JP2019534289A5 - - Google Patents
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- Publication number
- JP2019534289A5 JP2019534289A5 JP2019522839A JP2019522839A JP2019534289A5 JP 2019534289 A5 JP2019534289 A5 JP 2019534289A5 JP 2019522839 A JP2019522839 A JP 2019522839A JP 2019522839 A JP2019522839 A JP 2019522839A JP 2019534289 A5 JP2019534289 A5 JP 2019534289A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- formula
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- SQRJBNMYQXRZBL-OKHVLMGVSA-N CCC(C[C@H](OC([C@H]1O)[C@@H](Oc(c(Oc2ccc([C@H](CC(N[C@H](C(NCCC[N](C)(C)C)=O)c3c(-c4cc([C@H](C(N)=O)NC[C@@H]5NC([C@H](CC(N)=O)NC([C@@H]([C@@H]6O)NC(CCC(C)C)=O)=O)=O)ccc4O)c(O)cc(O)c3)=O)O)cc2Cl)cc5c2)c2Oc2ccc6cc2Cl)OC(CO)C1O)OC1C)([C@@H]1O)NCc(cc1)ccc1-c(cc1)ccc1Cl Chemical compound CCC(C[C@H](OC([C@H]1O)[C@@H](Oc(c(Oc2ccc([C@H](CC(N[C@H](C(NCCC[N](C)(C)C)=O)c3c(-c4cc([C@H](C(N)=O)NC[C@@H]5NC([C@H](CC(N)=O)NC([C@@H]([C@@H]6O)NC(CCC(C)C)=O)=O)=O)ccc4O)c(O)cc(O)c3)=O)O)cc2Cl)cc5c2)c2Oc2ccc6cc2Cl)OC(CO)C1O)OC1C)([C@@H]1O)NCc(cc1)ccc1-c(cc1)ccc1Cl SQRJBNMYQXRZBL-OKHVLMGVSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662415191P | 2016-10-31 | 2016-10-31 | |
| US62/415,191 | 2016-10-31 | ||
| PCT/US2017/059289 WO2018081797A1 (en) | 2016-10-31 | 2017-10-31 | Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534289A JP2019534289A (ja) | 2019-11-28 |
| JP2019534289A5 true JP2019534289A5 (https=) | 2020-12-10 |
| JP7104424B2 JP7104424B2 (ja) | 2022-07-21 |
Family
ID=62024092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522839A Expired - Fee Related JP7104424B2 (ja) | 2016-10-31 | 2017-10-31 | 相乗的に抗菌効力及び耐久性を改善するポケット再設計バンコマイシン類似体への末梢修飾 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10934326B2 (https=) |
| EP (1) | EP3532483A4 (https=) |
| JP (1) | JP7104424B2 (https=) |
| AU (1) | AU2017348434B2 (https=) |
| CA (1) | CA3042039C (https=) |
| WO (1) | WO2018081797A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL270685B (en) | 2017-05-22 | 2022-09-01 | Insmed Inc | Cleavable derivatives of lipoglycopeptide and their uses |
| EP4139328A4 (en) * | 2020-04-20 | 2024-05-22 | The Scripps Research Institute | GUANIDINE-MODIFIED C-TERMINAL VANCOMYCIN COMPOUNDS, COMPOSITIONS AND METHODS |
| CN117069794B (zh) * | 2023-06-20 | 2024-02-13 | 广州中医药大学(广州中医药研究院) | 一种糖肽类抗生素荧光探针化合物及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919756A (en) * | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
| CA2497159A1 (en) | 2002-08-30 | 2004-03-11 | K.U. Leuven Research And Development | Glycopeptide antibiotic and semisynthetic derivatives thereof and their use as antiviral agents |
| US8778874B2 (en) | 2004-11-29 | 2014-07-15 | National University Corporation Nagoya University | Glycopeptide antibiotic monomer derivatives |
| WO2012129493A1 (en) * | 2011-03-24 | 2012-09-27 | Seachaid Pharmaceuticals, Inc. | Vancomycin derivatives |
| US10081655B2 (en) * | 2011-11-14 | 2018-09-25 | Jawaharlal Nehru Centre For Advanced | Cationic antibacterial composition |
| CA2954653C (en) * | 2014-07-10 | 2023-01-24 | The Scripps Research Institute | N-(hydrophobe-substituted)vancosaminyl [.psi.[c(=nh)nh]tpg4]vancomycin and [.psi.[ch2nh]tpg4]vancomycin |
| WO2018010475A1 (zh) * | 2016-07-15 | 2018-01-18 | 上海来益生物药物研究开发中心有限责任公司 | 糖肽类衍生物及其药学可接受的盐、制备方法和应用 |
-
2017
- 2017-10-31 AU AU2017348434A patent/AU2017348434B2/en not_active Ceased
- 2017-10-31 JP JP2019522839A patent/JP7104424B2/ja not_active Expired - Fee Related
- 2017-10-31 CA CA3042039A patent/CA3042039C/en active Active
- 2017-10-31 WO PCT/US2017/059289 patent/WO2018081797A1/en not_active Ceased
- 2017-10-31 EP EP17864216.1A patent/EP3532483A4/en not_active Withdrawn
- 2017-10-31 US US16/344,300 patent/US10934326B2/en active Active
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