JP2013541333A5 - - Google Patents
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- JP2013541333A5 JP2013541333A5 JP2013529096A JP2013529096A JP2013541333A5 JP 2013541333 A5 JP2013541333 A5 JP 2013541333A5 JP 2013529096 A JP2013529096 A JP 2013529096A JP 2013529096 A JP2013529096 A JP 2013529096A JP 2013541333 A5 JP2013541333 A5 JP 2013541333A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- bacteriophage
- protein
- fragment
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241001515965 unidentified phage Species 0.000 claims 35
- 108090000623 proteins and genes Proteins 0.000 claims 30
- 102000004169 proteins and genes Human genes 0.000 claims 30
- 239000012634 fragment Substances 0.000 claims 20
- 241000894006 Bacteria Species 0.000 claims 11
- 241000588626 Acinetobacter baumannii Species 0.000 claims 10
- 241000588724 Escherichia coli Species 0.000 claims 10
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 230000000844 anti-bacterial effect Effects 0.000 claims 9
- 230000000845 anti-microbial effect Effects 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
- 241000191967 Staphylococcus aureus Species 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 208000015181 infectious disease Diseases 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000000069 prophylactic effect Effects 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 101000870242 Bacillus phage Nf Tail knob protein gp9 Proteins 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000009089 cytolysis Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000004400 mucous membrane Anatomy 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 206010011409 Cross infection Diseases 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 206010023424 Kidney infection Diseases 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 208000032376 Lung infection Diseases 0.000 claims 1
- 206010029803 Nosocomial infection Diseases 0.000 claims 1
- 206010037596 Pyelonephritis Diseases 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 231100000676 disease causative agent Toxicity 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38401510P | 2010-09-17 | 2010-09-17 | |
| US61/384,015 | 2010-09-17 | ||
| PCT/PT2011/000031 WO2012036580A2 (en) | 2010-09-17 | 2011-09-19 | Antibacterial phage, phage peptides and methods of use thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015243657A Division JP6234983B2 (ja) | 2010-09-17 | 2015-12-14 | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
| JP2016181177A Division JP6355691B2 (ja) | 2010-09-17 | 2016-09-16 | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541333A JP2013541333A (ja) | 2013-11-14 |
| JP2013541333A5 true JP2013541333A5 (https=) | 2015-04-16 |
| JP6058540B2 JP6058540B2 (ja) | 2017-01-11 |
Family
ID=45755483
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013529096A Active JP6058540B2 (ja) | 2010-09-17 | 2011-09-19 | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
| JP2015243657A Active JP6234983B2 (ja) | 2010-09-17 | 2015-12-14 | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
| JP2016181177A Active JP6355691B2 (ja) | 2010-09-17 | 2016-09-16 | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015243657A Active JP6234983B2 (ja) | 2010-09-17 | 2015-12-14 | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
| JP2016181177A Active JP6355691B2 (ja) | 2010-09-17 | 2016-09-16 | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9222077B2 (https=) |
| EP (4) | EP4332217A3 (https=) |
| JP (3) | JP6058540B2 (https=) |
| CN (1) | CN103732235B (https=) |
| AU (3) | AU2011302722B2 (https=) |
| BR (1) | BR112013006400B1 (https=) |
| CA (3) | CA3154006C (https=) |
| ES (3) | ES2825050T3 (https=) |
| PL (1) | PL3789031T3 (https=) |
| PT (2) | PT2616087T (https=) |
| RU (2) | RU2614114C2 (https=) |
| SG (1) | SG188566A1 (https=) |
| WO (1) | WO2012036580A2 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG188566A1 (en) * | 2010-09-17 | 2013-04-30 | Tecnifar Ind Tecnica Farmaceutica S A | Antibacterial phage, phage peptides and methods of use thereof |
| DK2833899T3 (da) * | 2012-03-19 | 2020-09-28 | Tecnifar Ind Tecnica Farmaceutica S A | Sammensætninger, der omfatter cocktails af antibakterielle fager, og anvendelser deraf til behandling af bakterieinfektioner |
| DK2847323T3 (en) * | 2012-05-07 | 2018-08-20 | Micreos B V | Bacteriophage for biological control of Salmonella and in the preparation or processing of food |
| EP2799063A1 (en) * | 2013-04-30 | 2014-11-05 | Ferring B.V. | Bacteriophage therapy |
| EP2865383A1 (en) * | 2013-10-25 | 2015-04-29 | Pherecydes Pharma | Phage therapy of pseudomonas infections |
| EP2893933A1 (en) * | 2014-01-10 | 2015-07-15 | Pherecydes Pharma | Phage Therapy of E coli infections |
| CN103981154B (zh) * | 2014-05-28 | 2016-07-06 | 大连理工大学 | 一种铜绿假单胞菌噬菌体及其在水貂出血性肺炎预防中的应用 |
| AU2015279705B2 (en) | 2014-06-26 | 2021-04-01 | The Rockefeller University | Acinetobacter lysins |
| EP3018201A1 (en) * | 2014-11-07 | 2016-05-11 | Pherecydes Pharma | Phage therapy |
| CN113215115B (zh) | 2014-12-16 | 2024-07-02 | C3J治疗公司 | 用于体外病毒基因组工程的组合物和方法 |
| AU2016324307B2 (en) * | 2015-09-17 | 2021-10-21 | Contrafect Corporation | Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby |
| AU2017241670B2 (en) * | 2016-03-28 | 2020-10-08 | Illumina, Inc. | Recombinase mutants |
| US11672839B2 (en) | 2016-12-05 | 2023-06-13 | Technechnophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Bacteriophage compositions comprising respiratory antibacterial phages and methods of use thereof |
| WO2018151417A1 (ko) * | 2017-02-17 | 2018-08-23 | 주식회사 인트론바이오테크놀로지 | 신규한 녹농균 박테리오파지 Pse-AEP-4 및 이의 녹농균 증식 억제 용도 |
| GB201712145D0 (en) * | 2017-07-28 | 2017-09-13 | Univ Leuven Kath | Novel dnase |
| US11958890B2 (en) | 2018-05-30 | 2024-04-16 | Lysando Ag | Antimicrobial proteins |
| WO2020130652A2 (ko) * | 2018-12-18 | 2020-06-25 | 연세대학교 산학협력단 | 세균을 용균하는 신규한 박테리오파지 |
| WO2020139279A2 (en) * | 2018-12-24 | 2020-07-02 | Mikroliz Biyoteknoloji San. Ve Tic. Ltd. Sti. | Acinetobacter baumannii bacteriophage mikab48 or lytic protein derived from the bacteriophage |
| WO2020254967A1 (en) * | 2019-06-17 | 2020-12-24 | Phagelux Canada Inc. | Bacterial control through dispersion of bacteriophage powders |
| RU2717420C1 (ru) * | 2019-06-28 | 2020-03-23 | Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" | Штамм бактериофага Pseudomonas aeruginosa N 327 (500321), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов |
| RU2717973C1 (ru) * | 2019-06-28 | 2020-03-27 | Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" | Штамм бактериофага Pseudomonas aeruginosa N 322 (500316), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов |
| RU2717972C1 (ru) * | 2019-06-28 | 2020-03-27 | Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" | Штамм бактериофага Pseudomonas aeruginosa N 324 (500318), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов |
| RU2717022C1 (ru) * | 2019-06-28 | 2020-03-17 | Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" | Штамм бактериофага Pseudomonas aeruginosa N 328 (500322), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов |
| RU2717435C1 (ru) * | 2019-06-28 | 2020-03-23 | Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" | Штамм бактериофага Pseudomonas aeruginosa N 326 (500320), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов |
| RU2717451C1 (ru) * | 2019-06-28 | 2020-03-23 | Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" | Штамм бактериофага Pseudomonas aeruginosa N 323 (500317), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов |
| RU2717026C1 (ru) * | 2019-06-28 | 2020-03-17 | Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" | Штамм бактериофага Pseudomonas aeruginosa N 325 (500319), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов |
| RU2707505C1 (ru) * | 2019-09-17 | 2019-11-27 | федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО "ПИМУ" Минздрава России) | Способ лечения бактериальных инфекций дыхательных путей |
| US20210187046A1 (en) | 2019-12-19 | 2021-06-24 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Cocktail compositions comprising respiratory antibacterial phages and methods of use thereof |
| CN113214364B (zh) * | 2020-01-21 | 2022-11-22 | 天津大学 | 一种多重耐药鲍曼不动杆菌识别元件的挖掘与验证 |
| FR3110574A1 (fr) * | 2020-05-20 | 2021-11-26 | Vetophage | Capture de bacteries a l’aide de bacteriophages ou de proteines de bacteriophage |
| WO2021235876A1 (ko) | 2020-05-22 | 2021-11-25 | 주식회사 라이센텍 | 신규한 폴리펩타이드, 융합 폴리펩타이드, 및 이를 포함하는 그람음성균에 대한 항생제 |
| WO2022040592A1 (en) * | 2020-08-20 | 2022-02-24 | The Board Of Regents Of The University Of Texas System | Combination immunotherapy methods for the treatment of cancer |
| EP4337764A1 (en) * | 2021-05-12 | 2024-03-20 | Biomx Ltd. | Staphylococcus bacteriophage and uses thereof |
| TR2021018752A2 (tr) * | 2021-11-30 | 2023-06-21 | Yildiz Teknoloji Gelistirme Boelgesi Teknopark Anonim Sirketi | S. aureus lizisine yönelik antimikrobiyal ajan. |
| CN114807106B (zh) * | 2022-04-25 | 2023-09-01 | 昆明市延安医院 | 一种裂解酶pEf51和穿孔素蛋白pEf191的应用 |
| WO2024182314A2 (en) * | 2023-02-27 | 2024-09-06 | The Regents Of The University Of California | Proteins that inhibit cyclic-oligonucleotide-based anti-phage signaling system (cbass) |
| US20250160335A1 (en) * | 2023-11-16 | 2025-05-22 | The United States Of America, As Represented By The Secretary Of Agriculture | Formulation of a lytic bacteriophage cocktail for biocontrol of shiga toxin-producing escherichia coli strains |
| WO2025262649A1 (en) * | 2024-06-21 | 2025-12-26 | Technophage | Compositions comprising antibacterial bacteriophages and methods of use thereof |
| CN119139561A (zh) * | 2024-11-15 | 2024-12-17 | 浙江大学 | 一种噬菌体复合水凝胶及其制备方法和在促进牙槽骨修复中的应用 |
| CN119639692B (zh) * | 2025-01-23 | 2026-01-30 | 兆维生物科技私人投资有限公司 | T4rna连接酶2突变体及其制备方法和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| DK0575908T3 (da) * | 1992-06-25 | 2000-07-24 | Aventis Res & Tech Gmbh & Co | Pseudomonas aeroginosa og dens anvendelse til fremstilling af L-rhamnose |
| WO1995027043A1 (en) | 1994-04-05 | 1995-10-12 | Exponential Biotherapies, Inc. | Antibacterial therapy with genotypically modified bacteriophage |
| RU2112800C1 (ru) * | 1996-03-29 | 1998-06-10 | Государственный научный центр прикладной микробиологии | Штамм пилеспецифического бактериофага pseudomonas aeruginosa гнцпм n 03, используемый для приготовления лечебного препарата против синегнойной палочки |
| CA2251724A1 (en) | 1996-04-15 | 1997-10-23 | Paul Averback | Compositions containing bacteriophages and methods of using bacteriophages to treat infections |
| US5863560A (en) | 1996-09-11 | 1999-01-26 | Virotex Corporation | Compositions and methods for topical application of therapeutic agents |
| US7138419B2 (en) * | 2000-12-27 | 2006-11-21 | Corus Pharma, Inc. | Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate |
| DE10115310A1 (de) | 2001-03-28 | 2002-10-10 | Nodar A Daniela | Bakteriophagen-Präparation |
| DE60315636T2 (de) * | 2002-03-25 | 2008-05-08 | University Of Warwick, Coventry | Zur therapie und prophylaxe bakterieller infektionen geeignete bakteriophagen |
| GB0300597D0 (en) * | 2003-01-10 | 2003-02-12 | Microbiological Res Authority | Phage biofilms |
| US20050095222A1 (en) | 2003-10-29 | 2005-05-05 | Taro Suzuki | Allergen inhibitor, allergen-inhibiting method, allergen-inhibiting fiber and allergen-inhibiting sheet |
| EP1812025B1 (en) | 2004-11-02 | 2012-09-05 | Chr. Hansen A/S | Stabilized bacteriophage formulations |
| AU2005301048A1 (en) | 2004-11-02 | 2006-05-11 | Chr. Hansen A/S | Bacteriophage compositions |
| US20090191254A1 (en) | 2004-12-06 | 2009-07-30 | The Govt. Of The U.S.A., Centers For Disease Control And Prevention | Inhibition of biofilm formation using bacteriophage |
| EP1888088A4 (en) | 2005-05-26 | 2012-07-04 | Chr Hansen As | BACTERIAL REGULATION IN ANIMAL CONTAINMENT SYSTEMS |
| DK2037946T3 (en) * | 2006-05-05 | 2015-04-27 | Gangagen Inc | ANTIMICROBIAL ACTIVITIES DERIVED BY PHAGER |
| IE20060488A1 (en) * | 2006-06-29 | 2008-01-09 | Teagasc Agric Food Dev Authori | Recombinant staphylococcal phage lysin as an antibacterial agent |
| CN101003793A (zh) * | 2007-01-11 | 2007-07-25 | 中国人民解放军第三军医大学 | 噬菌体对环境中致病菌的净化技术 |
| WO2008121830A2 (en) | 2007-03-30 | 2008-10-09 | National Research Council Of Canada | Phage receptor binding proteins for antibacterial therapy and other novel uses |
| EP2103308A1 (de) * | 2008-03-20 | 2009-09-23 | PhytoLine GmbH | Verfahren zur Herstellung eines Gemisches von Bakteriophagen und deren Verwendung für die Therapie von Antibiotika-resistenten Staphylococcen |
| CA2638130A1 (en) * | 2008-07-21 | 2010-01-21 | Canadian Forest Products Ltd. | Composite wood product and method of manufacture utilizing wood infected by bark beetles |
| CA2736062A1 (en) * | 2008-07-24 | 2010-01-28 | The United State Of America, As Represented By The Secretary Of Agricuure | Triple acting antimicrobials that are refractory to resistance development |
| GB0815484D0 (en) * | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| CA2739717A1 (en) * | 2008-10-10 | 2010-04-15 | Lusomedicamenta, S.A. | Antibacterial phage peptides and methods of use thereof |
| KR101016918B1 (ko) * | 2009-01-08 | 2011-02-25 | 주식회사 인트론바이오테크놀로지 | 박테리아 특이적 넓은 항균 활성을 갖는 신규한 리신 단백질 |
| JP5701777B2 (ja) * | 2009-02-06 | 2015-04-15 | テクノファージ， インベスティガサン エ デセンボルビメント エム ビオテクノロジア，エスエー | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
| KR101701890B1 (ko) | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| SG188566A1 (en) * | 2010-09-17 | 2013-04-30 | Tecnifar Ind Tecnica Farmaceutica S A | Antibacterial phage, phage peptides and methods of use thereof |
| CN103635584B (zh) * | 2011-04-12 | 2017-10-27 | 冈戈根股份有限公司 | 嵌合抗菌多肽 |
-
2011
- 2011-09-19 SG SG2013019385A patent/SG188566A1/en unknown
- 2011-09-19 CA CA3154006A patent/CA3154006C/en active Active
- 2011-09-19 ES ES18192766T patent/ES2825050T3/es active Active
- 2011-09-19 JP JP2013529096A patent/JP6058540B2/ja active Active
- 2011-09-19 PT PT11820825T patent/PT2616087T/pt unknown
- 2011-09-19 EP EP23178561.9A patent/EP4332217A3/en active Pending
- 2011-09-19 EP EP18192766.6A patent/EP3443970B1/en active Active
- 2011-09-19 ES ES20194660T patent/ES2956367T3/es active Active
- 2011-09-19 US US13/823,519 patent/US9222077B2/en active Active
- 2011-09-19 CN CN201180054190.XA patent/CN103732235B/zh active Active
- 2011-09-19 RU RU2013117275A patent/RU2614114C2/ru active
- 2011-09-19 EP EP20194660.5A patent/EP3789031B1/en active Active
- 2011-09-19 EP EP11820825.5A patent/EP2616087B1/en active Active
- 2011-09-19 PT PT181927666T patent/PT3443970T/pt unknown
- 2011-09-19 AU AU2011302722A patent/AU2011302722B2/en active Active
- 2011-09-19 PL PL20194660.5T patent/PL3789031T3/pl unknown
- 2011-09-19 RU RU2017106290A patent/RU2725726C2/ru active
- 2011-09-19 CA CA2811472A patent/CA2811472C/en active Active
- 2011-09-19 BR BR112013006400-5A patent/BR112013006400B1/pt active IP Right Grant
- 2011-09-19 CA CA3048783A patent/CA3048783C/en active Active
- 2011-09-19 WO PCT/PT2011/000031 patent/WO2012036580A2/en not_active Ceased
- 2011-09-19 ES ES11820825T patent/ES2703629T3/es active Active
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2015
- 2015-11-13 AU AU2015255313A patent/AU2015255313C1/en active Active
- 2015-11-17 US US14/943,082 patent/US9399049B2/en active Active
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