MA39266B1 - Anticorps bispécifiques anti cd3epsilon et bcma - Google Patents
Anticorps bispécifiques anti cd3epsilon et bcmaInfo
- Publication number
- MA39266B1 MA39266B1 MA39266A MA39266A MA39266B1 MA 39266 B1 MA39266 B1 MA 39266B1 MA 39266 A MA39266 A MA 39266A MA 39266 A MA39266 A MA 39266A MA 39266 B1 MA39266 B1 MA 39266B1
- Authority
- MA
- Morocco
- Prior art keywords
- amino acid
- cd3epsilon
- bispecific antibodies
- kabat numbering
- human
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention concerne un anticorps bispécifique bi- ou trivalent se liant spécifiquement aux deux cibles que sont le domaine extracellulaire de l'antigène de maturation des lymphocytes b humain (bcma) et la cd3epsilon humaine, où les domaines variables vl et vh dans une chaîne légère et la chaîne lourde respective sont remplacés les uns par les autres, caractérisé en ce qu'il comprend un domaine constant cl dans lequel l'acide aminé à la position 124 est remplacé indépendamment par la lysine (k), l'arginine (r) ou l'histidine (h) (numérotation selon kabat), et dans le domaine constant respectif ch1 l'acide aminé à la position 147 et l'acide aminé en position 213 est remplacé indépendamment par l'acide glutamique (e), ou l'acide aspartique (d) (numérotation selon kabat) l'invention concerne également la fabrication et l'utilisation dudit anticorps.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14179705.0A EP2982692A1 (fr) | 2014-08-04 | 2014-08-04 | Anticorps bispécifiques contre la CD3epsilon et BCMA |
PCT/EP2015/067841 WO2016020332A1 (fr) | 2014-08-04 | 2015-08-03 | Anticorps bispécifiques anti cd3epsilon et bcma |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39266A MA39266A (fr) | 2016-02-10 |
MA39266B1 true MA39266B1 (fr) | 2017-01-31 |
Family
ID=51260770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39266A MA39266B1 (fr) | 2014-08-04 | 2015-08-03 | Anticorps bispécifiques anti cd3epsilon et bcma |
Country Status (21)
Country | Link |
---|---|
US (1) | US10253104B2 (fr) |
EP (2) | EP2982692A1 (fr) |
JP (2) | JP6703520B2 (fr) |
AU (2) | AU2015299101B2 (fr) |
CA (1) | CA2955685C (fr) |
CY (1) | CY1118168T1 (fr) |
DK (1) | DK2982694T3 (fr) |
ES (1) | ES2602051T3 (fr) |
HK (1) | HK1218299A1 (fr) |
HR (1) | HRP20161211T1 (fr) |
HU (1) | HUE031076T2 (fr) |
LT (1) | LT2982694T (fr) |
MA (1) | MA39266B1 (fr) |
ME (1) | ME02533B (fr) |
PL (1) | PL2982694T3 (fr) |
PT (1) | PT2982694T (fr) |
RS (1) | RS55410B1 (fr) |
SG (1) | SG11201700551TA (fr) |
SI (1) | SI2982694T1 (fr) |
SM (1) | SMT201600392B (fr) |
WO (1) | WO2016020332A1 (fr) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
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US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
PT2417156E (pt) | 2009-04-07 | 2015-04-29 | Roche Glycart Ag | Anticorpos trivalentes, biespecíficos |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
AR085404A1 (es) | 2011-02-28 | 2013-09-25 | Hoffmann La Roche | Proteinas de union a antigeno |
WO2012116927A1 (fr) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Protéines monovalentes de liaison à l'antigène |
KR101870555B1 (ko) | 2011-08-23 | 2018-06-22 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
WO2014056783A1 (fr) | 2012-10-08 | 2014-04-17 | Roche Glycart Ag | Anticorps exempts de fc comprenant deux fragments fab et procédés d'utilisation |
US9963513B2 (en) * | 2013-02-05 | 2018-05-08 | Engmab Sàrl | Method for the selection of antibodies against BCMA |
UA119320C2 (uk) | 2013-02-26 | 2019-06-10 | Рош Глікарт Аг | Активуюча т-клітини біспецифічна антигензв'язувальна молекула |
GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
JP6422956B2 (ja) | 2013-10-11 | 2018-11-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 多重特異性ドメイン交換共通可変軽鎖抗体 |
JPWO2015068847A1 (ja) | 2013-11-11 | 2017-03-09 | 中外製薬株式会社 | 改変された抗体可変領域を含む抗原結合分子 |
MA40510A (fr) | 2014-08-04 | 2017-06-14 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t |
CA2963692A1 (fr) * | 2014-10-09 | 2016-04-14 | Engmab Ag | Anticorps bispecifiques contre cd3epsilon et ror1 |
TW202313697A (zh) | 2014-11-11 | 2023-04-01 | 日商中外製藥股份有限公司 | 包含經改變之抗體可變區之抗原結合分子的資料庫 |
BR112017010324A2 (pt) | 2014-11-20 | 2018-05-15 | F. Hoffmann-La Roche Ag | método para tratar ou retardar a progressão de um câncer em um indivíduo, moléculas, métodos para aumentar a função imune em um indivíduo e para selecionar um paciente para tratamento, kits, composição farmacêutica e usos de uma combinação de uma molécula |
PL3221357T3 (pl) | 2014-11-20 | 2020-11-02 | F. Hoffmann-La Roche Ag | Wspólne łańcuchy lekkie i sposoby zastosowania |
WO2016087416A1 (fr) | 2014-12-03 | 2016-06-09 | F. Hoffmann-La Roche Ag | Anticorps multispécifiques |
EP3029068A1 (fr) | 2014-12-03 | 2016-06-08 | EngMab AG | Anticorps bispécifiques contre du CD3epsilon et BCMA pour utilisation dans le traitement de maladies |
SG10201914069SA (en) | 2015-05-18 | 2020-03-30 | Tcr2 Therapeutics Inc | Compositions and methods for tcr reprogramming using fusion proteins |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
EP3150636A1 (fr) * | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Anticorps multispécifiques tétravalents |
CN107849137B (zh) | 2015-10-02 | 2021-11-26 | 豪夫迈·罗氏有限公司 | 双特异性抗ceaxcd3 t细胞活化性抗原结合分子 |
PL3387015T3 (pl) | 2015-12-09 | 2022-02-14 | F. Hoffmann-La Roche Ag | Przeciwciało anty-CD20 typu II do ograniczania tworzenia przeciwciał przeciwlekowych |
ES2837428T3 (es) | 2016-01-08 | 2021-06-30 | Hoffmann La Roche | Procedimientos de tratamiento de cánceres positivos para CEA usando antagonistas de unión al eje PD-1 y anticuerpos biespecíficos anti-CEA/anti-CD3 |
MA44254A (fr) | 2016-02-17 | 2018-12-26 | Seattle Genetics Inc | Anticorps bcma et leur utilisation pour traiter le cancer et les troubles immunologiques |
ES2947230T3 (es) | 2016-03-22 | 2023-08-03 | Hoffmann La Roche | Moléculas biespecíficas para linfocitos T activadas por proteasa |
CN108884170A (zh) * | 2016-03-22 | 2018-11-23 | 豪夫迈·罗氏有限公司 | 蛋白酶活化的t细胞双特异性分子 |
US11242376B2 (en) | 2016-08-02 | 2022-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
PL3519437T3 (pl) | 2016-09-30 | 2022-01-17 | F. Hoffmann-La Roche Ag | Przeciwciała dwuswoiste przeciwko p95HER2 |
IL302917A (en) | 2016-10-07 | 2023-07-01 | Tcr2 Therapeutics Inc | Preparations and methods for reprogramming T-cell receptors using fusion proteins |
WO2018083204A1 (fr) * | 2016-11-02 | 2018-05-11 | Engmab Sàrl | Anticorps bispécifique contre bcma et cd3 et médicament immunologique pour une utilisation combinée dans le traitement du myélome multiple |
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IL293215A (en) | 2019-11-26 | 2022-07-01 | Novartis Ag | Chimeric antigen receptors that bind bcma and cd19 and their uses |
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2014
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MA39266A (fr) | 2016-02-10 |
SI2982694T1 (sl) | 2017-01-31 |
ME02533B (fr) | 2017-02-20 |
AU2015299101A1 (en) | 2017-02-16 |
AU2020273347A1 (en) | 2020-12-17 |
CY1118168T1 (el) | 2017-06-28 |
SMT201600392B (it) | 2017-01-10 |
JP6703520B2 (ja) | 2020-06-03 |
WO2016020332A1 (fr) | 2016-02-11 |
HK1218299A1 (zh) | 2017-02-10 |
AU2015299101B2 (en) | 2020-08-27 |
CA2955685A1 (fr) | 2016-02-11 |
JP2020122013A (ja) | 2020-08-13 |
NZ728534A (en) | 2023-12-22 |
SG11201700551TA (en) | 2017-02-27 |
US20170306036A1 (en) | 2017-10-26 |
EP2982692A1 (fr) | 2016-02-10 |
EP2982694A1 (fr) | 2016-02-10 |
HUE031076T2 (en) | 2017-06-28 |
HRP20161211T1 (hr) | 2016-11-18 |
JP2017532290A (ja) | 2017-11-02 |
PL2982694T3 (pl) | 2017-02-28 |
PT2982694T (pt) | 2016-09-29 |
US10253104B2 (en) | 2019-04-09 |
EP2982694B1 (fr) | 2016-06-22 |
LT2982694T (lt) | 2016-11-10 |
DK2982694T3 (en) | 2016-09-26 |
RS55410B1 (sr) | 2017-04-28 |
CA2955685C (fr) | 2023-09-19 |
ES2602051T3 (es) | 2017-02-17 |
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