AU2017235545A1 - Combination therapy using a LIV1-ADC and a chemotherapeutic - Google Patents

Combination therapy using a LIV1-ADC and a chemotherapeutic Download PDF

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Publication number
AU2017235545A1
AU2017235545A1 AU2017235545A AU2017235545A AU2017235545A1 AU 2017235545 A1 AU2017235545 A1 AU 2017235545A1 AU 2017235545 A AU2017235545 A AU 2017235545A AU 2017235545 A AU2017235545 A AU 2017235545A AU 2017235545 A1 AU2017235545 A1 AU 2017235545A1
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Australia
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ser
leu
gly
ala
glu
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Abandoned
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AU2017235545A
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English (en)
Inventor
Ana Kostic
Fu LI
Django Sussman
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Seagen Inc
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Seagen Inc
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Application filed by Seagen Inc filed Critical Seagen Inc
Publication of AU2017235545A1 publication Critical patent/AU2017235545A1/en
Assigned to SEAGEN INC. reassignment SEAGEN INC. Amend patent request/document other than specification (104) Assignors: SEATTLE GENETICS, INC.
Priority to AU2024201856A priority Critical patent/AU2024201856A1/en
Abandoned legal-status Critical Current

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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/3015—Breast
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
AU2017235545A 2016-03-15 2017-03-15 Combination therapy using a LIV1-ADC and a chemotherapeutic Abandoned AU2017235545A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024201856A AU2024201856A1 (en) 2016-03-15 2024-03-21 Combination therapy using a LIV1-ADC and a chemotherapeutic

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662308639P 2016-03-15 2016-03-15
US62/308,639 2016-03-15
US201662317792P 2016-04-04 2016-04-04
US62/317,792 2016-04-04
US201662367510P 2016-07-27 2016-07-27
US62/367,510 2016-07-27
PCT/US2017/022541 WO2017161007A1 (en) 2016-03-15 2017-03-15 Combination therapy using a liv1-adc and a chemotherapeutic

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024201856A Division AU2024201856A1 (en) 2016-03-15 2024-03-21 Combination therapy using a LIV1-ADC and a chemotherapeutic

Publications (1)

Publication Number Publication Date
AU2017235545A1 true AU2017235545A1 (en) 2018-10-25

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017235545A Abandoned AU2017235545A1 (en) 2016-03-15 2017-03-15 Combination therapy using a LIV1-ADC and a chemotherapeutic
AU2024201856A Abandoned AU2024201856A1 (en) 2016-03-15 2024-03-21 Combination therapy using a LIV1-ADC and a chemotherapeutic

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2024201856A Abandoned AU2024201856A1 (en) 2016-03-15 2024-03-21 Combination therapy using a LIV1-ADC and a chemotherapeutic

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Country Link
US (2) US11325980B2 (enExample)
EP (1) EP3429626A4 (enExample)
JP (3) JP2019508433A (enExample)
KR (3) KR20230169462A (enExample)
CN (1) CN108697801A (enExample)
AU (2) AU2017235545A1 (enExample)
BR (1) BR112018068129A2 (enExample)
CA (1) CA3016485A1 (enExample)
EA (1) EA201891968A1 (enExample)
IL (1) IL261505A (enExample)
MA (1) MA45324A (enExample)
MX (2) MX2018010847A (enExample)
SG (2) SG11201807526SA (enExample)
WO (1) WO2017161007A1 (enExample)

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CA3084495A1 (en) * 2017-12-01 2019-06-06 Seattle Genetics, Inc. Humanized anti-liv1 antibodies for the treatment of breast cancer
EA202191257A1 (ru) 2018-11-07 2021-12-06 Криспр Терапьютикс Аг Противораковая терапия на основе иммуноцитов, связывающих liv1
MX2022006891A (es) * 2019-12-09 2022-09-09 Seagen Inc Terapia combinada con liv1-adc y antagonista de pd-1.
TW202229346A (zh) * 2020-09-28 2022-08-01 美商西根公司 用於治療癌症之人化抗ｌｉｖ１抗體
JP2024510435A (ja) 2021-03-18 2024-03-07 シージェン インコーポレイテッド 生体活性化合物の内部移行複合体からの選択的薬物放出
WO2024188339A1 (zh) * 2023-03-15 2024-09-19 浙江博锐生物制药有限公司 抗liv-1抗体和抗liv-1抗体药物偶联物及其药物用途
WO2025162207A1 (zh) * 2024-01-31 2025-08-07 上海复宏汉霖生物技术股份有限公司 抗liv1抗体及使用方法
WO2026057076A1 (zh) * 2024-09-14 2026-03-19 杭州博之锐生物制药有限公司 基于抗liv-1抗体-药物偶联物的耐药癌症的治疗
WO2026057074A1 (zh) * 2024-09-14 2026-03-19 杭州博之锐生物制药有限公司 抗liv-1抗体-药物偶联物的组合疗法

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