MA39254B2 - Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh - Google Patents

Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh

Info

Publication number
MA39254B2
MA39254B2 MA39254A MA39254A MA39254B2 MA 39254 B2 MA39254 B2 MA 39254B2 MA 39254 A MA39254 A MA 39254A MA 39254 A MA39254 A MA 39254A MA 39254 B2 MA39254 B2 MA 39254B2
Authority
MA
Morocco
Prior art keywords
aggregating
high affinity
vhh derivative
antibodies based
domains
Prior art date
Application number
MA39254A
Other languages
English (en)
Other versions
MA39254A1 (fr
Inventor
Andrey Borisovich Ulitin
Stanislav Rudolfovich Evdokimov
Valeriy Vladimirovich Soloviev
Yulia Sergeevna Chernyh
Olga Vladimirovna Goncharova
Dmitriy Valerievich Korzhavin
Tatyana Veniaminovna Chernovskaya
Timofey Aleksandrovich Nemankin
Roman Alexeevich Ivanov
Dmitriy Valentinovich Morozov
Victoria Mikhailovna Ekimova
Ekaterina Vladimirovna Sofronova
Yakov Yurevich Ustyugov
Original Assignee
Biocad Cjsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocad Cjsc filed Critical Biocad Cjsc
Publication of MA39254A1 publication Critical patent/MA39254A1/fr
Publication of MA39254B2 publication Critical patent/MA39254B2/fr

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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

L'invention concerne des anticorps monoclonaux de type igg comprenant des domaines sous forme d'une combinaison d'un dérivé de vhh avec un domaine variable de chaîne légère vl. Ces anticorps peuvent comprendre des substituants d'aminoacides aux positions 44 et/ou 45 (selon la numérotation de kabat) ou leurs combinaisons. Les anticorps de l'invention possèdent une plus grande affinité et une meilleure stabilité d'agrégation.
MA39254A 2014-09-26 2015-03-23 Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh MA39254B2 (fr)

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RU2014138740A RU2609627C2 (ru) 2014-09-26 2014-09-26 Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh
PCT/RU2015/000163 WO2016048188A1 (fr) 2014-09-26 2015-03-23 Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh

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RU2680011C2 (ru) * 2016-04-29 2019-02-14 Закрытое Акционерное Общество "Биокад" Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы
JP7122672B2 (ja) * 2018-06-08 2022-08-22 パナソニックＩｐマネジメント株式会社 Ｖｈｈ抗体
EP3689907A1 (fr) 2019-01-31 2020-08-05 Numab Therapeutics AG Anticorps dirigés contre il-17a et leurs procédés d'utilisation
CN113631574A (zh) 2019-01-31 2021-11-09 努玛治疗有限公司 对TNFα和IL-17A具有特异性的多特异性抗体、靶向IL-17A的抗体及其使用方法
RU2754760C2 (ru) * 2019-04-02 2021-09-07 Закрытое Акционерное Общество "Биокад" Водная фармацевтическая композиция анти-il17a антитела и ее применение
CN112239501B (zh) * 2020-10-29 2022-01-07 东莞市朋志生物科技有限公司 抗新型冠状病毒的抗体、检测新型冠状病毒试剂和试剂盒
CN114380917B (zh) * 2022-03-25 2022-06-14 南京融捷康生物科技有限公司 针对IL-17A和TNFα的双特异性单域抗体及其用途
CN114380906B (zh) * 2022-03-25 2022-06-14 南京融捷康生物科技有限公司 一种抗il-17a的单域抗体及其用途
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JP2005289809A (ja) * 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
GB0417487D0 (en) * 2004-08-05 2004-09-08 Novartis Ag Organic compound
FR2879605B1 (fr) * 2004-12-16 2008-10-17 Centre Nat Rech Scient Cnrse Production de formats d'anticorps et applications immunologiques de ces formats
US8211648B2 (en) * 2005-07-22 2012-07-03 Kalobios Pharmaceuticals, Inc. Secretion of antibodies without signal peptides from bacteria
CA2651567A1 (fr) * 2006-05-09 2007-11-22 Genentech, Inc. Polypeptides de liaison a squelettes optimises
AU2008328781A1 (en) * 2007-11-27 2009-06-04 Ablynx N.V. Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
KR101710472B1 (ko) * 2007-11-30 2017-02-27 글락소 그룹 리미티드 항원-결합 작제물
DK2217268T3 (en) * 2007-12-07 2016-08-15 Zymogenetics Inc MONOCLONAL ANTI-HUMAN IL-21 ANTIBODIES
GB2461546B (en) 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
WO2010130832A2 (fr) * 2009-05-15 2010-11-18 Ablynx N.V. Séquences d'acides aminés dirigées contre dickkopf-1 et polypeptides comprenant ces dernières pour le traitement de maladies et de pathologies associées à la déperdition osseuse et/ou à l'ostéolyse
AU2012245073B2 (en) * 2011-04-21 2016-02-11 Garvan Institute Of Medical Research Modified variable domain molecules and methods for producing and using them b
UA117218C2 (uk) * 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
US10946104B2 (en) * 2012-01-13 2021-03-16 Apo-Tb.V. Aberrant cell-restricted immunoglobulins provided with a toxic moiety
GEP201706773B (en) * 2012-02-27 2017-11-27 Boehringer Ingelheim Int Cx3cr1-binding polypeptides
CN105190314A (zh) * 2013-01-21 2015-12-23 阿布维公司 用于炎性疾病的抗-tnf和抗-il17联合疗法生物标志物

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BR112016015867A2 (pt) 2018-06-05
JP2021072810A (ja) 2021-05-13
RU2014138740A (ru) 2016-04-20
WO2016048188A8 (fr) 2016-09-22
KR102600823B1 (ko) 2023-11-10
EA201600277A1 (ru) 2017-08-31
MX2016012769A (es) 2017-05-11
RU2609627C2 (ru) 2017-02-02
EP3199550A4 (fr) 2018-09-26
UY36319A (es) 2016-04-29
IL244762B1 (en) 2024-07-01
WO2016048188A1 (fr) 2016-03-31
US20200031952A1 (en) 2020-01-30
IL244762A0 (en) 2016-07-31
AR101984A1 (es) 2017-01-25
CN107001458A (zh) 2017-08-01
CA2941656A1 (fr) 2016-03-31
AU2015322141A1 (en) 2016-09-29
TWI585104B (zh) 2017-06-01
AU2015322141B2 (en) 2018-12-20
MA39254A1 (fr) 2018-05-31
MY192853A (en) 2022-09-13
CN107001458B (zh) 2022-02-18
EP3199550A1 (fr) 2017-08-02
SG11201607283RA (en) 2017-04-27
NZ724306A (en) 2018-10-26
UA125111C2 (uk) 2022-01-12
US10442869B2 (en) 2019-10-15
US20170066843A1 (en) 2017-03-09
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