MX2018000052A - Composiciones y métodos para la terapia combinada con virus del dengue y celulas dendríticas. - Google Patents

Composiciones y métodos para la terapia combinada con virus del dengue y celulas dendríticas.

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Publication number
MX2018000052A
MX2018000052A MX2018000052A MX2018000052A MX2018000052A MX 2018000052 A MX2018000052 A MX 2018000052A MX 2018000052 A MX2018000052 A MX 2018000052A MX 2018000052 A MX2018000052 A MX 2018000052A MX 2018000052 A MX2018000052 A MX 2018000052A
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Mexico
Prior art keywords
compositions
methods
dendritic cells
dengue virus
cancer
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Application number
MX2018000052A
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English (en)
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W Lyday Bruce
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Primevax Immuno Oncology Inc
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Publication date
Application filed by Primevax Immuno Oncology Inc filed Critical Primevax Immuno Oncology Inc
Publication of MX2018000052A publication Critical patent/MX2018000052A/es

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    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61K39/4615Dendritic cells
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    • A61K39/4644Cancer antigens
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Abstract

En la presente invención se describen composiciones y métodos para tratar el cáncer mediante la combinación de células dendríticas pulsadas con antígeno tumoral y virus del dengue. La combinación de las dos formas de intervención terapéutica proporciona una mayor reducción de las células cancerígenas, en comparación con la aplicación de los dos métodos por separado. El cáncer objetivo de las composiciones y métodos descritos en la presente invención, puede ser un cáncer sólido o un cáncer de sangre.
MX2018000052A 2015-07-02 2016-07-01 Composiciones y métodos para la terapia combinada con virus del dengue y celulas dendríticas. MX2018000052A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562231351P 2015-07-02 2015-07-02
PCT/US2016/040787 WO2017004567A1 (en) 2015-07-02 2016-07-01 Compositions and methods for combination therapy with dengue virus and dendritic cells

Publications (1)

Publication Number Publication Date
MX2018000052A true MX2018000052A (es) 2018-05-11

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MX2018000052A MX2018000052A (es) 2015-07-02 2016-07-01 Composiciones y métodos para la terapia combinada con virus del dengue y celulas dendríticas.

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US (6) US9730989B2 (es)
EP (1) EP3316897A4 (es)
JP (2) JP2018522880A (es)
CN (1) CN107921063A (es)
CA (1) CA2991212A1 (es)
DE (1) DE202016008300U1 (es)
MX (1) MX2018000052A (es)
WO (1) WO2017004567A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3316897A4 (en) 2015-07-02 2019-03-13 Primevax Immuno-Oncology, Inc. COMPOSITIONS AND METHODS FOR COMBINATION THERAPY WITH DENGUE VIRUS AND DENDRITIC CELLS
CA2999881A1 (en) * 2015-09-26 2017-03-30 PrimeVax Immuno-Oncology, Inc. Compositions and methods for producing dendritic cells
WO2018093907A1 (en) 2016-11-16 2018-05-24 PrimeVax Immuno-Oncology, Inc. Combination immunotherapies for treatment of cancer
CA3049225A1 (en) * 2017-01-04 2018-07-12 PrimeVax Immuno-Oncology, Inc. Compositions and methods for therapy with dengue virus
EP3638304A4 (en) * 2017-06-12 2021-02-24 Washington University CICAVIRUS STRAINS FOR TREATMENT OF GLIOBLASTOMES
SG11201912163WA (en) * 2017-06-15 2020-01-30 Primevax Immuno Oncology Inc Compositions and methods for cancer therapy with dengue virus and dendritic cells

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1015972A (en) 1905-09-25 1912-01-30 Westinghouse Electric & Mfg Co Electric switch.
US1035755A (en) 1908-07-21 1912-08-13 Glenn S Smith Draftsman's apparatus.
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
EP1056834A2 (en) * 1998-02-20 2000-12-06 The Rockefeller University Apoptotic cell-mediated antigen presentation to dendritic cells
US6524587B1 (en) * 1998-05-05 2003-02-25 Bruce W. Lyday Hyperthermia and immunotherapy for leukemias lymphomas, and solid tumors
US6048686A (en) 1998-05-05 2000-04-11 Randy Kyle Brown Hyperthermia and immunotherapy for cancer
KR100721745B1 (ko) 1999-03-26 2007-05-25 왈터 리드 아미 인스티튜트 오브 리써치 다가 뎅기 바이러스 백신
AU4040200A (en) * 1999-03-26 2000-10-16 Walter Reed Army Institute Of Research Attenuated dengue-2 virus vaccine
CA2367590A1 (en) 1999-03-31 2000-10-05 University Of Pittsburgh Of The Commonwealth System Of Higher Education In vitro induction of antigen-specific t-cells using dendritic cell-tumor cell or dendritic cell-viral cell derived immunogens
EP1484064A1 (en) 2003-06-04 2004-12-08 Gesellschaft für Biotechnologische Forschung Therapeutical composition containing dentritic cells and use thereof
CN101006172B (zh) * 2004-06-24 2012-09-05 株式会社载体研究所 包含导入了rna病毒的树突状细胞的抗癌剂
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
KR20170086700A (ko) * 2005-04-08 2017-07-26 아르고스 쎄라퓨틱스 인코포레이티드 수지상 세포 조성물 및 방법
PL2589602T3 (pl) 2006-08-15 2016-11-30 Rozwinięcie komponentów szczepionki przeciwko wirusowi dengi
US8097256B2 (en) * 2006-09-28 2012-01-17 Cedars-Sinai Medical Center Cancer vaccines and vaccination methods
BR112012023285A2 (pt) 2010-03-15 2018-12-11 Univ Pennsylvania métodos para gerar células dendríticas carregadas de antígeno e para eliciar uma resposta imune em um mamífero, e, composição preservável
CA2837145A1 (en) 2011-05-26 2012-11-29 Glaxosmithkline Biologicals Sa Inactivated dengue virus vaccine
EP2543386A1 (en) * 2011-07-05 2013-01-09 Sotio a.s. Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure
WO2013154778A1 (en) 2012-04-11 2013-10-17 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
TW201402143A (zh) * 2012-06-10 2014-01-16 Inviragen Inc 抗登革熱病毒疫苗之組成物及投藥方法
CA2939093A1 (en) 2014-02-14 2015-08-20 Immune Design Corp. Immunotherapy of cancer through combination of local and systemic immune stimulation
US20180127717A1 (en) 2015-05-07 2018-05-10 Baylor College Of Medicine Dendritic cell immunotherapy
EP3316897A4 (en) 2015-07-02 2019-03-13 Primevax Immuno-Oncology, Inc. COMPOSITIONS AND METHODS FOR COMBINATION THERAPY WITH DENGUE VIRUS AND DENDRITIC CELLS
CA2999881A1 (en) 2015-09-26 2017-03-30 PrimeVax Immuno-Oncology, Inc. Compositions and methods for producing dendritic cells
WO2018093907A1 (en) 2016-11-16 2018-05-24 PrimeVax Immuno-Oncology, Inc. Combination immunotherapies for treatment of cancer
CA3049225A1 (en) 2017-01-04 2018-07-12 PrimeVax Immuno-Oncology, Inc. Compositions and methods for therapy with dengue virus
SG11201912163WA (en) 2017-06-15 2020-01-30 Primevax Immuno Oncology Inc Compositions and methods for cancer therapy with dengue virus and dendritic cells

Also Published As

Publication number Publication date
DE202016008300U1 (de) 2017-07-14
US9849167B2 (en) 2017-12-26
US20190046622A1 (en) 2019-02-14
US9730989B2 (en) 2017-08-15
US20210187086A1 (en) 2021-06-24
EP3316897A4 (en) 2019-03-13
US20190247479A1 (en) 2019-08-15
CN107921063A (zh) 2018-04-17
JP2021176862A (ja) 2021-11-11
US10159727B2 (en) 2018-12-25
US20170000868A1 (en) 2017-01-05
US10946080B2 (en) 2021-03-16
US20180050098A1 (en) 2018-02-22
JP2018522880A (ja) 2018-08-16
US10357553B2 (en) 2019-07-23
US20170304422A1 (en) 2017-10-26
CA2991212A1 (en) 2017-01-05
WO2017004567A1 (en) 2017-01-05
EP3316897A1 (en) 2018-05-09

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