JP2017538678A5 - - Google Patents
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- JP2017538678A5 JP2017538678A5 JP2017524446A JP2017524446A JP2017538678A5 JP 2017538678 A5 JP2017538678 A5 JP 2017538678A5 JP 2017524446 A JP2017524446 A JP 2017524446A JP 2017524446 A JP2017524446 A JP 2017524446A JP 2017538678 A5 JP2017538678 A5 JP 2017538678A5
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- 239000003814 drug Substances 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 18
- 229940124597 therapeutic agent Drugs 0.000 claims 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 11
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 11
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 11
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
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- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
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- KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 1
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- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
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- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 1
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
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- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004100 adrenal gland Anatomy 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
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- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 1
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- 239000003112 inhibitor Substances 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
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- 229960003301 nivolumab Drugs 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462075663P | 2014-11-05 | 2014-11-05 | |
| US62/075,663 | 2014-11-05 | ||
| PCT/US2015/059271 WO2016073738A2 (en) | 2014-11-05 | 2015-11-05 | Immunoregulatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538678A JP2017538678A (ja) | 2017-12-28 |
| JP2017538678A5 true JP2017538678A5 (cg-RX-API-DMAC7.html) | 2018-11-22 |
Family
ID=55910032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017524446A Pending JP2017538678A (ja) | 2014-11-05 | 2015-11-05 | 免疫調節剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11242319B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3215141A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017538678A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107205970A (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017008809A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2964276A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201790806A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2017005462A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016073738A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3151820A4 (en) | 2014-06-06 | 2017-11-22 | Flexus Biosciences, Inc. | Immunoregulatory agents |
| UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| MX2017005462A (es) | 2014-11-05 | 2017-07-28 | Flexus Biosciences Inc | Agentes inmunorreguladores. |
| AR102537A1 (es) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
| JP2019522627A (ja) | 2016-05-04 | 2019-08-15 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法 |
| JP2019516681A (ja) | 2016-05-04 | 2019-06-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法 |
| CN109414420A (zh) | 2016-05-04 | 2019-03-01 | 百时美施贵宝公司 | 吲哚胺2,3-双加氧酶的抑制剂及其使用方法 |
| EP3452451A4 (en) | 2016-05-04 | 2019-11-13 | Bristol-Myers Squibb Company | INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE |
| CN109414421A (zh) | 2016-05-04 | 2019-03-01 | 百时美施贵宝公司 | 吲哚胺2,3-双加氧酶的抑制剂及其使用方法 |
| CN106552265A (zh) * | 2016-06-21 | 2017-04-05 | 聊城市奥润生物医药科技有限公司 | Sting激动剂与ido1抑制剂联合用药在抗肿瘤中的应用 |
| CN106075454A (zh) * | 2016-07-12 | 2016-11-09 | 中国医学科学院基础医学研究所 | 一种抗肿瘤药物制剂组合 |
| WO2018024188A1 (zh) * | 2016-08-02 | 2018-02-08 | 上海迪诺医药科技有限公司 | 多环化合物、其制备方法、药物组合物及应用 |
| EP3505517A4 (en) | 2016-08-23 | 2020-01-15 | Beijing InnoCare Pharma Tech Co., Ltd. | Fused heterocyclic derivative, preparation method therefor and medical use thereof |
| JP2019528300A (ja) | 2016-08-26 | 2019-10-10 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | インドールアミン２，３−ジオキシゲナーゼの阻害剤およびその使用方法 |
| EP3515914A4 (en) | 2016-09-24 | 2020-04-15 | BeiGene, Ltd. | NEW IMIDAZO [1,5-A] PYRIDINES SUBSTITUTED IN POSITION 5 OR 8 AS INDOLEAMINE AND / OR TRYPTOPHANE 2,3-DIOXYGENASES |
| PE20191353A1 (es) | 2016-10-14 | 2019-10-01 | Prec Biosciences Inc | Meganucleasas disenadas especificamente para el reconocimiento de secuencias en el genoma del virus de la hepatitis b |
| SG10201911243WA (en) | 2016-12-22 | 2020-02-27 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
| CN110191709A (zh) * | 2017-01-17 | 2019-08-30 | 德州大学系统董事会 | 可用作吲哚胺2,3-双加氧酶和/或色氨酸双加氧酶抑制剂的化合物 |
| WO2018209049A1 (en) | 2017-05-12 | 2018-11-15 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2019057123A1 (zh) | 2017-09-20 | 2019-03-28 | 杭州英创医药科技有限公司 | 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物 |
| WO2019074822A1 (en) | 2017-10-09 | 2019-04-18 | Bristol-Myers Squibb Company | INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE |
| US11203592B2 (en) | 2017-10-09 | 2021-12-21 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2019078968A2 (en) | 2017-10-18 | 2019-04-25 | Angex Pharmaceutical, Inc. | CYCLIC COMPOUNDS AS IMMUNOMODULATORS |
| US11447449B2 (en) | 2018-01-05 | 2022-09-20 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2019141095A1 (zh) * | 2018-01-19 | 2019-07-25 | 四川科伦博泰生物医药股份有限公司 | 脒类和胍类衍生物、其制备方法及其在医药上的应用 |
| CN110066271B (zh) * | 2018-01-23 | 2023-04-07 | 上海迪诺医药科技有限公司 | 吡咯衍生物、其制备方法、药物组合物及应用 |
| CN110092750B (zh) * | 2018-01-29 | 2023-07-21 | 北京诺诚健华医药科技有限公司 | 五氟硫烷基取代的酰胺类化合物、其制备方法及其在医药学上的应用 |
| CN111868032B (zh) * | 2018-02-11 | 2021-09-03 | 基石药业（苏州）有限公司 | 犬尿氨酸通路抑制剂 |
| WO2019179362A1 (zh) * | 2018-03-19 | 2019-09-26 | 四川科伦博泰生物医药股份有限公司 | 脒类和胍类衍生物、其制备方法及其在医药上的应用 |
| CN110357813A (zh) * | 2018-04-09 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途 |
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| US11046649B2 (en) | 2018-07-17 | 2021-06-29 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| US12059420B2 (en) | 2018-07-23 | 2024-08-13 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
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| US11253525B2 (en) | 2018-08-29 | 2022-02-22 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
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| ES2979163T3 (es) | 2018-10-31 | 2024-09-24 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de HPK1 |
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2015
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- 2015-11-05 CA CA2964276A patent/CA2964276A1/en not_active Abandoned
- 2015-11-05 EA EA201790806A patent/EA201790806A1/ru unknown
- 2015-11-05 BR BR112017008809A patent/BR112017008809A2/pt not_active IP Right Cessation
- 2015-11-05 US US15/524,113 patent/US11242319B2/en active Active
- 2015-11-05 JP JP2017524446A patent/JP2017538678A/ja active Pending
- 2015-11-05 EP EP15856241.3A patent/EP3215141A4/en not_active Withdrawn
- 2015-11-05 CN CN201580060428.8A patent/CN107205970A/zh active Pending
- 2015-11-05 WO PCT/US2015/059271 patent/WO2016073738A2/en not_active Ceased
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2021
- 2021-12-16 US US17/552,517 patent/US11932601B2/en active Active