JP2018521667A5 - - Google Patents
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- JP2018521667A5 JP2018521667A5 JP2018504165A JP2018504165A JP2018521667A5 JP 2018521667 A5 JP2018521667 A5 JP 2018521667A5 JP 2018504165 A JP2018504165 A JP 2018504165A JP 2018504165 A JP2018504165 A JP 2018504165A JP 2018521667 A5 JP2018521667 A5 JP 2018521667A5
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 47
- 210000004027 cell Anatomy 0.000 claims description 45
- 150000007523 nucleic acids Chemical group 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 23
- 239000000427 antigen Substances 0.000 claims description 21
- 102000036639 antigens Human genes 0.000 claims description 21
- 108091007433 antigens Proteins 0.000 claims description 21
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 239000012636 effector Substances 0.000 claims description 17
- 210000004443 dendritic cell Anatomy 0.000 claims description 12
- 210000002540 macrophage Anatomy 0.000 claims description 12
- 210000001616 monocyte Anatomy 0.000 claims description 12
- 230000000139 costimulatory effect Effects 0.000 claims description 9
- 230000003834 intracellular effect Effects 0.000 claims description 9
- 230000004936 stimulating effect Effects 0.000 claims description 7
- 102000004127 Cytokines Human genes 0.000 claims description 5
- 108090000695 Cytokines Proteins 0.000 claims description 5
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 206010057249 Phagocytosis Diseases 0.000 claims description 3
- 230000030741 antigen processing and presentation Effects 0.000 claims description 3
- 230000005889 cellular cytotoxicity Effects 0.000 claims description 3
- 230000008782 phagocytosis Effects 0.000 claims description 3
- 230000028327 secretion Effects 0.000 claims description 3
- 238000004520 electroporation Methods 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 3
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 3
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 3
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000009977 dual effect Effects 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 210000001589 microsome Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021187803A JP7600081B2 (ja) | 2015-07-28 | 2021-11-18 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2023077024A JP2023090882A (ja) | 2015-07-28 | 2023-05-09 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2025067231A JP2025105634A (ja) | 2015-07-28 | 2025-04-16 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562197675P | 2015-07-28 | 2015-07-28 | |
| US62/197,675 | 2015-07-28 | ||
| PCT/US2016/044440 WO2017019848A1 (en) | 2015-07-28 | 2016-07-28 | Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021187803A Division JP7600081B2 (ja) | 2015-07-28 | 2021-11-18 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521667A JP2018521667A (ja) | 2018-08-09 |
| JP2018521667A5 true JP2018521667A5 (enExample) | 2019-09-05 |
| JP7032304B2 JP7032304B2 (ja) | 2022-03-08 |
Family
ID=57885035
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018504165A Active JP7032304B2 (ja) | 2015-07-28 | 2016-07-28 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2021187803A Active JP7600081B2 (ja) | 2015-07-28 | 2021-11-18 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2023077024A Pending JP2023090882A (ja) | 2015-07-28 | 2023-05-09 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2025067231A Pending JP2025105634A (ja) | 2015-07-28 | 2025-04-16 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021187803A Active JP7600081B2 (ja) | 2015-07-28 | 2021-11-18 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2023077024A Pending JP2023090882A (ja) | 2015-07-28 | 2023-05-09 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2025067231A Pending JP2025105634A (ja) | 2015-07-28 | 2025-04-16 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (12) | US11034749B2 (enExample) |
| EP (1) | EP3328402A4 (enExample) |
| JP (4) | JP7032304B2 (enExample) |
| KR (2) | KR20240132100A (enExample) |
| CN (2) | CN108025024B (enExample) |
| AU (2) | AU2016298229B2 (enExample) |
| BR (1) | BR112018001858B1 (enExample) |
| HK (1) | HK1256141A1 (enExample) |
| IL (4) | IL315940A (enExample) |
| MX (2) | MX393707B (enExample) |
| RU (1) | RU2766690C2 (enExample) |
| WO (1) | WO2017019848A1 (enExample) |
| ZA (1) | ZA201800611B (enExample) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
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| EP3624834A1 (en) * | 2017-05-17 | 2020-03-25 | Thunder Biotech Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
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| CN111386284B (zh) * | 2017-09-26 | 2024-08-30 | 森罗治疗公司 | 嵌合吞噬受体分子和使用方法 |
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| KR102862251B1 (ko) | 2017-12-08 | 2025-09-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 요법을 위한 표현형 마커 및 관련 방법 |
| BR112020013201A2 (pt) * | 2017-12-27 | 2020-12-01 | Takeda Pharmaceutical Company Limited | nanopartícula lipídica, medicamento, métodos para expressar um receptor, para prevenir ou tratar câncer e para produzir um medicamento, uso da nanopartícula lipídica e do imunócito ex vivo, composição, imunócito ex vivo, e, célula ex vivo |
| CN108047332B (zh) * | 2018-01-15 | 2021-08-24 | 阿思科力(苏州)生物科技有限公司 | 以cd19为靶点的特异性抗体、car-nk细胞及其制备和应用 |
| JP7570231B2 (ja) * | 2018-02-02 | 2024-10-23 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | キメラ抗原受容体を発現する改変された単球／マクロファージ／樹状細胞、ならびにタンパク質凝集物に関連する疾患および障害における使用 |
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| WO2022203226A1 (ko) * | 2021-03-22 | 2022-09-29 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
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| KR20220132401A (ko) | 2021-03-23 | 2022-09-30 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
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