JP2018520993A5 - - Google Patents

Info

Publication number

JP2018520993A5

JP2018520993A5 JP2017557938A JP2017557938A JP2018520993A5 JP 2018520993 A5 JP2018520993 A5 JP 2018520993A5 JP 2017557938 A JP2017557938 A JP 2017557938A JP 2017557938 A JP2017557938 A JP 2017557938A JP 2018520993 A5 JP2018520993 A5 JP 2018520993A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

human

acid sequence

antibody

Prior art date

2016-05-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000003275 alpha amino acid group Chemical group 0.000 claims description 140
• 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 120
• 102000050320 human TNFRSF4 Human genes 0.000 claims description 120
• 239000000427 antigen Substances 0.000 claims description 88
• 102000036639 antigens Human genes 0.000 claims description 88
• 108091007433 antigens Proteins 0.000 claims description 88
• 230000035772 mutation Effects 0.000 claims description 50
• 238000000034 method Methods 0.000 claims description 40
• 108020004707 nucleic acids Proteins 0.000 claims description 30
• 102000039446 nucleic acids Human genes 0.000 claims description 30
• 150000007523 nucleic acids Chemical class 0.000 claims description 30
• 210000004027 cell Anatomy 0.000 claims description 21
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 18
• 239000008194 pharmaceutical composition Substances 0.000 claims description 16
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 15
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 15
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
• 102220468007 HLA class II histocompatibility antigen, DP beta 1 chain_P115A_mutation Human genes 0.000 claims description 14
• 102220468513 Homeobox protein Meis2_L88A_mutation Human genes 0.000 claims description 14
• 102220626433 Methyl-CpG-binding domain protein 2_P93A_mutation Human genes 0.000 claims description 14
• 102220480127 Protein-tyrosine sulfotransferase 1_N60A_mutation Human genes 0.000 claims description 14
• 102220515129 Vacuolar protein sorting-associated protein 4A_R62A_mutation Human genes 0.000 claims description 14
• 102220514840 Vacuolar protein sorting-associated protein 4A_R80A_mutation Human genes 0.000 claims description 14
• 150000001413 amino acids Chemical class 0.000 claims description 14
• 239000005557 antagonist Substances 0.000 claims description 14
• 102220220424 rs1060500863 Human genes 0.000 claims description 14
• 230000004073 interleukin-2 production Effects 0.000 claims description 12
• 102000004169 proteins and genes Human genes 0.000 claims description 12
• 108090000623 proteins and genes Proteins 0.000 claims description 12
• 206010028980 Neoplasm Diseases 0.000 claims description 11
• 239000012634 fragment Substances 0.000 claims description 10
• 230000028993 immune response Effects 0.000 claims description 10
• 108060003951 Immunoglobulin Proteins 0.000 claims description 9
• 102000018358 immunoglobulin Human genes 0.000 claims description 9
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 8
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 8
• 102000003816 Interleukin-13 Human genes 0.000 claims description 8
• 108090000176 Interleukin-13 Proteins 0.000 claims description 8
• 108010002350 Interleukin-2 Proteins 0.000 claims description 8
• 102000000588 Interleukin-2 Human genes 0.000 claims description 8
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 8
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 8
• 239000003112 inhibitor Substances 0.000 claims description 8
• 238000004519 manufacturing process Methods 0.000 claims description 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
• 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 7
• 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
• 102000003814 Interleukin-10 Human genes 0.000 claims description 6
• 108090000174 Interleukin-10 Proteins 0.000 claims description 6
• 230000006052 T cell proliferation Effects 0.000 claims description 6
• 239000000556 agonist Substances 0.000 claims description 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
• 231100000673 dose–response relationship Toxicity 0.000 claims description 6
• 210000003162 effector t lymphocyte Anatomy 0.000 claims description 6
• 210000004602 germ cell Anatomy 0.000 claims description 6
• 210000003289 regulatory T cell Anatomy 0.000 claims description 6
• 201000011510 cancer Diseases 0.000 claims description 5
• 239000003795 chemical substances by application Substances 0.000 claims description 5
• 230000008685 targeting Effects 0.000 claims description 5
• 101000764263 Homo sapiens Tumor necrosis factor ligand superfamily member 4 Proteins 0.000 claims description 4
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
• 102220512993 Uncharacterized protein KIAA0040_W58A_mutation Human genes 0.000 claims description 4
• 238000003501 co-culture Methods 0.000 claims description 4
• 208000035475 disorder Diseases 0.000 claims description 4
• 230000000694 effects Effects 0.000 claims description 4
• 230000002708 enhancing effect Effects 0.000 claims description 4
• 102000051450 human TNFSF4 Human genes 0.000 claims description 4
• 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims description 4
• 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 claims description 4
• 208000027866 inflammatory disease Diseases 0.000 claims description 4
• 230000031261 interleukin-10 production Effects 0.000 claims description 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
• 230000011664 signaling Effects 0.000 claims description 4
• 229960005486 vaccine Drugs 0.000 claims description 4
• 230000003612 virological effect Effects 0.000 claims description 4
• ZADWXFSZEAPBJS-SNVBAGLBSA-N (2r)-2-amino-3-(1-methylindol-3-yl)propanoic acid Chemical compound C1=CC=C2N(C)C=C(C[C@@H](N)C(O)=O)C2=C1 ZADWXFSZEAPBJS-SNVBAGLBSA-N 0.000 claims description 3
• 101001047627 Homo sapiens Immunoglobulin kappa variable 2-28 Proteins 0.000 claims description 3
• 102100022950 Immunoglobulin kappa variable 2-28 Human genes 0.000 claims description 3
• 241000187747 Streptomyces Species 0.000 claims description 3
• 230000000890 antigenic effect Effects 0.000 claims description 3
• 230000001363 autoimmune Effects 0.000 claims description 3
• 239000003153 chemical reaction reagent Substances 0.000 claims description 3
• 238000001514 detection method Methods 0.000 claims description 3
• 229950009034 indoximod Drugs 0.000 claims description 3
• KRTIYQIPSAGSBP-KLAILNCOSA-N linrodostat Chemical compound C1(CCC(CC1)C1=C2C=C(F)C=CC2=NC=C1)[C@@H](C)C(=O)NC1=CC=C(Cl)C=C1 KRTIYQIPSAGSBP-KLAILNCOSA-N 0.000 claims description 3
• 208000023275 Autoimmune disease Diseases 0.000 claims description 2
• 241000193830 Bacillus <bacterium> Species 0.000 claims description 2
• 229940045513 CTLA4 antagonist Drugs 0.000 claims description 2
• 101100348617 Candida albicans (strain SC5314 / ATCC MYA-2876) NIK1 gene Proteins 0.000 claims description 2
• 206010009944 Colon cancer Diseases 0.000 claims description 2
• 201000004624 Dermatitis Diseases 0.000 claims description 2
• 101100125027 Dictyostelium discoideum mhsp70 gene Proteins 0.000 claims description 2
• 241000588724 Escherichia coli Species 0.000 claims description 2
• 101000693916 Gallus gallus Albumin Proteins 0.000 claims description 2
• 102000012215 HSC70 Heat-Shock Proteins Human genes 0.000 claims description 2
• 108010036652 HSC70 Heat-Shock Proteins Proteins 0.000 claims description 2
• 101150031823 HSP70 gene Proteins 0.000 claims description 2
• 241000238631 Hexapoda Species 0.000 claims description 2
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims description 2
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims description 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
• 102000004388 Interleukin-4 Human genes 0.000 claims description 2
• 108090000978 Interleukin-4 Proteins 0.000 claims description 2
• 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
• 102000016943 Muramidase Human genes 0.000 claims description 2
• 108010014251 Muramidase Proteins 0.000 claims description 2
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 2
• 206010060862 Prostate cancer Diseases 0.000 claims description 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
• 241000589516 Pseudomonas Species 0.000 claims description 2
• 206010038389 Renal cancer Diseases 0.000 claims description 2
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
• 101100007329 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS1 gene Proteins 0.000 claims description 2
• 101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 claims description 2
• 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 2
• 206010052779 Transplant rejections Diseases 0.000 claims description 2
• 206010046851 Uveitis Diseases 0.000 claims description 2
• 206010047115 Vasculitis Diseases 0.000 claims description 2
• 230000001270 agonistic effect Effects 0.000 claims description 2
• 230000003042 antagnostic effect Effects 0.000 claims description 2
• 208000006673 asthma Diseases 0.000 claims description 2
• 230000010261 cell growth Effects 0.000 claims description 2
• 210000000991 chicken egg Anatomy 0.000 claims description 2
• 208000029742 colonic neoplasm Diseases 0.000 claims description 2
• 238000012258 culturing Methods 0.000 claims description 2
• 201000010099 disease Diseases 0.000 claims description 2
• 101150052825 dnaK gene Proteins 0.000 claims description 2
• 239000012636 effector Substances 0.000 claims description 2
• 210000005260 human cell Anatomy 0.000 claims description 2
• 210000002865 immune cell Anatomy 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims description 2
• 208000015181 infectious disease Diseases 0.000 claims description 2
• 201000010982 kidney cancer Diseases 0.000 claims description 2
• 201000005202 lung cancer Diseases 0.000 claims description 2
• 208000020816 lung neoplasm Diseases 0.000 claims description 2
• 206010025135 lupus erythematosus Diseases 0.000 claims description 2
• 229960000274 lysozyme Drugs 0.000 claims description 2
• 235000010335 lysozyme Nutrition 0.000 claims description 2
• 239000004325 lysozyme Substances 0.000 claims description 2
• 201000001441 melanoma Diseases 0.000 claims description 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
• 230000001629 suppression Effects 0.000 claims description 2
• 210000001519 tissue Anatomy 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 3
• YPBKTZBXSBLTDK-PKNBQFBNSA-N (3e)-3-[(3-bromo-4-fluoroanilino)-nitrosomethylidene]-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole Chemical group NS(=O)(=O)NCCNC1=NON\C1=C(N=O)/NC1=CC=C(F)C(Br)=C1 YPBKTZBXSBLTDK-PKNBQFBNSA-N 0.000 claims 1
• RFMMMVDNIPUKGG-YFKPBYRVSA-N N-acetyl-L-glutamic acid Chemical compound CC(=O)N[C@H](C(O)=O)CCC(O)=O RFMMMVDNIPUKGG-YFKPBYRVSA-N 0.000 claims 1
• 229950006370 epacadostat Drugs 0.000 claims 1
• 229940072221 immunoglobulins Drugs 0.000 claims 1
• 230000035939 shock Effects 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 1