JP2011530534A5 - - Google Patents
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- Publication number
- JP2011530534A5 JP2011530534A5 JP2011522274A JP2011522274A JP2011530534A5 JP 2011530534 A5 JP2011530534 A5 JP 2011530534A5 JP 2011522274 A JP2011522274 A JP 2011522274A JP 2011522274 A JP2011522274 A JP 2011522274A JP 2011530534 A5 JP2011530534 A5 JP 2011530534A5
- Authority
- JP
- Japan
- Prior art keywords
- spp
- use according
- infection
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000015181 infectious disease Diseases 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 6
- 241000894006 Bacteria Species 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000588655 Moraxella catarrhalis Species 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 1
- 241000456624 Actinobacteria bacterium Species 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 241001185363 Chlamydiae Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 206010011409 Cross infection Diseases 0.000 claims 1
- 241000588921 Enterobacteriaceae Species 0.000 claims 1
- 241000741267 Enterobacteriaceae bacterium Species 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000194029 Enterococcus hirae Species 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 201000008225 Klebsiella pneumonia Diseases 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 241000589248 Legionella Species 0.000 claims 1
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 1
- 241000186781 Listeria Species 0.000 claims 1
- 241000589289 Moraxellaceae Species 0.000 claims 1
- 241000204031 Mycoplasma Species 0.000 claims 1
- 241000588656 Neisseriaceae Species 0.000 claims 1
- 241000187654 Nocardia Species 0.000 claims 1
- 206010029803 Nosocomial infection Diseases 0.000 claims 1
- 206010035717 Pneumonia klebsiella Diseases 0.000 claims 1
- 241000186429 Propionibacterium Species 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000607493 Vibrionaceae Species 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18830708P | 2008-08-08 | 2008-08-08 | |
| US61/188,307 | 2008-08-08 | ||
| PCT/US2009/053142 WO2010017470A1 (en) | 2008-08-08 | 2009-08-07 | C7-fluoro substituted tetracycline compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014041460A Division JP5690957B2 (ja) | 2008-08-08 | 2014-03-04 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530534A JP2011530534A (ja) | 2011-12-22 |
| JP2011530534A5 true JP2011530534A5 (https=) | 2012-09-20 |
| JP5496202B2 JP5496202B2 (ja) | 2014-05-21 |
Family
ID=41110902
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522274A Active JP5496202B2 (ja) | 2008-08-08 | 2009-08-07 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
| JP2014041460A Expired - Fee Related JP5690957B2 (ja) | 2008-08-08 | 2014-03-04 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
| JP2015018405A Expired - Fee Related JP6041911B2 (ja) | 2008-08-08 | 2015-02-02 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014041460A Expired - Fee Related JP5690957B2 (ja) | 2008-08-08 | 2014-03-04 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
| JP2015018405A Expired - Fee Related JP6041911B2 (ja) | 2008-08-08 | 2015-02-02 | Ｃ７−フルオロ置換テトラサイクリン化合物 |
Country Status (31)
| Country | Link |
|---|---|
| US (11) | US8906887B2 (https=) |
| EP (3) | EP2682387B1 (https=) |
| JP (3) | JP5496202B2 (https=) |
| KR (3) | KR101746795B1 (https=) |
| CN (3) | CN105367440A (https=) |
| AR (3) | AR072990A1 (https=) |
| AU (1) | AU2009279473B2 (https=) |
| BR (1) | BRPI0916985B1 (https=) |
| CA (1) | CA2732883C (https=) |
| CO (1) | CO6351777A2 (https=) |
| CY (3) | CY1114689T1 (https=) |
| DK (2) | DK2323972T3 (https=) |
| ES (3) | ES2558512T3 (https=) |
| FR (1) | FR19C1012I2 (https=) |
| HR (2) | HRP20130928T1 (https=) |
| HU (2) | HUE026562T2 (https=) |
| IL (3) | IL211120A (https=) |
| LT (1) | LTC2323972I2 (https=) |
| LU (1) | LUC00107I2 (https=) |
| MX (2) | MX358961B (https=) |
| NL (1) | NL300971I2 (https=) |
| NO (1) | NO2019010I1 (https=) |
| NZ (3) | NZ603568A (https=) |
| PL (3) | PL2682387T3 (https=) |
| PT (2) | PT2323972E (https=) |
| RS (2) | RS54485B1 (https=) |
| SG (1) | SG10201806714PA (https=) |
| SI (2) | SI2682387T1 (https=) |
| SM (1) | SMT201600045B (https=) |
| TW (3) | TWI508934B (https=) |
| WO (1) | WO2010017470A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2323972E (pt) | 2008-08-08 | 2013-10-09 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina substituídos com c7-flúor |
| EP2427425B1 (en) | 2009-05-08 | 2017-03-08 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| IN2012DN02502A (https=) | 2009-08-28 | 2015-08-28 | Tetraphase Pharmaceuticals Inc | |
| WO2012021829A1 (en) * | 2010-08-12 | 2012-02-16 | Tetraphase Pharmaceuticals, Inc. | Methods of treating bacterial infections |
| TW201245116A (en) * | 2010-08-12 | 2012-11-16 | Tetraphase Pharmaceuticals Inc | Tetracycline analogs |
| WO2012065028A2 (en) | 2010-11-11 | 2012-05-18 | Concert Pharmaceuticals Inc. | Substituted tetracyclines |
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| CN104230960B (zh) * | 2013-06-06 | 2017-02-15 | 山东轩竹医药科技有限公司 | 四并环类间变性淋巴瘤激酶抑制剂 |
| MA40836A (fr) | 2014-10-23 | 2017-08-29 | Tetraphase Pharmaceuticals Inc | Procédures de semi-synthèse |
| WO2017097891A1 (en) | 2015-12-10 | 2017-06-15 | Sandoz Ag | Crystalline eravacycline |
| EP3778567A1 (en) | 2016-01-22 | 2021-02-17 | Sandoz Ag | Crystalline eravacycline bis-hydrochloride |
| BR112018072559A2 (pt) * | 2016-05-02 | 2019-02-19 | Paratek Pharmaceuticals, Inc. | método de tratar infecção do trato urinário. |
| CN107759503A (zh) * | 2016-08-16 | 2018-03-06 | 四川科伦博泰生物医药股份有限公司 | 一种四环素衍生物及其用途 |
| CA3034891A1 (en) | 2016-08-30 | 2018-03-08 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds and methods of treatment |
| CN110582486B (zh) * | 2016-10-19 | 2024-01-12 | 四相制药公司 | 艾若威四环素的结晶形式 |
| BR112019008897A2 (pt) | 2016-11-01 | 2019-08-13 | Paratek Pharm Innc | método para tratar pneumonia bacteriana adquirida na comunidade. |
| US12570604B2 (en) | 2018-11-09 | 2026-03-10 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a tetracycline compound and uses thereof |
| JP2025528065A (ja) * | 2022-05-29 | 2025-08-26 | ビー．ジー．ネゲブ テクノロジーズ アンド アプリケーションズ リミテッド， アット ベン‐グリオン ユニバーシティー | がんを処置するためのエラバサイクリン |
Family Cites Families (82)
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| GB935384A (en) * | 1959-03-30 | 1963-08-28 | Pfizer & Co C | Tetracycline derivatives and preparation thereof |
| US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| GB1034933A (en) | 1962-10-29 | 1966-07-06 | American Cyanamid Co | 4-demethylamino-4-substituted amino 6-demethyl tetracyclines |
| US3304227A (en) | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
| US3433709A (en) * | 1965-12-07 | 1969-03-18 | American Cyanamid Co | Biological transformation of alpha-6-deoxytetracyclines to tetracyclines |
| USRE34656E (en) | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
| US4704383A (en) | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| JP3016587B2 (ja) | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5308839A (en) | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| US5770588A (en) | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
| US5231017A (en) | 1991-05-17 | 1993-07-27 | Solvay Enzymes, Inc. | Process for producing ethanol |
| DE122006000058I1 (de) * | 1991-10-04 | 2007-01-18 | Wyeth Corp | 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline |
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| US5258371A (en) | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
| US6043225A (en) | 1992-06-12 | 2000-03-28 | Board Of Regents Of The University Of Washington | Diagnosis and treatment of arterial chlamydial granuloma |
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| US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
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| EP0599397B1 (en) | 1992-11-17 | 1996-08-28 | The Research Foundation Of State University Of New York | Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes |
| US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
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| US5668122A (en) | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
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| US5834449A (en) | 1996-06-13 | 1998-11-10 | The Research Foundation Of State University Of New York | Treatment of aortic and vascular aneurysms with tetracycline compounds |
| US5827840A (en) | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5919774A (en) | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
| US5837696A (en) | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
| US5773430A (en) | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
| US5929055A (en) | 1997-06-23 | 1999-07-27 | The Research Foundation Of State University Of New York | Therapeutic method for management of diabetes mellitus |
| US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| US6015804A (en) | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US5977091A (en) | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
| US6914057B1 (en) | 1998-09-28 | 2005-07-05 | The Research Foundation Of State University Of New York | Inhibitor of cataract formation |
| KR20010073190A (ko) | 1998-09-28 | 2001-07-31 | 제임스 알. 데니히 | 백내장 형성 억제제 |
| US5998390A (en) | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| US6231894B1 (en) | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
| AU2000257445A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-n-substituted phenyl tetracycline compounds |
| EA013908B1 (ru) * | 2000-07-07 | 2010-08-30 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| JP4963771B2 (ja) | 2000-07-07 | 2012-06-27 | トラスティーズ・オブ・タフツ・カレッジ | ７、８および９−置換テトラサイクリン化合物 |
| WO2002072031A2 (en) | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| JP2004530661A (ja) | 2001-03-14 | 2004-10-07 | パラテック ファーマシューティカルズ インコーポレイテッド | 抗真菌剤としての置換テトラサイクリン化合物 |
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| KR101083498B1 (ko) | 2002-03-21 | 2011-11-16 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
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| BRPI0607353A2 (pt) * | 2005-02-15 | 2009-09-01 | Wyeth Corp | composto de fórmula (i); composição farmacêutica; uso do composto para o tratamento ou controle de infecções bacterianas em animais de sangue quente; processo para a preparação de tetraciclinas 9-(n-substituìdas-n-substituìdas-glicil) de fórmulas 5; 7; 10; e tetraciclina 9-(n-substituìda-n-substituìda glicil) de fómulas 5; 7; 10 |
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| WO2008127361A2 (en) | 2006-10-11 | 2008-10-23 | President And Fellows Of Harvard College | Synthesis of enone intermediate |
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| JP2010523684A (ja) | 2007-04-12 | 2010-07-15 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 |
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| JP2011517697A (ja) | 2008-04-14 | 2011-06-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
| PT2323972E (pt) * | 2008-08-08 | 2013-10-09 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina substituídos com c7-flúor |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| EP2427425B1 (en) | 2009-05-08 | 2017-03-08 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| ES2440000T3 (es) | 2009-05-08 | 2014-01-27 | Tetraphase Pharmaceuticals, Inc. | Compuestos de 8-aza-tetraciclina |
| IN2012DN02502A (https=) | 2009-08-28 | 2015-08-28 | Tetraphase Pharmaceuticals Inc | |
| TW201245116A (en) | 2010-08-12 | 2012-11-16 | Tetraphase Pharmaceuticals Inc | Tetracycline analogs |
| WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
-
2009
- 2009-08-07 PT PT97912901T patent/PT2323972E/pt unknown
- 2009-08-07 KR KR1020167011703A patent/KR101746795B1/ko not_active Expired - Fee Related
- 2009-08-07 PL PL13172357T patent/PL2682387T3/pl unknown
- 2009-08-07 PL PL15180611T patent/PL3000805T3/pl unknown
- 2009-08-07 ES ES13172357.9T patent/ES2558512T3/es active Active
- 2009-08-07 EP EP13172357.9A patent/EP2682387B1/en active Active
- 2009-08-07 SI SI200931338T patent/SI2682387T1/sl unknown
- 2009-08-07 PT PT131723579T patent/PT2682387E/pt unknown
- 2009-08-07 HR HRP20130928AT patent/HRP20130928T1/hr unknown
- 2009-08-07 NZ NZ603568A patent/NZ603568A/en not_active IP Right Cessation
- 2009-08-07 KR KR1020177003709A patent/KR101856178B1/ko not_active Expired - Fee Related
- 2009-08-07 EP EP09791290.1A patent/EP2323972B1/en active Active
- 2009-08-07 US US12/462,795 patent/US8906887B2/en active Active
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