WO2022135468A1 - Anticorps bispécifique anti-bcma×cd3 et son utilisation - Google Patents
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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Abstract
L'invention concerne un nouvel anticorps bispécifique qui se lie spécifiquement à BCMA et à CD3, un acide nucléique codant l'anticorps bispécifique anti-BCMA×CD3, un vecteur contenant l'acide nucléique, une cellule hôte contenant l'acide nucléique ou le vecteur, et une composition pharmaceutique contenant l'anticorps ou un fragment de liaison à l'antigène associé. De plus, l'invention concerne en outre l'utilisation de l'anticorps bispécifique anti-BCMA×CD3 et de la composition pharmaceutique en immunothérapie, et pour la prévention et/ou le diagnostic de maladies.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011538880.X | 2020-12-23 | ||
| CN202011538880 | 2020-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022135468A1 true WO2022135468A1 (fr) | 2022-06-30 |
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ID=82158829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2021/140450 WO2022135468A1 (fr) | 2020-12-23 | 2021-12-22 | Anticorps bispécifique anti-bcma×cd3 et son utilisation |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2022135468A1 (fr) |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014140248A1 (fr) * | 2013-03-15 | 2014-09-18 | Amgen Research (Munich) Gmbh | Molécules liantes pour bcma et cd3 |
| CN104114578A (zh) * | 2011-11-15 | 2014-10-22 | 安进研发（慕尼黑）股份有限公司 | Bcma和cd3的结合分子 |
| CN104968682A (zh) * | 2013-02-05 | 2015-10-07 | 英格玛布股份公司 | 针对CD3ε和BCMA的双特异性抗体 |
| WO2016020332A1 (fr) * | 2014-08-04 | 2016-02-11 | Engmab Ag | Anticorps bispécifiques anti cd3epsilon et bcma |
| WO2016079177A1 (fr) * | 2014-11-20 | 2016-05-26 | Engmab Ag | Anticorps bispécifiques anti-cd3epsilon et bcma |
| WO2018083204A1 (fr) * | 2016-11-02 | 2018-05-11 | Engmab Sàrl | Anticorps bispécifique contre bcma et cd3 et médicament immunologique pour une utilisation combinée dans le traitement du myélome multiple |
| CN108350076A (zh) * | 2015-08-17 | 2018-07-31 | 詹森药业有限公司 | 抗-bcma抗体，结合bcma和cd3的双特异性抗原结合分子及其用途 |
| CN108659112A (zh) * | 2017-03-30 | 2018-10-16 | 上海市同济医院 | 一种非对称双特异性抗体 |
| WO2019149250A1 (fr) * | 2018-02-01 | 2019-08-08 | 南京驯鹿医疗技术有限公司 | Récepteur antigénique chimérique (car) se liant à bcma et ses applications |
| WO2019149269A1 (fr) * | 2018-02-01 | 2019-08-08 | 信达生物制药(苏州)有限公司 | Fragment variable à chaîne unique anti-antigène de maturation des lymphocytes b (bcma) entièrement humain, et application associée |
| CN110229232A (zh) * | 2019-06-19 | 2019-09-13 | 北京智仁美博生物科技有限公司 | 双特异性抗体及其用途 |
| WO2019237081A1 (fr) * | 2018-06-07 | 2019-12-12 | Cullinan Management, Inc. | Protéines de liaison multi-spécifiques et procédés d'utilisation associés |
-
2021
- 2021-12-22 WO PCT/CN2021/140450 patent/WO2022135468A1/fr active Application Filing
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| CN104114578A (zh) * | 2011-11-15 | 2014-10-22 | 安进研发（慕尼黑）股份有限公司 | Bcma和cd3的结合分子 |
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| WO2014140248A1 (fr) * | 2013-03-15 | 2014-09-18 | Amgen Research (Munich) Gmbh | Molécules liantes pour bcma et cd3 |
| WO2016020332A1 (fr) * | 2014-08-04 | 2016-02-11 | Engmab Ag | Anticorps bispécifiques anti cd3epsilon et bcma |
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| WO2018083204A1 (fr) * | 2016-11-02 | 2018-05-11 | Engmab Sàrl | Anticorps bispécifique contre bcma et cd3 et médicament immunologique pour une utilisation combinée dans le traitement du myélome multiple |
| CN108659112A (zh) * | 2017-03-30 | 2018-10-16 | 上海市同济医院 | 一种非对称双特异性抗体 |
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| WO2019237081A1 (fr) * | 2018-06-07 | 2019-12-12 | Cullinan Management, Inc. | Protéines de liaison multi-spécifiques et procédés d'utilisation associés |
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