BR112018001858A2 - monócitos/macrófagos modificados que expressam receptores de antígeno quimérico e usos dos mesmos - Google Patents

monócitos/macrófagos modificados que expressam receptores de antígeno quimérico e usos dos mesmos

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Publication number
BR112018001858A2
BR112018001858A2 BR112018001858A BR112018001858A BR112018001858A2 BR 112018001858 A2 BR112018001858 A2 BR 112018001858A2 BR 112018001858 A BR112018001858 A BR 112018001858A BR 112018001858 A BR112018001858 A BR 112018001858A BR 112018001858 A2 BR112018001858 A2 BR 112018001858A2
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Brazil
Prior art keywords
chimeric antigen
antigen receptors
expressing chimeric
modified
cell
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BR112018001858A
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English (en)
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BR112018001858B1 (pt
Inventor
H June Carl
Klichinsky Michael
Gill Saar
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Univ Pennsylvania
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Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of BR112018001858A2 publication Critical patent/BR112018001858A2/pt
Publication of BR112018001858B1 publication Critical patent/BR112018001858B1/pt

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4614—Monocytes; Macrophages
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Abstract

a presente invenção inclui métodos e composições para tratar câncer, seja um tumor sólido ou uma malignância hematológica. expressando-se um receptor de antígeno quimérico em um monócito, macrófago ou célula dendrítica, a célula modificada é recrutada ao microambiente tumoral onde atua como um efetor imune poderoso infiltrando-se o tumor e exterminando as células alvo. um aspecto inclui uma célula modificada e composições farmacêuticas que compreendem a célula modificada para terapia celular adotiva e tratamento de uma doença ou afecção associada à imunossupresão.
BR112018001858-9A 2015-07-28 2016-07-28 Composições compreendendo células modificadas que compreendem um receptor de antígeno quimérico (car), seus usos terapêuticos e método para modificar uma célula BR112018001858B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562197675P 2015-07-28 2015-07-28
US62/197,675 2015-07-28
PCT/US2016/044440 WO2017019848A1 (en) 2015-07-28 2016-07-28 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof

Publications (2)

Publication Number Publication Date
BR112018001858A2 true BR112018001858A2 (pt) 2018-09-18
BR112018001858B1 BR112018001858B1 (pt) 2022-02-08

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BR112018001858-9A BR112018001858B1 (pt) 2015-07-28 2016-07-28 Composições compreendendo células modificadas que compreendem um receptor de antígeno quimérico (car), seus usos terapêuticos e método para modificar uma célula

Country Status (13)

Country Link
US (12) US11034749B2 (pt)
EP (1) EP3328402A4 (pt)
JP (3) JP7032304B2 (pt)
CN (2) CN108025024B (pt)
AU (2) AU2016298229B2 (pt)
BR (1) BR112018001858B1 (pt)
CA (1) CA2992742A1 (pt)
HK (1) HK1256141A1 (pt)
IL (3) IL292507A (pt)
MX (2) MX2018001182A (pt)
RU (1) RU2766690C2 (pt)
WO (1) WO2017019848A1 (pt)
ZA (1) ZA201800611B (pt)

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