MX385203B - Compuestos y métodos para tratar infecciones bacterianas. - Google Patents

Compuestos y métodos para tratar infecciones bacterianas.

Info

Publication number
MX385203B
MX385203B MX2019013291A MX2019013291A MX385203B MX 385203 B MX385203 B MX 385203B MX 2019013291 A MX2019013291 A MX 2019013291A MX 2019013291 A MX2019013291 A MX 2019013291A MX 385203 B MX385203 B MX 385203B
Authority
MX
Mexico
Prior art keywords
compounds
methods
sup
bacterial infections
treating bacterial
Prior art date
Application number
MX2019013291A
Other languages
English (en)
Other versions
MX2019013291A (es
Inventor
- VEGA Camilo VELEZ
Jan Romero
- PREVOIR Janelle COMITA
Jing Zhang
Mark Sylvester
Ruben Tommasi
Satenig Guler
- REVILLE Thomas Francois DURAND
Xiaoyun Wu
Original Assignee
Entasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entasis Therapeutics Inc filed Critical Entasis Therapeutics Inc
Publication of MX2019013291A publication Critical patent/MX2019013291A/es
Publication of MX385203B publication Critical patent/MX385203B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

En la presente se proporcionan compuestos antibacterianos representados por la Formula I,(I); o una sal farmaceuticamente aceptable del mismo, en donde X, Y, R4, R5 y R6 son como se definen en la presente. Tambien se proporcionan composiciones farmaceuticas que comprenden los compuestos de Formula I.
MX2019013291A 2017-05-08 2018-05-08 Compuestos y métodos para tratar infecciones bacterianas. MX385203B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762502867P 2017-05-08 2017-05-08
PCT/US2018/031593 WO2018208769A1 (en) 2017-05-08 2018-05-08 Compounds and methods for treating bacterial infections

Publications (2)

Publication Number Publication Date
MX2019013291A MX2019013291A (es) 2020-01-15
MX385203B true MX385203B (es) 2025-03-14

Family

ID=62223332

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019013291A MX385203B (es) 2017-05-08 2018-05-08 Compuestos y métodos para tratar infecciones bacterianas.

Country Status (26)

Country Link
US (1) US11046694B2 (es)
EP (1) EP3630111B1 (es)
JP (1) JP7058322B2 (es)
KR (1) KR102611447B1 (es)
CN (1) CN110709081B (es)
AU (1) AU2018266640B2 (es)
CY (1) CY1125340T1 (es)
DK (1) DK3630111T3 (es)
EA (1) EA038393B1 (es)
ES (1) ES2907858T3 (es)
HR (1) HRP20220231T1 (es)
HU (1) HUE057592T2 (es)
IL (1) IL270380B (es)
LT (1) LT3630111T (es)
MA (1) MA48743A (es)
MX (1) MX385203B (es)
MY (1) MY201377A (es)
PE (1) PE20200333A1 (es)
PH (1) PH12019502509A1 (es)
PL (1) PL3630111T3 (es)
PT (1) PT3630111T (es)
SG (1) SG11201909443YA (es)
SI (1) SI3630111T1 (es)
SM (1) SMT202200110T1 (es)
TW (1) TWI791018B (es)
WO (1) WO2018208769A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
EP3833665B1 (en) 2018-08-09 2023-07-19 Antabio SAS Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN111675641B (zh) * 2020-06-04 2023-09-08 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） 单环β-内酰胺类化合物、单环内酰胺类化合物盐及其制备方法
EP4146651A4 (en) 2021-05-07 2024-06-05 Ningxia Academy of Agriculture and Forestry Sciences SULFONYLAMIDINE SUBSTITUTED COMPOUNDS AND THEIR USE AS BETA-LACTAMASE INHIBITORS
US11814385B2 (en) 2021-06-25 2023-11-14 University Of South Florida Small molecule inhibitors targeting Clostridioides difficile sporulation
WO2025064681A1 (en) * 2023-09-19 2025-03-27 Entasis Therapeutics Inc. Compounds and methods for treating bacterial infections

Family Cites Families (34)

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CZ282567B6 (cs) 1993-12-29 1997-08-13 Pfizer Inc. Diazabicyklické sloučeniny a farmaceutické prostředky na jejich bázi
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2825705B1 (fr) 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
FR2914923B1 (fr) 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
SI2231667T1 (sl) 2008-01-18 2013-12-31 Merck Sharp & Dohme Corp. Beta laktamazni inhibitorji
FR2930553B1 (fr) 2008-04-29 2010-05-21 Novexel Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases
EP3260551A1 (en) 2008-06-19 2017-12-27 Astra Zeneca Holding France Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1] octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases
FR2936798B1 (fr) 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2936951B1 (fr) 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2951171A1 (fr) 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
RU2560846C1 (ru) 2011-07-26 2015-08-20 Вокхардт Лимитед Фармацевтические композиции, содержащие сулбактам и ингибитор бета-лактамазы
EP2768503A1 (en) 2011-07-26 2014-08-27 Wockhardt Limited Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor
KR101512738B1 (ko) 2011-08-27 2015-04-17 욱크하르트 리미티드 1,6-디아자-비시클로[3,2,1]옥탄-7-온 유도체 및 세균 감염 치료에서의 그 유도체의 용도
JP5677634B2 (ja) * 2011-08-30 2015-02-25 ウォックハート リミテッド １，６−ジアザビシクロ［３，２，１］オクタン−７−オン誘導体および細菌感染の処置におけるそれらの使用
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UA117734C2 (uk) 2012-05-30 2018-09-25 Мейдзі Сейка Фарма Ко., Лтд. НОВИЙ ІНГІБІТОР β-ЛАКТАМАЗИ І СПОСІБ ЙОГО ОДЕРЖАННЯ
BR112015003592B1 (pt) 2012-08-25 2020-04-14 Wockhardt Ltd derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas
US20150258072A1 (en) 2012-09-03 2015-09-17 Wockhardt Limited Antibacterial compositions
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WO2014141132A1 (en) * 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS
SI3221313T1 (sl) 2014-11-17 2019-04-30 Entasis Therapeutics Limited Kombinacijska terapija za zdravljenje okužb z rezistentnimi bakterijami
SMT202200397T1 (it) 2016-09-16 2022-11-18 Entasis Therapeutics Ltd Composti inibitori di beta-lattamasi

Also Published As

Publication number Publication date
IL270380B (en) 2022-06-01
PT3630111T (pt) 2022-03-01
EP3630111B1 (en) 2021-11-24
SI3630111T1 (sl) 2022-05-31
EP3630111A1 (en) 2020-04-08
KR20200005586A (ko) 2020-01-15
MY201377A (en) 2024-02-21
MA48743A (fr) 2020-04-08
AU2018266640A1 (en) 2019-11-07
SG11201909443YA (en) 2019-11-28
ES2907858T3 (es) 2022-04-26
EA201992370A1 (ru) 2020-03-10
EA038393B1 (ru) 2021-08-20
CN110709081B (zh) 2023-09-22
JP7058322B2 (ja) 2022-04-21
HRP20220231T1 (hr) 2022-04-29
SMT202200110T1 (it) 2022-05-12
HUE057592T2 (hu) 2022-05-28
US20200165251A1 (en) 2020-05-28
BR112019023130A2 (pt) 2020-05-26
PH12019502509A1 (en) 2020-07-13
DK3630111T3 (en) 2022-03-14
LT3630111T (lt) 2022-03-10
MX2019013291A (es) 2020-01-15
TWI791018B (zh) 2023-02-01
PL3630111T3 (pl) 2022-05-23
CN110709081A (zh) 2020-01-17
KR102611447B1 (ko) 2023-12-06
AU2018266640B2 (en) 2022-03-03
PE20200333A1 (es) 2020-02-14
JP2020519687A (ja) 2020-07-02
WO2018208769A1 (en) 2018-11-15
TW201843152A (zh) 2018-12-16
CA3059773A1 (en) 2018-11-15
CY1125340T1 (el) 2024-02-16
US11046694B2 (en) 2021-06-29

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