BR112018001858B1 - Composições compreendendo células modificadas que compreendem um receptor de antígeno quimérico (car), seus usos terapêuticos e método para modificar uma célula - Google Patents

Composições compreendendo células modificadas que compreendem um receptor de antígeno quimérico (car), seus usos terapêuticos e método para modificar uma célula Download PDF

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BR112018001858B1
BR112018001858B1 BR112018001858-9A BR112018001858A BR112018001858B1 BR 112018001858 B1 BR112018001858 B1 BR 112018001858B1 BR 112018001858 A BR112018001858 A BR 112018001858A BR 112018001858 B1 BR112018001858 B1 BR 112018001858B1
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Brazil
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car
cell
antigen
antibody
cells
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BR112018001858-9A
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English (en)
Portuguese (pt)
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BR112018001858A2 (pt
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Saar Gill
Michael KLICHINSKY
Carl H. June
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The Trustees Of The University Of Pennsylvania
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Publication of BR112018001858A2 publication Critical patent/BR112018001858A2/pt
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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BR112018001858-9A 2015-07-28 2016-07-28 Composições compreendendo células modificadas que compreendem um receptor de antígeno quimérico (car), seus usos terapêuticos e método para modificar uma célula BR112018001858B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562197675P 2015-07-28 2015-07-28
US62/197,675 2015-07-28
PCT/US2016/044440 WO2017019848A1 (en) 2015-07-28 2016-07-28 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof

Publications (2)

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BR112018001858A2 BR112018001858A2 (pt) 2018-09-18
BR112018001858B1 true BR112018001858B1 (pt) 2022-02-08

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US (12) US11034749B2 (enExample)
EP (1) EP3328402A4 (enExample)
JP (4) JP7032304B2 (enExample)
KR (2) KR20240132100A (enExample)
CN (2) CN108025024B (enExample)
AU (2) AU2016298229B2 (enExample)
BR (1) BR112018001858B1 (enExample)
HK (1) HK1256141A1 (enExample)
IL (4) IL292507B2 (enExample)
MX (2) MX393707B (enExample)
RU (1) RU2766690C2 (enExample)
WO (1) WO2017019848A1 (enExample)
ZA (1) ZA201800611B (enExample)

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US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
US10434153B1 (en) 2015-05-20 2019-10-08 Kim Leslie O'Neill Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors
KR20240132100A (ko) * 2015-07-28 2024-09-02 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 키메릭 항원 수용체를 발현하는 변형된 단핵세포/대식세포 및 그의 용도
US11352439B2 (en) * 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
US10525082B2 (en) 2015-09-09 2020-01-07 Seattle Children's Hospital Genetic engineering of macrophages for immunotherapy
CN108137704A (zh) * 2015-10-13 2018-06-08 迅雷生物科技有限公司 免疫疗法中的巨噬细胞car（moto-car）
US10875919B2 (en) * 2016-04-26 2020-12-29 Alector Llc Chimeric receptors and methods of use thereof
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
ES2912269T3 (es) 2016-09-27 2022-05-25 Cero Therapeutics Inc Moléculas de receptor de engullimiento quimérico
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