JP2018522071A5 - - Google Patents
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- JP2018522071A5 JP2018522071A5 JP2018525514A JP2018525514A JP2018522071A5 JP 2018522071 A5 JP2018522071 A5 JP 2018522071A5 JP 2018525514 A JP2018525514 A JP 2018525514A JP 2018525514 A JP2018525514 A JP 2018525514A JP 2018522071 A5 JP2018522071 A5 JP 2018522071A5
- Authority
- JP
- Japan
- Prior art keywords
- skin
- composition
- serum
- stem cells
- exosomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199696P | 2015-07-31 | 2015-07-31 | |
| US62/199,696 | 2015-07-31 | ||
| PCT/US2016/044458 WO2017023690A1 (en) | 2015-07-31 | 2016-07-28 | Exosome compositions and methods for preparation and use thereof for regulating and conditioning skin and hair |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522071A JP2018522071A (ja) | 2018-08-09 |
| JP2018522071A5 true JP2018522071A5 (enExample) | 2018-09-20 |
| JP6980955B2 JP6980955B2 (ja) | 2021-12-15 |
Family
ID=57943605
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525514A Active JP6980955B2 (ja) | 2015-07-31 | 2016-07-28 | エキソソーム組成物ならびに調製方法ならびに皮膚および毛髪の調節および調整のためのその使用 |
| JP2018525513A Active JP6719559B2 (ja) | 2015-07-31 | 2016-07-28 | 軟組織修復のための、エキソソーム組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525513A Active JP6719559B2 (ja) | 2015-07-31 | 2016-07-28 | 軟組織修復のための、エキソソーム組成物およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20180147420A1 (enExample) |
| EP (2) | EP3328397B1 (enExample) |
| JP (2) | JP6980955B2 (enExample) |
| CA (2) | CA2993224A1 (enExample) |
| ES (1) | ES2952050T3 (enExample) |
| HR (1) | HRP20230865T1 (enExample) |
| HU (1) | HUE063486T2 (enExample) |
| PL (1) | PL3328397T3 (enExample) |
| RS (1) | RS64469B1 (enExample) |
| SM (1) | SMT202300249T1 (enExample) |
| WO (2) | WO2017023689A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11596656B2 (en) * | 2016-08-23 | 2023-03-07 | Albert Einstein College Of Medicine | Stem cell-produced microvesicles for treating tendon pathologies |
| CN107006452A (zh) * | 2017-04-20 | 2017-08-04 | 深圳市赛欧细胞生物科技有限公司 | 一种人脐带间充质干细胞源外泌体冻干保存方法及其应用 |
| CN107080753A (zh) * | 2017-04-20 | 2017-08-22 | 深圳市赛欧细胞生物科技有限公司 | 一种人脐带间充质干细胞源外泌体的美容制剂 |
| CN107245472B (zh) * | 2017-06-08 | 2021-08-06 | 北京智能宝生物科技有限公司 | 一种人间充质干细胞外泌体冻干粉的制备方法、使用方法 |
| WO2019004738A2 (ko) * | 2017-06-30 | 2019-01-03 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| WO2019004757A2 (ko) * | 2017-06-30 | 2019-01-03 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 가려움증 억제 또는 개선 용도 |
| KR20190003316A (ko) | 2017-06-30 | 2019-01-09 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| US11590175B2 (en) * | 2017-08-23 | 2023-02-28 | Merakris Therapeutics Llc | Compositions containing amniotic components and methods for preparation and use thereof |
| US12281330B2 (en) | 2017-09-11 | 2025-04-22 | SymbioCellTech | Adaptation of hollow-fiber-based cell culture technology for the manufacturing of (1) neo-islets, employed for the treatment of type 1 and type 2 diabetes mellitus, and (2) the generation of exosomes from various cell types, used in the treatment of different organ injuries and diseases |
| US11766402B2 (en) | 2017-11-16 | 2023-09-26 | Board Of Regents, The University Of Texas System | Methods for production of MSC-derived exosomes |
| WO2019103381A1 (ko) * | 2017-11-24 | 2019-05-31 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| KR20190060646A (ko) * | 2017-11-24 | 2019-06-03 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| KR102039302B1 (ko) * | 2017-11-24 | 2019-10-31 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| WO2019118817A1 (en) | 2017-12-14 | 2019-06-20 | Mayo Foundation For Medical Education And Research | Purified exosome products, method of making, and methods of using |
| WO2019139762A1 (en) * | 2018-01-09 | 2019-07-18 | Zen-Bio, Inc. | Exosome compositions and use thereof for joint disorders and diseases |
| AU2019242912B2 (en) | 2018-03-28 | 2025-07-17 | Board Of Regents, The University Of Texas System | Identification of epigenetic alterations in DNA isolated from exosomes |
| US20210244769A1 (en) * | 2018-05-04 | 2021-08-12 | Figene, Llc | Pain-reducing effects of fibroblasts and treatment of pain |
| RU2710368C2 (ru) * | 2018-05-29 | 2019-12-26 | Станислав Евгеньевич Волчков | Способ получения и концентрирования микроРНК-содержащих экзосом мультипотентных мезенхимально-стромальных клеток для применения в косметических и лекарственных средствах для стимуляции регенеративных процессов и замедления процессов старения |
| EP3801028A4 (en) | 2018-05-30 | 2022-04-13 | Direct Biologics LLC | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use |
| WO2019231133A1 (ko) * | 2018-05-31 | 2019-12-05 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| KR102649069B1 (ko) * | 2018-05-31 | 2024-03-19 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 안면 홍조 개선용 조성물 |
| CN108715834B (zh) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | 一种富含cd41+、cd81+微囊的血小板裂解液制备方法 |
| KR102176845B1 (ko) * | 2018-10-02 | 2020-11-10 | 주식회사 스템온 | 유도된 엑소좀을 포함하는 피부 재생 및 상처 치유용 조성물 |
| CA3286605A1 (en) | 2018-11-04 | 2025-11-29 | Fibrobiologics, Inc. | Treatment of cachexia using fibroblast cells and products thereof |
| EP3920946A4 (en) | 2019-02-07 | 2022-11-09 | Direct Biologics LLC | METHOD FOR TREATING OSTEOARTHRITIS USING A COMBINATION OF EXOSOMES OF MESENCHYMATE STEM CELLS, SYNOVIAL MESENCHYMATE STEM CELLS AND SCAFFOLDS |
| WO2020176801A1 (en) | 2019-02-28 | 2020-09-03 | Fagg William Samuel Iv | Amniotic fluid-derived extracellular vesicles and uses thereof for wound healing |
| WO2020180311A1 (en) * | 2019-03-06 | 2020-09-10 | Zen-Bio, Inc. | Plant-based exosome compositions and use thereof for rejuvenating skin |
| AU2020264444A1 (en) * | 2019-04-29 | 2021-11-18 | Direct Biologics Llc | Method for the treatment of periodontal disease using characterized mesenchymal stem cell growth factors and exosomes |
| CA3146433A1 (en) | 2019-07-18 | 2021-01-21 | Direct Biologics Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| JP2021040551A (ja) * | 2019-09-11 | 2021-03-18 | 富士フイルム株式会社 | 培地組成物、キット、間葉系幹細胞組成物の製造方法、間葉系幹細胞組成物、間葉系幹細胞、細胞培養上清および細胞外小胞 |
| CN110559254A (zh) * | 2019-10-20 | 2019-12-13 | 张新梅 | 一种外泌体组合物、其制备方法及应用 |
| CA3160078A1 (en) * | 2019-11-04 | 2021-05-14 | Omar Mohamed Salah Eldin Ahmed ELTOOKHY | Method for coating and drying heterogenous stem cell derived extra-cellular vesicles |
| CN110721198A (zh) * | 2019-11-08 | 2020-01-24 | 赵凯 | 一种预防癫痫产生脑损伤的外泌体喷雾的制作工艺 |
| JP7741559B2 (ja) * | 2020-01-20 | 2025-09-18 | イーブイ、セル、バイオテック、(コアンチョウ)、カンパニー、リミテッド | 細胞外小胞及びその皮膚製品における使用 |
| US20230051925A1 (en) * | 2020-01-20 | 2023-02-16 | Ev Cell Biotech (Guangzhou) Co., Ltd. | Vesicle and use thereof |
| US12077780B2 (en) | 2020-02-14 | 2024-09-03 | Allergan Sales, Llc | Conditioned medium from cells cultured under hypoxic conditions and uses thereof |
| KR20230004709A (ko) | 2020-04-22 | 2023-01-06 | 다이렉트 바이오로직스 엘엘씨 | 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물 |
| US20240390551A1 (en) * | 2021-01-20 | 2024-11-28 | Research & Business Foundation Sungkyunkwan University | Filler composition for reducing skin wrinkles comprising stem cell-derived exosomes, hyaluronic acid, and bdde and method for preparing same |
| KR102368442B1 (ko) * | 2021-02-19 | 2022-02-28 | 주식회사 엑소코바이오 | 생리활성이 강화된 엑소좀의 생산방법 및 이의 응용 |
| TW202235614A (zh) * | 2021-03-11 | 2022-09-16 | 長新生醫國際股份有限公司 | 幹細胞凍乾粉之製造方法 |
| CN113041259B (zh) * | 2021-03-23 | 2023-05-12 | 哈尔滨科技实业开发有限公司 | 牙髓干细胞外泌体制剂及制备方法和应用 |
| EP4313062A4 (en) * | 2021-03-31 | 2025-03-12 | Nutraceutical Wellness, Inc. | COMPOSITIONS COMPRISING EXOSOME-LIKE NANO-VESICLES OR PLANT-DERIVED EXOSOMES AND METHODS OF USE THEREOF |
| CN113384518A (zh) * | 2021-07-27 | 2021-09-14 | 山西遗传资源细胞库有限公司 | 一种干细胞外泌体应用于面膜的方法 |
| JPWO2023079655A1 (enExample) * | 2021-11-04 | 2023-05-11 | ||
| CN113940912B (zh) * | 2021-12-09 | 2024-04-16 | 深圳市泓浩生物科技有限公司 | 抗衰老的组合物及其应用 |
| CN116099056A (zh) * | 2023-04-07 | 2023-05-12 | 云南云科特色植物提取实验室有限公司 | 一种含仿生纹理结构的人工皮肤及其制备方法 |
| CN116790482A (zh) * | 2023-06-12 | 2023-09-22 | 成都诺医德医学检验实验室有限公司 | 一种刺激皮肤类器官分泌外泌体的方法 |
| US20250041348A1 (en) * | 2023-08-03 | 2025-02-06 | Wisconsin Alumni Research Foundation | Extracellular vesicle therapy to treat orthopedic injury |
| WO2025226276A1 (en) | 2024-04-25 | 2025-10-30 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
| CN118576721A (zh) * | 2024-05-27 | 2024-09-03 | 深圳市中安康华生物科技有限公司 | 一种外泌体复合生物制剂及其制备方法与应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5348945A (en) * | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
| US5593682A (en) * | 1995-12-29 | 1997-01-14 | Eastman Chemical Company | Skin treating composition |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| JP2004331602A (ja) * | 2003-05-09 | 2004-11-25 | Arysta Lifescience Corp | 皮膚外用剤 |
| EP1514539A3 (en) * | 2003-05-14 | 2005-05-04 | Signal Investment & Management Co. | Micro-encapsulated topical analgesic for pain relief and sleeve comprising it |
| US20060143782A1 (en) * | 2004-10-07 | 2006-07-06 | Sherry Ajluni | Glove with skin lotion |
| US8022037B2 (en) * | 2007-01-08 | 2011-09-20 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
| PL2254586T3 (pl) * | 2008-02-22 | 2015-09-30 | Agency For Science Tech And Research Astarstar | Cząstki mezenchymalnych komórek macierzystych |
| JP5805195B2 (ja) * | 2010-08-23 | 2015-11-04 | カンステム バイオテック カンパニー リミテッド | Nod2アゴニストで処理した幹細胞またはその培養物を含む免疫疾患および炎症性疾患の予防および治療用の薬学的組成物 |
| EP3563858A1 (en) * | 2010-10-18 | 2019-11-06 | Agency For Science, Technology And Research | Use of exosomes to promote or enhance wound healing |
| US9119974B2 (en) * | 2011-03-04 | 2015-09-01 | Ahmed H. Al-Qahtani | Skin cream |
| US9901600B2 (en) * | 2011-03-11 | 2018-02-27 | Children's Medical Center Corporation | Methods and compositions relating to mesenchymal stem cell exosomes |
| JP3171007U (ja) * | 2011-06-28 | 2011-10-13 | ヘルスアシスト株式会社 | 腕肩美容パックシート |
| US9427450B2 (en) * | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| EP2687219A1 (en) * | 2012-07-18 | 2014-01-22 | Universität Duisburg-Essen | Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions |
| CA2906502A1 (en) * | 2013-03-13 | 2014-10-02 | University Of Miami | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
| US20160120805A1 (en) * | 2013-06-05 | 2016-05-05 | The Trustees Of Columbia University In The City Of New York | Exosomes for orofacial diagnostics and therapeutics |
| JP2015101541A (ja) * | 2013-11-21 | 2015-06-04 | ポーラ化成工業株式会社 | 皮膚関連酵素活性化剤 |
| JP6253361B2 (ja) * | 2013-11-21 | 2017-12-27 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| US9464272B2 (en) * | 2013-12-12 | 2016-10-11 | Stemnion, Inc. | Cell-derived composition |
| CN104488850B (zh) * | 2014-11-28 | 2016-11-02 | 广州赛莱拉干细胞科技股份有限公司 | 一种制备人羊膜间充质干细胞外泌体冻干粉的方法 |
-
2016
- 2016-07-28 HU HUE16833569A patent/HUE063486T2/hu unknown
- 2016-07-28 EP EP16833569.3A patent/EP3328397B1/en active Active
- 2016-07-28 WO PCT/US2016/044453 patent/WO2017023689A1/en not_active Ceased
- 2016-07-28 JP JP2018525514A patent/JP6980955B2/ja active Active
- 2016-07-28 PL PL16833569.3T patent/PL3328397T3/pl unknown
- 2016-07-28 CA CA2993224A patent/CA2993224A1/en not_active Abandoned
- 2016-07-28 ES ES16833569T patent/ES2952050T3/es active Active
- 2016-07-28 WO PCT/US2016/044458 patent/WO2017023690A1/en not_active Ceased
- 2016-07-28 HR HRP20230865TT patent/HRP20230865T1/hr unknown
- 2016-07-28 SM SM20230249T patent/SMT202300249T1/it unknown
- 2016-07-28 EP EP16833568.5A patent/EP3328403A4/en not_active Withdrawn
- 2016-07-28 RS RS20230599A patent/RS64469B1/sr unknown
- 2016-07-28 CA CA2993227A patent/CA2993227C/en active Active
- 2016-07-28 JP JP2018525513A patent/JP6719559B2/ja active Active
-
2018
- 2018-01-31 US US15/884,545 patent/US20180147420A1/en not_active Abandoned
- 2018-01-31 US US15/884,921 patent/US20180177828A1/en not_active Abandoned
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