JP2018521667A5 - - Google Patents
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- JP2018521667A5 JP2018521667A5 JP2018504165A JP2018504165A JP2018521667A5 JP 2018521667 A5 JP2018521667 A5 JP 2018521667A5 JP 2018504165 A JP2018504165 A JP 2018504165A JP 2018504165 A JP2018504165 A JP 2018504165A JP 2018521667 A5 JP2018521667 A5 JP 2018521667A5
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 47
- 210000004027 cell Anatomy 0.000 claims description 45
- 150000007523 nucleic acids Chemical group 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 23
- 239000000427 antigen Substances 0.000 claims description 21
- 102000036639 antigens Human genes 0.000 claims description 21
- 108091007433 antigens Proteins 0.000 claims description 21
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 239000012636 effector Substances 0.000 claims description 17
- 210000004443 dendritic cell Anatomy 0.000 claims description 12
- 210000002540 macrophage Anatomy 0.000 claims description 12
- 210000001616 monocyte Anatomy 0.000 claims description 12
- 230000000139 costimulatory effect Effects 0.000 claims description 9
- 230000003834 intracellular effect Effects 0.000 claims description 9
- 230000004936 stimulating effect Effects 0.000 claims description 7
- 102000004127 Cytokines Human genes 0.000 claims description 5
- 108090000695 Cytokines Proteins 0.000 claims description 5
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 206010057249 Phagocytosis Diseases 0.000 claims description 3
- 230000030741 antigen processing and presentation Effects 0.000 claims description 3
- 230000005889 cellular cytotoxicity Effects 0.000 claims description 3
- 230000008782 phagocytosis Effects 0.000 claims description 3
- 230000028327 secretion Effects 0.000 claims description 3
- 238000004520 electroporation Methods 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 3
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 3
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 3
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000009977 dual effect Effects 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 210000001589 microsome Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021187803A JP7600081B2 (ja) | 2015-07-28 | 2021-11-18 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2023077024A JP2023090882A (ja) | 2015-07-28 | 2023-05-09 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2025067231A JP2025105634A (ja) | 2015-07-28 | 2025-04-16 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562197675P | 2015-07-28 | 2015-07-28 | |
| US62/197,675 | 2015-07-28 | ||
| PCT/US2016/044440 WO2017019848A1 (en) | 2015-07-28 | 2016-07-28 | Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021187803A Division JP7600081B2 (ja) | 2015-07-28 | 2021-11-18 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521667A JP2018521667A (ja) | 2018-08-09 |
| JP2018521667A5 true JP2018521667A5 (enExample) | 2019-09-05 |
| JP7032304B2 JP7032304B2 (ja) | 2022-03-08 |
Family
ID=57885035
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018504165A Active JP7032304B2 (ja) | 2015-07-28 | 2016-07-28 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2021187803A Active JP7600081B2 (ja) | 2015-07-28 | 2021-11-18 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2023077024A Pending JP2023090882A (ja) | 2015-07-28 | 2023-05-09 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2025067231A Pending JP2025105634A (ja) | 2015-07-28 | 2025-04-16 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021187803A Active JP7600081B2 (ja) | 2015-07-28 | 2021-11-18 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2023077024A Pending JP2023090882A (ja) | 2015-07-28 | 2023-05-09 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
| JP2025067231A Pending JP2025105634A (ja) | 2015-07-28 | 2025-04-16 | キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (13) | US11034749B2 (enExample) |
| EP (1) | EP3328402A4 (enExample) |
| JP (4) | JP7032304B2 (enExample) |
| KR (2) | KR20240132100A (enExample) |
| CN (3) | CN108025024B (enExample) |
| AU (3) | AU2016298229B2 (enExample) |
| BR (1) | BR112018001858B1 (enExample) |
| HK (1) | HK1256141A1 (enExample) |
| IL (4) | IL297905A (enExample) |
| MX (2) | MX393707B (enExample) |
| RU (1) | RU2766690C2 (enExample) |
| WO (1) | WO2017019848A1 (enExample) |
| ZA (1) | ZA201800611B (enExample) |
Families Citing this family (108)
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| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| US10434153B1 (en) | 2015-05-20 | 2019-10-08 | Kim Leslie O'Neill | Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors |
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| US11352439B2 (en) * | 2015-08-13 | 2022-06-07 | Kim Leslie O'Neill | Macrophage CAR (MOTO-CAR) in immunotherapy |
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| EP3334764A2 (en) * | 2015-10-13 | 2018-06-20 | Brigham Young University | Macrophage chimeric antigen receptor (moto-car) in imunotherapy |
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| JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
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| MX2019010171A (es) | 2017-02-27 | 2019-10-15 | Juno Therapeutics Inc | Composiciones, articulos de fabricacion y metodos relacionados con la dosificacion en la terapia celular. |
| EP3624834A1 (en) * | 2017-05-17 | 2020-03-25 | Thunder Biotech Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
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| JP7357626B2 (ja) | 2017-11-01 | 2023-10-06 | ジュノー セラピューティクス インコーポレイテッド | 操作された細胞の治療用組成物を生成するためのプロセス |
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| CA3089991A1 (en) * | 2018-02-02 | 2019-08-08 | The Trustees Of The University Of Pennsylvania | Modified monocytes/macrophages/dendritic cells expressing chimeric antigen receptors and uses in diseases and disorders associated with protein aggregates |
| CN112004829A (zh) * | 2018-03-12 | 2020-11-27 | 南克维斯特公司 | Cd33car修饰的高亲和力nk细胞(t-hank)用于降低髓系衍生的抑制细胞的抑制活性(或降低对nk细胞活性的负面影响)的用途 |
| WO2019183266A1 (en) | 2018-03-21 | 2019-09-26 | ALX Oncology Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
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| WO2020047371A1 (en) * | 2018-08-31 | 2020-03-05 | The Trustees Of The University Of Pennsylvania | Activation of antigen presenting cells and methods for using the same |
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| KR20220131801A (ko) | 2021-03-22 | 2022-09-29 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
| WO2022203226A1 (ko) * | 2021-03-22 | 2022-09-29 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
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| KR20220132401A (ko) | 2021-03-23 | 2022-09-30 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
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