AU2016298229B2 - Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof - Google Patents

Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof Download PDF

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AU2016298229B2
AU2016298229B2 AU2016298229A AU2016298229A AU2016298229B2 AU 2016298229 B2 AU2016298229 B2 AU 2016298229B2 AU 2016298229 A AU2016298229 A AU 2016298229A AU 2016298229 A AU2016298229 A AU 2016298229A AU 2016298229 B2 AU2016298229 B2 AU 2016298229B2
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car
cell
cells
antibody
macrophages
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AU2016298229A1 (en
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Saar GILL
Carl H. June
Michael KLICHINSKY
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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AU2016298229A 2015-07-28 2016-07-28 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof Active AU2016298229B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022263479A AU2022263479B2 (en) 2015-07-28 2022-11-01 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof
AU2026200155A AU2026200155A1 (en) 2015-07-28 2026-01-10 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof

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US201562197675P 2015-07-28 2015-07-28
US62/197,675 2015-07-28
PCT/US2016/044440 WO2017019848A1 (en) 2015-07-28 2016-07-28 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof

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US (13) US11034749B2 (enExample)
EP (1) EP3328402A4 (enExample)
JP (4) JP7032304B2 (enExample)
KR (2) KR20240132100A (enExample)
CN (3) CN108025024B (enExample)
AU (3) AU2016298229B2 (enExample)
BR (1) BR112018001858B1 (enExample)
HK (1) HK1256141A1 (enExample)
IL (4) IL292507B2 (enExample)
MX (2) MX393707B (enExample)
RU (1) RU2766690C2 (enExample)
WO (1) WO2017019848A1 (enExample)
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Families Citing this family (105)

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Publication number Priority date Publication date Assignee Title
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
US10434153B1 (en) 2015-05-20 2019-10-08 Kim Leslie O'Neill Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors
CN108025024B (zh) * 2015-07-28 2022-11-29 宾夕法尼亚大学董事会 表达嵌合抗原受体的修饰单核细胞/巨噬细胞及其用途
US11352439B2 (en) * 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
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