JP2017532290A5 - - Google Patents
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- JP2017532290A5 JP2017532290A5 JP2017505793A JP2017505793A JP2017532290A5 JP 2017532290 A5 JP2017532290 A5 JP 2017532290A5 JP 2017505793 A JP2017505793 A JP 2017505793A JP 2017505793 A JP2017505793 A JP 2017505793A JP 2017532290 A5 JP2017532290 A5 JP 2017532290A5
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- 235000001014 amino acid Nutrition 0.000 claims description 38
- 150000001413 amino acids Chemical group 0.000 claims description 38
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 14
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 14
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 14
- 208000034578 Multiple myelomas Diseases 0.000 claims description 11
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000004475 Arginine Substances 0.000 claims description 10
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 10
- 239000004472 Lysine Substances 0.000 claims description 10
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 10
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 10
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 8
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 8
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 8
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 8
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims description 8
- 235000003704 aspartic acid Nutrition 0.000 claims description 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 8
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 235000013922 glutamic acid Nutrition 0.000 claims description 8
- 239000004220 glutamic acid Substances 0.000 claims description 8
- 102000046935 human TNFRSF17 Human genes 0.000 claims description 8
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 8
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 6
- 208000021161 Plasma cell disease Diseases 0.000 claims description 5
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 2
- 230000008859 change Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 2
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 230000001131 transforming effect Effects 0.000 claims description 2
- 210000004180 plasmocyte Anatomy 0.000 description 5
- 210000001185 bone marrow Anatomy 0.000 description 4
- 208000037914 B-cell disorder Diseases 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010061728 Bone lesion Diseases 0.000 description 1
- 206010020631 Hypergammaglobulinaemia benign monoclonal Diseases 0.000 description 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000006994 Precancerous Conditions Diseases 0.000 description 1
- 206010053614 Type III immune complex mediated reaction Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
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- 201000005328 monoclonal gammopathy of uncertain significance Diseases 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
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- 208000025883 type III hypersensitivity disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179705.0 | 2014-08-04 | ||
| EP14179705.0A EP2982692A1 (en) | 2014-08-04 | 2014-08-04 | Bispecific antibodies against CD3epsilon and BCMA |
| PCT/EP2015/067841 WO2016020332A1 (en) | 2014-08-04 | 2015-08-03 | Bispecific antibodies against cd3epsilon and bcma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020082524A Division JP2020122013A (ja) | 2014-08-04 | 2020-05-08 | Ｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532290A JP2017532290A (ja) | 2017-11-02 |
| JP2017532290A5 true JP2017532290A5 (enExample) | 2019-04-04 |
| JP6703520B2 JP6703520B2 (ja) | 2020-06-03 |
Family
ID=51260770
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505793A Active JP6703520B2 (ja) | 2014-08-04 | 2015-08-03 | Ｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
| JP2020082524A Pending JP2020122013A (ja) | 2014-08-04 | 2020-05-08 | Ｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020082524A Pending JP2020122013A (ja) | 2014-08-04 | 2020-05-08 | Ｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10253104B2 (enExample) |
| EP (2) | EP2982692A1 (enExample) |
| JP (2) | JP6703520B2 (enExample) |
| AU (2) | AU2015299101B2 (enExample) |
| CA (1) | CA2955685C (enExample) |
| CY (1) | CY1118168T1 (enExample) |
| DK (1) | DK2982694T3 (enExample) |
| ES (1) | ES2602051T3 (enExample) |
| HR (1) | HRP20161211T1 (enExample) |
| HU (1) | HUE031076T2 (enExample) |
| LT (1) | LT2982694T (enExample) |
| MA (1) | MA39266B1 (enExample) |
| ME (1) | ME02533B (enExample) |
| PL (1) | PL2982694T3 (enExample) |
| PT (1) | PT2982694T (enExample) |
| RS (1) | RS55410B1 (enExample) |
| SG (1) | SG11201700551TA (enExample) |
| SI (1) | SI2982694T1 (enExample) |
| SM (1) | SMT201600392B (enExample) |
| WO (1) | WO2016020332A1 (enExample) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US20100256340A1 (en) | 2009-04-07 | 2010-10-07 | Ulrich Brinkmann | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| RU2013141078A (ru) | 2011-02-28 | 2015-04-10 | Ф. Хоффманн-Ля Рош Аг | Одновалентные антигенсвязывающие белки |
| BR112013019975A2 (pt) | 2011-02-28 | 2017-08-01 | Hoffmann La Roche | proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira" |
| KR101870555B1 (ko) | 2011-08-23 | 2018-06-22 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| KR20150064068A (ko) | 2012-10-08 | 2015-06-10 | 로슈 글리카트 아게 | 2개의 Fab 단편을 포함하는 FC-부재 항체 및 이용 방법 |
| WO2014122143A1 (en) * | 2013-02-05 | 2014-08-14 | Engmab Ag | Method for the selection of antibodies against bcma |
| KR20180023035A (ko) | 2013-02-26 | 2018-03-06 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
| GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
| CA2922912A1 (en) | 2013-10-11 | 2015-04-16 | F. Hoffmann-La Roche Ag | Multispecific domain exchanged common variable light chain antibodies |
| KR20250075744A (ko) | 2013-11-11 | 2025-05-28 | 추가이 세이야쿠 가부시키가이샤 | 개변된 항체 가변영역을 포함하는 항원 결합 분자 |
| JP6464255B2 (ja) | 2014-08-04 | 2019-02-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性ｔ細胞活性化抗原結合分子 |
| US11952421B2 (en) | 2014-10-09 | 2024-04-09 | Bristol-Myers Squibb Company | Bispecific antibodies against CD3EPSILON and ROR1 |
| TWI880146B (zh) | 2014-11-11 | 2025-04-11 | 日商中外製藥股份有限公司 | 包含經改變之抗體可變區之抗原結合分子的資料庫 |
| EA201791121A1 (ru) | 2014-11-20 | 2018-04-30 | Ф. Хоффманн-Ля Рош Аг | Активирующие т-клетки биспецифические антигенсвязывающие молекулы против folri и cd3 |
| DK3221357T3 (da) | 2014-11-20 | 2020-08-10 | Hoffmann La Roche | Fælles letkæder og fremgangsmåder til anvendelse |
| EP3221355B1 (en) | 2014-11-20 | 2020-10-07 | F.Hoffmann-La Roche Ag | Combination therapy of t cell activating bispecific antigen binding molecules cd3 and folate receptor 1 (folr1) and pd-1 axis binding antagonists |
| EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| CN107001482B (zh) | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
| PT3298033T (pt) | 2015-05-18 | 2020-09-22 | Tcr2 Therapeutics Inc | Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| AR106201A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | Moléculas biespecíficas de unión a antígeno activadoras de células t |
| EP3150636A1 (en) * | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Tetravalent multispecific antibodies |
| IL313608A (en) | 2015-12-09 | 2024-08-01 | Hoffmann La Roche | Antibody against CD20 type II to reduce the formation of antibodies against drugs |
| CN108368179B (zh) | 2016-01-08 | 2022-08-23 | 豪夫迈·罗氏有限公司 | 使用pd-1轴结合拮抗剂和抗cea/抗cd3双特异性抗体治疗cea阳性癌症的方法 |
| MA44254A (fr) | 2016-02-17 | 2018-12-26 | Seattle Genetics Inc | Anticorps bcma et leur utilisation pour traiter le cancer et les troubles immunologiques |
| HUE061946T2 (hu) | 2016-03-22 | 2023-09-28 | Hoffmann La Roche | Proteáz-aktivált T-sejt bispecifikus molekulák |
| SG11201808085WA (en) * | 2016-03-22 | 2018-10-30 | Hoffmann La Roche | Protease-activated t cell bispecific molecules |
| CA3032498A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| EP3519437B1 (en) | 2016-09-30 | 2021-09-08 | F. Hoffmann-La Roche AG | Bispecific antibodies against p95her2 |
| CN109689686B (zh) | 2016-10-07 | 2020-08-25 | T细胞受体治疗公司 | 使用融合蛋白进行t细胞受体重编程的组合物和方法 |
| KR102687833B1 (ko) | 2016-11-02 | 2024-07-24 | 브리스톨-마이어스 스큅 컴퍼니 | 다발성 골수종 치료를 위한 bcma 및 cd3에 대응하는 이중 특이적 항체 및 면역학적 약물의 복합용도 |
| EP3544996A2 (en) | 2016-11-22 | 2019-10-02 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN110582509A (zh) | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
| US20200055948A1 (en) | 2017-04-28 | 2020-02-20 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| EP3694878A1 (en) | 2017-09-14 | 2020-08-19 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatment for cancer |
| US20200254093A1 (en) | 2017-09-14 | 2020-08-13 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
| BR112020005028A2 (pt) | 2017-09-14 | 2020-09-15 | Glaxosmithkline Intellectual Property Development Limited | tratamento em combinação para câncer |
| US11999802B2 (en) | 2017-10-18 | 2024-06-04 | Novartis Ag | Compositions and methods for selective protein degradation |
| CN111787938A (zh) | 2017-11-15 | 2020-10-16 | 诺华股份有限公司 | 靶向bcma的嵌合抗原受体、靶向cd19的嵌合抗原受体及组合疗法 |
| RU2020121458A (ru) | 2017-11-30 | 2021-12-30 | Новартис Аг | Химерный антигенный рецептор, нацеливающийся на bcma, и его пути применения |
| TW201938194A (zh) | 2017-12-05 | 2019-10-01 | 日商中外製藥股份有限公司 | 包含結合cd3及cd137的改變的抗體可變區之抗原結合分子 |
| US11667713B2 (en) | 2017-12-28 | 2023-06-06 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| CN112218651A (zh) | 2018-01-08 | 2021-01-12 | 诺华公司 | 用于与嵌合抗原受体疗法组合的免疫增强rna |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| US20210038659A1 (en) | 2018-01-31 | 2021-02-11 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| MA51793A (fr) | 2018-02-08 | 2020-12-16 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène et procédés d'utilisation |
| WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EA202091871A1 (ru) | 2018-03-30 | 2021-06-22 | Мерус Н.В. | Поливалентное антитело |
| PE20210320A1 (es) | 2018-06-01 | 2021-02-16 | Novartis Ag | Moleculas de union contra bcma y usos de las mismas |
| CA3100187A1 (en) * | 2018-06-26 | 2020-01-02 | Abl Bio, Inc. | Anti-bcma antibody and use thereof |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| SG11202100221VA (en) | 2018-07-19 | 2021-02-25 | Regeneron Pharma | Chimeric antigen receptors with bcma specificity and uses thereof |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| KR20210040989A (ko) | 2018-08-03 | 2021-04-14 | 추가이 세이야쿠 가부시키가이샤 | 서로 연결된 2개의 항원 결합 도메인을 포함하는 항원 결합 분자 |
| ES3042082T3 (en) | 2018-08-31 | 2025-11-18 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| US20210171909A1 (en) | 2018-08-31 | 2021-06-10 | Novartis Ag | Methods of making chimeric antigen receptor?expressing cells |
| EP3849513A1 (en) * | 2018-09-11 | 2021-07-21 | Ichnos Sciences SA | Compositions comprising a bispecific antibody, bufffer and one or more stabilizing agents |
| KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
| WO2020067399A1 (en) | 2018-09-28 | 2020-04-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region |
| JP2022509454A (ja) | 2018-10-31 | 2022-01-20 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 癌の処置法 |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| WO2020172571A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| JP7631211B2 (ja) | 2019-02-25 | 2025-02-18 | ノバルティス アーゲー | ウイルス送達のためのメソポーラスシリカ粒子組成物 |
| EP3942025A1 (en) | 2019-03-21 | 2022-01-26 | Novartis AG | Car-t cell therapies with enhanced efficacy |
| CN121102493A (zh) | 2019-03-21 | 2025-12-12 | 瑞泽恩制药公司 | 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合 |
| EP3953455A1 (en) | 2019-04-12 | 2022-02-16 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| EP3959320A1 (en) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
| UY38701A (es) | 2019-05-21 | 2020-12-31 | Novartis Ag | Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas |
| EP3986928A1 (en) * | 2019-06-19 | 2022-04-27 | F. Hoffmann-La Roche AG | Method for the generation of a protein expressing cell by targeted integration using cre mrna |
| WO2020254352A1 (en) * | 2019-06-19 | 2020-12-24 | F. Hoffmann-La Roche Ag | Method for the generation of a trivalent antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| CN111269315B (zh) | 2019-06-19 | 2022-04-08 | 北京智仁美博生物科技有限公司 | 针对bcma的单克隆抗体 |
| JP7515567B2 (ja) | 2019-08-06 | 2024-07-12 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 生物医薬組成物及び関連する方法 |
| FI3819007T3 (fi) | 2019-11-11 | 2024-09-25 | Amgen Res Munich Gmbh | Annosteluohjelma anti-bcma-aineille |
| JP7714545B2 (ja) | 2019-11-26 | 2025-07-29 | ノバルティス アーゲー | キメラ抗原受容体及びその使用 |
| TWI774137B (zh) | 2019-11-26 | 2022-08-11 | 大陸商上海岸邁生物科技有限公司 | 針對cd3和bcma的抗體和自其製備的雙特異性結合蛋白 |
| IL293288A (en) * | 2019-12-06 | 2022-07-01 | Regeneron Pharma | Methods for the treatment of multiple myeloma with bispecific anti-bcma and anti-cd3 antibodies |
| JP2023509708A (ja) | 2020-01-03 | 2023-03-09 | マレンゴ・セラピューティクス，インコーポレーテッド | 抗ｔｃｒ抗体分子およびその使用 |
| EP4097139A4 (en) * | 2020-01-28 | 2024-03-27 | Promab Biotechnologies, Inc. | PLAP-CD3 EPSILON BISPECIFIC ANTIBODIES |
| KR20220147109A (ko) | 2020-02-27 | 2022-11-02 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
| KR20220146530A (ko) | 2020-02-27 | 2022-11-01 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포의 제조 방법 |
| KR102505383B1 (ko) | 2020-03-31 | 2023-03-02 | 추가이 세이야쿠 가부시키가이샤 | Dll3 표적 다중 특이성 항원 결합 분자 및 그의 사용 |
| EP4165169A1 (en) | 2020-06-11 | 2023-04-19 | Novartis AG | Zbtb32 inhibitors and uses thereof |
| AU2021291405A1 (en) * | 2020-06-19 | 2022-09-29 | F. Hoffmann-La Roche Ag | Immune activating Fc domain binding molecules |
| KR20230025672A (ko) | 2020-06-19 | 2023-02-22 | 에프. 호프만-라 로슈 아게 | Cd3 및 cd19에 결합하는 항체 |
| EP4199960A2 (en) | 2020-08-21 | 2023-06-28 | Novartis AG | Compositions and methods for in vivo generation of car expressing cells |
| CN114573703A (zh) * | 2020-12-02 | 2022-06-03 | 康诺亚生物医药科技（成都）有限公司 | 一种t细胞衔接器治疗剂的开发和应用 |
| WO2022135468A1 (zh) * | 2020-12-23 | 2022-06-30 | 信达生物制药(苏州)有限公司 | 抗bcma×cd3双特异性抗体及其用途 |
| IL306132A (en) * | 2021-03-24 | 2023-11-01 | Janssen Biotech Inc | Proteins containing CD3 antigen binding sites and uses thereof |
| CA3178093A1 (en) * | 2021-03-26 | 2022-09-26 | Zymeworks Inc. | Cysteine engineered antibody constructs, conjugates and methods of use |
| KR20240004462A (ko) | 2021-04-08 | 2024-01-11 | 마렝고 테라퓨틱스, 인크. | Tcr에 결합하는 다기능성 분자 및 이의 용도 |
| TW202309294A (zh) | 2021-04-27 | 2023-03-01 | 瑞士商諾華公司 | 病毒載體生產系統 |
| AU2021443318A1 (en) | 2021-04-30 | 2023-09-07 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| BR112023024804A2 (pt) | 2021-05-28 | 2024-02-15 | Glaxosmithkline Ip Dev Ltd | Terapias de combinação para tratar câncer |
| CN119569887A (zh) * | 2021-06-24 | 2025-03-07 | 益科思特(北京)医药科技发展有限公司 | 结合bcma和cd3的双特异性抗体及其制备方法与应用 |
| EP4380981A2 (en) | 2021-08-03 | 2024-06-12 | GlaxoSmithKline Intellectual Property Development Limited | Biopharmaceutical compositions and stable isotope labeling peptide mapping method |
| CA3229746A1 (en) | 2021-08-20 | 2023-02-23 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| CN118159294A (zh) | 2021-10-05 | 2024-06-07 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于治疗癌症的联合疗法 |
| IL312700A (en) * | 2021-11-10 | 2024-07-01 | Janssen Biotech Inc | Stable formulations comprising a bispecific bcma/cd3 antibody |
| WO2023144702A1 (en) | 2022-01-25 | 2023-08-03 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy for cancer |
| KR20250057914A (ko) | 2022-09-09 | 2025-04-29 | 베이징 맵웍스 바이오테크 컴퍼니 리미티드 | 다중-특이적 항체 결합 bcma, gprc5d 및 cd3 및 이의 용도 |
| JP2025532313A (ja) * | 2022-09-30 | 2025-09-29 | 諾納生物（蘇州）有限公司 | Ｃｄ３を標的とする抗体及びその用途 |
| WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
| WO2024100170A1 (en) * | 2022-11-11 | 2024-05-16 | F. Hoffmann-La Roche Ag | Antibodies binding to hla-a*02/foxp3 |
| CN120303298A (zh) | 2022-12-05 | 2025-07-11 | 葛兰素史密斯克莱知识产权发展有限公司 | 使用b细胞成熟抗原拮抗剂的治疗方法 |
| CN118725113A (zh) * | 2023-03-28 | 2024-10-01 | 三优生物医药(上海)有限公司 | 一种靶向cd3的抗体或其抗原结合片段及其用途 |
| TW202517293A (zh) * | 2023-07-07 | 2025-05-01 | 美商再生元醫藥公司 | 含有抗bcmax抗cd3雙特異性抗體之穩定化配製物 |
| WO2025042742A1 (en) * | 2023-08-18 | 2025-02-27 | Bristol-Myers Squibb Company | Compositions comprising antibodies that bind bcma and cd3 and methods of treatment |
| US20250242018A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration |
| US20250242056A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
| WO2026006495A1 (en) | 2024-06-25 | 2026-01-02 | Alloy Therapeutics, Inc. | Anti-wt1/hla-a2 antibody and uses thereof |
| WO2026006492A2 (en) | 2024-06-25 | 2026-01-02 | Ypsilon Therapeutics, Inc. | Anti-prame/hla-a2 antibodies and uses thereof |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| ES2246069T3 (es) | 1997-05-02 | 2006-02-01 | Genentech, Inc. | Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos. |
| DK1049787T3 (da) | 1998-01-23 | 2005-04-04 | Vlaams Interuniv Inst Biotech | Antistofderivater med flere anvendelsesmuligheder |
| US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
| WO2001024812A1 (en) | 1999-10-06 | 2001-04-12 | N.V. Nutricia | USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| EP2301971A1 (en) | 2001-02-20 | 2011-03-30 | ZymoGenetics, L.L.C. | Antibodies that bind both BCMA and TACI |
| CN101218251A (zh) | 2005-02-28 | 2008-07-09 | 森托科尔公司 | 异二聚体蛋白结合组合物 |
| CA2603408C (en) | 2005-03-31 | 2018-08-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| PT1999154E (pt) | 2006-03-24 | 2013-01-24 | Merck Patent Gmbh | Domínios proteicos heterodiméricos modificados |
| WO2007117600A2 (en) | 2006-04-07 | 2007-10-18 | Macrogenics, Inc. | Combination therapy for treating autoimmune diseases |
| US20090182127A1 (en) | 2006-06-22 | 2009-07-16 | Novo Nordisk A/S | Production of Bispecific Antibodies |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| WO2009080525A1 (de) | 2007-12-21 | 2009-07-02 | BSH Bosch und Siemens Hausgeräte GmbH | Sprühvorrichtung für ein bügeleisen |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| PL2235064T3 (pl) | 2008-01-07 | 2016-06-30 | Amgen Inc | Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych |
| CA2720682A1 (en) | 2008-04-25 | 2009-10-29 | Zymogenetics, Inc. | Levels of bcma protein expression on b cells and use in diagnostic methods |
| MX2011009430A (es) | 2009-03-10 | 2011-11-18 | Biogen Idec Inc | Anticuerpos anti-bcma. |
| US9067986B2 (en) | 2009-04-27 | 2015-06-30 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US20130089554A1 (en) | 2009-12-29 | 2013-04-11 | Emergent Product Development Seattle, Llc | RON Binding Constructs and Methods of Use Thereof |
| JP6022444B2 (ja) | 2010-05-14 | 2016-11-09 | ライナット ニューロサイエンス コーポレイション | ヘテロ二量体タンパク質ならびにそれを生産および精製するための方法 |
| MX2013001336A (es) | 2010-08-13 | 2013-03-08 | Roche Glycart Ag | Anticuerpos ani-tenascina c a2 y metodos de utilizacion. |
| PL2635607T3 (pl) | 2010-11-05 | 2020-05-18 | Zymeworks Inc. | Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC |
| US20130273055A1 (en) | 2010-11-16 | 2013-10-17 | Eric Borges | Agents and methods for treating diseases that correlate with bcma expression |
| SG190726A1 (en) | 2010-11-30 | 2013-07-31 | Chugai Pharmaceutical Co Ltd | Cytotoxicity-inducing therapeutic agent |
| RU2013141078A (ru) | 2011-02-28 | 2015-04-10 | Ф. Хоффманн-Ля Рош Аг | Одновалентные антигенсвязывающие белки |
| BR112013023918A2 (pt) | 2011-03-25 | 2016-12-13 | Glenmark Pharmaceuticals Sa | imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para produzir uma imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para construir uma interface proteína-proteína de um domínio de uma proteína de múltiplos domínios e uso de um domínio doador de um primeiro e de um segundo membro de uma super-família de imunoglobulina de ocorrência natural |
| BR112013024574B1 (pt) | 2011-03-29 | 2022-08-09 | Roche Glycart Ag | Anticorpo e uso do anticorpo |
| US20130101599A1 (en) | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
| EP3693394A1 (en) | 2011-05-27 | 2020-08-12 | Glaxo Group Limited | Antigen binding proteins |
| DE102011053039A1 (de) | 2011-06-03 | 2012-12-06 | Reinhold Hubner | Schienenvorrichtung, Verschiebevorrichtung sowie Schirmständer |
| WO2013002362A1 (ja) | 2011-06-30 | 2013-01-03 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
| US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
| RS56879B1 (sr) * | 2011-08-23 | 2018-04-30 | Roche Glycart Ag | Bispecifične molekule koje vezuju antigen za aktiviranje t ćelija |
| KR101870555B1 (ko) * | 2011-08-23 | 2018-06-22 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| CN104011221B (zh) | 2011-12-20 | 2019-01-08 | 米迪缪尼有限公司 | 用于双特异性抗体支架的经修饰的多肽 |
| EA201990959A1 (ru) | 2012-04-11 | 2020-02-10 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| CA2870821C (en) | 2012-04-20 | 2022-06-14 | Merus B.V. | Methods and means for the production of ig-like molecules |
| UY35148A (es) * | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| JP6464255B2 (ja) * | 2014-08-04 | 2019-02-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性ｔ細胞活性化抗原結合分子 |
-
2014
- 2014-08-04 EP EP14179705.0A patent/EP2982692A1/en not_active Ceased
-
2015
- 2015-08-03 CA CA2955685A patent/CA2955685C/en active Active
- 2015-08-03 US US15/501,620 patent/US10253104B2/en active Active
- 2015-08-03 PT PT151795457T patent/PT2982694T/pt unknown
- 2015-08-03 DK DK15179545.7T patent/DK2982694T3/en active
- 2015-08-03 WO PCT/EP2015/067841 patent/WO2016020332A1/en not_active Ceased
- 2015-08-03 AU AU2015299101A patent/AU2015299101B2/en active Active
- 2015-08-03 MA MA39266A patent/MA39266B1/fr unknown
- 2015-08-03 EP EP15179545.7A patent/EP2982694B1/en active Active
- 2015-08-03 HU HUE15179545A patent/HUE031076T2/en unknown
- 2015-08-03 ME MEP-2016-205A patent/ME02533B/me unknown
- 2015-08-03 RS RS20160781A patent/RS55410B1/sr unknown
- 2015-08-03 JP JP2017505793A patent/JP6703520B2/ja active Active
- 2015-08-03 LT LTEP15179545.7T patent/LT2982694T/lt unknown
- 2015-08-03 SG SG11201700551TA patent/SG11201700551TA/en unknown
- 2015-08-03 SI SI201530004A patent/SI2982694T1/sl unknown
- 2015-08-03 ES ES15179545.7T patent/ES2602051T3/es active Active
- 2015-08-03 PL PL15179545T patent/PL2982694T3/pl unknown
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2016
- 2016-09-15 CY CY20161100920T patent/CY1118168T1/el unknown
- 2016-09-21 HR HRP20161211TT patent/HRP20161211T1/hr unknown
- 2016-10-31 SM SM201600392T patent/SMT201600392B/it unknown
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2020
- 2020-05-08 JP JP2020082524A patent/JP2020122013A/ja active Pending
- 2020-11-20 AU AU2020273347A patent/AU2020273347A1/en not_active Abandoned
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