HK1256141A1 - 表達嵌合抗原受體的修飾單核細胞/巨噬細胞及其用途 - Google Patents
表達嵌合抗原受體的修飾單核細胞/巨噬細胞及其用途Info
- Publication number
- HK1256141A1 HK1256141A1 HK18115222.8A HK18115222A HK1256141A1 HK 1256141 A1 HK1256141 A1 HK 1256141A1 HK 18115222 A HK18115222 A HK 18115222A HK 1256141 A1 HK1256141 A1 HK 1256141A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- chimeric antigen
- antigen receptors
- expressing chimeric
- macrophage expressing
- modified monocytes
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title 1
- 210000002540 macrophage Anatomy 0.000 title 1
- 210000001616 monocyte Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
- A61K39/464468—Mesothelin [MSLN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/892—Reproductive system [uterus, ovaries, cervix, testes]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562197675P | 2015-07-28 | 2015-07-28 | |
PCT/US2016/044440 WO2017019848A1 (en) | 2015-07-28 | 2016-07-28 | Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1256141A1 true HK1256141A1 (zh) | 2019-09-13 |
Family
ID=57885035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18115222.8A HK1256141A1 (zh) | 2015-07-28 | 2018-11-28 | 表達嵌合抗原受體的修飾單核細胞/巨噬細胞及其用途 |
Country Status (14)
Country | Link |
---|---|
US (12) | US11034749B2 (zh) |
EP (1) | EP3328402A4 (zh) |
JP (3) | JP7032304B2 (zh) |
KR (2) | KR20240132100A (zh) |
CN (2) | CN108025024B (zh) |
AU (2) | AU2016298229B2 (zh) |
BR (1) | BR112018001858B1 (zh) |
CA (1) | CA2992742A1 (zh) |
HK (1) | HK1256141A1 (zh) |
IL (3) | IL297905A (zh) |
MX (2) | MX2018001182A (zh) |
RU (1) | RU2766690C2 (zh) |
WO (1) | WO2017019848A1 (zh) |
ZA (1) | ZA201800611B (zh) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
US10434153B1 (en) | 2015-05-20 | 2019-10-08 | Kim Leslie O'Neill | Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors |
CN108025024B (zh) * | 2015-07-28 | 2022-11-29 | 宾夕法尼亚大学董事会 | 表达嵌合抗原受体的修饰单核细胞/巨噬细胞及其用途 |
US11352439B2 (en) | 2015-08-13 | 2022-06-07 | Kim Leslie O'Neill | Macrophage CAR (MOTO-CAR) in immunotherapy |
CA2997912A1 (en) * | 2015-09-09 | 2017-03-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Genetic engineering of macrophages for immunotherapy |
US10875919B2 (en) * | 2016-04-26 | 2020-12-29 | Alector Llc | Chimeric receptors and methods of use thereof |
JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
JP2019536471A (ja) | 2016-09-27 | 2019-12-19 | セロ・セラピューティクス・インコーポレイテッドCERO Therapeutics, Inc. | キメラエンガルフメント受容体分子 |
CN107286246B (zh) * | 2016-12-28 | 2019-12-17 | 时力生物科技(北京)有限公司 | 治疗脑胶质瘤的嵌合抗原受体修饰的树突状细胞及其制备方法 |
US10415017B2 (en) | 2017-05-17 | 2019-09-17 | Thunder Biotech, Inc. | Transgenic macrophages, chimeric antigen receptors, and associated methods |
KR102508182B1 (ko) * | 2017-05-17 | 2023-03-09 | 썬더 바이오테크 인크. | 형질전환 대식세포, 키메라 항원 수용체, 및 관련 방법 |
AU2018341244A1 (en) | 2017-09-26 | 2020-03-05 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules and methods of use |
US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
CN118593692A (zh) | 2017-12-27 | 2024-09-06 | 武田药品工业株式会社 | 含核酸脂质纳米粒子及其用途 |
CN108047332B (zh) * | 2018-01-15 | 2021-08-24 | 阿思科力(苏州)生物科技有限公司 | 以cd19为靶点的特异性抗体、car-nk细胞及其制备和应用 |
WO2019152781A1 (en) | 2018-02-02 | 2019-08-08 | The Trustees Of The University Of Pennsylvania | Modified monocytes/macrophages/dendritic cells expressing chimeric antigen receptors and uses in diseases and disorders associated with protein aggregates |
EP3743446A1 (en) * | 2018-03-12 | 2020-12-02 | Nantkwest, Inc. | Use of cd33car modified high affinity nk cells (t-hank) to reduce myeloid-derived suppressor cells suppressor activity (or reduce negative impact on nk cell activity) |
KR20200133376A (ko) | 2018-03-21 | 2020-11-27 | 알렉소 온콜로지 인크. | 신호-조절 단백질 알파에 대한 항체 및 사용 방법 |
WO2019191332A1 (en) * | 2018-03-28 | 2019-10-03 | Cero Therapeutics, Inc. | Chimeric engulfment receptors and uses thereof for neurodegenerative diseases |
CN112218886A (zh) * | 2018-03-28 | 2021-01-12 | 森罗治疗公司 | 嵌合吞噬受体的表达载体、基因修饰的宿主细胞及其用途 |
CN112218887A (zh) * | 2018-03-28 | 2021-01-12 | 森罗治疗公司 | 细胞免疫疗法组合物及其用途 |
CN110615843B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
WO2020016897A1 (en) | 2018-07-19 | 2020-01-23 | Oncohost Ltd | Il-31 improves efficacy of macrophage-based adoptive cell therapy for cancer |
EP3844500A4 (en) * | 2018-08-27 | 2022-05-11 | NantBio, Inc. | RP182 COMPOSITIONS AND METHODS |
CN112771166A (zh) | 2018-08-31 | 2021-05-07 | 诺伊尔免疫生物科技株式会社 | 表达car的t细胞和car表达载体 |
CN109266618B (zh) * | 2018-10-18 | 2021-04-23 | 赛元生物科技(杭州)有限公司 | 能够靶向肿瘤细胞的巨噬细胞及其制备方法 |
WO2020097193A1 (en) | 2018-11-06 | 2020-05-14 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
WO2020180882A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
US12018061B2 (en) * | 2019-03-08 | 2024-06-25 | St Phi Therapeutics Co., Ltd. | Chimeric endocytic receptors and method of use thereof |
EP3962497A4 (en) * | 2019-04-30 | 2023-01-18 | Myeloid Therapeutics, Inc. | MODIFIED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF |
US11026973B2 (en) * | 2019-04-30 | 2021-06-08 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
EP3976196A4 (en) * | 2019-05-29 | 2023-06-14 | Orbis Health Solutions, LLC | RELEASE VECTORS AND PARTICLES FOR THE EXPRESSION OF CHIMERA RECEPTORS AND METHODS OF USE |
CN114302708A (zh) | 2019-06-26 | 2022-04-08 | 武田药品工业株式会社 | 转染方法 |
WO2021013764A1 (en) * | 2019-07-19 | 2021-01-28 | Institut Gustave Roussy | P21 expressing monocytes for cancer cell therapy |
CN112279923B (zh) * | 2019-07-22 | 2023-07-18 | 南京助天中科科技发展有限公司 | 一种嵌合抗原受体及其应用 |
WO2021019706A1 (ja) * | 2019-07-31 | 2021-02-04 | 国立大学法人信州大学 | Car発現免疫細胞を含む細胞集団の製造方法 |
GB2628935A (en) | 2019-09-03 | 2024-10-09 | Myeloid Therapeutics Inc | Methods and compositions for genomic integration |
EP4031696A4 (en) * | 2019-09-20 | 2023-02-22 | Navi Bio-Therapeutics, Inc. | PERSONALIZED CANCER IMMUNOTHERAPY |
KR102498546B1 (ko) * | 2019-09-27 | 2023-02-09 | 한국생명공학연구원 | 항체를 분비하는 대식세포의 제조방법 및 이를 이용한 항암치료 기술 |
GB2608279B (en) * | 2019-12-11 | 2024-08-28 | Myeloid Therapeutics Inc | Therapeutic cell compositions and methods for manufacture and uses thereof |
US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
CN110954701B (zh) * | 2019-12-18 | 2023-07-21 | 重庆医科大学 | 一种肝纤维化或肝硬化的诊断试剂盒 |
CN113106067B (zh) * | 2020-01-10 | 2024-06-21 | 南京大学 | 一种嵌合抗原受体-单核/巨噬细胞(car-m)的构建及其应用 |
IL298693A (en) | 2020-06-04 | 2023-02-01 | Carisma Therapeutics Inc | New structures for chimeric antigen receptors |
CN111840324B (zh) * | 2020-06-16 | 2023-05-12 | 上海市第一人民医院 | 应用于骨肉瘤细胞成像或治疗的Au DENPs-巨噬细胞复合物 |
CA3187138A1 (en) * | 2020-06-26 | 2021-12-30 | Carisma Therapeutics Inc. | Mrna transfection of immune cells |
CN111925448B (zh) * | 2020-08-03 | 2022-06-21 | 山东大学 | 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用 |
GB202014920D0 (en) | 2020-09-22 | 2020-11-04 | Unikum Therapeutics Aps | Methods for treating cancer and autoimmune and inflammatory diseases |
JP2023549140A (ja) * | 2020-11-04 | 2023-11-22 | マイエロイド・セラピューティクス,インコーポレーテッド | 操作されたキメラ融合タンパク質組成物およびその使用方法 |
CN112830974B (zh) * | 2021-01-08 | 2022-07-26 | 深圳市珈钰生物科技有限公司 | 一种嵌合抗原受体、载体、人树突状细胞、细胞系、实体肿瘤治疗药物及制备方法和应用 |
EP4279596A1 (en) * | 2021-01-15 | 2023-11-22 | National University Corporation Tokai National Higher Education and Research System | Chimeric target factor receptor |
WO2022186625A1 (ko) * | 2021-03-03 | 2022-09-09 | 서울대학교산학협력단 | 키메릭 항원 수용체-대식 세포의 제조 방법 및 그 세포의 용도 |
WO2022197949A2 (en) | 2021-03-17 | 2022-09-22 | Myeloid Therapeutics, Inc. | Engineered chimeric fusion protein compositions and methods of use thereof |
KR20220131801A (ko) | 2021-03-22 | 2022-09-29 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
WO2022203226A1 (ko) * | 2021-03-22 | 2022-09-29 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
KR20220132401A (ko) | 2021-03-23 | 2022-09-30 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
WO2022203227A1 (ko) * | 2021-03-23 | 2022-09-29 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
KR20220136876A (ko) | 2021-04-01 | 2022-10-11 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
WO2022211376A1 (ko) * | 2021-04-01 | 2022-10-06 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
WO2022215920A1 (ko) * | 2021-04-06 | 2022-10-13 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
CN114934071B (zh) * | 2021-04-30 | 2023-10-17 | 四川大学华西医院 | 一种表达免疫调节因子的car载体及其应用 |
CN113321743B (zh) * | 2021-07-02 | 2022-10-21 | 海南精准医疗科技有限公司 | 一种靶向赖氨酰氧化酶1的嵌合抗原受体及其用途 |
KR20230089464A (ko) | 2021-12-13 | 2023-06-20 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
KR20230089462A (ko) | 2021-12-13 | 2023-06-20 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
CN114410588B (zh) * | 2022-01-29 | 2022-11-04 | 西安电子科技大学 | 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用 |
CN114657143B (zh) * | 2022-03-11 | 2022-10-25 | 西安电子科技大学 | 一种肿瘤微环境调控型car-单核/巨噬细胞及其制备方法和应用 |
WO2023194608A1 (en) | 2022-04-07 | 2023-10-12 | Institut Curie | Myeloid cells modified by chimeric antigen receptor and uses thereof for anti-cancer therapy |
WO2023194607A1 (en) | 2022-04-07 | 2023-10-12 | Institut Curie | Myeloid cells modified by chimeric antigen receptor with cd40 and uses thereof for anti-cancer therapy |
US20240156963A1 (en) * | 2022-04-18 | 2024-05-16 | Wisconsin Alumni Research Foundation | Combinational immunotherapies using car-m, car-nk, car-eos, and car-n cells |
CN118178626A (zh) * | 2022-04-29 | 2024-06-14 | 苏州易慕峰生物科技有限公司 | 抗原递呈细胞及car-t细胞联合在抗肿瘤中的应用 |
GB202208605D0 (en) | 2022-06-13 | 2022-07-27 | Unikum Therapeutics Aps | Engineered immune cells |
WO2024034656A1 (ja) * | 2022-08-09 | 2024-02-15 | Agc株式会社 | 増殖性マクロファージ様細胞(pMAC)の製造方法 |
WO2024133517A1 (en) * | 2022-12-21 | 2024-06-27 | Universität Zürich | Methods for macrophage polarization |
CN115957335B (zh) * | 2023-01-03 | 2024-05-28 | 华中科技大学同济医学院附属协和医院 | 基于嵌合抗原受体修饰的单核细胞外囊泡类似物、制备方法及应用 |
CN116218786B (zh) * | 2023-03-09 | 2024-01-23 | 山东大学齐鲁医院 | 一种多重基因编辑的通用型巨噬细胞及在制备抗肿瘤药物中的应用 |
WO2024210160A1 (en) | 2023-04-07 | 2024-10-10 | Takeda Pharmaceutical Company Limited | Conjugation complex |
CN118059217A (zh) * | 2023-12-20 | 2024-05-24 | 西安电子科技大学 | 一种表观遗传药物联合过继单核/巨噬细胞免疫治疗在制备肿瘤疾病生物药品中的应用 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334764A (en) | 1966-10-25 | 1967-08-08 | John P Fouser | Infant nurser |
US20040053837A1 (en) | 1998-09-30 | 2004-03-18 | Ludwig Institute For Cancer Research | Composition and method for modulating vasculogenesis or angiogenesis |
AU2001297703B2 (en) * | 2000-11-07 | 2006-10-19 | City Of Hope | CD19-specific redirected immune cells |
JP2005530695A (ja) * | 2002-02-15 | 2005-10-13 | ザイコス インク. | 生理活性物質を細胞内に導入するエレクトロポレーション法 |
US7994298B2 (en) | 2004-09-24 | 2011-08-09 | Trustees Of Dartmouth College | Chimeric NK receptor and methods for treating cancer |
JP4843613B2 (ja) * | 2004-10-13 | 2011-12-21 | クルセル ホランド ベー ヴェー | 改良されたアデノウイルスベクターおよびその使用方法 |
CA2583843C (en) | 2004-10-13 | 2010-09-21 | Crucell Holland B.V. | Improved adenoviral vectors and uses thereof |
RU2433825C2 (ru) | 2004-12-06 | 2011-11-20 | Медисинова, Инк. | Способ лечения невропатической боли и связанных с ней синдромов |
JP4604892B2 (ja) | 2005-07-15 | 2011-01-05 | 船井電機株式会社 | 情報記録/再生装置 |
FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
NZ579238A (en) * | 2007-02-23 | 2012-04-27 | Baylor Res Inst | Activation of human antigen-presenting cells through clec-6 |
US8450112B2 (en) | 2008-04-09 | 2013-05-28 | Maxcyte, Inc. | Engineering and delivery of therapeutic compositions of freshly isolated cells |
AU2011220721B2 (en) * | 2010-02-25 | 2015-02-05 | Abt Holding Company | Modulation of macrophage activation |
JP5975983B2 (ja) * | 2010-04-16 | 2016-08-23 | ベリカム ファーマシューティカルズ, インコーポレイテッド | 固形腫瘍を処置するための方法 |
SG190997A1 (en) * | 2010-12-09 | 2013-07-31 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
WO2013051718A1 (ja) * | 2011-10-07 | 2013-04-11 | 国立大学法人三重大学 | キメラ抗原受容体 |
JP6021617B2 (ja) | 2012-12-05 | 2016-11-09 | カンタツ株式会社 | 撮像レンズ |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
EP2958942B1 (en) * | 2013-02-20 | 2020-06-03 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
WO2014153114A1 (en) | 2013-03-14 | 2014-09-25 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
DE102013215794A1 (de) | 2013-08-09 | 2015-02-12 | Krones Ag | Vorrichtung und Verfahren zum Ausrichten von unrunden Behältern |
GB201315036D0 (en) | 2013-08-22 | 2013-10-02 | Renishaw Plc | Apparatus and method for building objects by selective solidification of powder material |
CA2959141A1 (en) | 2014-08-28 | 2016-03-03 | Bioatla, Llc | Conditionally active chimeric antigen receptors for modified t-cells |
US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
EP3270936A4 (en) | 2015-03-17 | 2018-08-08 | Chimera Bioengineering Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
JP6985934B2 (ja) | 2015-04-29 | 2021-12-22 | フレッド ハッチンソン キャンサー リサーチ センター | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
CN104829733B (zh) * | 2015-05-25 | 2018-06-05 | 广州百暨基因科技有限公司 | 抗原结合单元稳定的嵌合抗原受体及制备方法与应用 |
GB201509413D0 (en) | 2015-06-01 | 2015-07-15 | Ucl Business Plc | Fusion protein |
US20170216354A1 (en) | 2015-06-12 | 2017-08-03 | Batu Biologics, Inc. | Clinically useful non-antigen pulsed dendritic cells |
CN108025024B (zh) * | 2015-07-28 | 2022-11-29 | 宾夕法尼亚大学董事会 | 表达嵌合抗原受体的修饰单核细胞/巨噬细胞及其用途 |
EP3334764A2 (en) | 2015-10-13 | 2018-06-20 | Brigham Young University | Macrophage chimeric antigen receptor (moto-car) in imunotherapy |
IL298693A (en) * | 2020-06-04 | 2023-02-01 | Carisma Therapeutics Inc | New structures for chimeric antigen receptors |
-
2016
- 2016-07-28 CN CN201680054514.2A patent/CN108025024B/zh active Active
- 2016-07-28 WO PCT/US2016/044440 patent/WO2017019848A1/en active Application Filing
- 2016-07-28 KR KR1020247027659A patent/KR20240132100A/ko active Application Filing
- 2016-07-28 JP JP2018504165A patent/JP7032304B2/ja active Active
- 2016-07-28 IL IL297905A patent/IL297905A/en unknown
- 2016-07-28 IL IL292507A patent/IL292507A/en unknown
- 2016-07-28 MX MX2018001182A patent/MX2018001182A/es unknown
- 2016-07-28 BR BR112018001858-9A patent/BR112018001858B1/pt active IP Right Grant
- 2016-07-28 US US15/747,555 patent/US11034749B2/en active Active
- 2016-07-28 AU AU2016298229A patent/AU2016298229B2/en active Active
- 2016-07-28 RU RU2018107047A patent/RU2766690C2/ru active
- 2016-07-28 KR KR1020187005871A patent/KR102697827B1/ko active IP Right Grant
- 2016-07-28 EP EP16831340.1A patent/EP3328402A4/en active Pending
- 2016-07-28 CN CN202211374453.1A patent/CN115747168A/zh active Pending
- 2016-07-28 CA CA2992742A patent/CA2992742A1/en active Pending
-
2018
- 2018-01-14 IL IL256892A patent/IL256892B/en unknown
- 2018-01-26 MX MX2022008288A patent/MX2022008288A/es unknown
- 2018-01-29 ZA ZA2018/00611A patent/ZA201800611B/en unknown
- 2018-11-28 HK HK18115222.8A patent/HK1256141A1/zh unknown
-
2020
- 2020-04-24 US US16/858,183 patent/US11306133B2/en active Active
-
2021
- 2021-09-16 US US17/477,206 patent/US11407805B2/en active Active
- 2021-09-16 US US17/477,057 patent/US20220033465A1/en not_active Abandoned
- 2021-09-16 US US17/477,448 patent/US11332511B2/en active Active
- 2021-09-16 US US17/477,114 patent/US11359002B2/en active Active
- 2021-09-16 US US17/477,485 patent/US11306134B2/en active Active
- 2021-09-16 US US17/477,461 patent/US20220033467A1/en not_active Abandoned
- 2021-09-16 US US17/477,436 patent/US11319358B2/en active Active
- 2021-09-16 US US17/477,475 patent/US11325963B2/en active Active
- 2021-11-18 JP JP2021187803A patent/JP2022028831A/ja active Pending
-
2022
- 2022-03-10 US US17/691,842 patent/US11498954B2/en active Active
- 2022-10-06 US US17/938,501 patent/US20230279074A1/en active Pending
- 2022-11-01 AU AU2022263479A patent/AU2022263479A1/en active Pending
-
2023
- 2023-05-09 JP JP2023077024A patent/JP2023090882A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1256141A1 (zh) | 表達嵌合抗原受體的修飾單核細胞/巨噬細胞及其用途 | |
IL275619A (en) | Amplified chimeric antigen receptors and their uses | |
HK1258274A1 (zh) | 抗體/t細胞受體嵌合構建體及其用途 | |
HK1255067A1 (zh) | 抗c10orf54抗體及其用途 | |
HK1249405A1 (zh) | 抗dll3嵌合抗原受體及其使用方法 | |
HK1245807A1 (zh) | 抗mertk的激活型抗體及其應用 | |
IL255336A0 (en) | Chimeric antigen receptors and methods of using them | |
HK1243440A1 (zh) | 抗白細胞介素-33抗體及其用途 | |
EP3259352A4 (en) | Chimeric antigen receptors and uses thereof | |
AU2015269219B2 (en) | Mesothelin-targeted chimeric antigen receptors and uses thereof | |
HK1224332A1 (zh) | 人類間皮素嵌合性抗原受體及其用途 | |
HUE045307T2 (hu) | EGFRVIII-ellenes antitestek és alkalmazásaik | |
HK1259455A1 (zh) | 抗原受體及其用途 | |
EP3347474A4 (en) | CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF | |
IL247315A0 (en) | Anti-acth antibodies and their uses | |
IL275040A (en) | T cells containing two chimeric receptors for different antigens and their use | |
SG10201913084PA (en) | Anti-il-25 antibodies and uses thereof | |
GB201810451D0 (en) | Anti-placenta-chondroitin-sulfate chimeric antigen receptor and application thereof | |
ZA201801636B (en) | Macrophage chimeric antigen receptor (moto-car) in imunotherapy | |
AU2015903719A0 (en) | Chimeric antigen receptor and uses thereof | |
AU2014902457A0 (en) | Chimeric antigen receptor and uses thereof |