JP2018172439A5 - - Google Patents

Download PDF

Info

Publication number
JP2018172439A5
JP2018172439A5 JP2018140050A JP2018140050A JP2018172439A5 JP 2018172439 A5 JP2018172439 A5 JP 2018172439A5 JP 2018140050 A JP2018140050 A JP 2018140050A JP 2018140050 A JP2018140050 A JP 2018140050A JP 2018172439 A5 JP2018172439 A5 JP 2018172439A5
Authority
JP
Japan
Prior art keywords
molecule
amino acid
seq
acid sequence
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018140050A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018172439A (ja
JP7212468B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2018172439A publication Critical patent/JP2018172439A/ja
Publication of JP2018172439A5 publication Critical patent/JP2018172439A5/ja
Priority to JP2021094042A priority Critical patent/JP2021143189A/ja
Application granted granted Critical
Publication of JP7212468B2 publication Critical patent/JP7212468B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018140050A 2010-03-05 2018-07-26 標的免疫調節抗体および融合タンパク質に基づく組成物および方法 Active JP7212468B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021094042A JP2021143189A (ja) 2010-03-05 2021-06-04 標的免疫調節抗体および融合タンパク質に基づく組成物および方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31125510P 2010-03-05 2010-03-05
US61/311,255 2010-03-05
US201161435671P 2011-01-24 2011-01-24
US61/435,671 2011-01-24

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2016145162A Division JP6378262B2 (ja) 2010-03-05 2016-07-25 標的免疫調節抗体および融合タンパク質に基づく組成物および方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021094042A Division JP2021143189A (ja) 2010-03-05 2021-06-04 標的免疫調節抗体および融合タンパク質に基づく組成物および方法

Publications (3)

Publication Number Publication Date
JP2018172439A JP2018172439A (ja) 2018-11-08
JP2018172439A5 true JP2018172439A5 (OSRAM) 2018-12-20
JP7212468B2 JP7212468B2 (ja) 2023-01-25

Family

ID=44542873

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012556279A Active JP6066732B2 (ja) 2010-03-05 2011-03-04 標的免疫調節抗体および融合タンパク質に基づく組成物および方法
JP2016145162A Active JP6378262B2 (ja) 2010-03-05 2016-07-25 標的免疫調節抗体および融合タンパク質に基づく組成物および方法
JP2018140050A Active JP7212468B2 (ja) 2010-03-05 2018-07-26 標的免疫調節抗体および融合タンパク質に基づく組成物および方法
JP2021094042A Pending JP2021143189A (ja) 2010-03-05 2021-06-04 標的免疫調節抗体および融合タンパク質に基づく組成物および方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2012556279A Active JP6066732B2 (ja) 2010-03-05 2011-03-04 標的免疫調節抗体および融合タンパク質に基づく組成物および方法
JP2016145162A Active JP6378262B2 (ja) 2010-03-05 2016-07-25 標的免疫調節抗体および融合タンパク質に基づく組成物および方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021094042A Pending JP2021143189A (ja) 2010-03-05 2021-06-04 標的免疫調節抗体および融合タンパク質に基づく組成物および方法

Country Status (10)

Country Link
US (7) US8993524B2 (OSRAM)
EP (3) EP3798237A1 (OSRAM)
JP (4) JP6066732B2 (OSRAM)
CA (3) CA3083324A1 (OSRAM)
DK (1) DK2542590T4 (OSRAM)
ES (1) ES2638521T5 (OSRAM)
IL (5) IL323000A (OSRAM)
PL (1) PL2542590T5 (OSRAM)
PT (1) PT2542590T (OSRAM)
WO (1) WO2011109789A2 (OSRAM)

Families Citing this family (251)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
AU2007237096C1 (en) 2006-04-07 2012-12-13 EyePoint Pharmaceuticals, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
AU2009223838B2 (en) 2008-03-03 2012-07-26 The University Of Miami Allogeneic cancer cell-based immunotherapy
US8217149B2 (en) 2008-12-09 2012-07-10 Genentech, Inc. Anti-PD-L1 antibodies, compositions and articles of manufacture
SG178991A1 (en) 2009-09-03 2012-04-27 Schering Corp Anti-gitr antibodies
JP2013512251A (ja) * 2009-11-24 2013-04-11 アンプリミューン、インコーポレーテッド Pd−l1/pd−l2の同時阻害
PL2542590T5 (pl) 2010-03-05 2020-08-10 The Johns Hopkins University Kompozycje i sposoby dla ukierunkowanych immunomodulatorowych przeciwciał i białek fuzyjnych
DK2663579T3 (en) 2011-01-14 2017-07-31 Univ California THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF
EP2686020B1 (en) 2011-03-17 2017-02-22 The University of Birmingham Re-directed immunotherapy
CA2831820C (en) * 2011-04-01 2021-05-25 Universitat Stuttgart Recombinant tnf ligand family member polypeptides with antibody binding domain and uses thereof
SG185920A1 (en) 2011-05-27 2012-12-28 Abbott Biotherapeutics Corp Dac hyp compositions and methods
US20130095065A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for Treating Vascular Leak Syndrome and Cancer
BR112014009526B8 (pt) 2011-10-17 2023-01-17 Herlev Hospital Composição de vacina compreendendo pd-l1, kit de partes compreendendo tal composição e uso dos mesmos para tratar ou prevenir câncer
JP6602012B2 (ja) * 2012-02-10 2019-11-06 シアトル ジェネティクス インコーポレーテッド Cd30+癌の検出と治療
PE20150605A1 (es) 2012-04-27 2015-05-28 Cytomx Therapeutics Inc Anticuerpos activables que se unen al receptor del factor de crecimiento epidermico
NZ701821A (en) * 2012-04-30 2016-06-24 Biocon Ltd Targeted/immunomodulatory fusion proteins and methods for making same
CA2889298C (en) * 2012-11-30 2024-01-02 Anton Belousov Identification of patients in need of pd-l1 inhibitor cotherapy
WO2014121085A1 (en) * 2013-01-31 2014-08-07 Thomas Jefferson University Pd-l1 and pd-l2-based fusion proteins and uses thereof
WO2014121099A1 (en) 2013-01-31 2014-08-07 Thomas Jefferson University Agonist fusion protein for cd40 ox40 and uses thereof
US9834610B2 (en) 2013-01-31 2017-12-05 Thomas Jefferson University Fusion proteins for modulating regulatory and effector T cells
WO2015116178A1 (en) * 2014-01-31 2015-08-06 Thomas Jefferson University Fusion proteins for modulating regulatory and effector t cells
ES2885423T3 (es) 2013-02-07 2021-12-13 Massachusetts Gen Hospital Procedimientos para la expansión o el empobrecimiento de células T reguladoras
US9988456B2 (en) 2013-03-12 2018-06-05 Biocon Limited Fusion immunomodulatory proteins and methods for making same
NZ711567A (en) 2013-03-13 2020-04-24 Genentech Inc Antibody formulations
WO2014168715A1 (en) * 2013-04-08 2014-10-16 R-Pharm Overseas, Inc. B7 ligands/cd20 inhibitor composition and use thereof
CA2908198A1 (en) 2013-04-18 2014-10-23 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
BR112016001611B1 (pt) 2013-07-25 2024-01-09 Cytomx Therapeutics, Inc Anticorpo ativável multiespecífico, uso terapêutico do mesmo, molécula de ácido nucleico isolada, vetor e método para produzir um anticorpo ativável multiespecífico
HK1225740A1 (zh) 2013-08-22 2017-09-15 Acceleron Pharma Inc. TGF-β受体II型变体及其用途
US9540440B2 (en) 2013-10-30 2017-01-10 Cytomx Therapeutics, Inc. Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
RU2016122957A (ru) * 2013-11-11 2017-12-19 Армо Байосайенсиз, Инк. Способы применения интерлейкина-10 для лечения заболеваний и расстройств
WO2015089283A1 (en) 2013-12-11 2015-06-18 Cytomx Therapeutics, Inc. Antibodies that bind activatable antibodies and methods of use thereof
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
US11213583B2 (en) * 2014-02-05 2022-01-04 Cedars-Sinai Medical Center Methods and compositions for treating cancer and infectious diseases
SG10202108879SA (en) * 2014-02-10 2021-09-29 Merck Patent Gmbh TARGETED TGFβ INHIBITION
US20170165364A1 (en) * 2014-02-21 2017-06-15 Idac Theranostics, Inc. Therapeutic agent for solid cancer
US10532088B2 (en) 2014-02-27 2020-01-14 Lycera Corporation Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods
CA2936962C (en) 2014-03-14 2024-03-05 Novartis Ag Antibody molecules to lag-3 and uses thereof
US20150307620A1 (en) * 2014-04-16 2015-10-29 University Of Connecticut Linked immunotherapeutic agonists that costimulate multiple pathways
US9896441B2 (en) 2014-05-05 2018-02-20 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
EP3209641A4 (en) 2014-05-05 2018-06-06 Lycera Corporation Benzenesulfonamido and related compounds for use as agonists of ror and the treatement of disease
CN103965364B (zh) * 2014-05-19 2016-06-08 亚飞(上海)生物医药科技有限公司 一种人源pdl2hsa系列融合蛋白及其制备与应用
WO2015178746A1 (ko) * 2014-05-23 2015-11-26 주식회사 제넥신 Pd-l1 융합 단백질 및 이의 용도
SG10201912986PA (en) 2014-05-28 2020-02-27 Agenus Inc Anti-gitr antibodies and methods of use thereof
CA2951234C (en) 2014-06-06 2022-05-31 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
US11168137B2 (en) 2014-06-11 2021-11-09 Idac Theranostics, Inc. Method for reducing side effects of immune checkpoint control agent
KR102493543B1 (ko) * 2014-07-21 2023-01-30 데리니아, 인크. 자가면역 질환의 치료를 위한 조절 t 세포를 선택적으로 활성화시키는 분자
CA2955947A1 (en) 2014-07-25 2016-01-28 Cytomx Therapeutics, Inc. Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
PL3482766T3 (pl) 2014-08-11 2020-11-16 Delinia, Inc. Modyfikowane warianty il-2, które selektywnie aktywują limfocyty t regulatorowe do leczenia chorób autoimmunologicznych
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
EP3193932B1 (en) 2014-09-15 2023-04-26 F. Hoffmann-La Roche AG Antibody formulations
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
TWI757803B (zh) 2014-11-14 2022-03-11 瑞士商赫孚孟拉羅股份公司 包含tnf家族配位三聚體之抗原結合分子
WO2016118577A1 (en) * 2015-01-22 2016-07-28 Medimmune, Llc Thymosin-beta-four fusion proteins
MA41460A (fr) 2015-02-03 2017-12-12 Oncomed Pharm Inc Agents de liaison à la tnfrsf et leurs utilisations
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
IL284985B2 (en) 2015-02-18 2023-03-01 Enlivex Therapeutics R& D Ltd Combined immunotherapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
BR112017018224A2 (pt) * 2015-03-11 2018-04-17 Cellectis métodos para manipulação de célula t alogênica para aumentar sua persistência e/ou implante em pacientes
JP6826055B2 (ja) 2015-03-13 2021-02-03 サイトメックス セラピューティクス インコーポレイテッド 抗pdl1抗体、活性化可能抗pdl1抗体、およびその使用方法
EP3277305B1 (en) 2015-03-31 2021-07-21 F. Hoffmann-La Roche AG Antigen binding molecules comprising a trimeric tnf family ligand
EP3281010B1 (en) 2015-04-10 2020-12-30 The Regents of The University of California Methods of determining patient populations amenable to immunomodulatory treatment of cancer
PT3283508T (pt) 2015-04-17 2021-06-21 Alpine Immune Sciences Inc Proteínas imuno modulatórias com afinidades afináveis
CA2982452A1 (en) 2015-04-21 2016-10-27 Enlivex Therapeutics Ltd. Therapeutic pooled blood apoptotic cell preparations and uses thereof
AU2016258977C1 (en) * 2015-05-04 2022-07-14 Pieris Pharmaceuticals Gmbh Anti-cancer fusion polypeptide
JP2018515491A (ja) 2015-05-05 2018-06-14 リセラ・コーポレイションLycera Corporation RORγの作動薬及び疾患の療法として使用するジヒドロ−2H−ベンゾ[b][1,4]オキサジンスルホンアミド及び関連化合物
CN115109158A (zh) 2015-05-07 2022-09-27 阿吉纳斯公司 抗ox40抗体及其使用方法
CN107849142B (zh) 2015-05-15 2022-04-26 综合医院公司 拮抗性抗肿瘤坏死因子受体超家族抗体
US10690674B2 (en) 2015-06-03 2020-06-23 Bristol-Myers Squibb Company Anti-GITR antibodies for cancer diagnostics
JP6838004B2 (ja) 2015-06-11 2021-03-03 リセラ・コーポレイションLycera Corporation RORγのアゴニストとしての使用及び疾患の治療のためのアリールジヒドロ−2H−ベンゾ[b][1,4]オキサジンスルホンアミド及び関連化合物
US10513558B2 (en) 2015-07-13 2019-12-24 Cytomx Therapeutics, Inc. Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of use thereof
CN111375066B (zh) 2015-07-16 2023-04-25 百欧肯治疗有限公司 治疗癌症的组合物及方法
MA42459A (fr) 2015-07-16 2018-05-23 Bioxcel Therapeutics Inc Nouvelle approche pour le traitement du cancer par immunomodulation
WO2017019729A1 (en) 2015-07-27 2017-02-02 The General Hospital Corporation Antibody derivatives with conditionally enabled effector function
EP3331550B1 (en) 2015-08-04 2022-11-02 Acceleron Pharma Inc. Composition for treating myeloproliferative disorders
KR20180038553A (ko) 2015-08-25 2018-04-16 아르모 바이오사이언시스 인코포레이티드 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법
US20190135929A1 (en) 2015-08-28 2019-05-09 The General Hospital Corporation Agonistic anti-tumor necrosis factor receptor 2 antibodies
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
WO2017037634A1 (en) * 2015-08-31 2017-03-09 National Research Council Of Canada Tgf-β-receptor ectodomain fusion molecules and uses thereof
US20180251548A1 (en) * 2015-09-14 2018-09-06 Compass Therapeutics Llc Compositions and methods for treating cancer via antagonism of the cd155/tigit pathway and tgf-beta
RU2766200C1 (ru) 2015-10-01 2022-02-09 Хит Байолоджикс, Инк. Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
RS62258B1 (sr) 2015-10-02 2021-09-30 Hoffmann La Roche Bispecifična antitela specifična za pd1 i tim3
KR20180053674A (ko) 2015-10-02 2018-05-23 에프. 호프만-라 로슈 아게 공자극 tnf 수용체에 특이적인 이중특이성 항체
US20170107510A1 (en) * 2015-10-14 2017-04-20 Batu Biologics, Inc. Dna nanoparticle based checkpoint inhibitors
MX2018005315A (es) * 2015-10-30 2018-08-14 Aleta Biotherapeutics Inc Composiciones y metodos para el tratamiento del cancer.
AU2016343805A1 (en) 2015-10-30 2018-06-07 Aleta Biotherapeutics Inc. Compositions and methods for tumor transduction
US11219645B2 (en) 2015-11-18 2022-01-11 Duke University Tumor infiltrating lymphocytes for treatment of cancer
AU2016356780A1 (en) 2015-11-19 2018-06-28 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
IL299072A (en) 2015-12-02 2023-02-01 Memorial Sloan Kettering Cancer Center Antibodies and methods of use thereof
BR112018012352A2 (pt) 2015-12-16 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-lag3 e fragmentos de ligação ao antígeno
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
WO2017129537A1 (en) * 2016-01-25 2017-08-03 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer by measuring the level of a plasma biomarker
WO2017134592A1 (en) * 2016-02-03 2017-08-10 Biocon Limited Anti-cd20/immunomodulatory fusion proteins and methods for making same
US11730761B2 (en) 2016-02-18 2023-08-22 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
EP3231813A1 (en) 2016-03-29 2017-10-18 F. Hoffmann-La Roche AG Trimeric costimulatory tnf family ligand-containing antigen binding molecules
EP3455262A4 (en) * 2016-05-13 2020-04-08 The General Hospital Corporation ANTAGONIST ANTIBODIES OF THE NECROSIS FACTOR RECEPTOR SUPERFAMILY AGAINST TUMORS
WO2017200796A1 (en) 2016-05-17 2017-11-23 Albert Einstein College Of Medicine, Inc. Engineered pd-1 variants
AU2017268469C1 (en) * 2016-05-20 2025-01-02 President And Fellows Of Harvard College Gene therapy methods for age-related diseases and conditions
KR20230091191A (ko) 2016-05-27 2023-06-22 아게누스 인코포레이티드 항-tim-3 항체 및 이의 사용 방법
US20200339659A1 (en) 2016-06-21 2020-10-29 Io Biotech Aps Pdl1 peptides for use in cancer vaccines
CA3029902A1 (en) 2016-07-07 2018-01-11 The Board Of Trustees Of The Leland Stanford Junior University Antibody adjuvant conjugates
CN118307682A (zh) * 2016-09-27 2024-07-09 埃皮辛特瑞柯斯公司 免疫调节性融合蛋白
BR112019007369A2 (pt) 2016-10-11 2019-07-16 Agenus Inc anticorpos anti-lag-3 e métodos de uso dos mesmos
WO2018071837A1 (en) * 2016-10-14 2018-04-19 Baylor College Of Medicine Radiofrequency field hyperthermia and solid tumor immunomodulation
US20190256573A1 (en) * 2016-10-14 2019-08-22 Emory University Nanoparticles Having Molecules That Bind or Block PD-L1 and Uses In Treating Cancer
EA201991142A1 (ru) 2016-11-08 2019-10-31 Варианты il-2 для лечения аутоиммунных заболеваний
WO2018089628A1 (en) 2016-11-09 2018-05-17 Agenus Inc. Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
CA3082255A1 (en) 2016-11-23 2020-06-10 Translational Drug Development, Llc Benzamide and active compound compositions and methods of use
US11230596B2 (en) 2016-11-30 2022-01-25 Mereo Biopharma 5, Inc. Methods for treatment of cancer comprising TIGIT-binding agents
MA46963A (fr) 2016-12-03 2019-10-09 Juno Therapeutics Inc Méthodes pour déterminer le dosage de céllules car-t
US20190350978A1 (en) 2016-12-05 2019-11-21 Juno Therapeutics, Inc. Production of engineered cells for adoptive cell therapy
AU2018205888B2 (en) 2017-01-05 2021-09-02 Kahr Medical Ltd. A PD1-41BBL fusion protein and methods of use thereof
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
US11299530B2 (en) 2017-01-05 2022-04-12 Kahr Medical Ltd. SIRP alpha-CD70 fusion protein and methods of use thereof
SI3565828T1 (sl) 2017-01-05 2022-04-29 Kahr Medical Ltd. SIRP1 alfa-41BBL fuzijski protein in postopki za njegovo uporabo
AU2018205233A1 (en) * 2017-01-07 2019-07-11 Merck Patent Gmbh Dosing regimens and dosage forms for targeted TGFβ inhibition
TWI787230B (zh) 2017-01-20 2022-12-21 法商賽諾菲公司 抗TGF-β抗體及其用途
TW202421659A (zh) 2017-01-20 2024-06-01 美商健臻公司 骨靶向抗體
CA3051696A1 (en) * 2017-02-01 2018-08-09 Acceleron Pharma Inc. Tgf.beta. and actrii antagonists for use in increasing immune activity
IL268346B2 (en) 2017-02-06 2024-08-01 Orionis Biosciences BV Targeted chimeric proteins and uses thereof
KR102745835B1 (ko) 2017-02-27 2024-12-24 샤턱 랩스 인코포레이티드 Tigit- 및 light-기반 키메라 단백질
CN118184797A (zh) 2017-02-27 2024-06-14 沙塔克实验室有限公司 基于vsig8的嵌合蛋白
CA3054132A1 (en) 2017-02-27 2018-08-30 Shattuck Labs, Inc. Csf1r-based chimeric proteins
CN118255902A (zh) 2017-03-02 2024-06-28 加拿大国家研究委员会 TGF-β受体胞外域融合分子及其用途
WO2018167780A1 (en) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of prognosing and treating cancer
EP3596469A1 (en) 2017-03-12 2020-01-22 Yeda Research and Development Co., Ltd. Methods of diagnosing and prognosing cancer
BR112019019973A2 (pt) * 2017-03-24 2020-04-28 Orpheus Bioscience Inc pantlds para tratamento de transtornos autoimunes
CN107082812B (zh) * 2017-03-29 2018-11-13 上海科医联创生物科技有限公司 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用
JP7426825B2 (ja) 2017-04-03 2024-02-02 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 抗pd-1抗体と突然変異il-2とまたはil-15とのイムノコンジュゲート
US11285207B2 (en) 2017-04-05 2022-03-29 Hoffmann-La Roche Inc. Bispecific antibodies specifically binding to PD1 and LAG3
JP2020517256A (ja) 2017-04-19 2020-06-18 エルスター セラピューティクス, インコーポレイテッド 多重特異性分子およびその使用
US11643473B2 (en) 2017-04-24 2023-05-09 Alexion Pharmaceuticals, Inc. Antibody immune cell inhibitor fusion proteins
EP3618863B1 (en) 2017-05-01 2023-07-26 Agenus Inc. Anti-tigit antibodies and methods of use thereof
EP4241848A3 (en) 2017-05-04 2023-11-01 Acceleron Pharma Inc. Tgf-beta receptor type ii fusion proteins and uses thereof
WO2018205985A1 (zh) 2017-05-12 2018-11-15 江苏恒瑞医药股份有限公司 含有TGF-β受体的融合蛋白及其医药用途
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
JP7356354B2 (ja) 2017-05-12 2023-10-04 クリスパー セラピューティクス アクチェンゲゼルシャフト 細胞の操作のための材料及び方法並びに免疫腫瘍学におけるその使用
CN110869392A (zh) 2017-05-16 2020-03-06 百时美施贵宝公司 用抗gitr激动性抗体治疗癌症
WO2018213747A1 (en) * 2017-05-19 2018-11-22 Merrimack Pharmaceuticals, Inc. 4-1bb agonist and cd40 agonist bispecific molecules
EA201992755A1 (ru) 2017-05-19 2020-04-22 Уси Байолоджикс (Шанхай) Ко. Лтд. Новые моноклональные антитела к белку 4, ассоциированному с цитотоксическими т-лимфоцитами, (ctla-4)
CN111432828A (zh) * 2017-05-26 2020-07-17 约翰霍普金斯大学 用以调节免疫耐受的多功能抗体-配体捕获剂
WO2018222901A1 (en) 2017-05-31 2018-12-06 Elstar Therapeutics, Inc. Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
BR112019025188A2 (pt) 2017-06-01 2020-06-23 Cytomx Therapeutics, Inc. Anticorpos anti-pdl1 ativáveis e métodos de uso dos mesmos
CN107857819A (zh) * 2017-07-03 2018-03-30 江苏西迪尔生物技术有限公司 多功能融合蛋白及其应用
PL3661954T3 (pl) 2017-08-03 2022-05-16 Amgen Inc. Muteiny interleukiny 21 i sposoby leczenia
AU2018309339C1 (en) 2017-08-04 2025-08-21 BioNTech SE Binding agents binding to PD-L1 and CD137 and use thereof
CN107602705B (zh) * 2017-09-13 2018-08-31 北京鼎成肽源生物技术有限公司 一种基于蛋白互作用于检测细胞pd1表达情况的融合蛋白及其应用
CA3077223A1 (en) 2017-09-27 2019-04-04 Epicentrx, Inc. Immunomodulatory fusion proteins
EP3688022A4 (en) * 2017-09-29 2021-09-22 NantCell, Inc. ANTIGEN PROTEINS AND PROCEDURES FOR THEREFORE
CA3077509A1 (en) 2017-10-10 2019-04-18 Alpine Immune Sciences, Inc. Ctla-4 variant immunomodulatory proteins and uses thereof
CN111247171A (zh) 2017-10-14 2020-06-05 西托姆克斯治疗公司 抗体、可活化抗体、双特异性抗体和双特异性可活化抗体及其使用方法
CA3079264A1 (en) * 2017-10-18 2019-04-25 Intrexon Corporation Polypeptide compositions comprising spacers
JP2021502360A (ja) * 2017-11-09 2021-01-28 メディミューン,エルエルシー 二重特異的融合ポリペプチド及びその使用方法
EP3716980A1 (en) 2017-12-01 2020-10-07 Juno Therapeutics, Inc. Methods for dosing and for modulation of genetically engineered cells
WO2019113123A1 (en) * 2017-12-04 2019-06-13 Precithera, Inc. TGF-ß RECEPTOR FUSION PROTEINS AND OTHER TGF-ß ANTAGONISTS FOR REDUCING TGF-ß SIGNALING
JP7348899B2 (ja) * 2017-12-08 2023-09-21 マレンゴ・セラピューティクス,インコーポレーテッド 多重特異性分子及びその使用
AU2019205273B2 (en) 2018-01-03 2024-04-04 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
CN111727197A (zh) 2018-01-12 2020-09-29 美国安进公司 抗pd-1抗体和治疗方法
CN110151309B (zh) * 2018-02-14 2022-02-15 上海美杰医疗科技有限公司 多模态消融治疗术前规划方法及其设备
US10780120B2 (en) * 2018-03-06 2020-09-22 The Trustees Of The University Of Pennsylvania Prostate-specific membrane antigen cars and methods of use thereof
JP7319992B2 (ja) 2018-03-09 2023-08-02 アジェナス インコーポレイテッド 抗cd73抗体およびそれらの使用方法
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
WO2019178364A2 (en) 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
EP3773657A4 (en) * 2018-03-26 2021-12-08 Altor Bioscience LLC ANTI-PDL1, IL-15 AND TGF BETA RECEPTOR COMBINATION MOLECULES
AU2019256383A1 (en) 2018-04-17 2020-11-26 Celldex Therapeutics, Inc. Anti-CD27 and anti-PD-L1 antibodies and bispecific constructs
US12103959B2 (en) 2018-05-03 2024-10-01 Acceleron Pharma Inc. Multispecific binders of TGFBeta-superfamily ligands and uses thereof
US12168683B2 (en) 2018-05-03 2024-12-17 Acceleron Pharma Inc. Binders of TGFβ-superfamily ligands and uses thereof
KR20210006405A (ko) * 2018-05-04 2021-01-18 메르크 파텐트 게엠베하 암의 치료를 위한 PD-1/PD-L1, TGFβ 및 DNA-PK의 조합 억제
SG11202011080QA (en) 2018-05-11 2020-12-30 Crispr Therapeutics Ag Methods and compositions for treating cancer
CA3103427A1 (en) * 2018-06-15 2019-12-19 Acceleron Pharma Inc. Bi-and tri-functional fusion proteins and uses thereof
WO2019246563A1 (en) 2018-06-22 2019-12-26 Kite Pharma, Inc. Chimeric transmembrane proteins and uses thereof
US11001635B2 (en) * 2018-06-29 2021-05-11 Gensun Biopharma Inc. Antitumor antagonists
CN112955465A (zh) 2018-07-03 2021-06-11 马伦戈治疗公司 抗tcr抗体分子及其用途
KR20210042909A (ko) * 2018-07-09 2021-04-20 프레시전 인코포레이티드 융합 구조물 및 그의 이용 방법
CA3104780A1 (en) 2018-07-11 2020-01-16 Kahr Medical Ltd. Sirpalpha-4-1bbl variant fusion protein and methods of use thereof
US12286466B2 (en) 2018-07-11 2025-04-29 Kahr Medical Ltd. PD1-4-1BBL variant fusion protein and methods of use thereof
EP3833391A4 (en) 2018-08-08 2022-08-10 Orionis Biosciences, Inc. CHIMERIC PROTEINS TARGETED AT SIRP1alpha AND THEIR USES
US10780121B2 (en) 2018-08-29 2020-09-22 Shattuck Labs, Inc. FLT3L-based chimeric proteins
WO2020047329A1 (en) * 2018-08-29 2020-03-05 Shattuck Labs, Inc. Chimeric proteins comprising extracellular domains and uses thereof
CN109053895B (zh) 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
JP7695187B2 (ja) 2018-09-24 2025-06-18 アイポイント ファーマシューティカルズ, インコーポレイテッド HPTP-β(VE-PTP)およびVEGFを標的にする多特異性抗体
WO2020069372A1 (en) 2018-09-27 2020-04-02 Elstar Therapeutics, Inc. Csf1r/ccr2 multispecific antibodies
US20220034880A1 (en) * 2018-10-01 2022-02-03 The Board Of Trustees Of The Leland Stanford Junior University High specificity and sensitivity immunosorbent diagnostic assays with simultaneous resolution of multiple antibody isotypes
BR112021007318A2 (pt) 2018-10-17 2021-08-31 Biolinerx Ltd. Tratamento de adenocarcinoma pancreático metastático
CA3114803A1 (en) * 2018-10-24 2020-04-30 Shire-Nps Pharmaceuticals, Inc. Glp-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions
EP3873611A1 (en) 2018-11-01 2021-09-08 Merck Patent GmbH Anti-tim-3 antibodies
CA3117371A1 (en) 2018-11-01 2020-05-07 Merck Patent Gmbh Methods of administering anti-tim-3 antibodies
KR102881644B1 (ko) 2018-11-09 2025-11-06 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 TGF-β 수용체 융합 단백질 약학적 조성물 및 이의 용도
US20220025061A1 (en) * 2018-12-10 2022-01-27 Bioxcel Therapeutics, Inc. Combination therapies for treating disease using an innate immunity modifier and an ox40 agonist
KR20210142594A (ko) 2018-12-26 2021-11-25 시티 오브 호프 활성화 가능한 차폐된 항-ctla4 결합 단백질
CN119661722A (zh) 2019-02-21 2025-03-21 马伦戈治疗公司 结合t细胞相关癌细胞的多功能分子及其用途
CA3130628A1 (en) 2019-02-21 2020-08-27 Marengo Therapeutics, Inc. Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
CN119039441A (zh) 2019-02-21 2024-11-29 马伦戈治疗公司 与nkp30结合的抗体分子及其用途
CA3130794A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
CA3134144A1 (en) 2019-03-29 2020-10-08 Myst Therapeutics, Llc Ex vivo methods for producing a t cell therapeutic and related compositions and methods
JP2022531185A (ja) 2019-04-30 2022-07-06 クリスパー セラピューティクス アクチェンゲゼルシャフト 遺伝子改変t細胞を標的化するcd19を使用するb細胞悪性病変の同種細胞療法
US12109235B2 (en) * 2019-06-21 2024-10-08 Kite Pharma, Inc. TGF-beta receptors and methods of use
EP3986920B1 (en) 2019-06-24 2025-04-16 Universität Stuttgart Tnfr2 agonists with improved stability
EP3990116A1 (en) 2019-06-28 2022-05-04 Gensun Biopharma Inc. ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD
WO2021011864A1 (en) * 2019-07-18 2021-01-21 Memorial Sloan Kettering Cancer Center METHODS AND COMPOSITIONS FOR TARGETING TGF-β SIGNALING IN CD4+ HELPER T CELLS FOR CANCER IMMUNOTHERAPY
WO2021025140A1 (ja) * 2019-08-08 2021-02-11 小野薬品工業株式会社 二重特異性タンパク質
CN114787196A (zh) * 2019-08-29 2022-07-22 南特生物科学公司 修饰的n-810及其方法
US20220289825A1 (en) * 2019-08-30 2022-09-15 Nanjing Shunxin Pharmaceuticals Co., Ltd., Of Chiatai Tianqing Pharmaceutical Group FUSION PROTEIN TARGETING PD-L1 AND TGF-ß AND USE THEREOF
CN115151635A (zh) * 2019-09-18 2022-10-04 斯比根公司 用编码新的嵌合抗原受体的基因转导的基因修饰nk细胞系及其用途
CN110734498A (zh) * 2019-10-15 2020-01-31 上海科棋药业科技有限公司 一种用于解除免疫抑制的融合蛋白及其应用
EP4048704A4 (en) 2019-10-21 2023-11-22 Nanjing Leads Biolabs Co., Ltd. RECOMBINANT PROTEIN TARGETING PD-1 AND TGFß
WO2021081258A1 (en) 2019-10-23 2021-04-29 Cue Biopharma, Inc. TGF-β POLYPEPTIDES
WO2021093760A1 (zh) * 2019-11-12 2021-05-20 江苏恒瑞医药股份有限公司 含有TGF-β受体的融合蛋白及其医药用途
WO2021104434A1 (en) * 2019-11-27 2021-06-03 Shanghai Epimab Biotherapeutics Co., Ltd. TGFβ/PD-L1 BISPECIFIC BINDING PROTEINS
AU2020391231A1 (en) 2019-11-27 2022-07-14 Turnstone Biologics Corp. Method of producing tumor-reactive T cell composition using modulatory agents
CN113004414B (zh) * 2019-12-20 2022-09-06 广东菲鹏制药股份有限公司 抗PD1和TGFβ的双功能抗体及其制备方法,以及含有其的药物组合物
CN113121699A (zh) * 2019-12-30 2021-07-16 国典(北京)医药科技有限公司 Pttrap1双特异性融合蛋白及其应用
WO2021138407A2 (en) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Multifunctional molecules that bind to cd33 and uses thereof
GB2609554B (en) 2020-01-03 2025-08-20 Marengo Therapeutics Inc Anti-TCR antibody molecules and uses thereof
CN115103685B (zh) * 2020-01-23 2025-08-05 格纳西尼有限公司 包含程序性细胞死亡配体1蛋白的融合蛋白及其用途
US11912751B2 (en) * 2020-01-31 2024-02-27 Globetek Science Foundation Bi-functional fusion proteins comprised of TGF-B and immune checkpoint domains
IL295934A (en) 2020-02-27 2022-10-01 Myst Therapeutics Llc Methods for ex vivo enrichment and expansion of tumor reactive t cells and related compositions thereof
WO2021209049A1 (zh) * 2020-04-16 2021-10-21 南通壹宸生物医药科技有限公司 一种pd-1突变体多肽及其制备和用途
JP2023523011A (ja) 2020-04-24 2023-06-01 マレンゴ・セラピューティクス,インコーポレーテッド T細胞関連のがん細胞に結合する多機能性分子およびその使用
AU2021264846B2 (en) * 2020-04-28 2025-03-06 Sinocelltech Ltd. TGFβR2 extracellular domain truncated molecule, fusion protein of TGFβR2 extracellular domain truncated molecule and anti-EGFR antibody, and anti-tumor use of fusion protein
CN111690070A (zh) * 2020-05-13 2020-09-22 深圳市众循精准医学研究院 一种sPD-1-Fc-sTGFβRII融合蛋白及其应用
WO2021260675A1 (en) 2020-06-24 2021-12-30 Yeda Research And Development Co. Ltd. Agents for sensitizing solid tumors to treatment
AU2021305234A1 (en) * 2020-07-10 2023-02-09 Precigen, Inc. Fusion constructs and methods of using thereof
AU2021331076A1 (en) 2020-08-26 2023-04-06 Marengo Therapeutics, Inc. Antibody molecules that bind to NKp30 and uses thereof
KR20230074487A (ko) 2020-08-26 2023-05-30 마렝고 테라퓨틱스, 인크. Trbc1 또는 trbc2를 검출하는 방법
WO2022046920A2 (en) 2020-08-26 2022-03-03 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
WO2022057061A1 (en) * 2020-09-16 2022-03-24 Suzhou Neologics Bioscience Co., Ltd. Pd-l1 antibodies, fusion proteins, and uses thereof
MX2023004725A (es) * 2020-10-23 2024-02-23 Hq Han Antagonistas bifuncionales del factor de necrosis tumoral alfa y del factor de crecimiento transformante beta y usos de los mismos.
MX2023005565A (es) * 2020-11-11 2024-02-23 Hq Han Antagonistas bifuncionales de activina/tgf-beta y rankl y usos de los mismos.
CN114539415B (zh) * 2020-11-24 2024-02-02 普米斯生物技术(珠海)有限公司 一种抗PD-L1/VEGF/TGF-β多特异性抗体及其用途
US20240082394A1 (en) * 2020-12-15 2024-03-14 Bicara Therapeutics Inc. Combination therapy for the treatment of cancer
JP2023553209A (ja) * 2020-12-15 2023-12-20 バイカラ セラピューティクス インコーポレイテッド 融合タンパク質の医薬製剤
EP4294422A4 (en) * 2021-02-17 2025-04-02 Cura Therapeutics, Inc. ANTI-PATHOGEN INTERLEUKIN-TGF-BETA RECEPTOR FUSION POLYPEPTIDES
AR125753A1 (es) 2021-05-04 2023-08-09 Agenus Inc Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos
AU2022291370A1 (en) * 2021-06-07 2024-01-04 Flagship Pioneering Innovations Vii, Llc Compositions and methods for targeted delivery of therapeutic agents
WO2023004377A1 (en) * 2021-07-21 2023-01-26 Mayo Foundation For Medical Education And Research Promoting immune surveillance against cancer cells
WO2023027561A1 (ko) * 2021-08-27 2023-03-02 세라노틱스(주) B7-h3 및 tgfβ에 특이적으로 결합하는 이중 특이적 분자 및 이의 용도
AU2022350320A1 (en) * 2021-09-24 2024-04-11 Bionsystems Inc Fusion protein dimer including pd-1 and il-21, and use thereof
JP2024536932A (ja) 2021-10-11 2024-10-08 ワイ-トラップ, インコーポレイテッド Il-23シグナル伝達を阻害する組成物および方法
JP2024544534A (ja) * 2021-11-11 2024-12-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Cd20-pd1結合分子及びその使用方法
EP4514834A1 (en) * 2022-04-28 2025-03-05 Immatics US, Inc. Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof
CA3260155A1 (en) * 2022-06-29 2024-01-04 Cdres Pharma Llc Immunologically active polypeptide
WO2024215772A2 (en) * 2023-04-11 2024-10-17 Flagship Pioneering Innovations Vii, Llc Compositions and methods
AU2024204722A1 (en) * 2023-05-31 2024-12-19 Fbd Biologics Limited Cd47/pd-l1-targeting protein complex and methods of use thereof
CN116514913B (zh) * 2023-06-07 2025-03-21 澳门大学 具有抗肿瘤活性的tnfr2靶向肽及其应用
TW202517668A (zh) * 2023-06-26 2025-05-01 寶泰生醫股份有限公司 治療癌症的組合物與方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4244946A (en) 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA2103059C (en) 1991-06-14 2005-03-22 Paul J. Carter Method for making humanized antibodies
US5631146A (en) 1995-01-19 1997-05-20 The General Hospital Corporation DNA aptamers and catalysts that bind adenosine or adenosine-5'-phosphates and methods for isolation thereof
US7060808B1 (en) 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
US5691145A (en) 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US5736167A (en) 1997-02-27 1998-04-07 Chang; Hui Hwa Mold device for making safety shoe
US20030125251A1 (en) 2001-06-21 2003-07-03 Wakefield Lalage M. Transforming growth factor beta (TGF-beta) antagonist selectively neutralizes "pathological" TGF-beta
US7033787B2 (en) * 2001-12-21 2006-04-25 Ludwig Institute For Cancer Research Isolated cytokine receptor LICR-2
AU2003215136A1 (en) * 2002-02-08 2003-09-02 University Of Medicine And Dentistry Of New Jersey Ifn-a/b-independent mechanism of antiviral protection
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
FR2850384A1 (fr) * 2003-01-28 2004-07-30 Centre Nat Rech Scient Antigenes mimant les domaines extracellulaires de proteines membranaires de type iii issues de microorganismes intracellulaires pathogenes, anticorps conformationnels derives, et leurs applications
JP4635255B2 (ja) * 2003-09-02 2011-02-23 独立行政法人産業技術総合研究所 抗体医薬
US8101720B2 (en) * 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
US8399618B2 (en) * 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
WO2005097832A2 (en) * 2004-03-31 2005-10-20 Genentech, Inc. Humanized anti-tgf-beta antibodies
US7795389B2 (en) 2004-09-28 2010-09-14 The Board Of Regents Of The University Of Texas System Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins
WO2006052900A2 (en) 2004-11-09 2006-05-18 University Of Southern California Targeted innate immunity
JP2008526889A (ja) * 2005-01-10 2008-07-24 リサーチ ディベロップメント ファウンデーション 癌治療のための標的化キメラ分子
US20060193849A1 (en) * 2005-02-25 2006-08-31 Antisoma Plc Biological materials and uses thereof
US20090175819A1 (en) * 2005-11-15 2009-07-09 Apollo Life Sciences Limited Molecule and chimeric molecules thereof
US7820165B2 (en) * 2005-11-21 2010-10-26 Merck Serono, S.A. Compositions and methods of producing hybrid antigen binding molecules and uses thereof
JP2009525048A (ja) 2006-02-01 2009-07-09 ザ ジョンズ ホプキンス ユニバーシティー 腫瘍性障害または感染症に対する免疫学的予防法または免疫療法のためのポリペプチド−核酸複合体
WO2008073160A2 (en) 2006-08-17 2008-06-19 The Trustees Of Columbia University In The City Of New York Methods for converting or inducing protective immunity
WO2009042162A2 (en) * 2007-09-25 2009-04-02 Genzyme Corporation Compositions and methods for inhibiting interleukin pathways
WO2009059450A1 (en) 2007-11-05 2009-05-14 Shanghai Jiaotong University Peptide ligand directed drug delivery
WO2009114110A1 (en) 2008-03-08 2009-09-17 Immungene, Inc. Engineered fusion molecules immunotherapy in cancer and inflammatory diseases
WO2009152610A1 (en) * 2008-06-20 2009-12-23 The Royal Institution For The Advancement Of Learning/Mcgill University Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof
US20110177070A1 (en) 2008-07-02 2011-07-21 Emergent Product Development Seatlle, LLC TGF-Beta Antagonist Multi-Target Binding Proteins
RS54233B1 (sr) * 2008-08-25 2015-12-31 Amplimmune Inc. Kompozicije pd-1 antagonista i postupci za njihovu primenu
JP2013512251A (ja) * 2009-11-24 2013-04-11 アンプリミューン、インコーポレーテッド Pd−l1/pd−l2の同時阻害
PL2542590T5 (pl) * 2010-03-05 2020-08-10 The Johns Hopkins University Kompozycje i sposoby dla ukierunkowanych immunomodulatorowych przeciwciał i białek fuzyjnych
NZ701821A (en) * 2012-04-30 2016-06-24 Biocon Ltd Targeted/immunomodulatory fusion proteins and methods for making same

Similar Documents

Publication Publication Date Title
JP2018172439A5 (OSRAM)
JP6783886B2 (ja) 抗ctla4モノクローナル抗体またはその抗原結合断片、医薬組成物および使用
JP2015527366A5 (OSRAM)
CN110520445B (zh) 抗pd-l1/抗pd-1天然抗体结构样异源二聚体形式双特异抗体及其制备
JP2017526350A5 (OSRAM)
JP2020508655A5 (OSRAM)
JP2017522891A5 (OSRAM)
KR102378289B1 (ko) IgA 다중-특이적 결합 분자
JP2020519643A5 (OSRAM)
JP2019535763A5 (OSRAM)
JP2017504578A5 (OSRAM)
RU2018104703A (ru) Опухолеспецифичное антитело против egfr и его применение
NZ750366A (en) Chimeric antigen receptors targeting bcma and methods of use thereof
JP2016536322A5 (OSRAM)
JP2019521643A5 (OSRAM)
FI3628049T3 (fi) Tgf-beeta-reseptorin tyypin ii fuusioproteiineja ja niiden käyttöjä
JP2020503885A5 (OSRAM)
JP2013515508A5 (OSRAM)
JP2018517431A5 (OSRAM)
JP2017504577A5 (OSRAM)
JP2018519296A5 (OSRAM)
BR112021010026A2 (pt) anticorpo cd3 e seu uso farmacêutico
JP2009523459A5 (OSRAM)
JP2020512820A (ja) 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトIgM定常領域
JP2022009816A5 (OSRAM)