CA2989586A1 - Pd-l1 antagonist combination treatments - Google Patents
Pd-l1 antagonist combination treatments Download PDFInfo
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- CA2989586A1 CA2989586A1 CA2989586A CA2989586A CA2989586A1 CA 2989586 A1 CA2989586 A1 CA 2989586A1 CA 2989586 A CA2989586 A CA 2989586A CA 2989586 A CA2989586 A CA 2989586A CA 2989586 A1 CA2989586 A1 CA 2989586A1
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| SMT202000561T1 (it) | 2011-11-28 | 2021-01-05 | Merck Patent Gmbh | Anticorpi anti-pd-l1 e usi relativi |
| KR101503341B1 (ko) | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| CN112263677A (zh) | 2015-02-26 | 2021-01-26 | 默克专利股份公司 | 用于治疗癌症的pd-1/pd-l1抑制剂 |
| SG11201707383PA (en) | 2015-03-13 | 2017-10-30 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| MX390878B (es) | 2015-06-16 | 2025-03-21 | Merck Patent Gmbh | Usos medicos de antagonista de ligando 1 de muerte programada (pd-l1). |
| RU2711380C2 (ru) | 2015-07-16 | 2020-01-16 | Байоксэл Терапьютикс, Инк. | Новый подход к лечению рака с применением иммуномодуляции |
| CN108367072B (zh) | 2015-12-07 | 2022-12-27 | 默克专利股份有限公司 | 含抗-pd-l1抗体avelumab的水性药物制剂 |
| KR20180103150A (ko) * | 2016-01-25 | 2018-09-18 | 화이자 인코포레이티드 | 암을 치료하기 위한 ox40 작용제 및 4-1bb 작용제 단클론 항체의 조합 |
| EP3464356A1 (en) * | 2016-05-26 | 2019-04-10 | Merck Patent GmbH | Pd-1 / pd-l1 inhibitors for cancer treatment |
| BR112019006504A2 (pt) | 2016-10-06 | 2019-06-25 | Pfizer Inc. | regime de dosagem de avelumabe para o tratamento de câncer |
| EP4032911A1 (en) | 2017-01-06 | 2022-07-27 | Eutilex Co., Ltd. | Anti-human 4-1bb antibodies and use thereof |
| JP7256127B2 (ja) | 2017-03-01 | 2023-04-11 | ジェネンテック， インコーポレイテッド | がんのための診断及び治療方法 |
| EP3372615A1 (en) | 2017-03-06 | 2018-09-12 | Merck Patent GmbH | Composition comprising avelumab |
| WO2018162446A1 (en) | 2017-03-06 | 2018-09-13 | Merck Patent Gmbh | Aqueous anti-pd-l1 antibody formulation |
| EP3600410A1 (en) | 2017-03-30 | 2020-02-05 | Merck Patent GmbH | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
| JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| JP7474193B2 (ja) * | 2017-06-25 | 2024-04-24 | システィミューン， インク． | 多重特異性抗体とその作製及び使用方法 |
| TW201922793A (zh) * | 2017-11-16 | 2019-06-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｐｄ－１抗體和ｖｅｇｆｒ抑制劑聯合治療小細胞肺癌的用途 |
| EA202091751A1 (ru) * | 2018-01-22 | 2020-11-06 | Бристол-Маерс Сквибб Компани | Композиции и способы лечения рака |
| CA3090620A1 (en) * | 2018-03-06 | 2019-09-12 | Institut Curie | Inhibitor of setdb1 histone methyltransferase for use in cancer combination therapy |
| CA3095076A1 (en) * | 2018-03-29 | 2019-10-03 | Adagene Inc. | Anti-pd-l1 antibodies and use thereof |
| MY202157A (en) * | 2018-04-09 | 2024-04-09 | Oricell Therapeutics Co Ltd | Anti-pd-l1 antibody and use thereof |
| MY204232A (en) | 2018-05-10 | 2024-08-16 | Regeneron Pharma | High concentration vegf receptor fusion protein containing formulations |
| US20210147549A1 (en) * | 2018-07-11 | 2021-05-20 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc-ANTIGEN BINDING DOMAIN CONSTRUCTS TARGETED TO PD-L1 |
| WO2020081767A1 (en) | 2018-10-18 | 2020-04-23 | Genentech, Inc. | Diagnostic and therapeutic methods for sarcomatoid kidney cancer |
| JP2022509448A (ja) * | 2018-10-31 | 2022-01-20 | ジェネンテック， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１シグナル伝達阻害剤に不応答性のがんの処置方法および医薬 |
| WO2020123477A1 (en) * | 2018-12-10 | 2020-06-18 | Bioxcel Therapeutics, Inc. | Combination therapies for treating disease using an innate immunity modifier and an ox40 agonist |
| CN113164599B (zh) * | 2018-12-24 | 2023-08-01 | 正大天晴药业集团股份有限公司 | 抗pd-l1单克隆抗体治疗癌症的用途 |
| WO2020151759A1 (zh) | 2019-01-25 | 2020-07-30 | 正大天晴药业集团股份有限公司 | 治疗肿瘤的联用药物组合物 |
| EP3955925A4 (en) * | 2019-04-18 | 2023-03-22 | QLSF Biotherapeutics Inc. | HUMANIZED ANTI-PD-L1 ANTIBODIES |
| CN113905761A (zh) * | 2019-06-10 | 2022-01-07 | 正大天晴药业集团南京顺欣制药有限公司 | 治疗驱动基因阳性肺癌的联用药物组合物 |
| CN110746493A (zh) * | 2019-09-06 | 2020-02-04 | 中国药科大学 | 一种pd-l1拮抗剂多肽及其应用 |
| CN110760517B (zh) * | 2019-10-09 | 2022-04-29 | 天津大学 | 拮抗pd-1骆驼抗体类似物ap基因及蛋白和应用 |
| IL296687A (en) | 2020-03-25 | 2022-11-01 | Ocular Therapeutix Inc | Ocular implant containing a tyrosine kinase inhibitor |
| EP4144371A4 (en) * | 2020-04-30 | 2024-05-22 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | COMBINATION MEDICINAL PRODUCTS FOR THE TREATMENT OF KIDNEY CANCER |
| WO2022068894A1 (zh) * | 2020-09-30 | 2022-04-07 | 上海齐鲁制药研究中心有限公司 | 同时靶向pd-l1和vegf的双功能分子及其医药用途 |
| WO2022111618A1 (zh) * | 2020-11-26 | 2022-06-02 | 正大天晴药业集团股份有限公司 | 用于治疗肺癌的抗PD-L1抗体和c-Met激酶抑制剂的联用药物组合物 |
| EP4583930A1 (en) | 2023-04-11 | 2025-07-16 | Ocular Therapeutix, Inc. | Ocular implant comprising axitinib polymorph iv |
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| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| WO1991010741A1 (en) | 1990-01-12 | 1991-07-25 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| JPH07263576A (ja) | 1994-03-25 | 1995-10-13 | Hitachi Ltd | 半導体集積回路装置およびその製造方法 |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| DE69637481T2 (de) | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE69738539T2 (de) | 1996-12-03 | 2009-03-26 | Amgen Fremont Inc. | Vollkommen humane Antikörper die EGFR binden |
| CA2312208C (en) | 1997-12-05 | 2011-01-25 | The Scripps Research Institute | Humanization of murine antibody |
| TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| US7141581B2 (en) | 1999-07-02 | 2006-11-28 | Agouron Pharmaceuticals, Inc. | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use |
| WO2002086083A2 (en) | 2001-04-20 | 2002-10-31 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
| WO2004004771A1 (ja) | 2002-07-03 | 2004-01-15 | Ono Pharmaceutical Co., Ltd. | 免疫賦活組成物 |
| MXPA05006828A (es) | 2002-12-23 | 2005-09-08 | Wyeth Corp | Anticuerpos contra pd-1, y sus usos. |
| EP2270051B1 (en) | 2003-01-23 | 2019-05-15 | Ono Pharmaceutical Co., Ltd. | Antibody specific for human PD-1 and CD3 |
| CN1832743A (zh) * | 2003-04-03 | 2006-09-13 | 美国辉瑞有限公司 | 包含ag013736的剂型 |
| EP1613320A1 (en) | 2003-04-03 | 2006-01-11 | Pfizer Inc. | Dosage forms comprising ag013736 |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| SI1704166T1 (sl) | 2004-01-07 | 2015-06-30 | Novartis Vaccines And Diagnostics, Inc. | M-scf specifiäśno monoklonsko protitelo in uporabe le-tega |
| RU2007116150A (ru) | 2004-11-02 | 2008-11-10 | Пфайзер Инк. (US) | Полиморфные формы 6-[2-(метилкарбамоил)фенилсульфанил]-3-е-[2-[пиридин-2-ил)этенил]индазола |
| WO2006048745A1 (en) | 2004-11-02 | 2006-05-11 | Pfizer Inc. | Methods for preparing indazole compounds |
| CN101094836A (zh) | 2004-11-02 | 2007-12-26 | 辉瑞大药厂 | 制备吲唑化合物的方法 |
| BRPI0518203A2 (pt) | 2004-11-02 | 2009-03-10 | Pfizer | mÉtodos para preparaÇço de compostos indazol |
| CN101052633A (zh) | 2004-11-02 | 2007-10-10 | 辉瑞大药厂 | 制备吲唑化合物的方法 |
| JP4361545B2 (ja) | 2005-05-09 | 2009-11-11 | 小野薬品工業株式会社 | ＰｒｏｇｒａｍｍｅｄＤｅａｔｈ１（ＰＤ−１）に対するヒトモノクローナル抗体および抗ＰＤ−１抗体単独または他の免疫療法と併用した癌治療方法 |
| US20080274192A1 (en) | 2005-05-19 | 2008-11-06 | Pfizer Inc. | Pharmaceutical Compositions Comprising an Amorphous Form of a Vegf-R-Inhibitor |
| HRP20151102T1 (xx) | 2005-07-01 | 2015-11-20 | E. R. Squibb & Sons, L.L.C. | Humana monoklonska antitijela za ligand programirane smrti 1 (pd-l1) |
| US20100055111A1 (en) | 2007-02-14 | 2010-03-04 | Med. College Of Georgia Research Institute, Inc. | Indoleamine 2,3-dioxygenase, pd-1/pd-l pathways, and ctla4 pathways in the activation of regulatory t cells |
| EP3252047B1 (en) | 2007-04-05 | 2022-05-11 | Pfizer Products Inc. | Crystalline forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole suitable for the treatment of abnormal cell growth in mammals |
| NZ582150A (en) | 2007-06-18 | 2012-08-31 | Msd Oss Bv | Antibodies to human programmed death receptor pd-1 |
| PT2851374T (pt) | 2007-12-14 | 2017-06-20 | Pfizer | Moléculas de ligação ao recetor humano ox40 |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| JP2012510429A (ja) | 2008-08-25 | 2012-05-10 | アンプリミューン、インコーポレーテッド | Ｐｄ−１アンタゴニストおよびその使用方法 |
| AU2009296392B2 (en) | 2008-09-26 | 2016-06-02 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| KR20250091300A (ko) | 2008-12-09 | 2025-06-20 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ | Ｐｄ−１抗体およびｐｄ−ｌ１抗体ならびにその使用 |
| JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害 |
| DK2504364T3 (da) | 2009-11-24 | 2017-11-06 | Medimmune Ltd | Målrettede bindemidler mod b7-h1 |
| CA2791930A1 (en) | 2010-03-11 | 2011-09-15 | Kerry Louise Tyson | Pd-1 antibody |
| WO2012012518A2 (en) * | 2010-07-20 | 2012-01-26 | University Of Miami | Inhibition of nonsense mediated decay pathways |
| DK2612151T3 (en) | 2010-08-31 | 2017-10-02 | Genentech Inc | BIOMARKETS AND METHODS OF TREATMENT |
| CN105481983B (zh) | 2010-09-09 | 2021-09-03 | 辉瑞公司 | 4-1bb结合分子 |
| EP3536708A1 (en) * | 2011-04-19 | 2019-09-11 | Pfizer Inc | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| AR087405A1 (es) | 2011-08-01 | 2014-03-19 | Genentech Inc | Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek |
| JP6038920B2 (ja) | 2011-08-23 | 2016-12-07 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 抗ｏｘ４０抗体およびそれを使用する方法 |
| WO2013046133A1 (en) | 2011-09-30 | 2013-04-04 | Pfizer Inc. | Pharmaceutical compositions of n-methyl-2-[3-((e)-2-pyridin-2-yl-vinyl)-1h-indazol-6-ylsulfanyl]-benzamide |
| KR20140088556A (ko) | 2011-11-11 | 2014-07-10 | 화이자 인코포레이티드 | 만성 골수성 백혈병을 치료하기 위한 n-메틸-2-[3-((e)-2-피리딘-2-일-비닐)-1h-인다졸-6-일설파닐]-벤즈아미드 |
| SMT202000561T1 (it) * | 2011-11-28 | 2021-01-05 | Merck Patent Gmbh | Anticorpi anti-pd-l1 e usi relativi |
| CA2863818A1 (en) | 2012-02-06 | 2013-08-15 | Brendan CURTI | Cancer treatment and monitoring methods using ox40 agonists |
| KR102125658B1 (ko) | 2012-05-04 | 2020-06-22 | 화이자 인코포레이티드 | 전립선 관련된 항원 및 백신 기재 면역치료 요법 |
| SG10201700698WA (en) | 2012-05-15 | 2017-02-27 | Bristol Myers Squibb Co | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| RU2689760C2 (ru) | 2012-05-31 | 2019-05-30 | Дженентек, Инк. | Способы лечения рака с применением антагонистов аксиального связывания pd-1 и vegf антагонистов |
| US9682143B2 (en) | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| KR102389677B1 (ko) | 2013-03-15 | 2022-04-21 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| CN105073128A (zh) | 2013-04-03 | 2015-11-18 | Ibc药品公司 | 用于诱导对疾病的免疫应答的组合疗法 |
| JP2016516092A (ja) | 2013-04-12 | 2016-06-02 | モルフォシス・アー・ゲー | Ｍ−ｃｓｆを標的とする抗体 |
| DE102013008118A1 (de) | 2013-05-11 | 2014-11-13 | Merck Patent Gmbh | Arylchinazoline |
| EP3035964B1 (en) * | 2013-08-20 | 2020-09-23 | Merck Sharp & Dohme Corp. | Treating cancer with a combination of a pd-1 antagonist and dinaciclib |
| IL313188B1 (en) | 2013-09-11 | 2025-08-01 | Medimmune Ltd | Anti-B7-H1 antibodies for tumor treatment |
| AR097584A1 (es) * | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| CA2926856A1 (en) | 2013-10-25 | 2015-04-30 | Dana-Farber Cancer Institute, Inc. | Anti-pd-l1 monoclonal antibodies and fragments thereof |
| ES2991853T3 (es) | 2013-11-05 | 2024-12-05 | Cognate Bioservices Inc | Combinaciones de inhibidores del punto de control y terapéuticos para tratar el cáncer |
| US9457019B2 (en) | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| CA2929715A1 (en) | 2013-11-07 | 2015-05-14 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie2 kinase useful in the treatment of cancer |
| US20160303231A1 (en) | 2013-12-11 | 2016-10-20 | Robert Iannone | Treating cancer with a combination of a pd-1 antagonist and a vegfr inhibitor |
| US20150190506A1 (en) | 2013-12-17 | 2015-07-09 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| EP3647324A1 (en) | 2013-12-17 | 2020-05-06 | F. Hoffmann-La Roche AG | Methods of treating cancers using pd-1 axis binding antagonists and taxanes |
| EP3083690A1 (en) | 2013-12-17 | 2016-10-26 | F.Hoffmann-La Roche Ag | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
| US9045545B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision medicine by targeting PD-L1 variants for treatment of cancer |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| US10570202B2 (en) | 2014-02-04 | 2020-02-25 | Pfizer Inc. | Combination of a PD-1 antagonist and a VEGFR inhibitor for treating cancer |
| EP3107538B1 (en) | 2014-02-18 | 2020-05-27 | Health Research, Inc. | Combination therapy for hepatocellular carcinoma |
| KR20240144452A (ko) | 2014-03-05 | 2024-10-02 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합물을 이용한 신장암의 치료 |
| KR20170003692A (ko) | 2014-05-15 | 2017-01-09 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합물을 사용한 폐암의 치료 |
| BR112017000497B1 (pt) | 2014-07-11 | 2023-12-26 | Ventana Medical Systems, Inc | Anticorpo isolado, célula hospedeira procariótica, imunoconjugado e método de detecção da presença ou do nível de expressão de pd-l1 |
| EP3171896A4 (en) | 2014-07-23 | 2018-03-21 | Mayo Foundation for Medical Education and Research | Targeting dna-pkcs and b7-h1 to treat cancer |
| WO2016022813A1 (en) | 2014-08-07 | 2016-02-11 | Aerpio Therapeutics, Inc. | Combination of immunotherapies with activators of tie-2 |
| EP3185866A1 (en) | 2014-08-25 | 2017-07-05 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
| CN112546238A (zh) * | 2014-09-01 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| ES2771926T3 (es) | 2014-09-13 | 2020-07-07 | Novartis Ag | Terapias de combinación |
| JP2017535528A (ja) | 2014-10-03 | 2017-11-30 | ノバルティス アーゲー | 組み合わせ治療 |
| US9988452B2 (en) | 2014-10-14 | 2018-06-05 | Novartis Ag | Antibody molecules to PD-L1 and uses thereof |
| WO2016059602A2 (en) | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Methods of treating cancer and related compositions |
| PL3212670T3 (pl) | 2014-10-29 | 2021-06-14 | Five Prime Therapeutics, Inc. | Leczenie skojarzone nowotworów |
| KR20170096112A (ko) | 2014-11-17 | 2017-08-23 | 제넨테크, 인크. | Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 |
| MX2017007321A (es) | 2014-12-02 | 2017-08-25 | Celgene Corp | Terapias de combinacion. |
| GB201421647D0 (en) | 2014-12-05 | 2015-01-21 | Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie | CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
| EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
| CN112263677A (zh) | 2015-02-26 | 2021-01-26 | 默克专利股份公司 | 用于治疗癌症的pd-1/pd-l1抑制剂 |
| MX390878B (es) | 2015-06-16 | 2025-03-21 | Merck Patent Gmbh | Usos medicos de antagonista de ligando 1 de muerte programada (pd-l1). |
| CA3000386A1 (en) | 2015-09-30 | 2017-04-06 | Merck Patent Gmbh | Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| EP3464356A1 (en) | 2016-05-26 | 2019-04-10 | Merck Patent GmbH | Pd-1 / pd-l1 inhibitors for cancer treatment |
| BR112019006504A2 (pt) | 2016-10-06 | 2019-06-25 | Pfizer Inc. | regime de dosagem de avelumabe para o tratamento de câncer |
| EP3600410A1 (en) | 2017-03-30 | 2020-02-05 | Merck Patent GmbH | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
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| MX390878B (es) | 2025-03-21 |
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| EP3310810A1 (en) | 2018-04-25 |
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| MY193229A (en) | 2022-09-26 |
| AU2016280003A1 (en) | 2018-02-01 |
| JP6876629B2 (ja) | 2021-05-26 |
| CN107750166B (zh) | 2022-02-11 |
| TW201709933A (zh) | 2017-03-16 |
| AU2016280003B2 (en) | 2021-09-16 |
| RU2018101314A (ru) | 2019-07-16 |
| NZ737018A (en) | 2021-11-26 |
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| PH12017501857A1 (en) | 2018-02-26 |
| UA126892C2 (uk) | 2023-02-22 |
| RU2766890C2 (ru) | 2022-03-16 |
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