AU2017348434B2 - Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability - Google Patents

Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability Download PDF

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Publication number
AU2017348434B2
AU2017348434B2 AU2017348434A AU2017348434A AU2017348434B2 AU 2017348434 B2 AU2017348434 B2 AU 2017348434B2 AU 2017348434 A AU2017348434 A AU 2017348434A AU 2017348434 A AU2017348434 A AU 2017348434A AU 2017348434 B2 AU2017348434 B2 AU 2017348434B2
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AU
Australia
Prior art keywords
vancomycin
compound
ala
pharmaceutically acceptable
acceptable salt
Prior art date
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Ceased
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AU2017348434A
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English (en)
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AU2017348434A1 (en
Inventor
Dale L. Boger
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Scripps Research Institute
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Scripps Research Institute
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Publication date
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Publication of AU2017348434A1 publication Critical patent/AU2017348434A1/en
Application granted granted Critical
Publication of AU2017348434B2 publication Critical patent/AU2017348434B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2017348434A 2016-10-31 2017-10-31 Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability Ceased AU2017348434B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662415191P 2016-10-31 2016-10-31
US62/415,191 2016-10-31
PCT/US2017/059289 WO2018081797A1 (en) 2016-10-31 2017-10-31 Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Publications (2)

Publication Number Publication Date
AU2017348434A1 AU2017348434A1 (en) 2019-05-16
AU2017348434B2 true AU2017348434B2 (en) 2021-10-07

Family

ID=62024092

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017348434A Ceased AU2017348434B2 (en) 2016-10-31 2017-10-31 Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Country Status (6)

Country Link
US (1) US10934326B2 (https=)
EP (1) EP3532483A4 (https=)
JP (1) JP7104424B2 (https=)
AU (1) AU2017348434B2 (https=)
CA (1) CA3042039C (https=)
WO (1) WO2018081797A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL270685B (en) 2017-05-22 2022-09-01 Insmed Inc Cleavable derivatives of lipoglycopeptide and their uses
EP4139328A4 (en) * 2020-04-20 2024-05-22 The Scripps Research Institute GUANIDINE-MODIFIED C-TERMINAL VANCOMYCIN COMPOUNDS, COMPOSITIONS AND METHODS
CN117069794B (zh) * 2023-06-20 2024-02-13 广州中医药大学(广州中医药研究院) 一种糖肽类抗生素荧光探针化合物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000153A1 (en) * 1996-06-28 1998-01-08 Eli Lilly And Company Amides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2497159A1 (en) 2002-08-30 2004-03-11 K.U. Leuven Research And Development Glycopeptide antibiotic and semisynthetic derivatives thereof and their use as antiviral agents
US8778874B2 (en) 2004-11-29 2014-07-15 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
WO2012129493A1 (en) * 2011-03-24 2012-09-27 Seachaid Pharmaceuticals, Inc. Vancomycin derivatives
US10081655B2 (en) * 2011-11-14 2018-09-25 Jawaharlal Nehru Centre For Advanced Cationic antibacterial composition
CA2954653C (en) * 2014-07-10 2023-01-24 The Scripps Research Institute N-(hydrophobe-substituted)vancosaminyl [.psi.[c(=nh)nh]tpg4]vancomycin and [.psi.[ch2nh]tpg4]vancomycin
WO2018010475A1 (zh) * 2016-07-15 2018-01-18 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000153A1 (en) * 1996-06-28 1998-01-08 Eli Lilly And Company Amides

Also Published As

Publication number Publication date
JP7104424B2 (ja) 2022-07-21
AU2017348434A1 (en) 2019-05-16
EP3532483A4 (en) 2020-09-02
WO2018081797A1 (en) 2018-05-03
EP3532483A1 (en) 2019-09-04
CA3042039C (en) 2023-09-26
US20200071359A1 (en) 2020-03-05
US10934326B2 (en) 2021-03-02
JP2019534289A (ja) 2019-11-28
CA3042039A1 (en) 2018-05-03

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired