CY1121838T1 - Συνθεσεις που περιλαμβανουν νανοσωματιδια οξειδιου του αφνιου (iv) ή οξειδιου του ρηνιου (iv) σε συνδυασμο με ιονιζουσες ακτινοβολιες για αντιμετωπιση καρκινου - Google Patents

Συνθεσεις που περιλαμβανουν νανοσωματιδια οξειδιου του αφνιου (iv) ή οξειδιου του ρηνιου (iv) σε συνδυασμο με ιονιζουσες ακτινοβολιες για αντιμετωπιση καρκινου

Info

Publication number
CY1121838T1
CY1121838T1 CY20191100762T CY191100762T CY1121838T1 CY 1121838 T1 CY1121838 T1 CY 1121838T1 CY 20191100762 T CY20191100762 T CY 20191100762T CY 191100762 T CY191100762 T CY 191100762T CY 1121838 T1 CY1121838 T1 CY 1121838T1
Authority
CY
Cyprus
Prior art keywords
oxide
nanoparticles
ionizing radiation
haphium
rhenium
Prior art date
Application number
CY20191100762T
Other languages
English (en)
Inventor
Elsa BORGHI
Laurent Levy
Agnès Pottier
Original Assignee
Nanobiotix
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanobiotix filed Critical Nanobiotix
Publication of CY1121838T1 publication Critical patent/CY1121838T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1087—Ions; Protons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1089—Electrons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η παρούσα αίτηση σχετίζεται με ενεργοποιήσιμα ανόργανα νανοσωματίδια τα οποία μπορούν να χρησιμοποιηθούν στον τομέα υγείας, ιδιαίτερα στην ανθρώπινη υγεία, για να διαταράξουν, μεταβάλλουν ή καταστρέψουν τα καρκινικά κύτταρα, ιστούς ή όργανα -στόχους. Πιο συγκεκριμένα σχετίζεται με νανοσωματίδια τα οποία μπορούν να δημιουργήσουν μία εκπληκτικά αποτελεσματική θεραπευτική επίδραση, όταν συγκεντρώνονται μέσα στον όγκο και εκτίθενται σε ιονίζουσες ακτινοβολίες. Η εφεύρεση επίσης σχετίζεται με φαρμακευτικές συνθέσεις που περιλαμβάνουν έναν πληθυσμό από νανοσωματίδια όπως ορίστηκαν προηγουμένως, όπως επίσης και με τις χρήσεις τους.
CY20191100762T 2013-01-25 2019-07-17 Συνθεσεις που περιλαμβανουν νανοσωματιδια οξειδιου του αφνιου (iv) ή οξειδιου του ρηνιου (iv) σε συνδυασμο με ιονιζουσες ακτινοβολιες για αντιμετωπιση καρκινου CY1121838T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361756533P 2013-01-25 2013-01-25
EP13305087 2013-01-25
EP14701965.7A EP2948179B1 (en) 2013-01-25 2014-01-24 Compositions comprising nanoparticles of hafnium (iv) oxide or rhenium (iv) oxide in combination with ionizing radiations for treating cancer
PCT/EP2014/051367 WO2014114732A1 (en) 2013-01-25 2014-01-24 Inorganic nanoparticles compositions in combination with ionizing radiations for treating cancer

Publications (1)

Publication Number Publication Date
CY1121838T1 true CY1121838T1 (el) 2020-07-31

Family

ID=47710064

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100762T CY1121838T1 (el) 2013-01-25 2019-07-17 Συνθεσεις που περιλαμβανουν νανοσωματιδια οξειδιου του αφνιου (iv) ή οξειδιου του ρηνιου (iv) σε συνδυασμο με ιονιζουσες ακτινοβολιες για αντιμετωπιση καρκινου

Country Status (23)

Country Link
US (4) US10098952B2 (el)
EP (1) EP2948179B1 (el)
JP (2) JP6619231B2 (el)
KR (2) KR102225239B1 (el)
CN (1) CN105120897B (el)
AR (1) AR094577A1 (el)
AU (1) AU2014209899B2 (el)
BR (1) BR112015017490A2 (el)
CA (2) CA2897362C (el)
CY (1) CY1121838T1 (el)
EA (1) EA034242B1 (el)
HK (1) HK1216609A1 (el)
IL (1) IL239767B (el)
MA (1) MA38318A1 (el)
MX (1) MX369664B (el)
PL (1) PL2948179T3 (el)
RS (1) RS59042B1 (el)
SG (1) SG11201505277VA (el)
SI (1) SI2948179T1 (el)
TW (1) TW201442726A (el)
UA (1) UA116007C2 (el)
WO (1) WO2014114732A1 (el)
ZA (1) ZA201505510B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2857260C (en) 2011-12-16 2019-10-15 Nanobiotix Nanoparticles comprising metallic and hafnium oxide materials, preparation and uses thereof
KR102225239B1 (ko) 2013-01-25 2021-03-09 나노비오?笭? 암 치료용 이온화 방사선과 조합된 무기 나노입자 조성물
EP2886128A1 (en) * 2013-12-20 2015-06-24 Nanobiotix Pharmaceutical composition comprising nanoparticles, preparation and uses thereof
TW201705977A (zh) 2015-05-28 2017-02-16 奈諾生技公司 作為治療疫苗之奈米顆粒
US11278723B2 (en) * 2016-12-21 2022-03-22 Nanobiotix S.A. Nanoparticles for use for treating a neuronal disorder
JP2020504732A (ja) * 2016-12-21 2020-02-13 ナノビオティックスＮａｎｏｂｉｏｔｉｘ 脳活動の増強に使用するための、又はストレスの処置に使用するためのナノ粒子
EP3424533A1 (en) * 2017-07-05 2019-01-09 Nh Theraguix Methods for treating tumors
EP3654976A1 (en) * 2017-07-21 2020-05-27 Varian Medical Systems, Inc. Methods of use of ultra-high dose rate radiation and therapeutic agents
JP2022540652A (ja) 2019-07-12 2022-09-16 オレゴン ヘルス アンド サイエンス ユニバーシティ 分裂期キナーゼ阻害剤と免疫チェックポイント阻害剤との同時送達のための治療用構築物
US20220249389A1 (en) * 2019-07-12 2022-08-11 Oregon Health & Science University Immunotherapeutic constructs and methods of their use
WO2021011496A1 (en) * 2019-07-12 2021-01-21 Oregon Health & Science University Immunotherapeutic constructs and methods of their use
WO2021215952A1 (ru) 2020-04-24 2021-10-28 Общество С Ограниченной Ответственностью "Индженик" Способ получения частиц бактериофагов семейства levivirus

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006244A2 (en) * 1998-07-30 2000-02-10 Hainfeld James F Loading metal particles into cell membrane vesicles and metal particle use for imaging and therapy
BR0115127A (pt) * 2000-11-20 2004-02-17 Oncolytics Biotech Inc Método de fornecer um vìrus a um tumor sólido para reduzir crescimento do tumor
US6756063B2 (en) * 2001-03-29 2004-06-29 Zoltan Laboratories, Llc Methods and compositions for the treatment of human and animal cancers
FR2884149B1 (fr) * 2005-04-12 2007-06-08 Henri Mehier Tube implantable destine a l'injection notamment de fluide caloporteur dans tout ou partie d'un tissu humain ou animal
EP2130553A1 (en) * 2008-06-05 2009-12-09 Nanobiotix Inorganic nanoparticles of high density to destroy cells in-vivo
US8395131B2 (en) * 2009-06-20 2013-03-12 Xiaodong Wu Method for three dimensional (3D) lattice radiotherapy
EP2275137A1 (en) * 2009-07-10 2011-01-19 Nanobiotix Metallic nanoparticles, preparation and uses thereof
EP2555800B1 (en) 2010-04-05 2018-03-21 Nanospectra Biosciences, Inc. Enhancement of radiation therapy by targeted high-z nanoparticles
CA2857260C (en) * 2011-12-16 2019-10-15 Nanobiotix Nanoparticles comprising metallic and hafnium oxide materials, preparation and uses thereof
KR102225239B1 (ko) 2013-01-25 2021-03-09 나노비오?笭? 암 치료용 이온화 방사선과 조합된 무기 나노입자 조성물

Also Published As

Publication number Publication date
WO2014114732A1 (en) 2014-07-31
KR102225239B1 (ko) 2021-03-09
SG11201505277VA (en) 2015-08-28
RS59042B1 (sr) 2019-08-30
US20210283256A1 (en) 2021-09-16
MX2015009409A (es) 2016-03-16
AU2014209899B2 (en) 2018-05-24
CN105120897B (zh) 2017-12-05
JP2018168162A (ja) 2018-11-01
SI2948179T1 (sl) 2019-09-30
PL2948179T3 (pl) 2019-10-31
US11020480B2 (en) 2021-06-01
CN105120897A (zh) 2015-12-02
KR102385193B1 (ko) 2022-04-12
MA38318A1 (fr) 2017-02-28
KR20150108923A (ko) 2015-09-30
US11819548B2 (en) 2023-11-21
US20150374818A1 (en) 2015-12-31
EP2948179A1 (en) 2015-12-02
CA3179586A1 (en) 2014-07-31
IL239767B (en) 2018-10-31
TW201442726A (zh) 2014-11-16
US10098952B2 (en) 2018-10-16
JP2016505061A (ja) 2016-02-18
IL239767A0 (en) 2015-08-31
BR112015017490A2 (pt) 2017-07-11
ZA201505510B (en) 2016-12-21
JP6619231B2 (ja) 2019-12-11
UA116007C2 (uk) 2018-01-25
AU2014209899A1 (en) 2015-07-23
US20240100163A1 (en) 2024-03-28
EA034242B1 (ru) 2020-01-21
MX369664B (es) 2019-11-14
KR20210027536A (ko) 2021-03-10
AR094577A1 (es) 2015-08-12
EA201591378A1 (ru) 2016-04-29
US20190008962A1 (en) 2019-01-10
CA2897362A1 (en) 2014-07-31
CA2897362C (en) 2023-02-14
HK1216609A1 (zh) 2016-11-25
EP2948179B1 (en) 2019-06-19

Similar Documents

Publication Publication Date Title
CY1121838T1 (el) Συνθεσεις που περιλαμβανουν νανοσωματιδια οξειδιου του αφνιου (iv) ή οξειδιου του ρηνιου (iv) σε συνδυασμο με ιονιζουσες ακτινοβολιες για αντιμετωπιση καρκινου
CY1123258T1 (el) Μεθοδος θεραπειας για τον καρκινο
CY1118600T1 (el) Μεταλλικα νανοσωματιδια, παρασκευη και χρησεις αυτων
CY1122186T1 (el) Μεθοδοι θεραπειας καρκινου
CY1124436T1 (el) Δικυκλικες ετεροκυκλικες ενωσεις και χρησεις αυτων στη θεραπεια
CY1123983T1 (el) Ειδικα σε axl συζευγματα αντισωματος-φαρμακου για τη θεραπεια καρκινου
EA201890009A1 (ru) Ингибиторы ezh2 для лечения лимфомы
CL2018001152A1 (es) Composiciones y métodos para el tratamiento del cáncer
CY1119676T1 (el) Συνθεσεις και μεθοδοι για τη θεραπεια του καρκινου
BR112016012713A2 (pt) Método para tratamento de câncer em um paciente necessitado, e, método de selecionar um paciente para um método de tratamento
WO2016025635A3 (en) Combination therapy for treating cancer
MX2019010601A (es) Terapia de combinacion para tratar cancer.
EA201992251A1 (ru) Противораковые вакцины и способы лечения с их применением
BR112015026297A2 (pt) terapia combinada composta por um inibidor tor quinase e um composto de 5-quinazolinona substituído para o tratamento de câncer
CY1122968T1 (el) Φαρμακευτικη συνθεση η οποια περιλαμβανει μια ενωση διαμινο-ετεροκυκλικου καρβοξαμιδιου ως δραστικο συστατικο
BR112017009552A8 (pt) Métodos para alvejar o controle transcricional em regiões de super-realçador
CY1123366T1 (el) Παραγωγα 8-αμινο-2-οξο-1,3-διαζα-σπειρο-[4.5]-δeκανιου
BR112018002530A2 (pt) combinações e usos e tratamentos destas
CY1122746T1 (el) Ιατρικες αγωγες με βαση την αναμορελινη
CY1126041T1 (el) Σκευασμα φαρμακου για χρηση στον αποτελεσματικο ελεγχο οξεος ή/και χρονιου πονου
MX2018000052A (es) Composiciones y métodos para la terapia combinada con virus del dengue y celulas dendríticas.
BR112017028012A2 (pt) Terapia combinada com um conjugado anticorpo- fármaco anti-her2 e um inibidor de bcl-2
GT201400071A (es) Combinación terapéutica para el tratamiento de cáncer
BR112018000415A2 (pt) ?dispositivo de eletroestimulação?
TR201910251T4 (tr) Kanserin tedavi edilmesine yönelik iyonlaştırıcı radyasyonlar ile kombinasyon halinde hafniyum (ıv) oksidin veya renyum (ıv) oksidin nanopartiküllerini içeren bileşimler.