conjugates combinations in cancer treatment
Chakraborty et al. A phase 1, open-label, dose-escalation study of the safety and efficacy of anti-CD38 antibody drug conjugate (STI-6129) in patients with relapsed or refractory multiple myeloma
Martin et al. Society of gynecologic oncology journal club: controversial conversations in gynecologic cancer–the ABCs of ADCs (antibody drug conjugates)
Richardson et al. Antibody drug conjugates in the treatment of epithelial ovarian cancer
JP2024502465A5 (enExample)
Grimsley et al. Monoclonal antibodies in cancer