BR112016003868A8 - Método, aparelho, mídia de armazenamento não transitório, e, programa de computador - Google Patents

Método, aparelho, mídia de armazenamento não transitório, e, programa de computador

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Publication number
BR112016003868A8
BR112016003868A8 BR112016003868A BR112016003868A BR112016003868A8 BR 112016003868 A8 BR112016003868 A8 BR 112016003868A8 BR 112016003868 A BR112016003868 A BR 112016003868A BR 112016003868 A BR112016003868 A BR 112016003868A BR 112016003868 A8 BR112016003868 A8 BR 112016003868A8
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BR
Brazil
Prior art keywords
computer program
perform
trainer
storage media
tissue
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BR112016003868A
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English (en)
Other versions
BR112016003868A2 (pt
Inventor
Jan Van Ooijen Hendrik
Franciscus Johannes Verhaegh Wilhelmus
Van De Stolpe Anja
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Koninklijke Philips Nv
Innosign B V
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Application filed by Koninklijke Philips Nv, Innosign B V filed Critical Koninklijke Philips Nv
Publication of BR112016003868A2 publication Critical patent/BR112016003868A2/pt
Publication of BR112016003868A8 publication Critical patent/BR112016003868A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C99/00—Subject matter not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Computing Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Algebra (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

MÉTODO, APARELHO, MÍDIA DE ARMAZENAMENTO NÃO TRANSITÓRIO, E, PROGRAMA DE COMPUTADOR. A presente invenção refere-se a um método que compreende inferir a atividade de uma via de sinalização celular PI3K em um tecido e/ou em células e/ou em um fluido corpóreo de um paciente, com base ao menos nos níveis de expressão de um ou mais genes-alvo da via de sinalização celular PI3K medidos em uma amostra extraída do tecido e/ou das células e/ou do fluido corpóreo do paciente. A presente invenção refere-se, adicionalmente, a um aparelho que compreende um processador digital configurado para executar esse tipo de método, a uma mídia de armazenamento não transitório que armazena instruções que são executáveis por um dispositivo de processamento digital para executar esse tipo de método, e a um programa de computador que compreende meios de código de programa para fazer com que um dispositivo de processamento digital execute esse tipo de método.
BR112016003868A 2014-01-03 2014-12-30 Método, aparelho, mídia de armazenamento não transitório, e, programa de computador BR112016003868A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14150145 2014-01-03
PCT/EP2014/079468 WO2015101635A1 (en) 2014-01-03 2014-12-30 Assessment of the pi3k cellular signaling pathway activity using mathematical modelling of target gene expression.

Publications (2)

Publication Number Publication Date
BR112016003868A2 BR112016003868A2 (pt) 2017-12-05
BR112016003868A8 true BR112016003868A8 (pt) 2022-11-08

Family

ID=49920140

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016003868A BR112016003868A8 (pt) 2014-01-03 2014-12-30 Método, aparelho, mídia de armazenamento não transitório, e, programa de computador

Country Status (10)

Country Link
US (2) US11261495B2 (pt)
EP (1) EP3013986B1 (pt)
JP (1) JP6077178B2 (pt)
CN (2) CN112795650A (pt)
AU (1) AU2014375206B2 (pt)
BR (1) BR112016003868A8 (pt)
CA (1) CA2923092C (pt)
DK (1) DK3013986T3 (pt)
ES (1) ES2613521T3 (pt)
WO (1) WO2015101635A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7065610B6 (ja) 2014-10-24 2022-06-06 コーニンクレッカ フィリップス エヌ ヴェ 複数の細胞シグナル伝達経路活性を用いる治療応答の医学的予後及び予測
JP7065609B6 (ja) 2014-10-24 2022-06-06 コーニンクレッカ フィリップス エヌ ヴェ 複数の細胞シグナル伝達経路活性を用いる治療応答の医学的予後及び予測
WO2016062891A1 (en) 2014-10-24 2016-04-28 Koninklijke Philips N.V. ASSESSMENT OF TGF-β CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
ES2861400T3 (es) 2015-08-14 2021-10-06 Koninklijke Philips Nv Evaluación de la actividad de la ruta de señalización celular de NFkB usando modelos matemáticos de la expresión de genes diana
RU2019100441A (ru) * 2016-06-13 2020-07-14 Конинклейке Филипс Н.В. Способ логического вывода об активности транскрипционного фактора пути сигнальной трансдукции у субъекта
EP3763732A1 (en) 2016-11-25 2021-01-13 Koninklijke Philips N.V. Method to distinguish tumor suppressive foxo activity from oxidative stress
EP3431582A1 (en) 2017-07-18 2019-01-23 Koninklijke Philips N.V. Cell culturing materials
EP3462348A1 (en) 2017-09-28 2019-04-03 Koninklijke Philips N.V. Bayesian inference
JP7257405B2 (ja) * 2017-10-02 2023-04-13 コーニンクレッカ フィリップス エヌ ヴェ 免疫細胞型及び免疫応答の機能状況の決定
EP3461915A1 (en) * 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat1/2 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3502279A1 (en) * 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
US20210052875A1 (en) * 2018-01-24 2021-02-25 Thomas Jefferson University Biodiffusion chamber
EP3812474A1 (en) 2019-10-22 2021-04-28 Koninklijke Philips N.V. Methods of prognosis in high-grade serous ovarian cancer
CN113785075A (zh) 2019-05-03 2021-12-10 皇家飞利浦有限公司 高级别浆液性卵巢癌的预后方法
EP3739588A1 (en) 2019-05-13 2020-11-18 Koninklijke Philips N.V. Assessment of multiple signaling pathway activity score in airway epithelial cells to predict airway epithelial abnormality and airway cancer risk
EP3882363A1 (en) 2020-03-17 2021-09-22 Koninklijke Philips N.V. Prognostic pathways for high risk sepsis patients
EP3978628A1 (en) 2020-10-01 2022-04-06 Koninklijke Philips N.V. Prognostic pathways for viral infections
EP4136261A1 (en) 2020-04-16 2023-02-22 InnoSIGN B.V. Prognostic pathways for viral infections
EP3940704A1 (en) 2020-07-14 2022-01-19 Koninklijke Philips N.V. Method for determining the differentiation state of a stem cell
EP3960875A1 (en) 2020-08-28 2022-03-02 Koninklijke Philips N.V. Pcr method and kit for determining pathway activity
EP3965119A1 (en) 2020-09-04 2022-03-09 Koninklijke Philips N.V. Methods for estimating heterogeneity of a tumour based on values for two or more genome mutation and/or gene expression related parameter, as well as corresponding devices
EP3974540A1 (en) 2020-09-25 2022-03-30 Koninklijke Philips N.V. Method for predicting immunotherapy resistance
EP4015651A1 (en) 2020-12-17 2022-06-22 Koninklijke Philips N.V. Treatment prediction and effectiveness of anti-tnf alpha treatment in ibd patients
EP4039825A1 (en) 2021-02-09 2022-08-10 Koninklijke Philips N.V. Comparison and standardization of cell and tissue culture
JP2024514404A (ja) 2021-03-11 2024-04-02 コーニンクレッカ フィリップス エヌ ヴェ 高リスク敗血症患者のための予後経路

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1592791A2 (en) * 2003-02-10 2005-11-09 National Institute of Advanced Industrial Science and Technology Regulation of gene expression by dna interference
TW200920405A (en) * 2007-08-24 2009-05-16 Oncotherapy Science Inc PKIB and NAALADL2 for target genes of prostate cancer therapy and diagnosis
WO2010009337A2 (en) * 2008-07-16 2010-01-21 Dana-Farber Cancer Institute, Inc. Signatures and pcdeterminants associated with prostate cancer and methods of use thereof
RU2012148699A (ru) * 2010-04-16 2014-05-27 Дженентек, Инк. Foxo3a как прогностический биомаркер для эффективности ингибитора пути киназы pi3k/акт
EP2549399A1 (en) 2011-07-19 2013-01-23 Koninklijke Philips Electronics N.V. Assessment of Wnt pathway activity using probabilistic modeling of target gene expression
CN111961726A (zh) 2012-12-26 2020-11-20 皇家飞利浦有限公司 使用靶基因表达的线性组合评价细胞信号传导途径活性
WO2014174003A1 (en) 2013-04-26 2014-10-30 Koninklijke Philips N.V. Medical prognosis and prediction of treatment response using multiple cellular signalling pathway activities
EP3461916A1 (en) * 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat3 cellular signaling pathway activity using mathematical modelling of target gene expression

Also Published As

Publication number Publication date
AU2014375206A1 (en) 2016-03-03
CN105492630A (zh) 2016-04-13
JP6077178B2 (ja) 2017-02-08
CA2923092A1 (en) 2015-07-09
CA2923092C (en) 2019-12-17
US11261495B2 (en) 2022-03-01
BR112016003868A2 (pt) 2017-12-05
JP2016536976A (ja) 2016-12-01
ES2613521T3 (es) 2017-05-24
AU2014375206B2 (en) 2021-09-30
US20220259666A1 (en) 2022-08-18
EP3013986B1 (en) 2016-11-16
CN112795650A (zh) 2021-05-14
WO2015101635A1 (en) 2015-07-09
US20160298196A1 (en) 2016-10-13
EP3013986A1 (en) 2016-05-04
DK3013986T3 (en) 2017-02-27

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25A Requested transfer of rights approved

Owner name: INNOSIGN B.V. (NL)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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