JP2018203766A5 - - Google Patents
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- Publication number
- JP2018203766A5 JP2018203766A5 JP2018166053A JP2018166053A JP2018203766A5 JP 2018203766 A5 JP2018203766 A5 JP 2018203766A5 JP 2018166053 A JP2018166053 A JP 2018166053A JP 2018166053 A JP2018166053 A JP 2018166053A JP 2018203766 A5 JP2018203766 A5 JP 2018203766A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- snag
- bacterial
- snag nanofiber
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002121 nanofiber Substances 0.000 claims 79
- 239000000203 mixture Substances 0.000 claims 77
- 230000001580 bacterial effect Effects 0.000 claims 40
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 30
- 241000191967 Staphylococcus aureus Species 0.000 claims 27
- 238000000338 in vitro Methods 0.000 claims 24
- 230000004083 survival effect Effects 0.000 claims 24
- 208000035143 Bacterial infection Diseases 0.000 claims 20
- 208000022362 bacterial infectious disease Diseases 0.000 claims 20
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 15
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 15
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 15
- -1 N-acetylglucosamine monosaccharide Chemical class 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 239000000835 fiber Substances 0.000 claims 14
- 230000000694 effects Effects 0.000 claims 12
- 230000035755 proliferation Effects 0.000 claims 12
- 238000011200 topical administration Methods 0.000 claims 12
- 208000015181 infectious disease Diseases 0.000 claims 10
- 206010052428 Wound Diseases 0.000 claims 9
- 208000027418 Wounds and injury Diseases 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- 241000186359 Mycobacterium Species 0.000 claims 4
- 230000001747 exhibiting effect Effects 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 241000894007 species Species 0.000 claims 3
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 241000193738 Bacillus anthracis Species 0.000 claims 2
- 241000588832 Bordetella pertussis Species 0.000 claims 2
- 241000589969 Borreliella burgdorferi Species 0.000 claims 2
- 241000589567 Brucella abortus Species 0.000 claims 2
- 241001509299 Brucella canis Species 0.000 claims 2
- 241001148106 Brucella melitensis Species 0.000 claims 2
- 241001148111 Brucella suis Species 0.000 claims 2
- 241000589875 Campylobacter jejuni Species 0.000 claims 2
- 201000005019 Chlamydia pneumonia Diseases 0.000 claims 2
- 241000606153 Chlamydia trachomatis Species 0.000 claims 2
- 241000193155 Clostridium botulinum Species 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 241000194031 Enterococcus faecium Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000589602 Francisella tularensis Species 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000590002 Helicobacter pylori Species 0.000 claims 2
- 241000589248 Legionella Species 0.000 claims 2
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 2
- 241000589902 Leptospira Species 0.000 claims 2
- 241000589929 Leptospira interrogans Species 0.000 claims 2
- 241000186779 Listeria monocytogenes Species 0.000 claims 2
- 241000186362 Mycobacterium leprae Species 0.000 claims 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 2
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims 2
- 241000607760 Shigella sonnei Species 0.000 claims 2
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 2
- 241001147691 Staphylococcus saprophyticus Species 0.000 claims 2
- 241000193985 Streptococcus agalactiae Species 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- 241000193996 Streptococcus pyogenes Species 0.000 claims 2
- 241000589884 Treponema pallidum Species 0.000 claims 2
- 241000607479 Yersinia pestis Species 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 229940065181 bacillus anthracis Drugs 0.000 claims 2
- 229940056450 brucella abortus Drugs 0.000 claims 2
- 229940038698 brucella melitensis Drugs 0.000 claims 2
- 229940038705 chlamydia trachomatis Drugs 0.000 claims 2
- 208000002925 dental caries Diseases 0.000 claims 2
- 208000010643 digestive system disease Diseases 0.000 claims 2
- 238000007922 dissolution test Methods 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 229940023064 escherichia coli Drugs 0.000 claims 2
- 229940118764 francisella tularensis Drugs 0.000 claims 2
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 2
- 238000001631 haemodialysis Methods 0.000 claims 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 210000003780 hair follicle Anatomy 0.000 claims 2
- 229940037467 helicobacter pylori Drugs 0.000 claims 2
- 230000000322 hemodialysis Effects 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 210000002200 mouth mucosa Anatomy 0.000 claims 2
- 208000030773 pneumonia caused by chlamydia Diseases 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229940115939 shigella sonnei Drugs 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 238000001228 spectrum Methods 0.000 claims 2
- 229940030998 streptococcus agalactiae Drugs 0.000 claims 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 2
- 229940076156 streptococcus pyogenes Drugs 0.000 claims 2
- 210000003606 umbilical vein Anatomy 0.000 claims 2
- 208000031729 Bacteremia Diseases 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 206010011409 Cross infection Diseases 0.000 claims 1
- 241000238424 Crustacea Species 0.000 claims 1
- 208000035874 Excoriation Diseases 0.000 claims 1
- 206010016936 Folliculitis Diseases 0.000 claims 1
- 208000005422 Foreign-Body reaction Diseases 0.000 claims 1
- 206010017964 Gastrointestinal infection Diseases 0.000 claims 1
- 208000034693 Laceration Diseases 0.000 claims 1
- DUKURNFHYQXCJG-UHFFFAOYSA-N Lewis A pentasaccharide Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(O)C(O)C(CO)O2)O)C(NC(C)=O)C(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)OC1CO DUKURNFHYQXCJG-UHFFFAOYSA-N 0.000 claims 1
- 238000000134 MTT assay Methods 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 206010029803 Nosocomial infection Diseases 0.000 claims 1
- 208000025157 Oral disease Diseases 0.000 claims 1
- 208000009344 Penetrating Wounds Diseases 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 208000007313 Reproductive Tract Infections Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010041899 Stab wound Diseases 0.000 claims 1
- 208000002847 Surgical Wound Diseases 0.000 claims 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000005299 abrasion Methods 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 208000019836 digestive system infectious disease Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 239000010408 film Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 208000024693 gingival disease Diseases 0.000 claims 1
- 208000007565 gingivitis Diseases 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 239000003022 immunostimulating agent Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 230000037323 metabolic rate Effects 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 208000030194 mouth disease Diseases 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32465710P | 2010-04-15 | 2010-04-15 | |
| US61/324,657 | 2010-04-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016095328A Division JP6400628B2 (ja) | 2010-04-15 | 2016-05-11 | ポリ−ｎ−アセチルグルコサミンナノファイバーの抗菌性の適用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018203766A JP2018203766A (ja) | 2018-12-27 |
| JP2018203766A5 true JP2018203766A5 (https=) | 2019-02-14 |
| JP6761453B2 JP6761453B2 (ja) | 2020-09-23 |
Family
ID=44799052
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505181A Withdrawn JP2013523898A (ja) | 2010-04-15 | 2011-04-15 | ポリ−ｎ−アセチルグルコサミンナノファイバーの抗菌性の適用 |
| JP2016095328A Active JP6400628B2 (ja) | 2010-04-15 | 2016-05-11 | ポリ−ｎ−アセチルグルコサミンナノファイバーの抗菌性の適用 |
| JP2018166053A Expired - Fee Related JP6761453B2 (ja) | 2010-04-15 | 2018-09-05 | ポリ−ｎ−アセチルグルコサミンナノファイバーの抗菌性の適用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505181A Withdrawn JP2013523898A (ja) | 2010-04-15 | 2011-04-15 | ポリ−ｎ−アセチルグルコサミンナノファイバーの抗菌性の適用 |
| JP2016095328A Active JP6400628B2 (ja) | 2010-04-15 | 2016-05-11 | ポリ−ｎ−アセチルグルコサミンナノファイバーの抗菌性の適用 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US8858964B2 (https=) |
| EP (1) | EP2563371A4 (https=) |
| JP (3) | JP2013523898A (https=) |
| KR (1) | KR101883797B1 (https=) |
| CN (2) | CN103108638B (https=) |
| AU (1) | AU2011239466B2 (https=) |
| BR (1) | BR112012025844A2 (https=) |
| CA (1) | CA2796068C (https=) |
| IL (1) | IL222375A (https=) |
| MX (1) | MX342912B (https=) |
| NZ (2) | NZ703163A (https=) |
| WO (1) | WO2011130646A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008219065B2 (en) | 2007-02-19 | 2014-01-30 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| BR112012025844A2 (pt) | 2010-04-15 | 2017-07-18 | Marine Polymer Tech Inc | uso de nanofibras snag |
| CA2832859C (en) | 2011-04-15 | 2020-06-16 | Marine Polymer Technologies, Inc. | Treatment of disease with poly-n-acetylglucosamine nanofibers |
| US20140322722A1 (en) * | 2011-09-30 | 2014-10-30 | The Research Institute At Nationwide Children's Hospital | Compositions and methods for detection of defensins in a patient sample |
| RU2014151567A (ru) * | 2012-05-22 | 2016-07-10 | Новартис Аг | Конъюгат менингококка серогруппы х |
| US20150237837A1 (en) * | 2012-06-18 | 2015-08-27 | Duke University | Non-Human Model for Wound Healing |
| WO2014098865A1 (en) | 2012-12-20 | 2014-06-26 | Hill's Pet Nutrition, Inc. | Pattern recognition receptor expression as a measure of systemic health |
| US20150024014A1 (en) | 2013-03-14 | 2015-01-22 | Marine Polymer Technologies, Inc. | Treatment of disease with poly-n-acetylglucosamine nanofibers |
| JP2015048436A (ja) * | 2013-09-03 | 2015-03-16 | 公立大学法人福井県立大学 | 植物の耐病性を向上させる、生物由来キチン質含有物、その使用方法、及びその製造方法 |
| EP3034612A1 (en) | 2014-12-16 | 2016-06-22 | Greenaltech, S.L. | Chitin and chitosan producing methods |
| US10500222B2 (en) * | 2015-10-19 | 2019-12-10 | Wayne State University | Compositions and methods relating to treatment of infection |
| CN107460140B (zh) * | 2016-06-02 | 2020-11-13 | 浙江科技学院 | 一种芽孢杆菌hz16中抑制军团菌活性物的制备方法 |
| CN111212569B (zh) * | 2017-08-31 | 2025-01-24 | 辛格隆股份公司 | 用于制备细菌素和抗微生物肽的方法和组合物 |
| WO2019217796A1 (en) * | 2018-05-11 | 2019-11-14 | Marine Polymer Technologies, Inc. | Use of poly-n-acetylglucosamine nanofibers for the treatment of gingival recession |
| BR102021021376A2 (pt) * | 2021-10-25 | 2023-05-09 | União Brasileira De Educação Católica - Ubec | Composição, processo de produção da composição e uso da composição de nanofibras que compreende pva, quitosana, antibiótico e peptídeo de defesa do hospedeiro |
| IT202200004574A1 (it) | 2022-03-10 | 2023-09-10 | Sergio Ammendola | Nanoparticelle di N-acetilglucosammina e loro applicazioni |
| KR102846669B1 (ko) * | 2022-04-14 | 2025-08-13 | 충남대학교산학협력단 | miRNA 24가 봉입된 키토산 나노입자를 유효성분으로 포함하는 에드워드시엘라 피스시시다에 대한 어류용 항생 조성물 |
| CN115671368B (zh) * | 2022-10-28 | 2024-03-22 | 东华大学 | 一种用于生物膜清除的纳米纤维复合贴片及其制备方法 |
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