JP2017537892A5 - - Google Patents
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- JP2017537892A5 JP2017537892A5 JP2017523286A JP2017523286A JP2017537892A5 JP 2017537892 A5 JP2017537892 A5 JP 2017537892A5 JP 2017523286 A JP2017523286 A JP 2017523286A JP 2017523286 A JP2017523286 A JP 2017523286A JP 2017537892 A5 JP2017537892 A5 JP 2017537892A5
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- 230000000694 effects Effects 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 34
- 239000005557 antagonist Substances 0.000 claims description 32
- 239000003814 drug Substances 0.000 claims description 31
- 229940122315 Notch pathway inhibitor Drugs 0.000 claims description 30
- 108700041286 delta Proteins 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 28
- 239000002955 immunomodulating agent Substances 0.000 claims description 25
- 108010070047 Notch Receptors Proteins 0.000 claims description 23
- 102000005650 Notch Receptors Human genes 0.000 claims description 23
- 229940044551 receptor antagonist Drugs 0.000 claims description 22
- 239000002464 receptor antagonist Substances 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 18
- 239000000427 antigen Substances 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 230000002708 enhancing effect Effects 0.000 claims description 10
- 239000000556 agonist Substances 0.000 claims description 8
- 102000002698 KIR Receptors Human genes 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
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- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims description 5
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 4
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims description 4
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 4
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 4
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims description 4
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 4
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 4
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 4
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims description 4
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 4
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 4
- 102000017578 LAG3 Human genes 0.000 claims description 4
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 4
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- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims description 4
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- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 4
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- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
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- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 4
- 201000010982 kidney cancer Diseases 0.000 claims description 4
- 239000003446 ligand Substances 0.000 claims description 4
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- 102000003390 tumor necrosis factor Human genes 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 3
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- 210000001185 bone marrow Anatomy 0.000 claims description 3
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- 230000002459 sustained effect Effects 0.000 claims description 3
- 230000004614 tumor growth Effects 0.000 claims description 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 229940123494 CD20 antagonist Drugs 0.000 claims description 2
- 229940121697 CD27 agonist Drugs 0.000 claims description 2
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 229940123205 CD28 agonist Drugs 0.000 claims description 2
- 229940123189 CD40 agonist Drugs 0.000 claims description 2
- 101150013553 CD40 gene Proteins 0.000 claims description 2
- 229940123828 CD80 antagonist Drugs 0.000 claims description 2
- 229940121850 CD86 agonist Drugs 0.000 claims description 2
- 229940121764 CD86 antagonist Drugs 0.000 claims description 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 206010014733 Endometrial cancer Diseases 0.000 claims description 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 2
- 208000032612 Glial tumor Diseases 0.000 claims description 2
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims description 2
- 206010018338 Glioma Diseases 0.000 claims description 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims description 2
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims description 2
- 101000978766 Homo sapiens Neurogenic locus notch homolog protein 1 Proteins 0.000 claims description 2
- 101000577199 Homo sapiens Neurogenic locus notch homolog protein 2 Proteins 0.000 claims description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 2
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 102000015696 Interleukins Human genes 0.000 claims description 2
- 108010063738 Interleukins Proteins 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims description 2
- 206010029260 Neuroblastoma Diseases 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 229940124060 PD-1 antagonist Drugs 0.000 claims description 2
- 229940123751 PD-L1 antagonist Drugs 0.000 claims description 2
- 229940121678 PD-L2 antagonist Drugs 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims description 2
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims description 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 2
- 229940123803 TIM3 antagonist Drugs 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 102000044457 human DLL4 Human genes 0.000 claims description 2
- 102000045609 human NOTCH1 Human genes 0.000 claims description 2
- 102000046883 human NOTCH2 Human genes 0.000 claims description 2
- 102000058223 human VEGFA Human genes 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 230000003308 immunostimulating effect Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 229940079322 interferon Drugs 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 210000002536 stromal cell Anatomy 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- 239000008177 pharmaceutical agent Substances 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 101000577202 Homo sapiens Neurogenic locus notch homolog protein 3 Proteins 0.000 description 1
- 229940123309 Immune checkpoint modulator Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462073634P | 2014-10-31 | 2014-10-31 | |
| US62/073,634 | 2014-10-31 | ||
| US201562127172P | 2015-03-02 | 2015-03-02 | |
| US62/127,172 | 2015-03-02 | ||
| US201562192133P | 2015-07-14 | 2015-07-14 | |
| US62/192,133 | 2015-07-14 | ||
| US201562242567P | 2015-10-16 | 2015-10-16 | |
| US62/242,567 | 2015-10-16 | ||
| PCT/US2015/058327 WO2016070051A2 (en) | 2014-10-31 | 2015-10-30 | Combination therapy for treatment of disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537892A JP2017537892A (ja) | 2017-12-21 |
| JP2017537892A5 true JP2017537892A5 (OSRAM) | 2018-12-06 |
| JP6827415B2 JP6827415B2 (ja) | 2021-02-10 |
Family
ID=55858530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523286A Active JP6827415B2 (ja) | 2014-10-31 | 2015-10-30 | 疾患の処置のための併用療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20160176962A1 (OSRAM) |
| EP (1) | EP3212233B1 (OSRAM) |
| JP (1) | JP6827415B2 (OSRAM) |
| CN (1) | CN107530419B (OSRAM) |
| AU (1) | AU2015338974B2 (OSRAM) |
| CA (1) | CA2966042A1 (OSRAM) |
| DK (1) | DK3212233T3 (OSRAM) |
| ES (1) | ES2808153T3 (OSRAM) |
| MX (1) | MX382902B (OSRAM) |
| PT (1) | PT3212233T (OSRAM) |
| WO (1) | WO2016070051A2 (OSRAM) |
Families Citing this family (46)
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| EP3485908B1 (en) | 2009-10-16 | 2021-08-18 | Mereo BioPharma 5, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| HRP20190044T1 (hr) | 2011-09-23 | 2019-02-22 | Oncomed Pharmaceuticals, Inc. | Agensi koji vežu vegf/dll4 i njihove uporabe |
| JP6461800B2 (ja) | 2012-10-04 | 2019-01-30 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | ヒトモノクローナル抗ｐｄ−ｌ１抗体および使用方法 |
| WO2014066532A1 (en) | 2012-10-23 | 2014-05-01 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-ctla-4 antibodies to treat cancer |
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| PE20160953A1 (es) | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
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| WO2019023786A1 (en) * | 2017-08-01 | 2019-02-07 | University Health Network | COMBINED THERAPIES FOR THE INHIBITION OF TTK PROTEIN KINASE |
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| CN111989108B (zh) | 2018-02-13 | 2024-07-16 | 嵌合体生物工程公司 | 利用rna去稳定元件协调基因表达 |
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| CN108753833B (zh) * | 2018-05-28 | 2021-12-03 | 上海海洋大学 | 斑马鱼notch3基因突变体的制备方法 |
| US12378307B2 (en) * | 2018-11-16 | 2025-08-05 | The Brigham And Women's Hospital, Inc. | Antibodies blocking DLL4-mediated notch signalling |
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| CN114786686A (zh) | 2019-08-18 | 2022-07-22 | 嵌合体生物工程公司 | Gold控制的转基因的联合疗法 |
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- 2015-10-30 AU AU2015338974A patent/AU2015338974B2/en active Active
- 2015-10-30 EP EP15856100.1A patent/EP3212233B1/en active Active
- 2015-10-30 WO PCT/US2015/058327 patent/WO2016070051A2/en not_active Ceased
- 2015-10-30 DK DK15856100.1T patent/DK3212233T3/da active
- 2015-10-30 PT PT158561001T patent/PT3212233T/pt unknown
- 2015-10-30 US US14/928,271 patent/US20160176962A1/en not_active Abandoned
- 2015-10-30 CN CN201580068724.2A patent/CN107530419B/zh active Active
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- 2015-10-30 JP JP2017523286A patent/JP6827415B2/ja active Active
- 2015-10-30 CA CA2966042A patent/CA2966042A1/en active Pending
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2021
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