JP2018522071A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018522071A5 JP2018522071A5 JP2018525514A JP2018525514A JP2018522071A5 JP 2018522071 A5 JP2018522071 A5 JP 2018522071A5 JP 2018525514 A JP2018525514 A JP 2018525514A JP 2018525514 A JP2018525514 A JP 2018525514A JP 2018522071 A5 JP2018522071 A5 JP 2018522071A5
- Authority
- JP
- Japan
- Prior art keywords
- skin
- composition
- serum
- stem cells
- exosomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 16
- 210000001808 exosome Anatomy 0.000 claims 7
- 239000012679 serum free medium Substances 0.000 claims 6
- 230000000699 topical effect Effects 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 5
- 230000035939 shock Effects 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- 230000003938 response to stress Effects 0.000 claims 3
- 239000008199 coating composition Substances 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 229960005150 glycerol Drugs 0.000 claims 2
- 239000003906 humectant Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 229960001295 tocopherol Drugs 0.000 claims 2
- 229930003799 tocopherol Natural products 0.000 claims 2
- 235000010384 tocopherol Nutrition 0.000 claims 2
- 239000011732 tocopherol Substances 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 241000195940 Bryophyta Species 0.000 claims 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- 208000032544 Cicatrix Diseases 0.000 claims 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims 1
- 208000035874 Excoriation Diseases 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 239000004264 Petrolatum Substances 0.000 claims 1
- 206010040844 Skin exfoliation Diseases 0.000 claims 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000035618 desquamation Effects 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 235000011929 mousse Nutrition 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- -1 one or more Substances 0.000 claims 1
- 229940101267 panthenol Drugs 0.000 claims 1
- 150000002948 pantothenic acids Chemical class 0.000 claims 1
- 235000020957 pantothenol Nutrition 0.000 claims 1
- 239000011619 pantothenol Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 229940066842 petrolatum Drugs 0.000 claims 1
- 235000019271 petrolatum Nutrition 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 230000036548 skin texture Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 claims 1
- 239000011720 vitamin B Substances 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199696P | 2015-07-31 | 2015-07-31 | |
| US62/199,696 | 2015-07-31 | ||
| PCT/US2016/044458 WO2017023690A1 (en) | 2015-07-31 | 2016-07-28 | Exosome compositions and methods for preparation and use thereof for regulating and conditioning skin and hair |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522071A JP2018522071A (ja) | 2018-08-09 |
| JP2018522071A5 true JP2018522071A5 (enExample) | 2018-09-20 |
| JP6980955B2 JP6980955B2 (ja) | 2021-12-15 |
Family
ID=57943605
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525514A Active JP6980955B2 (ja) | 2015-07-31 | 2016-07-28 | エキソソーム組成物ならびに調製方法ならびに皮膚および毛髪の調節および調整のためのその使用 |
| JP2018525513A Active JP6719559B2 (ja) | 2015-07-31 | 2016-07-28 | 軟組織修復のための、エキソソーム組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525513A Active JP6719559B2 (ja) | 2015-07-31 | 2016-07-28 | 軟組織修復のための、エキソソーム組成物およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20180147420A1 (enExample) |
| EP (2) | EP3328397B1 (enExample) |
| JP (2) | JP6980955B2 (enExample) |
| CA (2) | CA2993224A1 (enExample) |
| ES (1) | ES2952050T3 (enExample) |
| HR (1) | HRP20230865T1 (enExample) |
| HU (1) | HUE063486T2 (enExample) |
| PL (1) | PL3328397T3 (enExample) |
| RS (1) | RS64469B1 (enExample) |
| SM (1) | SMT202300249T1 (enExample) |
| WO (2) | WO2017023689A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11596656B2 (en) * | 2016-08-23 | 2023-03-07 | Albert Einstein College Of Medicine | Stem cell-produced microvesicles for treating tendon pathologies |
| CN107080753A (zh) * | 2017-04-20 | 2017-08-22 | 深圳市赛欧细胞生物科技有限公司 | 一种人脐带间充质干细胞源外泌体的美容制剂 |
| CN107006452A (zh) * | 2017-04-20 | 2017-08-04 | 深圳市赛欧细胞生物科技有限公司 | 一种人脐带间充质干细胞源外泌体冻干保存方法及其应用 |
| CN107245472B (zh) * | 2017-06-08 | 2021-08-06 | 北京智能宝生物科技有限公司 | 一种人间充质干细胞外泌体冻干粉的制备方法、使用方法 |
| WO2019004738A2 (ko) * | 2017-06-30 | 2019-01-03 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| WO2019004757A2 (ko) * | 2017-06-30 | 2019-01-03 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 가려움증 억제 또는 개선 용도 |
| KR20190003316A (ko) | 2017-06-30 | 2019-01-09 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| WO2019040790A1 (en) | 2017-08-23 | 2019-02-28 | Merakris Therapeutics, Llc | COMPOSITIONS CONTAINING AMNIOTIC COMPONENTS AND METHODS FOR THEIR PREPARATION AND USE |
| EP3681288B1 (en) * | 2017-09-11 | 2025-11-26 | Symbiocelltech, LLC | Adaptation of hollow-fiber-based cell culture technology for the manufacturing of neo-islets or exosomes from stem cells |
| CN111527199A (zh) | 2017-11-16 | 2020-08-11 | 得克萨斯大学体系董事会 | 用于制备来源于msc的外泌体的方法 |
| KR20190060646A (ko) | 2017-11-24 | 2019-06-03 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| WO2019103381A1 (ko) * | 2017-11-24 | 2019-05-31 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| KR102039302B1 (ko) * | 2017-11-24 | 2019-10-31 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| US12036325B2 (en) | 2017-12-14 | 2024-07-16 | Mayo Foundation For Medical Education And Research | Purified exosome products, method of making, and methods of using |
| WO2019139762A1 (en) * | 2018-01-09 | 2019-07-18 | Zen-Bio, Inc. | Exosome compositions and use thereof for joint disorders and diseases |
| JP7474702B2 (ja) | 2018-03-28 | 2024-04-25 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | エキソソームから単離されたｄｎａにおけるエピジェネティック変化の同定法 |
| US20210244769A1 (en) * | 2018-05-04 | 2021-08-12 | Figene, Llc | Pain-reducing effects of fibroblasts and treatment of pain |
| RU2710368C2 (ru) * | 2018-05-29 | 2019-12-26 | Станислав Евгеньевич Волчков | Способ получения и концентрирования микроРНК-содержащих экзосом мультипотентных мезенхимально-стромальных клеток для применения в косметических и лекарственных средствах для стимуляции регенеративных процессов и замедления процессов старения |
| US12453743B2 (en) | 2018-05-30 | 2025-10-28 | Direct Biologics, Llc | Mesenchymal stem cell (MSC) growth factor and extracellular vesicle preparation in frozen or powdered form and methods of use |
| KR102646145B1 (ko) * | 2018-05-31 | 2024-03-11 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| WO2019231133A1 (ko) * | 2018-05-31 | 2019-12-05 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| CN108715834B (zh) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | 一种富含cd41+、cd81+微囊的血小板裂解液制备方法 |
| KR102176845B1 (ko) * | 2018-10-02 | 2020-11-10 | 주식회사 스템온 | 유도된 엑소좀을 포함하는 피부 재생 및 상처 치유용 조성물 |
| EP3930734A4 (en) | 2019-02-28 | 2022-12-07 | Merakris Therapeutics, LLC | EXTRACELLULAR VESICLES DERIVED FROM AMBIENT WATER AND THEIR USES IN WOUND HEALING |
| WO2020180311A1 (en) * | 2019-03-06 | 2020-09-10 | Zen-Bio, Inc. | Plant-based exosome compositions and use thereof for rejuvenating skin |
| CA3138177A1 (en) * | 2019-04-29 | 2020-11-05 | Direct Biologics Llc | Method for the treatment of periodontal disease using characterized mesenchymal stem cell growth factors and exosomes |
| EP3999083A4 (en) | 2019-07-18 | 2023-07-26 | Direct Biologics LLC | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| JP2021040551A (ja) * | 2019-09-11 | 2021-03-18 | 富士フイルム株式会社 | 培地組成物、キット、間葉系幹細胞組成物の製造方法、間葉系幹細胞組成物、間葉系幹細胞、細胞培養上清および細胞外小胞 |
| CN110559254A (zh) * | 2019-10-20 | 2019-12-13 | 张新梅 | 一种外泌体组合物、其制备方法及应用 |
| CA3160078A1 (en) * | 2019-11-04 | 2021-05-14 | Omar Mohamed Salah Eldin Ahmed ELTOOKHY | Method for coating and drying heterogenous stem cell derived extra-cellular vesicles |
| CN110721198A (zh) * | 2019-11-08 | 2020-01-24 | 赵凯 | 一种预防癫痫产生脑损伤的外泌体喷雾的制作工艺 |
| WO2021147922A1 (zh) | 2020-01-20 | 2021-07-29 | 医微细胞生物技术(广州)有限公司 | 细胞外囊泡及其在皮肤产品的用途 |
| CN113134014B (zh) * | 2020-01-20 | 2023-09-26 | 医微细胞生物技术(广州)有限公司 | 囊泡在制备血友病药物中的应用 |
| US12077780B2 (en) | 2020-02-14 | 2024-09-03 | Allergan Sales, Llc | Conditioned medium from cells cultured under hypoxic conditions and uses thereof |
| US20240390551A1 (en) * | 2021-01-20 | 2024-11-28 | Research & Business Foundation Sungkyunkwan University | Filler composition for reducing skin wrinkles comprising stem cell-derived exosomes, hyaluronic acid, and bdde and method for preparing same |
| KR102368442B1 (ko) * | 2021-02-19 | 2022-02-28 | 주식회사 엑소코바이오 | 생리활성이 강화된 엑소좀의 생산방법 및 이의 응용 |
| TW202235614A (zh) * | 2021-03-11 | 2022-09-16 | 長新生醫國際股份有限公司 | 幹細胞凍乾粉之製造方法 |
| CN113041259B (zh) * | 2021-03-23 | 2023-05-12 | 哈尔滨科技实业开发有限公司 | 牙髓干细胞外泌体制剂及制备方法和应用 |
| CA3213489A1 (en) * | 2021-03-31 | 2022-10-06 | Giorgio Dell'acqua | Compositions comprising plant-derived exosome-like nanovesicles or exosomes and methods of use thereof |
| CN113384518A (zh) * | 2021-07-27 | 2021-09-14 | 山西遗传资源细胞库有限公司 | 一种干细胞外泌体应用于面膜的方法 |
| JPWO2023079655A1 (enExample) * | 2021-11-04 | 2023-05-11 | ||
| CN113940912B (zh) * | 2021-12-09 | 2024-04-16 | 深圳市泓浩生物科技有限公司 | 抗衰老的组合物及其应用 |
| CN116099056A (zh) * | 2023-04-07 | 2023-05-12 | 云南云科特色植物提取实验室有限公司 | 一种含仿生纹理结构的人工皮肤及其制备方法 |
| CN116410918B (zh) * | 2023-06-12 | 2023-08-25 | 成都诺医德医学检验实验室有限公司 | 一种皮肤类器官外泌体及其制备方法和应用 |
| WO2025030027A1 (en) * | 2023-08-03 | 2025-02-06 | Wisconsin Alumni Research Foundation | Extracellular vesicle therapy to treat orthopedic injury |
| CN118576721A (zh) * | 2024-05-27 | 2024-09-03 | 深圳市中安康华生物科技有限公司 | 一种外泌体复合生物制剂及其制备方法与应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5348945A (en) * | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
| US5593682A (en) * | 1995-12-29 | 1997-01-14 | Eastman Chemical Company | Skin treating composition |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| JP2004331602A (ja) * | 2003-05-09 | 2004-11-25 | Arysta Lifescience Corp | 皮膚外用剤 |
| EP1514539A3 (en) * | 2003-05-14 | 2005-05-04 | Signal Investment & Management Co. | Micro-encapsulated topical analgesic for pain relief and sleeve comprising it |
| US20060143782A1 (en) * | 2004-10-07 | 2006-07-06 | Sherry Ajluni | Glove with skin lotion |
| US8022037B2 (en) * | 2007-01-08 | 2011-09-20 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
| US20110003008A1 (en) * | 2008-02-22 | 2011-01-06 | Agency For Science, Technology And Research (A*Star) | Mesenchymal stem cell particles |
| CN103118691B (zh) * | 2010-08-23 | 2016-08-24 | 康干细胞生物科技有限公司 | 预防和治疗免疫病变和炎性疾病的包括用nod2激动剂处理的干细胞或其培养物的药物组合物 |
| JP5911874B2 (ja) * | 2010-10-18 | 2016-04-27 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 発毛を促進又は増強するためのエキソソームの使用 |
| US9119974B2 (en) * | 2011-03-04 | 2015-09-01 | Ahmed H. Al-Qahtani | Skin cream |
| CN109432126B (zh) * | 2011-03-11 | 2022-06-14 | 儿童医学中心公司 | 与间充质干细胞外来体相关的方法和组合物 |
| JP3171007U (ja) * | 2011-06-28 | 2011-10-13 | ヘルスアシスト株式会社 | 腕肩美容パックシート |
| US9427450B2 (en) * | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| EP2687219A1 (en) * | 2012-07-18 | 2014-01-22 | Universität Duisburg-Essen | Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions |
| CN105209881B (zh) * | 2013-03-13 | 2021-01-22 | 迈阿密大学 | 从细胞培养上清液和生物流体分离并纯化微泡的方法 |
| WO2014197747A1 (en) * | 2013-06-05 | 2014-12-11 | The Trustees Of Columbia University In The City Of New York | Exosomes for orofacial diagnostics and therapeutics |
| JP6253361B2 (ja) * | 2013-11-21 | 2017-12-27 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| JP2015101541A (ja) * | 2013-11-21 | 2015-06-04 | ポーラ化成工業株式会社 | 皮膚関連酵素活性化剤 |
| US9464272B2 (en) * | 2013-12-12 | 2016-10-11 | Stemnion, Inc. | Cell-derived composition |
| CN104488850B (zh) * | 2014-11-28 | 2016-11-02 | 广州赛莱拉干细胞科技股份有限公司 | 一种制备人羊膜间充质干细胞外泌体冻干粉的方法 |
-
2016
- 2016-07-28 SM SM20230249T patent/SMT202300249T1/it unknown
- 2016-07-28 ES ES16833569T patent/ES2952050T3/es active Active
- 2016-07-28 HU HUE16833569A patent/HUE063486T2/hu unknown
- 2016-07-28 JP JP2018525514A patent/JP6980955B2/ja active Active
- 2016-07-28 EP EP16833569.3A patent/EP3328397B1/en active Active
- 2016-07-28 WO PCT/US2016/044453 patent/WO2017023689A1/en not_active Ceased
- 2016-07-28 JP JP2018525513A patent/JP6719559B2/ja active Active
- 2016-07-28 PL PL16833569.3T patent/PL3328397T3/pl unknown
- 2016-07-28 EP EP16833568.5A patent/EP3328403A4/en not_active Withdrawn
- 2016-07-28 RS RS20230599A patent/RS64469B1/sr unknown
- 2016-07-28 CA CA2993224A patent/CA2993224A1/en not_active Abandoned
- 2016-07-28 CA CA2993227A patent/CA2993227C/en active Active
- 2016-07-28 HR HRP20230865TT patent/HRP20230865T1/hr unknown
- 2016-07-28 WO PCT/US2016/044458 patent/WO2017023690A1/en not_active Ceased
-
2018
- 2018-01-31 US US15/884,545 patent/US20180147420A1/en not_active Abandoned
- 2018-01-31 US US15/884,921 patent/US20180177828A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018522071A5 (enExample) | ||
| HRP20230865T1 (hr) | Kompozicije egzosoma i postupci za njihovu pripremu i primjenu za reguliranje i kondicioniranje kože i kose | |
| WO2012051629A3 (en) | Compositions and methods for treating keratin based fibers | |
| WO2013122861A3 (en) | Conditioning composition additive for providing immediate and long lasting benefits to keratin substrates | |
| MX2017010929A (es) | Polimeros de acido itaconico y usos de los mismos como un agente formador de pelicula en un producto cosmetico o para el cuidado personal. | |
| GB2571668A (en) | Stem cell conditioned media for clinical and cosmetic applications | |
| WO2018231988A3 (en) | COSMETIC COMPOSITIONS AND METHODS FOR USE IN SKIN REFRESH | |
| WO2020009937A8 (en) | Topical muscle relaxation compositions and methods | |
| WO2012068356A4 (en) | Compositions and methods for improving the appearance of facial pores | |
| CN103349618A (zh) | 一种平衡化妆水 | |
| CN104856901B (zh) | 一种八倍水保湿焕颜面膜及其制备方法 | |
| JP2016509040A5 (enExample) | ||
| CN103494722A (zh) | 罗氏槲果籽油桃保湿霜 | |
| CN104224664A (zh) | 一种芦荟面膜 | |
| CN104306277A (zh) | 一种黄瓜爽肤水及其制备方法 | |
| CN103405352B (zh) | 针层孔菌多糖ⅱ在制备保湿剂和保湿化妆品中的应用 | |
| ZA202201088B (en) | Personal care compositions and methods | |
| CN104306300A (zh) | 一种酸奶面膜 | |
| CN103520069B (zh) | 一种蜂胶和/或蜂蜜提取物在美甲产品中的应用 | |
| CN101972223B (zh) | 植物细胞驻颜素 | |
| CN102885709A (zh) | 祛斑去皱美容面霜及其制备方法 | |
| MX2013011995A (es) | Metodo y estuche de depilacion. | |
| PL425719A1 (pl) | Kompozycja kosmetyczna do złuszczania komórek naskórka oraz sposób jej wytwarzania | |
| SA518400776B1 (ar) | تركيبة للعناية بالبشرة وطريقتها | |
| CN107427424B (zh) | 用于增强皮肤屏障的口服施用的美容组合物 |